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Nurul Marfu'ah
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INDONESIA
Pharmasipha
Published by Universitas Darussalam Gontor
ISSN : 25810820     EISSN : 25809202     DOI : http://dx.doi.org/10.21111/pharmasipha.v5i1.5706
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Clinical Pharmacy; Biology Pharmacy; Natural Product Pharmacy; Drug, food and cosmetics analysis; Chemistry Pharmacy; and Islamization of Pharmacy
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 11 Documents
 1   2 
Search results for , issue "Vol 6, No 2 (2022): September" : 11 Documents clear
Pengaruh Variasi Humektan pada Formulasi Hand Sanitizer serta Evaluasi Sediaan dan Daya Hambat terhadap Stapyhlococcus aureus Qurrah A'yuniyyah Haryanto; Kurniawan Kurniawan; Solikah Ana Estikomah; Nurul Marfu'ah
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 6, No 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.7572

Abstract

The habits of the Indonesian people in carrying out hand hygiene activities are still very low with an average of only 12%. Along with the density of community activities, which consider hand washing a troublesome activity, it is also caused by the lack of clean water availability in the community. Therefore, there are hand sanitizer products that are practical without using water or commonly referred to as hand sanitizers. Hand sanitizer contains antiseptic substances that can kill germs on the palms due to the presence of alcohol (ethanol, propanol and isopropanol) and the phenol group (chlorhexidine and triclosan). Alcohol has the ability to inhibit bacterial growth, both against gram-positive and gram-negative bacteria, including MRSA (Methicilin Resistant of Staphylococcus aureus). The purpose of this study was to determine the effect of humectant variations on the evaluation of the preparation and the inhibition of Staphylococcus aureus bacteria. The results of the evaluation of the preparation of the hand sanitizer formulation are in accordance with the SNI No. 06-2588-1992, namely on the parameters of homogeneity, pH and dispersion. Meanwhile, the viscosity parameter is not in accordance with the standard. Variations in humectant concentration affect the evaluation of the preparation of the hand sanitizer gel formulation on the parameters of pH and dispersion. The formulation that had the greatest inhibition zone against Staphylococcus aureus was the formulation with the highest humectant concentration of propylene glycol, namely formulation 3 with an inhibitory power of 22.8 mm.
Evaluasi Penggunaan Obat dan Kesesuaian Dosis Kemoterapi Body Surface Area (BSA) Pasien Kanker Payudara di RSUD Sekayu Kiki Amelia; Doddy Rusli; Melinda Hikmah
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 6, No 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.8708

Abstract

Research has been conducted on the description of the use of chemotherapy drugs and evaluation of the suitability of doses with the method of body surfeace area (BSA) in breast cancer patients (ca.mamae) at the Sekayu Regional General Hospital. The purpose of this study is to find out an overview of the use of drugs and doses given in chemotherapy patients. This research is descriptive with retrospective data retrieval method where data is obtained from the medical records of patients diagnosed with breast cancer in the period January-December 2019. Data retrieval technique in the form of total sampling, obtained 18 samples according to inclusion criteria.The results of the study obtained is on the use of chemotherapy drugs all patients get fac drug regimen as many as 18 patients (100%) and evaluation of dose conformity calculation obtained by 17 patients (94.44%) obtained an inappropriate dose and 1 patient (5,56%) get the appropriate dosage. From the results of the study obtained that the chemotherapy drug used is a first-line chemotherapy drug is in accordance with the treatment guidelines and the dose used has not been in accordance with the calculation based on the body surface area (BSA).
Aktivitas Antibakteri Kombinasi Ekstrak Etanol Daun Johar (Cassia siemea Lamk) dan Daun Alpukat (Persea americana Mill) terhadap Streptococcus mutans Taufik Turahman; Desi Purwaningsih
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 6, No 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.8693

Abstract

Dental caries is a dental infection with a high prevalence in Indonesia, one of the causes is Streptococcus mutans which demineralizes the tissues causing dissolution and dental caries. To reduce the number of microorganisms, people can utilize natural materials. One of the plants that have potential as an antibacterial is johar leaf and avocado leaf. The purpose of this study was to determine the antibacterial activity of the combination of ethanol extract of johar leaves (Cassia siamea Lamk) and avocado leaves (Persea americana Mill.) against Streptococcus mutans. This study uses the diffusion method. Extraction of johar leaves and avocado leaves was carried out by maceration method then the extracts were combined 1:1 with concentration series of 25%, 50%, 75% and 100%. Antibacterial testing uses the diffusion method to determine the inhibition. Streptococcus mutans bacteria were cultured at a density of 108 CFU/ml in MHA (Muller Hinton Agar) medium. Inhibitory power is known by measuring the diameter of the inhibition zone formed around the well. The average inhibition test results were obtained at concentrations of 25% (6 mm), 50% (6.1 mm), 75% (7.1 mm) and 100% (9.3 mm). The positive control of ciprofloxacin (30 mm) and the negative control did not show the diameter of the inhibition zone. So that the greater the concentration of the extract combination, the greater the diameter of the inhibition zone obtained to inhibit the growth of Streptococcus mutans and there is a significant difference in the diameter of the inhibition zone of the combination of extracts and ciprofloxacin positive control.
Studi Rasionalitas Penggunaan Obat Favipiravir pada Pasien Covid-19 di RSUD Harapan Insan Sendawar Kabupaten Kutai Barat Tahun 2021 Teresia Delvi; Liniati Geografi; Clara Ritawany Sinaga
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 6, No 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.8607

Abstract

Corona Virus Disease 2019 (COVID-19) is an infectious disease caused by the SARS COV-2 virus. One of the antiviral groups that are often used worldwide for the treatment of COVID-19 is Favipiravir. Favipiravir use should be monitored because the accuracy of the drug will maximize the effect of therapy on the patient. Evaluation of Drug Use (EPO) of Favipiravir in terms of rationality needs to be done. Drugs that are not used rationally can cause side effects, the length of treatment will be longer, and even cause death effects in patients. The purpose of this study was to describe the characteristics of COVID-19 patients based on age, gender, and comorbidities and to find out the rationale for using Favipiravir inpatients at the HIS Hospital based on the criteria for the right diagnosis, the right patient, the right drug, the right dose, the right time interval for administration, appropriate duration of administration and clinical outcomes of COVID-19 patients (PCR, TCM, and antigen). This research is a type of nonexperimental research, the research was carried out in a descriptive evaluative way, and the data was collected retrospectively by looking at the medical record data. Determination of the rationale for using Favipiravir was carried out using the literature of the Indonesian COVID-19 Drug Informatorium edition 3, 100% correct patient, 100% correct drug, 100% correct diagnosis, correct dose 50.84%, correct duration of administration 61.01%, correct time interval administration of 81.35% and clinical outcomes (PCR (-) 74.57% %, TCM (-) 16.94%, and Antigen (-) 6.77%.
Aktivitas Antibakteri Fraksi Aquades, Diklorometana dan N-Heksana Daun Majapahit (Crescentia cujete L.) terhadap Bakteri Escherichia coli ATCC 25922 Secara In-Vitro Choirul Huda; Rahma Diyan Martha; Niken Desi Wulandhari
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 6, No 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.8495

Abstract

Escherichia coli is a gram - negative bacteria which is able to cause infectious diseases in humans, including urina ry tract infections, stomach cramps, and diarrhea. The purpose of this study was to determine the antibacterial activity of the Majapahit leaf fraction and the optimum concentration to inhibit Escherichia coli bacteria. Majapahit leaves were extracted by t he maceration method using 70% ethanol f ollowed by fractionation using aqua dest solvent, dichloromethane, and n - Hexane. Phytochemical screening of Majapahit leaf extract for the content of flavonoids, alkaloids, and saponins. Antibacterial activity test us ing paper disc diffusion method with positive control of chloramphenicol and negative control of 10% DMSO. The results of phytochemical screening of extracts were positive to flavonoid compounds, alkaloids, and saponins. The results of the antibacterial ac tivity test of the Majapahit leaf fraction had an antibacterial activity which was indicated by the presence of a clear zone around the disc. The aqua dest fraction is the most active fraction that can inhibit Escherichia coli bacteria. Based on the data a nalysis that has been carried out, it can be concluded that the use of different types of solvents did not produce significant differences in inhibiting Escherichia coli bacteria.
Mass Spectrometry (MS) Profiling on Potent Anticancer Fractions of Calthropella sp. Fitria Susilowati
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 6, No 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.8630

Abstract

A research on isolation and in vitro cytotoxic assay of active fractions of marine sponge Calthropella sp. from Krakal Beach Gunungkidul had been carried out. This study aims to analyze the Mass Spectrometry (MS) profile of potent anticancer fractions of marine sponge Calthropella sp. The two potent fractions (F1 and F2) were analyzed by High Resolution Liquid Chromatography-Mass Spectrometry (HR LC-MS) to identify the compounds exist in each fractions. The LC-MS analyses were conducted on the best elution system, isocratic elution of 80% MeCN (with 0.1% formic acid) + 20% milliQ H2O (with 0.1% formic acid). Based on LC-MS analyses, it is strongly predicted that F1 consist of 4'-N-methyl-5'- hydroxystaurosporine, 24-methyleneergost-4-ene-3-one, and one new compound. F2 is predicted to consist bengamide Q, clavepictine A, 4'-N-methyl-5’-hydroxystaurosporine, biemnic acid, carteriofenone A, and one new compound 
Aktivitas Antioksidan Kombinasi Ekstrak Etanol 96 % Kulit Buah Markisa Ungu dan Kuning secara In-Vitro Laila Fitria; Khoirul Ngibad
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 6, No 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.8682

Abstract

This study aimed to find the best combination of 96% ethanol extract from purple passion fruit (Passiflora edulis f. edulis Sims) peel and yellow passion fruit (Passiflora edulis Sims f. flavicarpa Deg) peel as in vitro antioxidants using the DPPH method. The 96% ethanol extract of purple and yellow passion fruit peel was obtained by the maceration method using 96% ethanol solvent. The combination treatment of purple and yellow passion fruit peel extracts was made with three comparisons of namely 1:1, 2:1, and 1:2, respectively. In vitro, antioxidant activity was assayed using the DPPH method to obtain the IC50 value. The results showed that the best combination of extracts as in vitro antioxidants was the combination of 96% ethanol extract from purple and yellow passion fruit peel with ratio (1:1) of 12.45 mg/L followed by the combination of extracts 1:2 (51.31 mg/L) and 2:1 (66.23 mg/L). In conclusion, the results suggest that the extracts combination of purple and yellow passion fruit peel with a ratio (1:1) can increase in vitro antioxidant activity.
Uji Aktivitas Antibakteri Kombinasi Ekstrak Daun Kelor dan Senggani terhadap Bakteri Escherichia coli dan Staphylococcus aureus secara In Vitro Amalia Eka Putri; Mita Uly Andini; Choirul Huda
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 6, No 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.8557

Abstract

Infection is one of the most common diseases today. One of them is an infection caused by Escherichia coli and Staphylococcus aureus bacteria that attack the digestive tract and cause diarrhea. The purpose of this study was to determine the antibacterial activity of Moringa and senggani leaf extracts against Escherichia coli and Staphylococcus aureus bacteria in vitro. By using the disc diffusion method. Moringa and senggani extract ratios of 1:1, 1:2, and 2:1 were used to test the antibacterial activity compared with positive control of chloramphenicol and negative control of DMSO. The results of the inhibition zone obtained in the Escherichia coli bacteria test at a ratio of 1:1 of 11.2 mm, 1:2 of 12 mm, and 2:1 of 11.3 mm. while in the Staphylococcus aureus test the ratio of 1:1 is 10.3 mm, 1:2 is 15.3 mm, and 2:1 is 13 mm. These results indicate that the resulting inhibition zone is in the strong category. It can be said that the combination of KLSG extract has antibacterial activity against Escherichia coli and Staphylococcus aureus.
Uji Aktivitas Antibakteri Perasan Jeruk Nipis (Citrus aurantifolia) terhadap Pertumbuhan Bakteri Propionibacterium acnes Jeremia Eden Frihendranus; Sister Sianturi; Wiwi Erwina
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 6, No 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.8597

Abstract

The main causes of skin infections is Propionibacterium acnes. The use of antibiotics can be an effective treatment of acne for example: clindamycin. Lime was a plant that is used as a treatment for acne’s inhibition. The lemon part often used to treat acne was the juice. The purpose of this study was to determine the activity of lime juice in inhibiting the growth of Propionibacterium acnes and to determine the minimum inhibitory concentration of lime juice against Propionibacterium acnes. The study used lime juice with various concentrations of 100%, 50%, 25%, and 12.5% on the growth of Propionibacterium acnes bacteria using the disc diffusion method. The data obtained were tested for normality Kolmogorov-Smirnov and homogeneity test. Then the Kruskall Wallis and Mann-Whiteney test were performed. Based on this study, lime juice was proven to be able to inhibit the growth of Propionibacterium acnes bacteria. The inhibition zone with the highest average concentration was at 100% concentration, which was 18.7 mm and the smallest average inhibition zone was found at a concentration of 12.5%, which was 11.5 mm. The results of the statistical test showed a significant difference with p-value= 0.029 between the positive control and the variation of the sample concentration.
Hubungan Pengetahuan dan Sikap terhadap Pola Pemilihan Obat Tradisional untuk Pengobatan Sendiri (Self Medication) pada Masyarakat DesaKalisoro Hanugrah Ardya Crisdian; Agnes Prawistya; Ersta Zuzvita; Rufaida Nur Fitriana
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 6, No 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.7645

Abstract

Self medication is the use of drugs by the public to reduce the symptomps of minor illnesses without a doctor’s advice. Self medication behavior may be influenced by gender, age, education level, employments status, income level and atitudes about self medication. Increased education and awerness of students about helath, the use of drugs for self medication will also increase. This study aims to identify the reklationship between knowledge anattitudes toward the pattern of using traditional medcine in the Kalisoro village. This research ia an observasional study with a cross sectional reseacrh design. The sampling thecnique was non- random sampling. Collecting data using a quistionnaire, Ehich has been tasted for validity and realibily. Data analysis was carried out using two methods, namely descriptive sattistical methods in the fgorm of respondents charateristic, knowledge, attitude and patterns, while correlation using the Eta Correlation Cooeficient. Inthis study there were many as 60 respondents who participated, with high level of knowledge as many as 95% of respondents who have positive attitude or partially. There is very low or very weak relationship in terms of knowledge, while in attitude there is a high or strong relation ship with each pattern of traditional medcine use which includes the frequency of use traditional medcines used, drug prices and sources of information.

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