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INDONESIA
Indonesian Journal of Medicine
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Core Subject : Health,
Indonesian Journal of Medicine (IJM) is an international, open-access, and double-blind peer-reviewed journal, focusing on the intersection of biomedical science, clinical medicine, and community medicine. The journal began its publication on August 20, 2015, and is published online three times yearly. It is academically designed for all physicians, health researchers, and health care professionals, regardless of their medical specialties, or type of employment.
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Articles 12 Documents
Search results for , issue "Vol 6, No 1 (2021)" : 12 Documents clear
Dietary Pattern As a Risk Factor of Diabetes Mellitus and Obesity: Meta-Analysis Septianawati, Linda Wahyu; Dewi, Yulia Lanti Retno; Pamungkasari, Eti Poncorini
Indonesian Journal of Medicine Vol 6, No 1 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Non-Communicable Disease is a disease that is considered unable to transmit or spread from one person to another but is a cause of death globally, especially diabetes mellitus and obesity. According to WHO, the number of deaths due to PTM in 2016 was 40.5 million (71%) worldwide. Diet is  one of the risk factors for Diabetes Mellitus and Obesity. This study aims to analyze the effect of diet as a risk factor for diabetes mellitus and obesity.Subjects and Method: This study was a syste­matic review and meta-analysis using a cross-sectional design. The articles used in this stu­dy were obtained from several databases, including PubMed, Google Scholar, Spring­er­link, and ScienceDirect. The articles used in this study were those published from 2011-2020. The article search was carried out by consi­dering the eligibility criteria defined using the PICO model. P: adults, I: unhealthy eating patterns, C: healthy eating patterns, and O: Diabetes Mellitus and Obesity. The keywords to search for articles were "dietary pattern", "risk", "obesity", and "diabetes mellitus," and "adjus­ted odds ratio". The articles included in this study were full-text articles with cross-sectional study design. Articles were collected using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3 application.Results: A total of 15 articles were reviewed in this study. The meta-analysis showed that an unhealthy diet increased the risk of Diabetes (aOR= 1.65; 95% CI= 1.29 to 2.11; p <0.001). The meta-analysis of 9 articles also showed that an unhealthy diet increased the risk of obesity (aOR= 1.42; 95% CI= 1.21 to 2.66; p <0.001). This meta-analysis combines primary studies from Swaziland, China, Ethiopia, Kenya, Ame­rica, Malaysia, Ghana, Romania, Nepal, Ire­land, and Korea.Conclusion: Unhealthy diet is a risk factor for diabetes mellitus and obesity.Keywords: dietary pattern, diabetes mellitus, obesity, cross-sectionalCorrespondence: Linda Wahyu Septiananwati. Masters Program in Public Health, Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: lindatian81@gmail.com.Indonesian Journal of Medicine (2021), 06(01): 82-94https://doi.org/10.26911/theijmed.2021.06.01.09. 
The Effectiveness of Acupuncture in Insomnia Patients: Meta Analysis Putri, Kurnia Eka; Murti, Bhisma; Prasetya, Hanung
Indonesian Journal of Medicine Vol 6, No 1 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Insomnia is a disease that has a negative impact on the health and well-being of the sufferer. Insomnia can occur in anyone, both men and women with various ages of vulnerability and in individuals with various socioeconomic backgrounds. This study aims to examine the effectiveness of acupuncture in insomnia patients.Subjects and Method: Meta-analysis was performed with PICO which is presented as follows: the population in this study was insomnia patients aged 16-85. The intervention is in the form of acupuncture therapy. The com­parison used was a sham/ placebo acupuncture. The outcome was insomnia. The meta-analysis study was applied to this study with electronic data sources: Clinical Key, Google Scholar, MEDLINE/ PubMed, Science Direct, Scopus. The article used is a full-text article with a randomized control trial (RCT) study design. There were 9 articles used in this study with a sample size of 649 people who were divided into two groups (372 people in the acupuncture group and 277 people in the sham / placebo acupuncture group). Articles were analyzed using the Review Manager 5.4 application. The results of this study aim to determine the Standardized Mean difference (SMD) and hete­rogeneity of the study sample.Results: There is high heterogeneity between one experiment and another (I2= 94%; p <0.001) so that what is used is the Random Effect Model (REM). The provision of acu­puncture therapy was able to reduce the degree of insomnia with the Standardized Mean Diffe­rent (SMD) of 0.98 compared to sham acu­puncture (SMD= -0.98; 95% CI= -1.71 to -0.25; p = 0.008).Conclusion: The provision of acupuncture therapy was able to reduce the degree of insomnia with the Standardized Mean Different (SMD) of 0.98 compared to sham acupuncture.Keywords: Acupuncture, InsomniaCorrespondence: Kurnia Eka Putri. Masters Program in Public Health, Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Indonesia. Email: anggi­pag@gmail.com.Mobile: +628995212646.Indonesian Journal of Medicine (2021), 06(01): 42-51https://doi.org/10.26911/theijmed.2021.06.01.05. 
Meta Analysis the Effect of Acupuncture Therapy on Pain Reduction in Osteoarthritis Patients Susilo, Fahmi Eko; Kristiyanto, Agus; Prasetya, Hanung
Indonesian Journal of Medicine Vol 6, No 1 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Osteoarthritis (OA) is the most common joint condition and is charac­terized by progressive erosion of the articular cartilage. Based on data from Basic Health Research (2018) the prevalence of joint disease in Indonesia is recorded at around 7.3% and osteoarthritis (OA) or arthritis is a common joint disease. As the two main non-surgical methods, physiotherapy and acu­puncture have been shown to be safe and effective in the therapy of osteoarthritis.Subjects and Method: This was a syste­matic review and meta-analysis study. The articles used in this study were obtained from several databases including PubMed, Google Scholar, and Springer Link. The articles used in this study were those published from 2000-2020. The article search was carried out by considering the eligibility criteria defined using the PICO model. The popu­lation in the study were patients with osteo­arthritis complaints with intervention in the form of acupuncture therapy, the comparison was the sham acupuncture outcome in the form of pain reduction. The keywords for finding articles are as follows: "Acupuncture" OR "Osteoarthritis" AND "Randomized Con­trolled Trials". The articles included in this study are full text articles with an obser­vational study design. Articles were collected using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3 application.Results: A total of 9 articles were reviewed in this study. A meta-analysis of 9 rando­mized control trials showed that acupuncture therapy reduced pain in osteoarthritis pati­ents (SMD= -0. 49; 95% CI= -0.88 to -0.10; p= 0.01).Conclusion: Acupuncture therapy reduces pain in osteoarthritis patients.Keywords: acupuncture, osteoarthritis, acupuncture osteoarthritis, randomized control trialCorrespondence: Fahmi Eko Susilo. Masters Program in Public Health. Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: fahmiekss@gmail.­com. Mobile: 081­393644991.Indonesian Journal of Medicine (2021), 06(01): 95-103https://doi.org/10.26911/theijmed.2021.06.01.10. 
Meta-Analysis: Effects of Obesity and Family History of Diabetes Mellitus on the Risk of Gestational Diabetes Mellitus Sitorukmi, Galuh; Dewi, Yulia Lanti Retno; Murti, Bhisma
Indonesian Journal of Medicine Vol 6, No 1 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Gestational diabetes mellitus is a serious complication of pregnancy, this is due to impaired carbohydrate tolerance which results in increased blood sugar levels and was first noticed during pregnancy. Gestational dia­betes mellitus is a global problem in terms of its incidence and impact. Studies suggest that obe­sity and a family history of diabetes mellitus are important risk factors for gestational diabetes mellitus. This study aimed to analyze the influ­ence of obesity and family history of diabetes mellitus on the incidence of gestational dia­betes mellitus by meta-analysis.Subjects and Method: This was a systematic review and meta-analysis carried out by follow­ing the PRISMA flow diagram. The electronic database for article searches is as follows: Pub­Med, Science Direct, Springer Link, Scopus, and Google Scholar. The search for articles was carried out on articles published from 2010 to 2020. The keywords used were "gestational dia­betes mellitus AND obesity", "gestational dia­betes mellitus AND family history. The inclu­sion criteria were full text articles, used Eng­lish, cross-sectional study design, and results reported in adjusted odds ratio (aOR). P= Preg­nant mother. I= Obesity and family history of diabetes mellitus. C= No obesity and no family history of diabetes mellitus. O= gestational dia­betes mellitus. Articles that meet the require­ments are analyzed using the Revman 5.3.Results: Nine articles were reviewed in this study with a total of 11,657 subjects. The results of the meta-analysis showed that obesity incre­ased the risk of gestational diabetes mellitus 1.81 times compared with non-obese (aOR= 1.81; 95% CI= 1.53 to 2.15; p <0.001). Having a family history of diabetes mellitus increased the risk of gestational diabetes mellitus 2.08 times compared with those without a family history of diabetes mellitus (aOR= 2.08; 95% CI= 1.34 to 3.22; p <0.001).Conclusion: Obesity and a family history of diabetes mellitus increase the risk of gesta­tional diabetes mellitus.Keywords: obesity, family history of diabetes mellitus, gestational diabetes mellitusCorrespondence: Galuh Sitorukmi. Masters Program in Public Health. Universitas Sebelas Maret, Jl.Ir. Sutami 36A, Surakarta 57126, Central Java. Email: galuh.sitorukmi1210@gmail.com. Mobile: 085­799333013.Indonesian Journal of Medicine (2021), 06(01): 1-13https://doi.org/10.26911/theijmed.2021.06.01.01. 
The Effect of Sleep Duration on Overweight or Obesity in Female Adolescents: A Meta-Analysis Study Jannah, Putri Isriyatil; Pamungkasari, Eti Poncorini; Prasetya, Hanung
Indonesian Journal of Medicine Vol 6, No 1 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Overweight or obesity is a con­dition of excessive accumulation of fat in the body which is indicated by a Body Mass Index value exceeding 25 kg/m2. WHO esti­mated that in 2022 adolescents will expe­rience more obe­sity cases than underweight cases. One of the behaviors that can reduce the risk of overweight and obesity is having adequate sleep duration. This study aimed to analyze the magnitude of the effect of sleep duration on overweight or obesity in female adolescents with a meta-analysis study.Subjects and Method: This was a syste­matic review and meta-analysis study. The study was carried out by following the PRISMA diagram. The process of the search for articles through a database that included: PubMed, Google Scholar, and Springer Link. The articles were selected in the period 2009-2020. The key­words used include: "sleep duration" AND adolescents, overweight AND "female adoles­cents", obesity AND adoles­cent, "sleep dura­tion" OR "overweight obe­sity" OR adolescents OR "cross-sectional", "sleep duration" AND "overweight obesity "AND adolescent," sleep timing "AND obesity AND girls. The inclusion criteria were full-text articles with cross-sectional study design, English and Indonesian articles, and articles that used multivariate analysis with adjusted Odds Ratio. The articles that qualify were analyzed using the Review Manager 5.3 application.Results: A total of 9 primary articles from Korea, China, and the USA had conducted a meta-analysis with a sample of 104,726 female adolescents. The results of the meta-analysis showed that female adolescentswith short sleep duration had a risk of overweight or obesity 1.44 times compared with female adolescents with long sleep duration (aOR= 1.44, 95% CI= 1.24 to 1.69, p<0.001).Conclusion: Short sleep duration signifi­cantly increases overweight/obesity in female adolescents.Keywords: duration of sleep, overweight or obesity, female adolescentsCorrespondence: Putri Isriyatil Jannah. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: putriisriyatil@gmail.­com. Mobile: 089634956745.Indonesian Journal of Medicine (2021), 06(01): 52-61https://doi.org/10.26911/theijmed.2021.06.01.06.   
The Effect of Kinesio Taping on the Reduction of Pain in Patients with Carpal Tunnel Syndrome: Meta-Analysis Setiawan, Cahyo; Tamtomo, Didik Gunawan; Prasetya, Hanung
Indonesian Journal of Medicine Vol 6, No 1 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Carpal tunnel syndrome (CTS) is the most common occurrence of nerve com­pression. Some cases of CTS have chronic sym­p­toms. The most common complaint is "Noc­turnal Acroparesthesia", which is tingling pain at night. Physiotherapy interventions can be do­ne to relieve complaints of CTS one of which is the use of Kinesio Taping. This study aimed to analyze the effect of Kinesio taping on the re­d­uction of pain in patients with carpal tunnel syn­drome from some previous studies.Subjects and Method: This was a systematic and meta-analysis study. The study used the PICO model as follows Population=Patients with Carpal Tunnel Syndrome, Intervention= Gi­­ven Kinesio Taping, Comparison= Not Given Kinesio Taping, and Outcome=Reductionof Pa­in. The articles used in this study were obtained from several databases including PubMed, Sci­enceDirect, and Google Scholar. The articles we­re collected in a month. The keywords for sear­ching the articles were as follows: "kinesio taping" OR "kinesio tape" OR "pain" OR "carpal tunnel syndrome" AND "Randomized Control­led Trial". The articles included in this study we­re full-text articles with a randomized con­trol­led trial study design. The articles were collected using PRISMA flow diagrams and ana­lyzed using the Review Manager 5.3 ap­p­l­i­cation.Results: The total of seven articles reviewed in this meta-analysis study was from Turkey, Po­land, the Republic of Korea, Egypt, and the USA. The studies showed that giving KT could reduce pain in CTS and it was statistically very significant (Standardized Mean Difference= -1.21; 95% CI= -2.14 to -0.28; p<0.01).Conclusion: Kinesio Taping can reduce pain in Carpal Tunnel Syndrome.Keywords: kinesio taping, reduction of pain, carpal tunnel syndrome.Correspondence: Cahyo Setiawan, Masters Program In Public Health, Sebelas Maret University, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: setiawan.cahyo10@gmail.com.Mobile Pho­ne: 089693257305.Indonesian Journal of Medicine (2021), 06(01): 104-111https://doi.org/10.26911/theijmed.2021.06.01.11. 
Determinants of Delay in Diagnosis and Treatment in Multi Drug-Resistant Tuberculosis Patients in Health Facilities Sutanto, Yusup Subagio; Murti, Paulus Wisnu Kuncoro; Reviono, Reviono; Probandari, Ari Natalia; Kurniawan, Hendra
Indonesian Journal of Medicine Vol 6, No 1 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Multidrug-resistant tubercu­lo­sis (MDR-TB) is a serious threat to global TB control programs. According to WHO, there are 23,000 cases of TB multidrug-/rifampicin-resistant (MDR/RR-TB) in Indonesia. In 2017, there were 442,000 of TB cases. There were 8,600 - 15,000 MDR/RR-TB cases, of which 2.4% were new cases and 13% were previously treated TB cases. This study aims to determine the factors that influence the delay in diagnosis and treatment of MDR-TB patients.Subjects and Method: This study was a cross-sectional study conducted at Dr. Moe­wardi hospital, from Sep­tem­ber to October 2017, Surakarta, Central Java. A sample of 73 MDR-TB patients with disabilities on medical records was selected for this study. The depen­dent variables were delay in diagnosis and delay in therapy of MDR-TB cases. The inde­pendent variables were age, gender, distance to health facilities, and type of health facilities. Data were collected from medical records of MDR-TB patients who were treated from March 2012 to March 2017. Data were analyzed using the chi-square model.Results: Median delay in diagnosis = 4 days. Median treatment delay = 12 days. The average patient who had delayed MDR-TB therapy (≥4 days) was 44 years old (Mean= 44.19; SD= 12.64). Delay in MDR-TB diagnosis was not significantly associated with gender (OR= 0.53; 95% CI= 0.18 to 1.57; p= 0.264), distance to health facility (OR= 1.56; 95% CI= 0.58 to 4.21; p= 0.389), and type of health facility (OR= 0.60; 95% CI= 0.26 to 1.41; p= 0.983). The average of patient who had delayed MDR-TB therapy (≥12 days) was 41 years old (Mean= 41.39; SD= 12.69). Treatment delay was not significantly related to gender (OR= 0.45; 95% CI= 0.16 to 1.26; p= 0.137), distance to health facility (OR=1.44; 95% CI= 0.55 to 3.78; p= 0.466), and type of health facility (OR= 2.31; 95% CI= 1.03 to 5.21; p= 2.967).Conclusion: There was no statistically sig­nificant relationship between gender, dis­tance from the patient's home to health facilities, and type of health facility with the delay in diag­nosis and treatment of MDR-TB patients.Keywords: diagnosis, treatment, TB-MDRCorrespondence: Yusup Subagio Sutanto. Department of Pulmo­nology and Respiratory Medicine, Faculty of Medicine Universitas Sebelas Maret/ Dr. Moe­wardi Hospital, Surakarta. Jl. Kolonel Sutarto No.132, Jebres, Surakarta, Central Java 57126. Email: dr_yusupsubagio@yahoo.com. Mobile: 0811284165.Indonesian Journal of Medicine (2021), 06(01): 14-22https://doi.org/10.26911/theijmed.2021.06.01.02
Correlation between Family Support and Self Care in Type 2 Diabetes Mellitus: Meta-Analysis Islami, Dian Dini; Tamtomo, Didik Gunawan; Prasetya, Hanung
Indonesian Journal of Medicine Vol 6, No 1 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Patients with Type 2 Diabetes Mellitus have a high risk of serious compli­cations. Complications resulting from diabetes can be minimized and prevented by imple­menting self-care behavior. The study revealed that one of the factors that affect self-care acti­vity is family support. The correlation of family support with self-care activity has been exten­sively investigated in several primary studies with several contradictions in the results. This study aimed to determine the correlation between family support and self-care activity in people with type 2 diabetes mellitus using the meta-analysis method.Subjects and Method: This study was a systematic review and meta-analysis. The meta-analysis was carried out by systematically reviewing articles published from 2010 to 2020 from the Pubmed, Google Scholar, DOAJ, and Springer Link databases using search key­words, namely ("Family Support" OR "Social Support") AND ("Self Management "OR" Self Care ") AND" Diabetes Mellitus Type 2". Article searches were carried out using PICO. The study population was people with type 2 diabetes mellitus. Intervention/exposure was getting family support compared to not getting family support, and the outcome was diabetes mellitus self-care. The search for articles was carried out for one month. The articles included in this study were full-text articles with a cross-sectional design. Articles were reviewed using the PRISMA flow diagram guidelines. Articles analyzed using Revman 5.3 Software.Conclusion: People with type 2 diabetes mellitus with good family support will increase self-care activity 2.22 times compared to people with type 2 diabetes mellitus who do not get family support. (aOR = 2.22 (95% CI = 1.84-2.68; p <0.001) The study of 7 articles originated from Africa.Keywords: family support, self-care, diabetes mellitus type 2Correspondence: Dian Dini Islami. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: dian.dinii94@gmail.co. Mobile: 085­72­9483960.Indonesian Journal of Medicine (2021), 06(01): 62-70https://doi.org/10.26911/theijmed.2021.06.01.07. 
The Effect of Ear Acupuncture in Reducing Body Weight in Obesity Patients: A Meta-Analysis Pangestu, Utami; Dewi, Yulia Lanti Retno; Prasetya, Hanung
Indonesian Journal of Medicine Vol 6, No 1 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Obesity is now no longer consi­dered a health problem in developed countries, but has also been faced by developing countries such as Indonesia. According to WHO, obesity worldwide has increased by more than two times from 1980. In 2016, there were 1.9 billion adults who were overweight and more than 600 million of them were obese or overweight. This study aims to analyze the effect of ear acu­puncture therapy on weight loss.Subjects and Method: This study was a systematic review and meta-analysis using the Randomized Controlled Trial design. The arti­cles used in this study were obtained from seve­ral databases including PubMed, Google Scholar, Springerlink, Hindawi, and Science­direct. The articles used in this study were those published from 2008-2020. The article search was carried out by considering the eli­gibility criteria defined using the PICO model. P: obese patients (BMI ≥25), I: ear acu­puncture therapy, C: no ear acupuncture thera­py O: weight loss. The keywords for searching articles are as follows: "auricular acupuncture", AND "obesity", "auricular acupuncture for obe­sity" and "acupuncture obesity randomized con­trolled trial". The articles included in this study are full text articles with a Randomized Con­trolled Trial. Articles were collected using PRISMA flow diagrams. Articles were analyzed using the Review Manager 5.3 application.Results: A total of 7 articles were reviewed in this study. The meta-analysis showed the results that ear acupuncture therapy was effec­tive for weight loss in obese people (SMD= -0.74; 95% CI= -1.31 to-0.16;  p<0.001). This meta-analysis combined primary research from Korea, Taiwan and Iran.Conclusion: Ear acupuncture therapy affects weight loss in obese people.Keywords: auricular acupuncture, obesity, randomized controlled trialCorrespondence: Utami Pangestu. Masters Program in Public Health, Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: utamipangestu@gmail.comIndonesian Journal of Medicine (2021), 06(01): 23-31https://doi.org/10.26911/theijmed.2021.06.01.03. 
Relationship between Family History of Diabetes Mellitus and Gestational Diabetes Mellitus: A Meta-Analysis Ammutammima, Ummu Fatihah; Tamtomo, Didik Gunawan; Murti, Bhisma
Indonesian Journal of Medicine Vol 6, No 1 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Gestational Diabetes Mellitus (GDM) is the most common metabolic disorder first diagnosed during pregnancy. According to the American Diabetes Association (ADA) in 2006, GDM occurred in 7% of pregnancies each year. Family history of diabetes is an important risk factor for GDM. The relationshipbetween family history of DM and GDM has been inves­tigated in several primary studies with several contradictions in the outcome. There­fore, this study aimed to determine the relationship between family history of diabetes and GDM using a meta-analysis method.Subjects and Method: The meta-analysis was conducted by systematically reviewing articles published from 2007 to 2020 from the Pubmed, Google Scholar, Science Direct, and ResearchGate databases. The keywords were "Risk factor" OR "family history" OR "family history DM") AND "GDM" AND "cross sectio­nal". The article search was carried out using PICO: the study population was pregnant women, the intervention/exposure was family history of DM, the comparison was no family history of DM, and the outcome was GDM. The article search was carried out for one month. The articles included in this study were full-text articles with a cross-sectional design. The arti­cles were reviewed using the PRISMA flow diagram guidelines. This study used Revman 5.3 Software to analyze the articles.Results: Family history of DM increased the risk of Gestational Diabetes Mellitus (aOR= 2.02; 95% CI= 1.54 - 2.67; p<0.001). This study used 11 articles from Ethiopia, Cameroon, Peru, Iran, Pakistan, Malaysia, Kuwait, Saudi Arabia, and India.Conclusion: Family history of diabetes melli­tus increases the risk of gestational diabetes mellitus.Keywords: Gestational diabetes mellitus, Family history of diabetesCorrespondence: Ummu fatihah Ammutammima. Masters Pro­gram in Public Health, Universitas Sebelas Maret, Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: ummuftha64@­gmail.­com. Mobile: 081717252573.Indonesian Journal of Medicine (2021), 06(01): 71-81https://doi.org/10.26911/theijmed.2021.06.01.08. 

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