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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Kesehatan Andalas Jurnal Sains dan Teknologi Farmasi Biomedical Journal of Indonesia Jurnal Fitofarmaka Indonesia JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Endurance: Kajian Ilmiah Problema Kesehatan JURNAL KESEHATAN PERINTIS Acta Biochimica Indonesiana Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Andalas obstetrics and gynecology journal Science Midwifery Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia Indonesian Journal of Cancer Jurnal Kedokteran Hewan

Daan Khambri

Fakultas Kedokteran, Universitas Andalas

Author-ID : 3367697

Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Penggunaan Obat Alternatif dan Komplementer Pada Pasien Kanker Payudara di Suatu Rumah Sakit Pemerintah di Kota Padang, Indonesia: Pengaruh Sosiodemografi Almasdy, Dedy; Septiyeni, Elsa; Khambri, Daan; Kurniasih, Nina
Jurnal Sains dan Teknologi Farmasi Vol 19 No Supl1 (2017): Vol 19 Supplement 1, December 2017
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar

Prevalensi penggunaan terapi alternatif komplementer (complementary alternative medicine / CAM) pada penderita kanker, khususnya pada penderita kanker payudara cukup tinggi. Tujuan dari penelitian ini adalah untuk mengetahui penggunaan CAM pada penderita kanker payudara pada suatu rumah sakit pemerintah di Kota Padang, Indonesia. Penelitian ini adalah penelitian potong lintang dengan pendekatan wawancara terstruktur. Responden penelitian ini adalah pasien yang didiagnosa sebagai penderita kanker payudara, sedangkan analisis dilakukan analisa secara deskriptif-analitik. 85 orang total responden dalam penelitian ini menunjukkan 9.41% (n=8) tidak pernah menggunakan CAM, 25.88% (n=22) telah menghentikan penggunaan CAM dan 64.71% (n=55) menggunakan CAM setidaknya satu jenis. Responden yang menggunakan CAM paling banyak pada tingkat pendidikan SMA, usia lansia akhir (56-65 tahun), bekerja sebagai ibu rumah tangga dan berpenghasilan kecil dari Rp 2.500.000,-. Tidak ada perbedaan yang signifikan antara penggunaan CAM dengan umur, pendidikan, pekerjaan dan pendapatan responden.

Faktor-Faktor Yang Mempengaruhi Kualitas Hidup Penderita Kanker Payudara Di Kota Padang Anggraini, Dessy; Semiarty, Rima; Rasyid, Rosfita; Khambri, Daan
Jurnal Endurance Vol 3, No 3 (2018): Jurnal Endurance: Kajian Ilmiah Problema Kesehatan
Publisher : Lembaga Layanan Pendidikan Tinggi (LLDIKTI) Wilayah X

Breast cancer is known as carsinoma mammae that malignant tumor growing in breast tissue. Patient of breast cancer will being have in the change of body shape, psychology (such as depression and anxiety level), socializing, sexual and daily activities. That is will affected to quality of life of patients (QOL). This study aims to determine the factors that affect the quality of life of breast cancer patients in the city of Padang West Sumatra. This research uses analytics design with cross sectional approach. The number of samples are 34 patients with total sampling technique which adjusted to inclusion and exclusion criteria. Data processing use univariat and bivariat method. The result showed that responden characteristic of breast cancer in padang city has average ages around 52,58±10,323 years old with the oldest is 74 years old and the youngest is 33 years old. The average height of respondents 153,77±5,346cm, the level of education is SMA and University (38,5%), the respondents’ job of this research are mostly unemployment (65,4%), the most stadium level is II and III which is 12 people each other (46,2%). Overall the quality of life of breast cancer sufferer in padang city from 2014-2017 was mostly excellent (15.4%), good (46.2%), moderately good (42.3%) and moderate (7.7% ). However, the symptoms was complained by the respondents are fatique (38,9%) and nausea (80,8%). It can be concluded that age, job, education level, bodymass index and stadium are not related to quality of life of breast cancer respondents in Padang city of West Sumatra. Kanker payudara disebut juga carcinoma mammae yaitu tumor ganas yang tumbuh pada jaringan payudara. Penderita kanker payudara akan mengalami perubahan fisik, psikologis (seperti tingkat depresi dan kecemasan), fungsi sosial, seksual serta aktifitas sehari-hari. Hal ini akan berpengaruh terhadap kualitas hidup atau quality of life (QOL) penderita. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berpengaruh terhadap kualitas hidup penderita kanker payudara di Kota Padang Sumatera Barat. Penelitian ini menggunakan desain analitik dengan pendekatan cross sectional. Sampel berjumlah 34 penderita, dengan teknik pengambilan sampel menggunakan total sampling yang disesuaikan dengan kriteria inklusi dan ekslusi. Pengolahan data menggunakan analisis univariat dan bivariat. Hasil penelitian menunjukkan bahwa karakteristik responden kanker payudara di kota Padang rerata umur responden adalah 52,50±10,332 tahun dengan usia tertua 74 tahun dan termuda 33 tahun. Tinggi badan responden penelitian rerata adalah 153,77±5,346cm. Tingkat pendidikan responden adalah SMA dan Perguruan Tinggi masing-masing 10 orang (38,5%). Pekerjaan responden penelitian ini adalah tidak bekerja 17 orang (65,4%), tingkat stadium terbanyak adalah stadium II dan III yaitu masing-masing 12 orang (46,2%). Kualitas hidup keseluruhan penderita kanker payudara di Kota Padang tahun 2014-2017 sebagian besar masuk dalam skala sangat baik (15,4%), baik (46,2%), agak baik (42,3%) dan sedang (7,7%). Namun gejala yang dikeluhkan responden adalah fatique sering pada 10 orang (38,9%), dan nause selalu pada 21 orang (80,8%). Dapat disimpulkan bahwa umur , pekerjaan, tingkat pendidikan, indeks masa tubuh dan stadium berpengaruh terhadap kualitas hidup responden kanker kanker payudara di Kota Padang Sumatera Barat.

Factors Related to Patient Satisfaction Level of Thyroid Tumor on Post- Operative Thyroidectomy Scar Based on Patient Scar Assessment Scale (PSAS) in General Hospital Dr. M. Djamil Padang Heryadi, Defri; Daan Khambri; Rony Rustam
Biomedical Journal of Indonesia Vol. 7 No. 1 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i1.277

A B S T R A C TIntroduction : Dr. M. Djamil Padang General Hospital (RSUP) still appliesconventional methods as thyroidectomy treatment. Satisfaction and comfort to thescar is one of the issues because conventional thyroidectomy surgery scars arelocated in the neck area that will affect the confidence of patients, especially women.Method: This research was a quantitative research using cross sectional studydesign. The research was conducted at The Oncology Surgery Polyclinic of RSUPDr.M. Djamil Padang with a sample of 50 respondents. Result: More than half ofthyroid tumor patients found were women (56%), most patients had totalthyroidectomy surgery (70%) with malignan tumor type (72%), and the most tumorsize in the T4 group (52%). The average age of patients during surgery was 54.26years. The average patient satisfaction score for post-thyroidectomy scars was 14.72with a total score of 16, the lowest score was 6 and the highest score was 22.Significant relationships were found in variable tumor size (p= 0.000), type of surgery(p= 0.005), tumor type (p=0.004) and gender (p = 0.028), while there was nostatistically significant relationship between age and patient satisfaction with post-thyroidectomy scars (p=0,176). Conclusion: There were significant relationshipsbetween gender, type of surgery, type of tumor, tumor size to patient satisfactionwith post-thyroidectomy scars, while age has no signifacnt relationship to patientsatisfaction with post-thyroidectomy scars. A small number of PSAS score showedthat the average patient was satisfied with post-thyroidectomy scar.

Glandula Tiroid Problem: Literature Review Abdul Hafiz, Muhammad Zaki; Daan khambri
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.295

Thyroid cancer is the most common endocrine system neoplasm.Based on the "Pathologycal Based Registration" in Indonesia, thyroidcancer is a cancer with the highest incidence in the ninth rank.According to statistics from the National Cancer Institute (NCI), theincidence of thyroid cancer in men is about 2.5 per 100.000population and women around 6.7 per 100.000 population. Thyroidcancer can affect all age groups and the frequency increases afterthe age of 50 years. Only about 5% can affect the age of 15-20 years.NCI also states that this thyroid cancer can affect 16.000 people peryear. Diagnosis is important to improve the quality of life forsufferers. Clinical diagnosis is the basis for determining furthermanagement, so that knowledge and skills are needed indetermining the diagnosis. The first treatment for a cancer is thebest chance for the patient to achieve optimal cure rates, as is thecase for thyroid cancer.

Giant Lipoma of The Breast: Special Clinical Finding Abdul Hafiz, Muhammad Zaki; Daan khambri; Anandia Putriyuni
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.296

Lipomas are the most common benign tumors of mesenchymal origin.Lipoma of breast is somewhat difficult to diagnose clinically because of fattyconsistency of breast. Giant lipoma is the mass of lipoma that exceeds atleast 10 cm in one dimension or weighs a minimum of 1000 gr.Only veryfew case reports giant lipoma of the breast available in literature becauserarity in size and location. Due to the fatty composition of the breast,difficulties in diagnosis, threatment, and reconstruction are oftenencountered.Presently, we have reported a case of this rare entity in 49years old female with giant tumor of the left breast that most of its mass,causing breast asymmetry and feel heavy. The operative finding: looks likelipoma between pectoralis major muscle and pectoralis minor muscle witha diameter of 31 cm and weighs 3.1 kg. After excision the tumor we need tomammoplasty.Pathology anatomy examination showed a lipoma.

Metilasi Promoter Gen BRCA1 dan Pengaruhnya terhadap Karakteristik Kanker Payudara Premenopausal Sporadik Etnis Minang Harahap, Wirsma Arif; Khambri, Daan; Arisanty, Dessy; -, Yanwirasti; Mubarika, Sofia
Cermin Dunia Kedokteran Vol 42, No 3 (2015): Nyeri
Publisher : PT. Kalbe Farma Tbk.

Karsinoma payudara sporadik merupakan kanker yang paling sering pada wanita premenopause etnis Minang. Terdapat perbedaan faktor risiko dan karakteristik tumor jika dibandingkan dengan pasien Kaukasian. Diduga faktor metilasi pada promoter BRCA1 berperan dalam kejadian ini. Penelitian ini bertujuan untuk mendeskripsikan kejadian metilasi promoter gen BRCA1 pada pasien kanker payudara premenopause sporadik etnis Minang. Penelitian menggunakan metoda deskriptif analitik pemeriksaan metilasi dengan teknik Bisulfit PCR pada promoter gen BRCA1 pada 43 jaringan kanker payudara sporadik usia premenopause etnis Minang yang diobati di RS M Jamil Padang. Faktor prognosis yang diperiksa adalah stadium, gradasi tumor, indeks mitosis, dan pemeriksaan imunohistokimia (Er,Pr,HER2,Ki67). Didapatkan 35 pasien kanker payudara yang memenuhi syarat, dengan perincian: 17,2% stadium II, 71,4% stadium III, dan 11,4% stadium IV. Subtipe adalah Luminal A 16 orang (17,1%), Luminal B 9 orang (25,7 %), HER2 3 orang (8,6%) dan TNBC 17 orang (48,6%). Metilasi pada jaringan kanker didapatkan pada 21 pasien (60 %). Metilasi berhubungan dengan derajat proliferasi tinggi (Ki67 >14%), stadium lanjut, dan subtipe jenis TNBC. Kanker payudara dengan metilasi pada promoter gen BRCA1 memiliki prognosis lebih buruk. Perlu penelitian lebih lanjut untuk melihat dampak klinis obat anti-metilasi pada penderita KPD dengan metilasi pada promoter BRCA1.Â Sporadic breast carcinoma is the most common cancer among premenopausal Minang ethnic women. There are differences of risk factors and tumor characteristics compared with Caucasian patients. It was assumed that promoter methylation in BRCA1 plays a role in this differences. This descriptive analytic study aimed to describe the incidence of promoter methylation in the BRCA1 gene in sporadic premenopausal ethnic Minang breast cancer patients. This research used methylation with bisulfate PCR technique method in the BRCA1 promoter in 43 sporadic premenopausal ethnic Minang breast cancer patients at M Djamil Hospital Padang. Stage, tumor grading, mitotic index, and immunohistochemical examination (Er, Pr, HER2, Ki67) are examined prognostic factor. Among eligible 35 breast cancer patients, 17.2% are stage II, 71.4% are stage III and 11.4% are stage IV. Cancer subtypes were Luminal A in 16 patients (17.1%), Luminal B in 9 patients (25.7%), HER2 in 3 patients (8.6%), and TNBCin 17 patients (48.6%). Methylation in cancer tissue was found in 21 patients (60%). Methylation associated with a high degree of proliferation (Ki67>14%), advanced stage and type of TNBC subtypes. Breast cancer with promoter methylation in the BRCA1 gene have a worse prognosis. Further research is needed to study the clinical impact of antimethylation in breast cancer patients with BRCA1 promoter methylation.

Rekonstruksi Pectoralis Major Myocutaneuos Flap untuk Defek Operasi Kanker Tiroid ., Oktahermoniza; Suyuthie, Heldrian Dwinanda; Oktavenra, Ari; Nora, Sondang; Khambri, Daan; Harahap, Wirsma Arif; Rustam, Rony; ., Azamris
Cermin Dunia Kedokteran Vol 49, No 1 (2022): Bedah
Publisher : PT. Kalbe Farma Tbk.

Latar Belakang: Pembedahan kanker daerah kepala dan leher umumnya menimbulkan defek luas dan biasanya memerlukan flap. Meskipun free flap saat ini merupakan gold standard untuk rekonstruksi daerah kepala leher, pectoralis major myocutaneous flap (PMMC) masih digunakan. Kasus: Perempuan usia 47 tahun, dengan kanker tiroid papiler T4aN0M0 dengan ulserasi di kulit leher, menjalani tiroidektomi total dan defek operasi direkonstruksi dengan pectoralis major myocutaneous flap. Hasil rekonstruksi dapat diterima secara fungsional dan estetik. Tidak ada komplikasi hematom ataupun abses post operasi. Simpulan: Pectoralis major myocutaneous flap masih merupakan salah satu metode utama untuk rekonstruksi operasi kepala leher dan dapat diterima secara fungsional dan estetik jika free flap tidak dapat dilakukan.Â Background: Surgery for head and neck cancer generally leaves a wide defect that usually needed a flap. Although free flap is currently the gold standard for reconstruction of the head and neck, the pectoralis major myocutaneous flap is still popularly used. Case: A 47-year old female with thyroid carcinoma, underwent total thyroidectomy and the surgical defect was reconstructed with pectoralis major myocutaneous flap. The results were viable, functional, and aesthetically acceptable. No postoperative complications such as hematoma or abscess observed. Conclusion: Pectoralis major myocutaneous flap was still one of the main methods for head and neck reconstruction surgery.Â

UJI IN VITRO DAN IN SILICO SENYAWA 5,7,2’,5’-TETRAHYDROXY FLAVAN-3-OL TERHADAP ENZIM ALPHA GLUCOSIDASE Frengki Frengki; Deddi Prima; Fatma Sri Wahyuni; Daan Khambri; Henny Vanda; Noni Zakiah; Jamilah Abbas; Berna Elya
Jurnal Fitofarmaka Indonesia Vol 5, No 2 (2018): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Several of Calophyllums genus have been searched and proven as medicinal plants and Calophyllum macrophyllum is one of its genus. We have been isolated a compound from ethyl acetate fraction of the stem-bark. The compound was flavan-3-ol (5,7,2’,5’-tetrahydroxy flavan-3-ol). This research aimed to determine inhibition antidiabetic activity and affinity of its compound on α-glycosidase enzyme. In vitro antidiabetic effect shown by IC50 9.10 µg/ml and docking by Arguslab 4.01 shown by ΔG -10,24 kkal/mol as in silico test. The inhibition activity of flavan-3-ol against the α-glucosidase enzyme that is very strong shows its promising potential as a candidate for antidiabetic drugs.

The Difference of Using Antibiotics Before and After Antimicrobial Resistance Control Program (PPRA) at RSUP Dr. M. Djamil Padang Ermawati Ermawati; Daan Khambri; Dedy Almasdy
Andalas Obstetrics And Gynecology Journal Vol 5, No 1 (2021)
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.5.1.29-42.2021

Antibiotics have been proven to be beneficial for human life since their discovery. This type of drug is the most widely used in infections caused by bacteria. the function is to inhibit growth or kill microorganisms. Therefore, more than 30-80% of patients in developed countries who are hospitalized receive antibiotics, either alone or in combination. Evaluating the implementation of PPRA at RSUP. Dr. M. Djamil by comparing the evaluation of antibiotic use before and after the application of PPRA in inpatients in the Obgyn.We conducted this research including a type of correlational analytical research with a retrospective approach. The research sample was taken by the Medical Record room of the RSUP. Dr. M. Djamil Padang. The research was carried out for 1 month, from May 1 to May 31, 2020. The population in this research was all inpatients of Obstetrics and Gynecology in Dr. M. Djamil Padang.There was an increase in the percentage of antibiotic use in 2019 in line with the higher percentage of surgery in 2019 compared to 2018. As regulated by the guidelines for the use of antibiotics in Dr. M. Djamil, for surgery, prophylactic antibiotics are given 30 minutes before the procedure to prevent infection due to the invasive action. The use of prophylactic antibiotics whether to continue is determined by the type of operation, the length of the operation, the amount of bleeding during the operation, the clinical patient, the laboratory value.There were no significant changes in the implementation of PPRA's work on the qualitative analysis of antibiotic use.Keywords: Antibiotics, PPRA, Evaluation

Analisis Survival Pasien Kanker Payudara Usia Muda di RSUP DR. M. Djamil Padang Tahun 2008-2017 M. Al Farisyi; Daan Khambri
Jurnal Kesehatan Andalas Vol 7 (2018): Supplement 4
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v7i0.917

semua wanita yang didiagnosa kanker payudara. KPD usia muda berhubungan dengan progresifitas yang tinggi, kecenderungan untuk rekurensi dan prognosis yang lebih buruk dibandingkan KPD usia tua. Penelitian ini bertujuan untuk menilai outcome dari pasien KPD usia muda yang mendapatkan pengobatan di RSUP Dr. M. Djamil Padang dari tahun 2008-2017. Desain penelitian ini adalah kohort retrospektif dengan analisis data menggunakan Kaplan Meier dengan Log Rank, pada 71 pasien yang telah didiagnosis KPD secara histopatologi dan mendapatkan terapi (bedah, kemoterapi, radioterapi, hormonal terapi ataupun targetting terapi). Hasil penelitian menunjukkan insiden KPD terbanyak pada range usia 35-40 tahun, dengan ukuran tumor T3, diferensiasi derajat sedang, histopatologi tipe duktal karsinoma dengan Triple Negative Breast Cancer (TNBC) sebagai subtipe yang terbanyak. Disease Free Survival (DFS) didapatkan rata-rata 87.48 bulan dan Overall Survival (OS) sebesar 79.13 bulan. Ukuran tumor didapatkan sebagai faktor yang berhubungan terhadap DFS (p = 0.00).

Co-Authors ., Azamris ., Oktahermoniza Abdul Hafiz, Muhammad Zaki Afrinita Eka Fitri Afriwardi Afriwardi Agus Susanta Ahmad Fakhrozi Helmi Aisha Rahmatya Aisyah Elliyanti Anandia Putriyuni Anandia Putriyuni Anggraini, Dessy Ari Oktavenra Ari Oktavenra Arif Budiman Asterina Aswiyanti Asri Azamris Azamris . Berna Elya Bobby Indra Utama Citra Ayu Fitrisia Deddi Prima Deddi Prima Putra Dedi Prima Putra Defri Heryadi Dessy Arisanty Edison Edison Eka Putri Eka Putri Ermawati Ermawati Eti Yerizel Fatma Sri Wahyuni Frengki Frengki Hafni Bachtiar Heldrian Dwinanda Suyuthie Heldrian Dwinanda Suyuthie Henni Vanda Henni Vanda Henni Vanda Henny Mulyani Henny Vanda Hera Novianti Heryadi, Defri Husna Yetti Isra Analdo Arza Jamilah Abbas M. Al Farisyi Muhammad Reno Akhyar Marpaung Muhammad Zaki Abdul Hafiz Niki Astria Nina Kurniasih Noni Zakiah Nora, Sondang Oktahermoniza Oktahermoniza . Oktavenra, Ari Pamelia Mayorita Ramadanus Ramadanus Ramadanus Rima Semiarty Rony Rustam Rony Rustam Rony Rustam Rony Rustam Rony Rustam Rosfita Rasyid Rulli Firmansyah Rustam, Rony Selfi Renita Rusdji Selfi Renita Rusjdi Septiyeni, Elsa Sofia Mubarika Sofia Mubarika H Sondang Nora Sondang Nora Sondang Nora Harahap Sorayya A'dilah Putri Suyuthie, Heldrian Dwinanda Syamel Muhammad Vashti Resti Putri Firdaus Vivi Sofia Vivi Sofia wessi windrasari Wirsma Arif Harahap Yanwirasti - Yanwirasti - Yopiq Triputra Zelly Dia Rofinda

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