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Pharmed: Journal of Pharmaceutical Science and Medical Research

pharmed
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Published by Universitas PGRI Madiun

ISSN : 26144840 EISSN : 26146118 DOI : -

Core Subject : Health,

Medicine & Pharmacology Public Health

Journal of Pharmaceutical Science and Medical Research is a pharmaceutical journal which publish twice a year, on February and August. Various topics of pharmacys and health that can be accepted in this journal are: Pharmaceutical sience; Herb medicine; Medical; Health; Biomedical; Pharmacoepidemiology.

Arjuna Subject : -

Articles 51 Documents

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ETNOBOTANI TANAMAN ANTIPIRETIK MASYARAKAT DUSUN MESU BOTO JATIROTO WONOGIRI JAWA TENGAH Arum Suproborini; Mochamad Soeprijadi Djoko Laksana; Dwi Fitri Yudiantoro
Pharmed: Journal of Pharmaceutical Science and Medical Research Vol 1, No 1 (2018)
Publisher : Universitas PGRI Madiun

Traditional medicine in Indonesia has been known to the public long before formal health services with modern medicine. Indonesia has many species of plants that have properties to cure various diseases and some other useful properties for human health. Antipyretic plants are plants that have the property as a febrifuge. The content of flavonoids in plants merit as a reliever fever (antipyretic). This study aims to determine the garden plants that can be utilized by the community as a febrifuge. (antipyretic). The research method used is survey method. The location of the observation and sampling of the plants was done by purposive random sampling technique by plot plot size 2x2 meter, 5x5 meter (adjust the location of the land). Based on research and observation, there are 8 species of antipyretic plants tumeric (Curcuma domestica), papaya (Carica papaya), dadap (Erythrina sp), hibiscus (Hibiscus rosasinensis), rambutan (Nephelium lappaceum), banana ( Musa paradisiaca), soursop (Annona muricata), and yam (Pachirrhyzus erosus) which can be utilized by the local community.

PENYULUHAN KESEHATAN RUTIN PUSKESMAS UNTUK MENCEGAH SEKOLAH DASAR DENGAN KEJADIAN DBD DI KOTA MADIUN TAHUN 2017 Puri Ratna Kartini; Santi Martini
Pharmed: Journal of Pharmaceutical Science and Medical Research Vol 1, No 1 (2018)
Publisher : Universitas PGRI Madiun

Dengue Hemorrhagic Fever (DHF) is still a health problem in Madiun City. Based on data from the Madiun City Health Office (2011-2015) there has been a significant increase in DHF incidence over the past 5 years. Most DHF patients in Madiun City are elementary school children. This indicates that the program of DHF especially in primary school in Madiun is still less effective, especially routine health counseling by the heakth service centre related to PSN through 3M plus activities. This study aims to analyze the influence of routine health counseling by the health service centre to the incidence of DHF in Primary School in Madiun City. This research is an observational analytic research with case control design. The population in this study is divided into 2 groups, namely the case population (SD with DHF incidence) of 33 SD and control population (SD not with DHF incidence). The sample in this study is divided into 2 groups, namely the case sample (SD with selected DHF incidence) of 30 SD and control sample (SD not with DHF incidence) of 30 SD. Sampling technique is by Simple Random Sampling. From the result of the analysis test, it is found out that the routine health education of Puskesmas has an effect on the occurrence of DHF in Primary School in Madiun City (p = 0,001).

UJI TOKSISITAS EKSTRAK ETANOL KAYU CEREMAI (Phyllanthus acidus L) TERHADAP LARVA UDANG Artemia salina DENGAN METODE BRINE SHRIMP LETHALITY TEST (BST) Desi Kusumawati
Pharmed: Journal of Pharmaceutical Science and Medical Research Vol 1, No 1 (2018)
Publisher : Universitas PGRI Madiun

The use of Otaheite gooseberry wood as a traditional medicine needs to be supported by scientific information about the efficacy and side effect. The objective of this research is to prove the presence of toxicity potency in ethanol extract of otaheite gooseberry wood using BST methods. An experimental research. Total sampel were 160 Brine shrimp (Artemia salina Leach) larvae. Ten larvae used in each 6 groups with 3 times replication. Each group was consecutively given 500 μg/ml, 300 μg/ml, 200 μg/ml, 100 μg/ml, 50 μg/ml, 0 μg/ml concentrate of ethanol extract of otaheite gooseberry wood, the sixth group was used as control. Data obtained by calculating amount of died larva in 24 hours after treatment. LC50 value was analyzed by probit analysis using SPSS 16.0 for windows,. Presumable compound contained in extract etanol Otaheite gooseberry wood in which have tokcixity testcase by “skrining fitokimia”. The average mortality of larvae at a concentration of 500, 300, 200, 100, 50, and 0 μg/ml consecutively were 9,33; 7,33; 4,67; 3,33; 2 and 0. The higher the extract concentration led to a growing number of high larval mortality. LC50 value of fruit extract of otaheite gooseberry wood was 275,035μg/ml. LC50 <1000 μg/ml indicates ethanol extract of otaheite gooseberry wood own a potential toxicity to larvae of Artemia salina Leach.

UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAUN BINAHONG (Anredera cordifolia (ten.) Steenis) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus DAN Pseudomonas aeruginosa Ani Sulistyarsi; Nanda Wahyu Pribadi
Pharmed: Journal of Pharmaceutical Science and Medical Research Vol 1, No 1 (2018)
Publisher : Universitas PGRI Madiun

Medicinal plants have been used from generation to generation to prevent, heal and maintain health. The aim of this research is to know the effect of binahong leaf extract (Anredera cordifolia (ten.) Steenis) on the growth of Staphylococcus aureus and Pseudomonas aeruginosa bacteria. The design of the study was a complete randomized design of 7 treatments, 3 replications. Binary extract by maceration test using ethyl acetate. The concentration of binahong extract used control (0%), 25%, 30%, 35%, 40%, 45%, 50% for Staphylococcus aureus and Pseudomonas aeruginosa bacteria. Data were analyzed by ANOVA oneway test, correlation and linear regression. The result showed that binahong against Staphylococcus aureus bacteria at 25% concentration, on bacterium Pseudomonas aeruginosa: concentration 50%. In KBM extract binahong test of Staphylococcus aureus bacteria with concentration 50%, on bacterium Pseudomonas aeruginosa with 100% concentration. ANOVA oneway test results: there is a significant difference between treatments. The value of sig (0,000) <p (0.05). The higher the concentration of binahong extract, the more able to inhibit and kill the bacteria Staphylococcus aureus (r = -0,805), Pseudomonas aureginosa (r = -0.616). The results of phytochemical tests found polyphenolic compounds, alkaloids and flavonoids

SINTESIS DAN UJI AKTIVITAS SENYAWA 2-BROMO-4,5-DIMETOKSIKALKON TERHDAP SEL KANKER T47D SECARA IN VITRO Retno Aliyatul Fikroh
Pharmed: Journal of Pharmaceutical Science and Medical Research Vol 1, No 1 (2018)
Publisher : Universitas PGRI Madiun

Synthesis of chalcone derivated has been synthhesized, structurally determined, and the in vitro cytotoxic activityof T47D cell was evaluated. A novel 2-bromo-4,5-dimethoxychalcone was synthesized by Claisen-Schmidt condensation of acetophenone with 6-bromoveratraldehyde. The synthesis of chalcone was carried out by reflux condition (65°C) for 24 hours using ethanol as a solvent and NaOH as a catalyst. The results showed that these coumpoun produced 81% in yield. The purity of synthesized product was determined by Thin Layer Chromatography. Structure identification was performed by FT-IR and 1H dan 13C-NMR spectrometer. In vitro activity test indicated that 2-bromo-4,5-dimethoxychalcone was not active for inhibiting the growth of T47D with IC50 value more than 100 µg/mL.

Upaya Pemenuhan Kebutuhan Nutrisi Pada Anak Dengan Demam Tifoid Enggel Bayu Pratama
Pharmed: Journal of Pharmaceutical Science and Medical Research Vol 1, No 2 (2018)
Publisher : Universitas PGRI Madiun

Demam Tifoid adalah penyakit infeksi menyerang saluran pencernaan yang mengakibatkan berkurangnya masukan nutrisi bagi tubuh untuk proses penyembuhan anak. Tujuan pemenuhan kebutuhan nutrisi pada anak dengan demam tifoid agar tidak terjadinya komplikasi serta tercukupinya kebutuhan nutrisi untuk proses metabolisme tubuh yang meningkat akibat infeksi. Metode penelitian ini menggunakan metode penelitian studi kasus. Informan dalam penelitian ini adalah orang tua dan pasien anak dengan demam tifoid yang mengalami masalah pemenuhan kebutuhan nutrisi. Data diperoleh dari pemeriksaan fisik pada pasien, keluarga, perawat ruangan, dan catatan perkembangan pasien melalui observasi secara langsung. Hasil penelitian menunjukkan bahwa anak dengan demam tifoid dengan masalah pemenuhan kebutuhan nutrisi ditemukan adanya bibir kering pecah-pecah, konstipasi, mual, muntah, penurunan nafsu makan dan penurunan berat badan. Pada evaluasi yang diperoleh antara lain pasien dapat mempertahankan berat badan, adanya peningkatan nafsu makan, tidak ada mual, muntah, tanda malnutrisi dan didapatkan nilai normal pada pemeriksaan hemoglobin. Dari hasil analisis peningkatan asupan makan pada anak dengan demam tifoid dapat tercapai dengan adanya kerjasama antara petugas kesehatan dan keluarga dalam pelaksanaan program terapeutik dalam peningkatan intake makanan, pemantauan asupan nutrisi yang dilakukan setiap hari dengan pemeriksaan berat badan, pemeriksaan klinis, dan masukan diit, serta kolaborasi pemberian diit dan nutrisi parenteral. Untuk mengatasi masalah pemenuhan kebutuhan nutrisi pada anak dengan demam tifoid perlu dilakukan tindakan keperawatan yang komprehensif. Keterlibatan orang tua dalam pemenuhan kebutuhan nutrisi pada pasien anak sangat berpengaruh dalam keberhasilan pemenuhan kebutuhan nutrisi anak selama di rumah sakit.

Polifarmacy And The Compliance of Geriatric With Chronic Disease Maya Arfania
Pharmed: Journal of Pharmaceutical Science and Medical Research Vol 1, No 2 (2018)
Publisher : Universitas PGRI Madiun

The various geriatric’s health problem require complex treatment, which is by giving various drugs. Therefore, polifarmacy is a concequences of geriatric’s treatment. Polipharmacy is a serious problem in a health system. Besides can increase the health cost, also it can cause compliance problem. The purpose of this research is to see an overview the compliance level of geriatrics with chronic disease who receive a polipharmacy prescription. This is a descriptive research with cross sectional design. Data were obtained from outpatient prescriptions of geriatric’s with chronic disease in Yogyakarta’s hospital. From 100 prescriptions, there were 50 male and 50 female patients. In this research, most patients recieve 2 diagnoses (51%) and 48% polypharmacy prescription. After the interview using MMAS 8 questionnare, there were 61% uncompliance geriatric’s patient , however the polypharmacy prescription isn’t significantly related to the patient’s compliance level. Keywords: Polipharmacy, geriatrics, chronic disease

Hubungan Kepatuhan Minum Obat Antihipertensi Terhadap Tercapainya Target Terapi Pasien Hipertensi di Puskesmas Wirobrajan Yogyakarta Fani Mardina Cahyani
Pharmed: Journal of Pharmaceutical Science and Medical Research Vol 1, No 2 (2018)
Publisher : Universitas PGRI Madiun

Center for Health Data and Information (Pusdatin) Province of Yogyakarta (DIY) 2016 based on Riskesdas 2013, DIY province with hypertension prevalence 12,8% rank 3 in Indonesia after North Sulawesi and South Kalimantan. The case data of family visits, hypertension disease has become the second most dominant disease for family groups in DIY. The top ten diseases diagnosed in outpatients in Puskesmas according to the report of integrated surveillance system, hypertension became the third order after diarrhea and influenza case. The purpose of this study was to determine the relation of adherence to antihypertensive medication to the achievement of hypertension therapy target at Wirobrajan Health Center Yogyakarta. This research is a type of observational research with cross sectional method. Method of sampling with total population with inclusion criteria that visit to Wirobrajan Health Center. The sample in this study were 50 patients. Primary data collection was conducted using MMAS questionnaire. The result of chi-square test between adherence level and the achievement of therapeutic target that is p value 0,005 <0,05 this indicates the relation between adherence level with the achievement of therapy target.Keywords: adherence, hypertension, therapeutic target

Perbandingan Efektivitas Antibakteri Minyak Atsiri Bawang Putih (Allium sativum) Dan Black Garlic Terhadap Bakteri Staphylococcus Aureus Dan Escherichia coli Dengan Metode Kirby-Bauer Dwi Puji Astuti; Charlis Palupi
Pharmed: Journal of Pharmaceutical Science and Medical Research Vol 1, No 2 (2018)
Publisher : Universitas PGRI Madiun

Tujuan dari penelitian ini adalah untuk mengetahui daya hambat minyak atsiri pada bawang putih (Allium sativum) dan Black garlic terhadap bakteri Staphylococcus aureus dan Escherichia coli dengan metode Kirby-Bauer. Penelitian ini adalah penelitian eksperimental dengan teknik pengambilan sampel secara sengaja. Hasil dari penelitian ini bahwa kadar minyak atsiri bawang putih (Allium sativum) sebanyak 0,26%, sedangkan pada Black garlic sebanyak 0,15% dari proses destilasi. Daya hambat terhadap bakteri Staphylococcus aureus dari bawang putih (Allium sativum) yaitu 15,5 mm, sedangkan dari Black garlic yaitu 13,5 mm dan daya hambat terhadap bakteri Escherichia coli dari bawang putih (Allium sativum) yaitu 29,33 mm, sedangkan dari Black garlic yaitu 13,16 mm. Hasil penelitian ini menunjukkan bahwa daya hambat minyak atsiri bawang putih (Allium sativum) dan minyak atsiri Black garlic pada bakteri Staphylococcus aureus tidak ada perbedaan yang bermakna sedangkan pada bakteri Escherichia coli ada perbedaan yang bermakna.

Perbandingan Efektivitas Kaplet Antipiretik Dua Merek Dagang Parasetamol Dan Produk Generik Terhadap Mencit (Mus Musculus) Jantan Ulfa Ni'ammah; Nasruhan Arifianto
Pharmed: Journal of Pharmaceutical Science and Medical Research Vol 1, No 2 (2018)
Publisher : Universitas PGRI Madiun

Penelitian ini bertujuan untuk membandingkan efektivitas antipiretik dari parasetamol bermerek dengan harga mahal, parasetamol bermerek dengan harga generik (murah) dan parasetamol generik pada mencit demam. Hewan coba dalam penelitian ini menggunakan mencit Mus musculus jantan. Tahapan penelitian pemberian perlakuan pada hewan coba meliputi sebelum diberi perlakuan mencit diukur suhu rektalnya (suhu awal), kemudian disuntik dengan pepton 5% secara subkutan. Satu jam kemudian suhu rektal kembali diukur, setelah itu mencit diberi perlakuan dengan bahan uji dan kontrol negatif. Hasil penelitian yang diperoleh berupa persentase daya antipiretik parasetamol bermerek dengan harga mahal, parasetamol bermerek dengan harga generik (murah) dan parasetamol produk generik berturut-turut sebesar 0,86%, 1,07% dan 0,41% pada waktu pengamatan menit ke-60. Efek antipiretik parasetamol paling efektif digunakan untuk menurunkan suhu rektal mencit demam yaitu parasetamol merek B dan efektivitas terkecil terdapat pada parasetamol generik.

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Contact Name
Puri Ratna Kartini

Contact Email
puri@unipma.ac.id

Phone
-

Journal Mail Official
pharmed@unipma.ac.id

Editorial Address
-

Location
Kota madiun,

Jawa timur

INDONESIA