Pharmaceutical Sciences and Research (PSR)
Vol. 4, No. 3

Identifikasi Interaksi Kimia Fisika Pada Kombinasi Antibiotika Amoksisilina Trihidrat - Kalium Klavulanat Dengan Kalorimeter Larutan Dan Rekristalisasi

Nugrahani, Ilma (Unknown)
Asyarie, Sukmadjaja (Unknown)
N.S, Sundani (Unknown)
Ibrahim, Slamet (Unknown)

Article Info

Publish Date
30 Dec 2007

Abstract

Physico-chemical interaction of amoxicillin trihydrate - potassium clavulanate has been investigated. The method used in this experiment was solution calorimeter analysis that was collaborated by the re-crystallization observation. Amoxicillin-clavulanate were mixed on the variety ratios (0:10; 9:1; ...; 1:9; 0:10) and analyzed by solution calorimeter in the HCl 0,1 N and phosphate buffer pH 6,8 solution as the gastrointestinal liquids. After that, the re-crystallizations of amoxicillin-clavulanate on the variety ratios were analyzed by polarization microscope and digital camera. The results of observation showed that amoxicillin-clavulanate have the physical-chemical interactions in the ratios 3:7; 5:5; 7:3 respectively in both of pH models of gastrointestinal liquids.

Copyrights © 2007




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Journal Info
Pharmaceutical Sciences and Research (PSR)
Website

Abbrev

publication:psr

Publisher

Universitas Indonesia

Subject

Description

Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products ...