Microbiology Indonesia
Vol. 13 No. 2 (2019): June 2019

Polyoxygenated Diterpene Produced by The Indonesian Marine Sponge Callyspongiasp. as an Inhibitor of the Human Pancreatic Cancer Cells

VIQQI KURNIANDA (Unknown)
SUCI FARADILLA (Unknown)
SOFYATUDDIN KARINA (Unknown)
SRI AGUSTINA (Unknown)
MARIA ULFAH (Unknown)
CHITRA OCTAVINA (Unknown)
FARAH SYAHLIZA (Unknown)
MUHAMMAD RIZKI RAMADHAN (Unknown)
SYAHRUL PURNAWAN (Unknown)
MUSRI MUSMAN (Unknown)

Article Info

Publish Date
16 Jan 2020

Abstract

The bioactive compound from the Indonesian Marine SpongeCallyspongia sp.isolated based on bioassay-guided separation with several steps of chromatography has been done. There are 4 major compound known as isocopalane diterpene derivatives together with a plausible new compound, isocopalanol, a polyoxygenated isocopalane diterpene. Isocopalanol has molecular weight [M+H]+ 412.576 m/z indicate that the compound has molecular formula C24H44O5 determined by LCMS-ESI. This compound has bioactivity IC50 = 0.1 μg / mL against human pancreatic cancer cell. 

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Journal Info
Microbiology Indonesia
Website

Abbrev

mionline

Publisher

Perhimpunan Mikrobiologi Indonesia

Subject

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology

Description

Microbiology Indonesia provides a unique venue for publishing original researches in microbiology (espesially from Indonesian reseachers), and ensures that authors could reach the widest possible audience. Microbiology Indonesia publishes a wide range of research disciplines on bacteria, archaea, ...