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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
Core Subject :
Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
Arjuna Subject : -
Articles 319 Documents
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Pendekatan Farmakogenomik Dalam Pengembangan Obat Baru Radji, Maksum
Majalah Ilmu Kefarmasian Vol. 2, No. 1
Publisher : UI Scholars Hub

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Abstract

The human population is heterogeneous and consists of populations of immense ethnic diversity. There are considerable allelic differences between human popula-tions as well as individuals within each ethnic group as a result of molecular hetero-geneity of the genome. This, in turn, is responsible for differential allelic expression of genes endowing them with polymorphic characters. The molecular diversity within genes is responsible amongst others, of disease resistance or susceptibility or for that matter drug response. Pharmacogenomics is the key to the understanding of differ-ential drug response in different patients in relation to genetic constitution. The revelation of such information at the molecular level would assist the pharmaceuti-cal industry to address a therapy directed to each individual. The objective of this article is to understand the nuances of the genetic repertoire and correlate it with disease gene identification, genes that have been or can be used as drug targets, identify candidate genes for drug development and recent trends in drug discovery.
Kepuasan Pasien Terhadap Pelayanan Resep Di Apotek KOPKAR Rumah Sakit Budhi Asih Jakarta Harianto, Harianto; Khasanah, Nana; Supardi, Sudibyo
Majalah Ilmu Kefarmasian Vol. 2, No. 1
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Abstract

The pharmaceutical services at a dispensary are prescription dispensing, self-medication and drug information. Patient's satisfaction is an essential factor in improving medicines sale at dispensary. The objective of survey is to know the patient's satisfaction who get the prescription service at Kopkar dispensary. Cross sectional study is conducted by collecting data from 100 adult patients who get the prescription service at Kopkar dispensary on November 2003 by questioner. Respondent are selected by the systematic random sampling. Data were analyzed by comparing between the perception of reality service and the perception of need service using correlation index. The result of this study are: (1) The patients have high satisfaction to the empathy and the cleaning waiting room, (2) The patients have moderate satisfaction to the drug service, the cashier service, the drug information, the drug completed, the drug price, the desk in waiting room, the fan and air conditioning service, and (3) the patients have low satisfaction to the television service.
Isolasi dan Elusidasi Struktur Senyawa Flavonoida Dari Crotalaria anagyroides Munim, Abdul
Majalah Ilmu Kefarmasian Vol. 2, No. 1
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Abstract

Four flavonoid glycosides have been isolated from the leaves of Crotalaria anagyroides. The glycosides are 1) apigenin 7-O-β-D-apiofuranosyl (1!6)-β-glucopyranosida, 2) apigenin 7-O-β-D-apiofuranosyl (1!2)-β-glucopyranoside, 3) chrysoeriol 7-O-β-D-apiofuranosyl (1!6)-β-D-glucopyranoside, 4) chrysoeriol 7-O-β-D-apiofuranosil (1!2)-β-D-glucopyranoside. Their structures were elucidated by spectroscopic methods of UV, 1H, 13C and 2D-NMR DEPT, COSY and HMBC experiments.
Pengaruh Polivinil Pirolidon Terhadap Laju Disolusi Furosemid Dalam Sistem Dispersi Padat Sutriyo, Sutriyo; Dewi, Rosmala; Filosane, Febrian Hevike
Majalah Ilmu Kefarmasian Vol. 2, No. 1
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Abstract

The research to accelerate furosemide dissolution rate has been done through physical property modification by solid dispersion forming polyvinylpyrolidone (PVP) carrier with solvent method. Pure furosemide posses property of being practically insoluble in water and has low bioavailability. In current research, six weight ratio of furosemide to PVP being used are 1:1; 1:3; 1:5; 1:9 and 1:15. Physical mixtures are made in equivalent weight ratio. The dissolution rate was examined by paddle method in phosphat buffer pH 5,8. Solid dispersion caracterised with in vitro dissolution study, X-ray diffraction, infra red spectrophotometer and differential scanning calorimetric. The result shows that solid dispersion of furosemide with PVP carrier is higher compare to physical mixture dissolution rate and pure furosemide. The ratio furosemide to PVP who has the highest dissolution rate is 1:15. The analyzing shows the existing of altering crystalline to amorphous state.
Biaya Tambahan Yang Dibayar Pasien Rawat Jalan Akibat Penulisan Resep Tidak Sesuai Dengan Formularium Rumah Sakit Supardi, Sudibyo; Azis, Sriana; Herman, MJ.; Jamal, Sarjaini; Mun'im, Abdul; Raharni, Raharni
Majalah Ilmu Kefarmasian
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Abstract

Almost all district public hospital already has their own formulary. The aims of study are to obtain percentage of noncompliance with the public hospital formulary, to obtain the average additional cost be paid by outpatients as a result of noncompliance with the hospital formulary, and to obtain the average of the outpatient's ability to pay for treatment. A cross sectional study has been carried out to 120 patients in RSU Kabupaten K and 100 patients in RSU Kabupaten B. Subjects of the study were adult outpatients with TB, hypertension and diabetes. Data were collected by well-trained district public hospital staff in interviewing patients. The questioner was first tried out to patients at RSU Kota Jakarta Timur. Data were analyzed by cost analysis. Results of the study are difference in drug item with formulary in RSU Kabupaten K is 66,7% for TB, 96,6% for hypertension; where as in RSU Kabupaten B 44,8% for TB, 82,3% for hypertension and 76,7% for diabetes. Average additional cost that must be paid by outpatients per encounter in RSU Kabupaten K is Rp 10.060 for TB, Rp 26.552 for hypertension; while in RSU Kabupaten B is Rp 5.818 for TB, Rp 8.956 for hypertension and Rp 15.218 for diabetes. The average outpatient's ability to pay for treatment in RSU Kabupaten K is Rp 19.807 and in RSU Kabupaten B is Rp 15.301, which are both less than outpatient treatment cost per encounter.
RNA Therapeutic, Pendekatan Baru Dalam Terapi Gen Malik, Amarila
Majalah Ilmu Kefarmasian Vol. 2, No. 2
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Abstract

Some diseases, such as cancer, hereditary and genetic diseases, as well as viral infectious diseases, have been treated unsatisfied by the conventional therapy so far, and even more, by the gene therapy. Together with the pharmaceutical industries, researchers put their best effort to hunt some molecules that can be more favorable for such kind of therapy. After a pivotal study reported in May, 2001, it is certain that Ribonucleic acid (RNA) could effectively silence gene expression in mammalian cell line, so it was then proposed in 2004 the term RNA therapeutics. Antisense RNA therapy which came into the stage earlier seemed to be the one that can answer all the problems in knocking out the unwanted messenger in gene expression. RNA interference (RNAi) concept, which came later in around 2000, began to look like a possible contender. It was reported in some studies that RNAi seems to have some more advantages over both stronger gene-silencing effects and greater ease of use. However, the main obstacle of all kind of gene therapy is, undoubtedly, on the delivery of this molecule to enter the target cell, and mostly, to where it is needed most inside the body. Some studies on genetic material delivery system have been reported, and their progress has been discussed.
Kemampuan Petugas Menggunakan Pedoman Evaluasi Pengelolaan Dan Pembiayaan Obat Azis, Sriana; Hherman, M; Mun'im, Abdul
Majalah Ilmu Kefarmasian Vol. 2, No. 2
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Abstract

One important aspect of district public health service is the management and budgeting of drugs. Up to this time no indicators can be used yet as guidelines for evaluating drug management and budgeting effectiveness in a district in Indonesia. The objective of this study is to determine the effect of training managing drug staff on the evaluation capability increase and their knowledge. Training has been conducted twice in 2 provinces, 4 districts ex HP IV each, covering Dinas Kesehatan, GFK, 5 PHCs per district and 300 outpatients. There are 7 groups of indicator which include a total of 29 indicators. Training involved computation of indicators of drug management and budgeting in a district. Tests were carried out before training and after the first and second training. Data were analyzed using paired t-test for the effect of training on the increase of knowledge and capability of managing drug staff in indicator computation for the evaluation of drug management and budgeting as well as linear regression for the relation between education and working experience of the staff and unpaired t-test for the difference in the increase in knowledge of pharmacy assistant and non pharmacy assistant. Results from the study on 54 managing drug staff in 8 district shows that knowledge increase significantly after the first and second training, whilst the latter increase is greater than the former one and that the increase in knowledge of pharmacy assistant exceeds that of non pharmacy assistant.
Pengaruh Pemberian Ekstrak Biji Klabet (Trigonella foenum-graecum L.) Terhadap Kadar Hormon Estradiol Dan FSH Plasma Tikus Putih Betina Galur Wistar Prepubertal Agustini, Kurnia; Wiryowidagdo, Sumali; Kusmana, Dadang
Majalah Ilmu Kefarmasian
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Abstract

Biji Klabet or Fenugreek (Trigonella foenum-graecum L.) contains steroidal sapogenins such as diosgenin, tigogenin, gitogenin, yamogenin and trigoneoside, that are suspected having an estrogen-like effect or as phytoestrogen. The objective of this study was to evaluate the estrogen-like effect of biji klabet alcohol extracts. This research used immature Wistar female rats, age of 19 days, which were represent the climacteric/menopause phase. The testing animals were divided into five groups, namely normal group, estradiol control group and three level dose groups of fenugreek extract (30 mg/200 gBW; 60 mg/200 gBW and 120 mg/200 gBW). The result showed that on 120 mg/200 gBW fenugreek extract significantly (a=0.05) increased estradiol and FSH level on immature rat. Analysis of vaginal smear showed vaginal lubrication effect, surprisingly on 120 mg/200 gBW could induce estrous cycle.
Risiko Penggunaan Pil Kontrasepsi Kombinasi Terhadap Kejadian Kanker Payudara Pada Reseptor KB Di Perjan RS Dr. Cipto Mangunkusumo Harianto, Harianto; Mutiara, Rina; Surachmat, Hery
Majalah Ilmu Kefarmasian Vol. 2, No. 2
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Abstract

World Health Organization (WHO) state that breast cancer is second cause of death among other cancer illness. Up to now, what become a major factor that caused the breast cancer has known yet, but it was believed that the relation of some factors can improve the risk of breast cancer. Breast cancer is believed happened because of a complicated interaction between many factors like genetic, environment and hormonal, which one of them is abundant estrogen hormone rate in womenÂ’s body. This research is aim to know the risk level that caused by the use of combination contraception pills, which is combination of estrogen and progesterone with the breast cancer risk. The research use case control method in hospital based with period of September-Desember 2004 at Perjan RS Dr. Cipto Mangunkusumo. The research results show that the user of combination contraception pills has the risk to have breast cancer 1,864 times bigger compare with them who doesnÂ’t take that pills. However, the combination contraception pills is not the major risk factor but itÂ’s only a light factor to increase the risk of breast cancer.
Karakterisik Granul Dan Tablet Propranolol Hidroklorida Dengan Metode Granulasi Peleburan Nugrahani, Ilma; Rahmat, Hasan; Djajadisastra, Joshita
Majalah Ilmu Kefarmasian
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Abstract

The effect of carnauba wax consentration to pharmacotechnical characteristics on the granules and tablets that made by hot melt granulation method have been studied. Fomula I? V with composition : 10, 20, 30, 40, and 50% w/w carnauba wax, propranolol hydrochloride 60 mg/tablet, and lactose to the 340 mg was mixed and melted, and than sieved to the mesh 16 siever. The granules were evaluated and lubricated by 1% magnesium stearat and 2% talcum. Then it were compressed into tablet which each weight was 350 mg and the tablets were evaluated. The results showed that hot melt granulatin form granules and tablets that acceptable pharmacotechnical properties.

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