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Nurul Marfu'ah
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Pharmasipha
Published by Universitas Darussalam Gontor
ISSN : 25810820     EISSN : 25809202     DOI : http://dx.doi.org/10.21111/pharmasipha.v5i1.5706
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Clinical Pharmacy; Biology Pharmacy; Natural Product Pharmacy; Drug, food and cosmetics analysis; Chemistry Pharmacy; and Islamization of Pharmacy
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 141 Documents
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Uji Brine Shrimp Lethality Test (BSLT) Ekstrak Etil Asetat Spons Calthropella sp. Asal Zona Intertidal Pantai Krakal Gunung Kidul Yogyakarta Fitria Susilowati
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 1, No 1 (2017): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v1i1.1118

Abstract

Sponge is one of the most prolific sources in regard of their secondary metabolites as bioactive compounds. This study aimed to isolate and investigate the toxicity of ethyl acetate extract of sponge Calthropella sp. from intertidal zone of Krakal Beach, Gunungkidul. The isolation was done by maceration with methanol:dichloromethane (1:2) v/v. The dichloromethane extract was evaporated and then partitioned in ethyl acetate:water (3:2 v/v). The interesting layer of ethyl acetate was evaporated to yield a viscous extract. The toxicity test was assessed by Brine Shrimp Lethality Test (BSLT). The isolation resulted 7 fractions of ethyl acetate: 71,1; 86,4; 69,3; 88,8; 78,7; 97,5; and 100,2 mg. BSLT showed the LC50 value of the ethyl acetate fractions on toxic and very toxic category.
Penerapan Model Pembelajaran Two Stay Two Stray (TSTS) pada Mahasiswa Farmasi Lija Oktya Artanti
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 1, No 1 (2017): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v1i1.1119

Abstract

This research aims to increase the ability of scientific work and the learning achievement of Basic Physics Course Pharmacy Students UNIDA Gontor through the implementation of cooperative learning model Two Stay Two Stray (TSTS) based on practicum. The approach used in this study is a qualitative approach that displays everything that happens naturally, is without any manipulation. This study includes classroom action research (PTK). Subject research is pharmacy students the first semester Class A Academic Year 2016/2017 totaling 30 students. Data collection techniques used in this study includes written tests, observation, interviews, and documentation. The stages of data analysis in this study consisted of three phases: (1) data reduction, (2) display data, and (3) conclusion. The results showed that the implementation of cooperative learning model of Two Stay Two Stray (TSTS) based practicum conducted in the Course of Basic Physics class A in Study program Pharmaceutical UNIDA Gontor can improve the ability of scientific work and achievement of learning physics. The ability of students overall scientific work has increased in the first cycle to the second cycle of 25.72%. The learning achievement increased in the first cycle to the second cycle of 20%.
Pengaruh Steroid Anabolik Methandienone terhadap Kualitas Spermatozoa Tikus Putih (Rattus norvegicus) Nurul Marfu'ah
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 1, No 1 (2017): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v1i1.1120

Abstract

Anabolic steroids are chemical derivative of the testosterone hormone that are commonly used in medical field, but in development it is abused by its users. Methandienone is one type of anabolic steroid that widely used in the world. The anabolic effects can develop muscle formation, but the androgenic effect can suppress testosterone synthesis. Low testosterone will disrupt spermatogenesis and ultimately decrease the quality of spermatozoa production. This study aim to determine effect of anabolic steroid methandienone to quality of spermatozoa in albino rats (Rattus norvegicus). Examination of the quality of spermatozoa was performed on cauda epididymal include speed, motility, viability, and morphology of spermatozoa. The results of this study showed that the average quality of spermatozoa between the control group and the treatment group statistically was not significantly different (P > 0.05). However, average quality of spermatozoa (speed of spermatozoa, percentage of motile spermatozoa, percentage of alive spermatozoa, percentage of normal spermatozoa) also showed a declining trend. Speed of spermatozoa was normal because it is able to move in 1-4 mm/min. Motility and morphology of spermatozoa was normal because the percentage of motile spermatozoa and normal spermatozoa showed more than 50%. Viability of spermatozoa in the treatment group was abnormal because the percentage of alive spermatozoa showed less than 25%.
Isolasi dan Uji Toksisitas Fraksi Etil Asetat Spons Ancorina sp. Asal Zona Intertidal Pantai Wediombo Gunung Kidul Yogyakarta Yuni Nurfiana
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 1, No 1 (2017): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v1i1.1121

Abstract

Sponges are one of the marine organisms that contain various bioactive compounds. The purpose of this study was to isolate and test the toxicity of the ethyl acetate fraction of Ancorina sp. from the intertidal zone of Wediombo Beach, Gunungkidul. Isolation was carried out by maceration method with methanol:dichloromethane 1:1 (v/v) solvent. The dichloromethane extract was evaporated and partitioned with ethyl acetate:water (1:2). The ethyl acetate extract was separated and evaporated to obtain a thick extract which was then fractionated using column chromatography. The toxicity test was carried out using the Brine Shrimp Lethality Test (BSLT) method. The isolation produced 7 ethyl acetate fractions, respectively, with masses: 71.1; 86.4; 69.3; 88.8; 78.7; 97.5; and 100.2 mg. The results of the toxicity test for the seven fractions showed a range of toxic and very toxic LC50 values.
Uji Aktivitas Antibakteri Ekstrak Etanol Biji Mangga (Mangifera indica L.) terhadap Propionibacterium acnes Zulvia Faridatul Munawaroh
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 1, No 1 (2017): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v1i1.1122

Abstract

This study aims to utilize mango seed waste and to determine the antibacterial activity of the mango seed. Utilization of mango seeds can be used as an alternative to prevent and treat acne due Propionibcterium acnes.In this study tested the in vitro antibacterial activity against Propionibacterium acnes bacteria. Crude drug percolation mango seed made with ethanol, antibacterial activity of mango seed extract was tested by paper disc diffusion method to determine the value of Minimal Inhibitory concentration (MIC).The ethanol extract mango seed with a concentration of 60% or 0,6g / ml ethanol extract of mango seed has inhibitory zone up to 13.67 mm, at a concentration of 40% or 0,4g / ml extract menghasilkan10,1 mm and at a concentration of 20% or 0,2g / ml extract resulted in inhibition zone diameter of 10.43 mm contained in Kisara 10-20 mm. The ethanol extract mango seed has antibacterial effectiveness against bacteria Propionibacterium acnes that is strong enough. are expected to inhibit the growth of bacteria that causes acne so as to prevent and eliminate acne.
Uji Kadar Lemak Keju Cheddar dengan Variasi Bahan Baku (Sapi, Kambing) serta Variasi Jenis Starter (Streptococcus lactis, Rhizophus oryzae) Solikah Ana Estikomah
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 1, No 1 (2017): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.434 KB) | DOI: 10.21111/pharmasipha.v1i1.1125

Abstract

Cheese is dairy product. Microorganism are most widely used in starter, especially the cheese starter is a group of lactic acid bacteria (LAB), which is capable of producing acid Bacteri acid lactit (BAL) often used as starter in cheesemaking. This purpose of this study is variation of milk and starter in to improve the quality.In this research the ceddar making was conducted the varation milk and starter. cheddar cheese produced in this study analyzed the value of curd,water, and fat contained with Anava then followed by DMRT 5% level of significance. The best quality in the cheddar cheese at K2B2 , the randemen value 21.66, water value 38.66 and fat value 34.51.
Uji Toksisitas Sub Akut Infusa Daun Afrika(Vernonina amygdalina Del.) terhadap Histopatologi HatiMencit (Mus musculus) Galur Balb/C Wafa Aufia; Surya Amal; Nurul Marfu'ah
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 1 (2018): Maret
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (868.418 KB) | DOI: 10.21111/pharmasipha.v2i1.2130

Abstract

Allah created everything in this world has its benefits, including plants. African Bitter Leaves (Vernonia amygdalina Del.) is an herbal plant that has been experimented as anticancer, antioxidant, antidiabetic and analgesic with the presence of sesquiterpene lactones, saponins, alkaloids, tannins, polyphenol, monoterpene, Quinones, and Saponins. It is employed as an herbal medicine in infuse preparations. This study aims to investigate the safety standard and the effects of African Bitter Leaves infuse (Vernonia amygdalina Del.) againts the liver histopathology in mice strain BALB/c. This study is an experimental research using Completely Randomized Design (CRD). The practices are grouped into 4 different with 3 times repeatedly. The practices given, among others, control (Aquades 0.25 ml), P1 (doses of 10% b/v), P2 (doses of 20% b/v) and P3 (doses of 30% b/v). The observed object is the liver histopathology in mice strain BALB/c at the centrilobular area, midlobular and periportal, then analysis by one-way ANOVA followed by Tukey's Post hoc test. The results of this study stated that the doses of 10% b/v destroyed 24% cell degeneration and 9% cell necrosis, at a dose of 20% b/v destroyed 53% cell degeneration and 21% cell necrosis, and at doses of 30% b/v destroyed 55% cell degeneration and 40% cell necrosis. Based on ANOVA results it can be concluded that the African Bitter Leaves infuse influence liver histopathology in mice strains BALB/c. Destroyed of liver histology include degenerate cells at doses 10% b/v, 20% b/v, 30% b/v, and necrosis cell at doses 20% b/v and 30% b/v.
Uji Toksisitas Sub Akut Iunfusa Daun Afrika (Vernonina amygdalina Del.) terhadap Histopatologi Ginjal Mencit Galur Balb/C Nida Faradisa; Nurul Marfu'ah; Surya Amal
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 1 (2018): Maret
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (686.759 KB) | DOI: 10.21111/pharmasipha.v2i1.2131

Abstract

Alloh created everything in this universe to take benefit from it, including African Leaf plant. One of the benefits of this leaf is to treat diabetes mellitus, malaria and dysentery. African leaf contains saponin type compounds, flavonoids and steroid glycosides. Drugs that enter the body will go through the phase of metabolism in the liver and excretion in the kidneys. Kidney that serves to dispose of metabolic waste and body toxins in the form of urine. The purpose of this research is to know the effect of African Leaf infusion on histopathology of mice kidney BALB/c. Samples in the form of BALB / c male strain of mice were 12 samples were divided into 4 treatment types with 3 replications. Treatment of control (aquades), African leaf infusion 10% b/v, 20% b/v and 30% b/v infused orally for 28 days. The data obtained were analyzed by Kruskall Wallis test and the data shows congestion value 0.241 > p 0.05 and hemorragic value 0.070 > p 0.05 which means there is no significant difference between treatment types. Therefore, it can be concluded that African leaf infusion has no effect on histopathology of renal mice BALB/c. However, the trend of results in this study indicates that the increased dose given to mice can reduce congestion and hemorrhage in the kidneys
Aktivitas Antibakteri Kayu Siwak (Salvadora persica) Fraksi Eter terhadap Bakteri Staphylococcus aureus Secara In Vitro Riza Amalia; Nurul Marfu'ah; Surya Amal
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 1 (2018): Maret
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (635.984 KB) | DOI: 10.21111/pharmasipha.v2i1.2132

Abstract

Using miswak is one of sunnah performed by Prophet Muhammad SAW and it contains a variety of compounds including these terpenoids, alkaloids, tannins and flavonoids which function as an antibacterial on the periodontal disease. Therefore, extraction and fractionation process were done to get the active compounds in miswak wood that has antibacterial activity against Staphylococcus aureus. This study is an experimental research with Complete Random Design methods. Ethanol extract separated using miswak from solvent of ether. Screening phytochemicals on thin Layer Chromatography (TLC) and test tube, the antibacterial activity was done using diffusion method with a concentration of 50% v/v, 25% v/v, 12.5% v/v and 6.25% v/v, metronidazole as a positive control and a DMSO as the negative control. The data obtained were then analyzed using One Way ANOVA test. Wood of miswak from ether fraction provide inhibition of 14.6-20.8 mm included strong category. The use of metronidazole as positive controls provide significant inhibitory against Staphylococcus aureus and the solvent DMSO as a negative control did not provide any inhibitory area. As for the description of the zone of inhibition against Staphylococcus aureus bacteria. Miswak wood from ether has antibacterial activity against Staphylococcus aureus with fraction of ether concentration of 12.5% v/v and smallest zone amounting 14.6 mm. Whereas at the greatest concentration found in the inhibition of 50% v/v with the average diameter of the zone of drag of 20.8 mm, with secondary metabolites contained in miswak fraction of ether is these terpenoids, alkaloids and tannins
Formulasi Tablet Effervescent Ekstrak Kulit Buah Ddelima Putih (Punica granatum var. album) dengan Variasi Asam Sitrat dan Asam Tartrat Rizqi Fajri Ramadhani; Andi Sri Suriati Amal; Fitria Susilowati
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 2, No 1 (2018): Maret
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (334.569 KB) | DOI: 10.21111/pharmasipha.v2i1.2133

Abstract

Allah created all the plants in this world with their own benefits. Pomegranate is one of the plants that has many benefits. One part of the pomegranate that can be utilized to be effervescent tablet is the fruit peel. One of the sources ingredients in the formulation of effervescent tablet is the source of acid. This study aims to find the best formula for effervescent tablets of extract leather White Pomegranate and investigating the effect of variation of citric and tartrate acid to characteristic of granule and tablet. The ratio of citric acid and tartare acid used was Formulation I (3: 2), Formulation II (2: 2), and Formulation III (4: 3). The method used was direct screw press method. The physical quality granule was tested including the flow time, angle of repose, and tap index. The physical quality of the effervescent tablet was tested including uniformity of weight, hardness, friability, and dissolving time. Analysis of the multiform statistics show that variations of citric and tartrate acid gives significant influence towards the angle of repose and hardness of the tablet, but no significant to the time of flow, tap index, uniformity of weight, friability, and dissolving time. The best formula was at the formulation III (citric acid: tartrate acid, 4:3).

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