Jurnal Farmasi Higea
Vol 4, No 2 (2012)

Penggunaan Biopolimer Polikaprolakton Sebagai Matrik Herbisida Lepas Lambat Asam 2,4-Diklorofenoksi Asetat

Akmal Djamaan (Fakultas Farmasi Universitas Andalas Padang)
Maria Ulfa (Sekolah Tinggi Ilmu Farmasi (STIFARM) Padang)
Netty Suharti (Sekolah Tinggi Ilmu Farmasi (STIFARM) Padang)



Article Info

Publish Date
26 Jan 2017

Abstract

The formulation of microcapsule of 2,4-dichlorophenoxy acetate acid using biopolymer polycaprolactone as a matrix using solvent evaporation method has been carried out. The microcapsule formula was used three types with the ratio 2:1, 1:1, 1:2 between 2,4-dichlorophenoxy acetate acid and polycaprolactone. Distribution particle test was used calibrated microscope. Active substance release test was detected by UV-Vis spectrophotometer. Polycaprolactone can be used as the matrix polymer for slow release preparations and influence to the release of active substance 2,4-dichlorophenoxyacetate acid. Result showed that recovery test of the formula-2 containing 86.5 % higher than formula-1, 84.5% and formula-3 78.2%. Model of the kinetics of the release active substance from microcapsule which correlation coefficient close to one is formula-1 which follow zero order kinetics.

Copyrights © 2012