Indian Journal of Forensic Medicine & Toxicology
Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology

A Woman with Tuberculosis Multidrug Resistance and QTc Prolongation Repetitive Interval: A Case Report

Tutik Kusmiati (Unknown)
Ni Made Mertaniasih (Unknown)
Johanes Nugroho Eko Putranto (Unknown)
Budi Suprapti (Unknown)
Soedarsono (Unknown)
Abdul Rahman Bahmid (Unknown)



Article Info

Publish Date
16 Aug 2021

Abstract

Background : Prolonged QTc interval is one of the side effects of the short-regimen MDR-TB. QTcprolongation is a risk factor for Torsades de pointes and is influenced by many factors. Case : 47-year-oldwoman who was diagnosed with MDR-TB through GeneXpert examination and received short-regimenMDR-TB. This patient experienced repeated QTc prolongation, with peak QTc interval 600 msec occurringat 4th month with mild hypokalemia without clinical symptoms. The patient completed 9 months of shortregimentherapy with improve chest x ray followed by negative sputum culture. Conclusion : Short-regimenMDR-TB contains several drugs that cause QTc prolongation. Clinical evaluation is required in patientswith QTc prolongation before changing the regiment.

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