Jurnal Kedokteran Hewan
Vol 14, No 3 (2020): September

POTENTIAL ANTIVIRAL OF CATECHINS AND THEIR DERIVATIVES TO INHIBIT SARS-COV-2 RECEPTORS OF M pro PROTEIN AND SPIKE GLYCOPROTEIN IN COVID-19 THROUGH THE IN SILICO APPROACH

Frengki Frengki (Faculty of Veterinary Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia)
Deddi Prima Putra (Faculty of Pharmacy, Andalas University, Padang, West Sumatra, Indonesia)
Fatma Sri Wahyuni (Faculty of Pharmacy, Andalas University, Padang, West Sumatra, Indonesia)
Daan Khambri (Faculty of Medicine, Andalas University, Padang, West Sumatra, Indonesia)
Henni Vanda (Faculty of Veterinary Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia)
Vivi Sofia (Faculty of Pharmacy, Ahmad Dahlan University, Yogyakarta, Indonesia)

Article Info

Publish Date
19 Sep 2020

Abstract

Catechin and their derivatives have been studied to have antiviral potential against COVID-19 through in silico method “pharmacokinetics screening and molecular docking”. Pharmacokinetics and toxicity profiles were obtained through the ADMETSAR server and SwissADME server. Then proceed with the prediction of affinity through the method molecular docking using the software application MOE 2007.09. The testmaterial is in the form of a 3D catechin structure and its derivatives as well as several control ligands downloaded via Pubmed. While templatethe Receptor M pro protein and the Spike glycoprotein are downloaded from pdb.org (PDB ID: 6LU7 and 6LXT). The pharmacokinetic profile of catechins is relatively better than all control ligands with the lowest toxicity. Molecular docking results also show that catechins and theirderivatives have a stronger affinity than control ligands. This research proves that catechin has antiviral potential through inhibition of Mpro protein and Spike glycoprotein COVID-19 virus.

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Journal Info
Jurnal Kedokteran Hewan
Website

Abbrev

JKH

Publisher

Universitas Syiah Kuala

Subject

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Veterinary

Description

Jurnal Kedokteran Hewan (J. Kedokt. Hewan), or Indonesian Journal of Veterinary Sciences is a scientific journal field of veterinary sciences published since 2007, published FOUR times a year in March, June, September, and December by Universitas Syiah Kuala (Syiah Kuala University) and Indonesian ...