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INDONESIA
Indonesian Journal of Medicine
Published by Universitas Sebelas Maret
ISSN : -     EISSN : 25490265     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Indonesian Journal of Medicine (IJM) is an international, open-access, and double-blind peer-reviewed journal, focusing on the intersection of biomedical science, clinical medicine, and community medicine. The journal began its publication on August 20, 2015, and is published online three times yearly. It is academically designed for all physicians, health researchers, and health care professionals, regardless of their medical specialties, or type of employment.
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Articles 8 Documents
 1 
Search results for , issue " Vol 2, No 2 (2017)" : 8 Documents clear
Effect of Antihipoglycemic Sechium edule Jacq. Swartz. Etanol Extract on Histopathologic Changes in Hyperglycemic Mus musculus L. Siahaan, Jekson Martiar
Indonesian Journal of Medicine Vol 2, No 2 (2017)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Streptozotocin as diabetogenic can damage the pancreatic β cells of animals tried through the oxidative stress process to increase blood sugar levels. Giving ethanolic extract of squash fruit has hypoglycemia effect because it contains flavonoids that act as antioxidants and antihiperglichemia. This study aimed is analyze the effect of ethanol extract of squash fruit to decrease blood sugar level and the change of pancreatic β cell diameter.Subjects and Method: This study was an experimental study with post-randomized controlled group design, using male white mice (Mus musculus L.) DD Webster strains randomized into 4 groups: negative control group, positive control group, group with extract ethanol of 100 mg/ kgBB, and a group of ethanol extract of 200 mg/ kgBW of pumpkin.Results: The results showed a significant reduction in blood sugar levels if compared with the control group. The presence of changes in β pankreas cell diameter on ethanol extract of 100 mg/ kgBB and 200 mg/ kgBB.Conclusion: The conclusion of this study is the extract of ethanol fruit of 200mg/ kgBB squash significantly reduce blood sugar level of mice, the change of β pankreas cell diameter on ethanol extract of 100mg/ kgBB and 200mg/ kgBB.Keywords: streptozotocin, antihipoglikemia, flavonoidCorrespondence: Jekson Martiar Siahaan. Physiology Teaching Staff ofMedicine Faculty, Methodist University of Indonesia Medan, Jl. Setia Budi Pasar 2, Medan 20132, Indonesia.Journal of Medicine (2017), 2(2): 86-93https://doi.org/10.26911/theijmed.2017.02.02.02
Factors Causing Acinetobacter Baumannii Resistance to Carbapenem Antibiotics in Patients with Healthcare Associated Infection (HCAI) at Dr. Moewardi Hospital, Surakarta Primaningtyas, Widana; Pamungkasari, Eti Poncorini; -, Sugiarto
Indonesian Journal of Medicine Vol 2, No 2 (2017)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Acinetobacterbaumannii is a negative gram opportunistic bacteriumhaving high survival ability in the environment. Carbapenem is a drug of choice for infections caused by Acinetobacterbaumannii, which in the last decade prevalence of Carbapenem Resistant Acinetobacterbaumannii (CRAB) has increased. CRAB is commonly found in a nosocomial infection case and even into disease outbreak and epidemics in various hospitals. However, CRAB in community-associated infection data is still limited primarily in Indonesia. Therefore the researchers intend to do study factors causing CRAB in hospital and community setting in patients with Healthcare Associated Infection (HCAI).Subjects and Method: This study was an observational analytic study, with case control design. The study was conducted in RS Dr. Moewardi Surakarta in March-August 2017. Taking subject used fixed disease sampling method with the number of samples were 104 subjects. The dependent variable was the incidence of Acinetobacterbaumannii resistance to carbapenem antibiotics in HCAI patients. Independent variables were history of antibiotic use, patient functional status, intensive unit maintenance and comorbid conditions. Dependent and independent variables were measured by using a questionnairechecklist and then analyzed by using multiple logistic regression analysis.Results: Previous antibiotic conformity history (OR = 0.12; 95% CI = 0.03 to 0.45; p = 0.002) and the patient functional status (OR = 6.72; 95% CI = 2.08 to 21.68; p = 0.001) increased risk of resistance of Acinetobacterbaumannii to carbapenem (CRAB) in Healthcare-Associated Infections (HCAI) patients and was statistically significant. Treatment at intensive unit (OR = 0.76; 95% CI = 0.26 to 2.23; p = 0.613) and comorbid conditions (OR = 0.38; 95% CI = 0.12 to 1.23; p = 0.106) increased risk of Acinetobacterbaumannii resistance to carbapenem (CRAB) in Healthcare Associated Infections (HCAI) patients although it was statistically insignificant.Conclusion:Previous antibiotic conformity history and functional status of patients are a factor affecting Acinetobacterbaumannii resistance to carbapenem (CRAB) in Healthcare-Associated Infections (HCAI) patients.Keyword: Acinetobacterbaumannii, carbapenem, healthcare associated infection.Correspondence: Widana Primaningtyas. Master Program in Public Health, Sebelas Maret University, Jl. Ir. Sutami 36 A, Surakarta 57126, Central Java. Email: widanadoctor@gmail.com Mobile: +6285229035800.Indonesian Journal of Medicine (2017), 2(2): 125-138https://doi.org/10.26911/theijmed.2017.02.02.07
The Proportion of Human Immunodeficiency Virus Patients in Circumcised and Uncircumcised Men with Unsafe Sexual Practices in Special Care Center in General Hospital Center Haji Adam Malik Hospital Medan -, Juliyanti; Rangkuti, Irwan Fahry; Siregar, Remenda
Indonesian Journal of Medicine Vol 2, No 2 (2017)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: The incidence of HIV was found to be higher in uncircumcised men compared to circumcised men. Circumcision was known to protect and fight against the acquired HIV infection. HIV infection was classified into sexual transmitted infections since it is mostly transmitted sexually (95%). The risk was higher in unsafe sexual practices, such as having multiple sexual partners and not using protections like condoms.Subjects and methods: This was a descriptive study with cross-sectional design study. There were 340 patients who came to the special care center in General Hospital Center Haji Adam Malik Hospital and participated in this study. Data such as history taking and clinical examination were then collected.Result: The proportion of HIV patients with unsafe sexual practices was lower in circumcised men group, which was 141 patients (41.5%), compared to uncircumcised men group which was 199 patients (58.5%).Conclusion: The proportion of HIV infection in uncircumcised men with unsafe sexual practices was higher than in circumcised men.Keywords: HIV, Circumcision, Sexual practiceCorespondence: Juliyanti. Department of Dermato-veneorology, Faculty of Medicine, University of North Sumatera, Indonesia. Mobile: 082174346045Indonesian Journal of Medicine (2017), 2(2): 94-99https://doi.org/10.26911/theijmed.2017.02.02.03
Effects of Bean Ethanol Extract (Phaseolus Vulgaris L.) on Superoxide Dismutase Activity in Wistar Mice (Micetus Norvegicus) Hyperglycemia Sinaga, Ade Putra Fratama; Ilyas, Syafruddin; Anggraini, Dwi Rita
Indonesian Journal of Medicine Vol 2, No 2 (2017)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Aloxan tetrahyd micee causes free radicals and higher reactive oxidative species (ROS) production, being able to lead to reduce insulin secretion from pancreatic β cells and receptor sensitivity in insulin-receptor cells resulting in hyperglycemia conditions. Bean extract ethanol can reduce oxidative stress. The purpose of this study was to determine bean’s ethanol extract effectiveness in lowering blood sugar levels and increasing the activity of superoxide dismutase (SOD) enzyme.Subjects and Methods: This was a randomized controlled trial (RCT) study. The samples were mice (Micetus norvegicus) of wistar strains randomized in five groups: P1-negative control, positive P2-control, P-3 ethanol extract group of 200mg / kgBW, P4-group 400mg / kgBW, P5-group 600 mg / kgBW. Dependent variables are blood sugar (mg/ dL) and superoxide dismutase enzymes. The independent variable is the bean extract of ethanol. Differences in blood sugar levels and superoxide enzyme levels of intergroup dismutase were tested by Anova test, followed by post hoc test, to determine the effectiveness of bean extract ethanol.Results: This study showed a statistically significant decrease in blood glucose levels after ethanol extract of green beans 600 mg / kg BW from day 14 to day 28 (p <0.05). This study did not show a decrease in blood sugar levels after ethanol extract of green beans 200 mg / kgBW and 400 mg / kgBW from day 7 until day 28 (p> 0.05). Giving ethanol extract of green beans did not affect the activity of superoxide dismutase enzyme (p = 0.830).Conclusion: Giving ethanol extract of green beans 600 mg / kgBW effectively decrease blood sugar in male wistar mice (Micetus norvegicus) from day 14 to day 28. Giving ethanol extract of green beans 200 mg/ kgBW, 400 mg / kgBW, and 600 mg / kgBW, is not effective to increase the activity of superoxide dismutase enzyme.Keywords: Phaseolus Vulgaris L., blood sugar level, superoxide dismutase enzymeCorrespondence: Ade Putra Fratama Sinaga. Masters Program on Biomedics, Faculty of Medicine, North Sumatra University. Email: adeputra535@ymail.com.Indonesian Journal of Medicine (2017), 2(2): 139-145https://doi.org/10.26911/theijmed.2017.02.02.08
The Result of Functional Mobility Scale (FMS) on Cerebral Palsy Spastic Diplegic that treated by SEMLS (Single Event Multi Level Surgey) method in Orthopaedic Hospital Prof. Dr. R. Soeharso, Surakarta Hadinoto, Seti Aji; Satriadi, Anung Budi; Wujoso, Hari
Indonesian Journal of Medicine Vol 2, No 2 (2017)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Cerebral Palsy is a permanent non-progressive brain disorders that occur in early childhood where abnormalities in the brain due to damage on immature brain can cause movement disorders and postural dysfunctionNowadays, the treatment of choice for CP Spastic diplegic is using SEMLS (Single Event Multi Level Surgery). There was many scoring to evaluate outcome of SEMLS, but only a few scoring system that can evaluate changing after SEMLS. Functional Mobility Scale (FMS) is an outcome measure designed to evaluate mobility of children with cerebral palsy (CP). FMS has been shown to detect both improvement and deterioration in mobility status during the rehabilitation period following multilevel orthopaedic surgery in children with spastic diplegicSubjects and Method:This was a cross sectional observasional study. The sample are obtained by sensus from January 1st 2014 untill March 1st 2015. The patient’s characteristic that we include in this study are gender, age when the patient had a surgery, and where the contracture are involved. We evaluate the outcome using FMS before operation, 3 month, 6 month, 9 month, and 12 month after operation on three different distance (5, 50, 500 meter) that represent home, school, and community. After that we analyze the result using regression logistic model to better understands about changes and time of changes on patient after SEMLS procedure. We also analyze the corelation between age, sex, and location of contracture with the outcome after SEMLS procedureResult : 51 patients were reviewed and identified, there were 31 males (61%) and 20 females (39%), mean age when the patient was operated was 8.07 years old, with the most common cases are CP Spastic Diplegic with hip, knee, ankle contracture bilateral about 41 patient (80.3%), knee ankle bilateral about 7 patient (13.2%), and hip ankle bilateral about 3 patient (5.88%). From evaluation of FMS scoring, we found most patient had an improvement on their mobility after SEMLS procedure (OR > 1), with the time changes for 5 and 50 meters distance is at six months (OR : 1.52) and (OR= 1.47), and 500 meters is at 12 months (OR= 3.45). We also found no significant relationships (p value > 0.05) between age (p value= 0.632), sex (p value= 0.576) and location of contracture (p value= 0.222) with the outcome of the FMS after SEMLSConclusion: We found that SEMLS gives a good result to increased mobility of patient with CP Spastic Diplegic. FMS Score were able to  asses the outcome of SEMLS procedure, and also responsive to change that occur after SEMLS. Age, sex, and  contracture’s location were not significantly influence the FMS outcome after SEMLSKeywords: CP Spastic Diplegic, SEMLS (Single Event Muti Level Surgery), FMS (Functional Mobility Scale).Correspondence: Seti Aji Hadinoto. Masters Program of Family Medicine, Sebelas Maret University, Jl. Ir. Sutami 36 A, Surakarta 57126, Central Java.Indonesian Journal of Medicine (2017), 2(2): 100-106https://doi.org/10.26911/theijmed.2017.02.02.04 
Effect of Probiotic Giving on Digestive Function in Patients Post-Perforated Colorectal Cancer surgery Hutapea, Impol; Bagus B.S.A, Ida; Alfianto, Untung
Indonesian Journal of Medicine Vol 2, No 2 (2017)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: One of the goals of colorectal cancer surgery is to facilitate the digestive tract to function properly. Surgery performed can lead new problems such as infection, sepsis, postoperative pain, and nausea vomiting.  Modulation of perioperative nutrition of intestinal microbiota such as probiotics is more and more applied as a strategy to reduce complications of elective surgical infection and accelerate the improvement of gastrointestinal symptoms such as flatus and defecation. The purpose of this study was to analyze the effect of giving probiotics on digestive function in patients after colorectal cancer surgery.Subjects and Methods: The subjects of this study were postoperative patients with colorectal cancer, with a total sample of 20. The sampling technique used non-random sampling. This type of the study is quasi experimental design with Post-test Only Control Design method. In this design, the sample is divided into two groups namely, group I was given probiotics and group II was not given probiotics then the follow up treatmen was conducted to assess the effect on the digestive function of patients after colorectal cancer surgery.Results: The majority of post-operative colorectal cancer patients were> 50 years (85%). The sex of post operative patients with colorectal cancer balanced between men and women, which was equally 50%. There was a significant difference between intestinal bowel surgery after colorectal cancer surgery which was given probiotics with no probiotics given (p <0.05). Similarly, post operative flatus colorectal cancer patients also had significant differences with the values (p <0.05). As for the defecation patients of post-surgery colorectal cancer , there was also a significant difference between the defecation patients of post-surgery of colorectal cancer surgery given probiotics and those not given probiotics with values (p <0.05).Conclusion: statistically, there was an effect of giving probiotics to digestive function including bowel sound, flatus, and defecation of post-surgery patient of colorectal cancer.Keywords: Probiotics, digestive function, colorectal cancerCorespondence: Impol Hutapea. Masters Program in Family Medicine, Sebelas Maret University. Email: papihamora@gmail.comIndonesian Journal of Medicine (2017), 2(2): 107-115https://doi.org/10.26911/theijmed.2017.02.02.05
Effect of Lawsonia inermis Linn. Ethanol Extract on the Superoxyde Dismutase Activity in Hyperglycemic Rattus norvegicus Antika, Maya Anjelir; Ilyas, Syafruddin; Sari, Mutiara Indah
Indonesian Journal of Medicine Vol 2, No 2 (2017)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Alloxan causes experimental diabetic conditions (hyperglycemia) in experi­mental animals through oxidation and the formation of free radicals (oxidative stress) that damage pancreatic β cells. The ethanol extract of the henna leaves can decrease oxidative stress. The purpose of this study is to know the effect of ethanol extract of henna leaves to decrease blood sugar level and increase superoksida enzyme activity.Subjects and Methods: This study is an experimental study. The study design of posttest only control group design, using mice (Rattus norvegicus) strains of wistar, was randomized in five groups: negative control, positive control, group obtaining ethanol extract of henna leaves 200 mg/kg BW, 400 mg/kg BW and 600 mg/kg BW.Results: This study showed a significant reduction in blood glucose levels when compared to the control group. Superoxide dismutase enzyme activity increased but was not statistically significant.Conclusion: Ethanol extract of henna leaves 400 mg/kg BW significantly decreased mice blood glucose level, there was no significant difference in the increase of superoxide dis­mutase enzyme activity.Keywords: Alloxan, antioxidant, flavonoids, hyperglycemia, oxidative stress.Correspondence: Maya Anjelir Antika. Masters Program of Biomedic, Faculty of Medicine, University of North Sumatera.Indonesian Journal of Medicine (2017), 2(2): 79-85https://doi.org/10.26911/theijmed.2017.02.02.01
Differences in Influence between Intravenous Methylprednisolone and Intramuscular Progesterone toward Erectile Function After Operation Transurethral Resection of the Prostate (TUR-P) in Patients Benign Prostate Hyperplasia (BPH) Yolanda, Monica; Tusarah, Setya Anton; Alifianto, Untung
Indonesian Journal of Medicine Vol 2, No 2 (2017)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Erectile function is an important factor for all men in an active sexual condition, as well as to assess the quality of sex life with their partners. Transurethral Resection of the Prostate (TURP) is a gold standard action for Benign Prostate Hyperplasia (BPH). The researcher tried to study to investigate the effect of corticosteroid and progesterone on erectile function in BPH patients who have done TURP surgery by using Erection Hardness Score (EHS). The purpose of this study was to investigate the effect of intra venous methylprednisolone on post-operative erection function of TURP in BPH patients. To investigate the effect of intra-muscular progesterone on postoperative erectile function of TURP in BPH patients. To investigate the different effect between methylprednisolone and progesterone on post-operative erection function of TURP in BPH patients.Subjects and Method: Subjects of all BPH patients who performed TUR-P surgery in the urology sub-section of Dr. Moewardi Hospital, Surakarta. The sampling technique in this study was incidental sampling. This study was a clinical experimental study using Pre and Post-test design-Only Control Design. 3 groups were divided to get different treatment, the first group was given methylprednisolone, the second group was given progesterone and the third group was given TURP therapy protocol only.Results: After 1 month of TURP treatment in BPH patients, the result obtained for the EHS which on a scale of 2 and 3. EHS on scale 2 for the methylprednisolone group was 9 patients (69.2%), the progesterone group had 6 patients (46.2%), and the control group had 8 of patients (66.7%). Meanwhile, EHS on scale 3 for the methylprednisolone group was 4 patients (30.8%), there were 7 patients (53.8%) of the progesterone group, and the control group had 4 patients (33.3%). After 3 months of TURP treatment in BPH patients, EHS on scale 2 in the methylprednisolone group there were 2 patients (15.4%), the progesterone group there were 0 patients (0.0%), and the control group there were 6 patients (50.0%). The methylprednisolone group had 9 patients (69.2%) on EHS 3 scale, the progesterone group had 4 patients (30.8%), and there were 6 patients (50.0%) in the control group. While, EHS scale of 4 the total of the patients in the methylprednisolone group was 2 patients (15.4%), the progesterone group had 9 patients (69.2%), and the control group had 0 patients (0.0%).Conclusion: the methylprednisolone improved the erectile function in post-operative TURP patients. Progesterone improved erectile function in post-operative TURP patients. Therefore, it can be concluded that progesterone was better than methylprednisolone. Keywords: Erectile dysfunction, Methylprednisolone, ProgesteroneCorrespondence: Monica Yolanda. Masters Program in Family Medicine, Sebelas Maret University, Jl. Ir. Sutami 36 A, Surakarta 57126, Central Java. Email: monica_mail83@yahoo.co.id.Indonesian Journal of Medicine (2017), 2(2): 116-124https://doi.org/10.26911/theijmed.2017.02.02.06 

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