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Pharmasipha

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Published by Universitas Darussalam Gontor

ISSN : 25810820 EISSN : 25809202 DOI : http://dx.doi.org/10.21111/pharmasipha.v5i1.5706

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Clinical Pharmacy; Biology Pharmacy; Natural Product Pharmacy; Drug, food and cosmetics analysis; Chemistry Pharmacy; and Islamization of Pharmacy

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 6 Documents

Search results for , issue "Vol 2, No 1 (2018): Maret" : 6 Documents clear

Formulasi Sediaan Lipstik Ekstrak Bunga Rosella (Hibiscus sabdariffa) sebagai Pewarna dan Minyak Zaitun (Olive oil) sebagai Emolien Asfy Nurany; Andi Sri Suriati Amal; Solikah Ana Estikomah
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 1 (2018): Maret
Publisher : University Of Darussalam Gontor

Islam is a beautiful religion and loves beauty. The using of a lipstick is to form a lip in an attractive appearance and to protect the lips from dryness with no side effects. The use of rosella as a dye and olive oil as an emollient in the formulation of the preparations due to the red pigments of anthocyanin in rosella (Hisbiscus sabdariffa l.) and olive oil can be used as an emollient to keep the moisture of the lips. The purpose of this study was to make a lipstick with a good stability. The simplisia of rosella flowers was macerated in ethanol 96%. The components of the lipstick used are cera alba petroleum jelly, aba, Cetyl alcohol, lanolin, titanium dioxide, nipagin, oleum rosae, olive oil and extracts of flowers rosella with concentrations of 0%, 2%, 4%, 6%, 8%, 10%. The lipstick mixture was then tested including: homogeneity, stability, grease, melting point and pH tests. Test a fondness and irritation test performed on the 25 panelists. The results showed that the concentrations of rosella extract 0% did not cause any color or white, the concentration of 2%-4% color posed red fade, the concentration of 6% was red, the concentration of 8%-10% was dark red. Concentration of the extract of 0%-4% did not experience the color change (stable) in a storage room temperature for 30 days. As for the material of 6%-10% color lipstick changes slowly, due to the occurrence of oxidation on lipstick. The result of fondness and irritation tests are that in the preparation of 1, 2, 3, 4, 5 and 6 does not cause irritation, itching and skin redness on the skin.

Aktifitas Antifungi Daun Ketepeng Cina (Cassia alata L.) Fraksi Etanol, N-Heksan, dan Kloroform terhadap Jamur Microsporium canis Mathlail Fajri; Nurul Marfu'ah; Lija Oktya Artanti
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 1 (2018): Maret
Publisher : University Of Darussalam Gontor

Plants created by Allah have many benefits. One plant that is widely used is Cassia alata L. Traditionally, the leaves are often used as an anthelmintic, ulcers, constipation, and skin diseases. Based on community experience, antifungal activity was investigated with ethanol, chloroform, and nhexane fraction of Cassia alata leaves to inhibit Microsporum canis, one of the dermatophyte fungi that causes tinea diseas. This study was an experimental study using a fraction of ethanol, chloroform and n-hexane Cassia alata were tested on Microsporum canis with a concentration of 12.5%, 22.5%, 32.5% and 42.5%. The results showed that the fraction of ethanol, chloroform, and n-heksan Cassia alata, has antifungal activity against Microsporum canis. The fraction that has the highest activity to inhibit the growth of Microsporum canis is the fraction of ethanol at a concentration of 42.5%, compared to the other two fractions and positive controls, generate inhibitory diameter of 27.88 mm (12.5%), 41.25 mm (22.5%), 48 mm (32.5%), 62 mm (42,5%). Phytochemical screening results indicate the presence of secondary metabolites content in each fraction, Secondary metabolites contained in the ethanol fraction are alkaloids, flavonoids, tannins, saponins and terpenoids, while in the chloroform fraction tannins, saponins, alkaloids, and flavonoids, and n-hexane fractions contain, alkaloids, saponins, tannins, and terpenoids.

Formulasi Tablet Effervescent Ekstrak Kulit Buah Ddelima Putih (Punica granatum var. album) dengan Variasi Asam Sitrat dan Asam Tartrat Rizqi Fajri Ramadhani; Andi Sri Suriati Amal; Fitria Susilowati
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 1 (2018): Maret
Publisher : University Of Darussalam Gontor

Allah created all the plants in this world with their own benefits. Pomegranate is one of the plants that has many benefits. One part of the pomegranate that can be utilized to be effervescent tablet is the fruit peel. One of the sources ingredients in the formulation of effervescent tablet is the source of acid. This study aims to find the best formula for effervescent tablets of extract leather White Pomegranate and investigating the effect of variation of citric and tartrate acid to characteristic of granule and tablet. The ratio of citric acid and tartare acid used was Formulation I (3: 2), Formulation II (2: 2), and Formulation III (4: 3). The method used was direct screw press method. The physical quality granule was tested including the flow time, angle of repose, and tap index. The physical quality of the effervescent tablet was tested including uniformity of weight, hardness, friability, and dissolving time. Analysis of the multiform statistics show that variations of citric and tartrate acid gives significant influence towards the angle of repose and hardness of the tablet, but no significant to the time of flow, tap index, uniformity of weight, friability, and dissolving time. The best formula was at the formulation III (citric acid: tartrate acid, 4:3).

Aktivitas Antibakteri Kayu Siwak (Salvadora persica) Fraksi Eter terhadap Bakteri Staphylococcus aureus Secara In Vitro Riza Amalia; Nurul Marfu'ah; Surya Amal
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 1 (2018): Maret
Publisher : University Of Darussalam Gontor

Using miswak is one of sunnah performed by Prophet Muhammad SAW and it contains a variety of compounds including these terpenoids, alkaloids, tannins and flavonoids which function as an antibacterial on the periodontal disease. Therefore, extraction and fractionation process were done to get the active compounds in miswak wood that has antibacterial activity against Staphylococcus aureus. This study is an experimental research with Complete Random Design methods. Ethanol extract separated using miswak from solvent of ether. Screening phytochemicals on thin Layer Chromatography (TLC) and test tube, the antibacterial activity was done using diffusion method with a concentration of 50% v/v, 25% v/v, 12.5% v/v and 6.25% v/v, metronidazole as a positive control and a DMSO as the negative control. The data obtained were then analyzed using One Way ANOVA test. Wood of miswak from ether fraction provide inhibition of 14.6-20.8 mm included strong category. The use of metronidazole as positive controls provide significant inhibitory against Staphylococcus aureus and the solvent DMSO as a negative control did not provide any inhibitory area. As for the description of the zone of inhibition against Staphylococcus aureus bacteria. Miswak wood from ether has antibacterial activity against Staphylococcus aureus with fraction of ether concentration of 12.5% v/v and smallest zone amounting 14.6 mm. Whereas at the greatest concentration found in the inhibition of 50% v/v with the average diameter of the zone of drag of 20.8 mm, with secondary metabolites contained in miswak fraction of ether is these terpenoids, alkaloids and tannins

Uji Toksisitas Sub Akut Iunfusa Daun Afrika (Vernonina amygdalina Del.) terhadap Histopatologi Ginjal Mencit Galur Balb/C Nida Faradisa; Nurul Marfu'ah; Surya Amal
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 1 (2018): Maret
Publisher : University Of Darussalam Gontor

Alloh created everything in this universe to take benefit from it, including African Leaf plant. One of the benefits of this leaf is to treat diabetes mellitus, malaria and dysentery. African leaf contains saponin type compounds, flavonoids and steroid glycosides. Drugs that enter the body will go through the phase of metabolism in the liver and excretion in the kidneys. Kidney that serves to dispose of metabolic waste and body toxins in the form of urine. The purpose of this research is to know the effect of African Leaf infusion on histopathology of mice kidney BALB/c. Samples in the form of BALB / c male strain of mice were 12 samples were divided into 4 treatment types with 3 replications. Treatment of control (aquades), African leaf infusion 10% b/v, 20% b/v and 30% b/v infused orally for 28 days. The data obtained were analyzed by Kruskall Wallis test and the data shows congestion value 0.241 > p 0.05 and hemorragic value 0.070 > p 0.05 which means there is no significant difference between treatment types. Therefore, it can be concluded that African leaf infusion has no effect on histopathology of renal mice BALB/c. However, the trend of results in this study indicates that the increased dose given to mice can reduce congestion and hemorrhage in the kidneys

Uji Toksisitas Sub Akut Infusa Daun Afrika(Vernonina amygdalina Del.) terhadap Histopatologi HatiMencit (Mus musculus) Galur Balb/C Wafa Aufia; Surya Amal; Nurul Marfu'ah
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 1 (2018): Maret
Publisher : University Of Darussalam Gontor

Allah created everything in this world has its benefits, including plants. African Bitter Leaves (Vernonia amygdalina Del.) is an herbal plant that has been experimented as anticancer, antioxidant, antidiabetic and analgesic with the presence of sesquiterpene lactones, saponins, alkaloids, tannins, polyphenol, monoterpene, Quinones, and Saponins. It is employed as an herbal medicine in infuse preparations. This study aims to investigate the safety standard and the effects of African Bitter Leaves infuse (Vernonia amygdalina Del.) againts the liver histopathology in mice strain BALB/c. This study is an experimental research using Completely Randomized Design (CRD). The practices are grouped into 4 different with 3 times repeatedly. The practices given, among others, control (Aquades 0.25 ml), P1 (doses of 10% b/v), P2 (doses of 20% b/v) and P3 (doses of 30% b/v). The observed object is the liver histopathology in mice strain BALB/c at the centrilobular area, midlobular and periportal, then analysis by one-way ANOVA followed by Tukey's Post hoc test. The results of this study stated that the doses of 10% b/v destroyed 24% cell degeneration and 9% cell necrosis, at a dose of 20% b/v destroyed 53% cell degeneration and 21% cell necrosis, and at doses of 30% b/v destroyed 55% cell degeneration and 40% cell necrosis. Based on ANOVA results it can be concluded that the African Bitter Leaves infuse influence liver histopathology in mice strains BALB/c. Destroyed of liver histology include degenerate cells at doses 10% b/v, 20% b/v, 30% b/v, and necrosis cell at doses 20% b/v and 30% b/v.

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Nurul Marfu'ah

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Jawa timur

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Nurul Marfu'ah

Contact Email nurulmarfuah@unida.gontor.ac.id

Phone +6285336431175

Journal Mail Official nurulmarfuah@unida.gontor.ac.id

Editorial Address University Of Darussalam Gontor Gontor For Girls Campus 1, Sambirejo, Mantingan, Ngawi, East Java, Indonesia, 63257

Location Kab. ponorogo, Jawa timur INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Nurul Marfu'ah

Contact Email
nurulmarfuah@unida.gontor.ac.id

Phone
+6285336431175

Journal Mail Official
nurulmarfuah@unida.gontor.ac.id

Editorial Address
University Of Darussalam Gontor Gontor For Girls Campus 1, Sambirejo, Mantingan, Ngawi, East Java, Indonesia, 63257

Location
Kab. ponorogo,

Jawa timur

INDONESIA