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Jurnal Kartika Kimia

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Published by Universitas Jenderal Achmad Yani

ISSN : 26551322 EISSN : 26550938 DOI : -

Core Subject : Science, Education, Engineering,

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education

Jurnal Kartika Kimia is National Journal that publish all research article/ review/ short communication related to progres of chemistry researchs. Scope of this journal are: 1) Analytical Chemistry ; 2) Inorganic Chemistry ; 3) Physical Chemistry ; 4) Organic Chemistry ; 5) Biochemistry also applied chemistry such as Material Chemistry, Environmental Chemistry, Catalyst, Food Chemistry, Natural Products Chemistry, and Computational Chemistry. Jurnal Kartika Kimia published by Department of Chemistry, Faculty of Sciences and Informatics, Jenderal Achmad Yani University. Jurnal Kartika Kimia publish 2 issues per year at May and November. Jurnal Kartika Kimia can be accessed via print (ISSN 2655-1322) and online (ISSN 2655-0938)

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Articles 87 Documents

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Antiinflammatory Activity from Marine Microalgae Chlorella vulgaris Extract Used Human Red Blood Cells Stability Method (HRBC) Dewi kurnia; Nadya Prisdayanti; Lia Marliani; Idar Idar; Zeily Nurochman
Jurnal Kartika Kimia Vol 2 No 2 (2019): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, Jenderal Achmad Yani University

The biologic protection response against disruption in the body can be an inflammatory reaction. Medications commonly used to treat inflammation are steroids and non-steroids which, if used over a long period, can cause adverse side effects. Several studies have shown that microalgae can be used as an anti-inflammatory agent. This research was conducted to determine the anti-inflammatory activity of the Chlorella vulgaris microalgae extract. Extraction was carried out by multilevel maceration method using n-hexane, chloroform, and ethanol. TLC monitoring results showed that the Chlorella vulgaris extract contained flavonoid, phenol, alkaloid, and steroid saponin compounds. The anti-inflammatory activity test of the extract was carried out used Human Red Blood Cell (HRBC) stability method with Na-diclophenac as a comparison standard. The results showed the inhibition value of red blood cell hemolysis (IC50) in n-hexane, chloroform and ethanol extracts respectively 150,399; 83.852 and 92.349% with the inhibition value of Na-diclophenac standard of 55.149%. Chloroform extract is known to have the most active anti-inflammatory activity which is 83,852 ppm. The results of this study indicate that the chloroform extract in Chlorella vulgaris microalgae has the potential as an anti-inflammatory agent that can be developed as an alternative anti-inflammatory drug from natural marine materials. Keywords: anti-inflammatory, Chlorella vurlgaris, Human Red Blood Cells (HRBC)

Natural Preservation of Woods using Sambiloto (Andrographis paniculata) Leaf Extract for Making Wooden Batik Crafts Istihanah Nurul Eskani; I Made Arya Utamaningrat
Jurnal Kartika Kimia Vol 2 No 2 (2019): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, Jenderal Achmad Yani University

Indonesia is one of wood craft producer. Indonesian crafts have been exported to many countries, such as Japan, Europe and America. Commonly, that crafts used chemical preservatives that identified not safe for environment. A lot of countries had banned the use of toxic preservatives such as arsenic and chromium-based preservatives. Therefore, it is important to use natural preservatives that are safer for human being and the environment. This research aimed to know the ability of Sambiloto (Andrographis paniculata) leaf extract to use as wood preservatives and to determine the preservative treatability of two woods, Mahoni (Swietenia mahogany) and Matoa (Pometia pinnata) woods as material for making interior products such as wooden batik crafts. Matoa and Mahoni wood were preserved by hot bath at temperature of ± 80oC using Sambiloto leaf extract with variation of concentration of 10%, 12.5% and 16.67% for immersion time of 1 hour, 2 hours and 3 hours. The retention value of each variation was calculated and compared with the preservative value for the interior product of SNI 03.5010-1.1999 (≥ 8 kg/m3). The results show that preservation of Matoa wood for indoor uses can be done using Sambiloto leaf extract with concentration of 12.5% and processing time of 2 hours. However, the retention values for Mahoni woods were lower than SNI for all treatment because of its extractive content that make it hard to be preserved. Keywords: batik, wooden crafts, natural preservation, sambiloto

Optimasi Pengendapan Albumin dengan Variasi Suhu, pH dan Konsentrasi Etanol dalam Plasma Darah melalui Metode Simplex Lattice Design Trisna Yuliana; Sandi Adityawarman; Agus Setiyawan
Jurnal Kartika Kimia Vol 2 No 2 (2019): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, Jenderal Achmad Yani University

Albumin is used to treat hypoalbumimenia in various diseases. The utilization of albumin raw materials from donor blood that has exceeded the time limit of use could be advantages, which are reducing dependence on imported albumin and could reduce the cost of processing waste blood. The purity and resulting of albumin can be influenced by various parameters including; temperature, pH and ethanol concentration. In this research, the optimization process is conduct using the Simplex Lattice Design method in order to obtain an optimal composition variation of 7 (seven) parameters variation composition to obtain albumin with a high concentration. Albumin is separated by ethanol fractionation method through differences in protein solubility in plasma. Based on Anova test, the 7 (seven) composition variations of the parameters showed significant differences with p = 0.0282 (<0.05) and F test > F table. The evaluation results show that the composition of the 5th composition formula shows the optimal albumin response with temperature parameters -10oC, pH 4.8 and ethanol concentration of 40%. The albumin content obtained with the composition is 53.59 ug. Keywords: Albumin, temperature, pH, ethanol and Simplex Lattice Design

Elektrodeposisi Komposit Hidroksiapatit-Kitosan dari Bahan Lokal pada Baja Tahan Karat SS 304 Sarah Nasma'ul Aulia; R. Henny Mulyani; Djoko Hadi Prajitno
Jurnal Kartika Kimia Vol 2 No 2 (2019): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, Jenderal Achmad Yani University

In this Research to determine the effect of processing time and the difference of the composition of chitosan in Hydroxyapatite (HA) solution to the weight efficiency of the result from the electrodeposition process, it was used 9 samples but only 3 were carried out into characterization testing they’re HA + Chitosan 10% sample (5 hours), HA + Chitosan 20% (1 hour), HA + Chitosan 20% (5 hours), the current density used during the electrodeposition process is 1.8 A / cm3. The process of stirring with an ultrasonic stirrer is important, so that the colloidal powder contained in the electrolyte solution becomes homogeneous. Characterization tests include X-ray Diffraction (XRD) testing, scanning Electron Microscopy (SEM) and Simulated Body Fluid (SBF). The addition of chitosan to HA alloy solutions is very useful to increase the stickiness of the sediment layer on the substrate, because the properties of HA is very fragile when in direct contact with human body fluids its because of the low level of stability. In this study the highest peak on the X-Ray Diffraction pattern was found in the composite HA + Chitosan 20% (1 hour), which is the position 31.91, and for the% weight of calcium (Ca) in the HA + Chitosan sample 20% (1 hour) also the highest among other samples was 27.03%. From the SBF test results, the highest corrosion rate in the HA + Chitosan 10% sample is 1.076 mpy, while for the HA + Chitosan sample 20% is only 0.058 mpy. Keywords: Electrodeposition, Hydroxyapatite, Chitosan, Ultrasonic Stirrer, XRD, SEM-EDS, SBF, Calsium

Pengaruh Variasi Konsentrasi Pati Talas Beneng (Xanthosoma undipes K. Koch) Sebagai Penghancur Terhadap Kadar Zat Aktif dan Uji Batas Mikroba Tablet Parasetamol 500 mg Indriatmoko Danang Dimas; Nani Suryani; Dwi Putri Lestari; Tarso Rudiana
Jurnal Kartika Kimia Vol 2 No 2 (2019): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, Jenderal Achmad Yani University

Sediaan tablet terdiri atas zat aktif dan eksipien. Eksipien atau zat tambahan pada formulasi tablet dapat berupa zat pengisi, zat pengikat dan adhesif, disintegran (penghancur), lubrikan, glidan, antiadheren, adsorben, zat penyedap, dan zat pewarna. Eksipien merupakan zat inert secara fisik, kimia, dan farmakologi yang ditambahkan ke dalam formulasi sediaan tablet untuk membantunya memenuhi persyaratan proses teknologi, persyaratan spesifikasi teknis, fisik, penampilan, persyaratan mutu resmi (farmakope). Eksipien penting untuk sediaan tablet adalah bahan penghancur. Bahan penghancur mempengaruhi pelepasan zat aktif obat dari sediaan untuk kemudian dapat memberikan efek terapi yang diinginkan. Salah satu bahan penghancur adalah amilum atau pati. Tanaman yang berpotensi memiliki kadar pati yang tinggi adalah talas beneng. Umbi Xanthosoma undipes K. Koch sendiri memiliki kadar pati sebesar 15.21%. Penelitian ini bertujuan untuk mengetahui pengaruh konsentrasi pati talas beneng terhadap kadar dan batas mikroba tablet parasetamol 500 mg. Pembuatan tablet dilakukan dengan kempa langsung dengan variasi konsentrasi pati talas beneng sebagai penghancur yaitu 0% (FI), 5% (FII), 10% (FIII) dan 15% (IV). Hasil penetapan kadar menunjukkan bahwa semua formulasi memenuhi persyaratan kadar Farmakope Indonesia yaitu FI = 100,27%; FII = 99,95%; FIII = 100,06%; dan FIV 99,85%. Uji batas mikroba menunjukkan bahwa Angka Lempeng Total FI = 20 cfu/g; FII = 35 cfu/g; FIII = 10 cfu/g; FIV = 50 cfu/g. Angka Kapang Kamir yaitu FI = 110 cfu/g; FII = 100 cfu/g; FIII = 50 cfu/g; FIV = 150 cfu/g. Uji bakteri patogen menunjukkan bahwa semua formula tidak tercemar bakteri patogen. Kata kunci: tablet, Xanthosoma undipes K.Koch, parasetamol, penetapan kadar, mikroba

Antifungal Activity of Red Galangal Oil (Alpinia purpurata K. SCHUM) Against Malassezia furfur Hernandi Sujono; Senadi Budiman; Yusi Fudiesta; Ahmad Sahroni; Jasmansyah Jasmansyah; Lela Lailatul Khumaisah
Jurnal Kartika Kimia Vol 2 No 2 (2019): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, Jenderal Achmad Yani University

Plant red galangal (Alpinia purpurata K. Schum) is one of the many spices used as bio-pharmacy products which contain essential oil that is active as an antifungal and antibacterial agent. Isolation of volatile oil from red galangal rhizome (Alpinia purpurata K. Schum) uses the method of water and steam distillation so as to get the rendemen 0.1062%, the density 0.9524 g/mL and the index of refraction by 1.4862. Results from GC-MS (Gas Chromatography-Mass Spectrometry) retrieved 30 compounds contained in red galangal rhizome oil with 10 major compounds i.e. 1,8-cineole (40.92%), acetyl chavicol (10.33%), cis β-farnesene (6.91%), 1-caryophillene (6.32%), 1-β-bisabolene (3.37%), β-elemene (3.23%), α-pinene (3.20%), β-sesquiphellandrene (2.32%), β-pinene (2.21%), and germacrene-D (1.90%). The inhibition test was done by agar diffusion method and different variations of concentration (1, 2, 3 and 4%) compared with ketoconazole 2% as positive controls and dimethyl sulfoxide (DMSO) as negative controls with an incubation period of 2x24 hours. The test results show that the essential oil of red galangal rhizome (Alpinia purpurata K. Schum) can inhibit the growth of the fungus Malassezia furfur with the inhibitory power on concentrations1, 2, 3 and 4% were 7.15 mm, 13.87 mm, 16.05 mm and 20.05 mm, respectively. As for comparison, ketoconazole 2% was used as positive (+) control that produces inhibitory zone 27.20 mm and dimethyl sulfoxide (DMSO) as negative control (-) which does not produce inhibitory zones. Keywords: Essential oil, red galangal rhizome (Alpinia purpurata K. Schum), Malassezia furfur

Identification of HV1 and HV2 D-Loop Regional Mitochondrial DNA Mutations from Type 2 Diabetes Mellitus Patients (DMT2) Rina Budi Satiyarti; Nenden Dwi Sejati; Rahmaniar Mulyani
Jurnal Kartika Kimia Vol 3 No 1 (2020): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, Jenderal Achmad Yani University

Diabetes mellitus tipe 2 (DMT2) adalah penyakit yang disebabkan oleh penurunan jumlan insulin oleh sel beta pankreas atau kerja insulin yang tidak efektif. Penyakit ini terakumulasi dari gaya hidup tidak sehat atau karena keturunan. Penyebab DMT2 dapat dikaitkan dengan disfungsi DNA mitokondria (mtDNA) yang disebabkan oleh penumpukkan mutasi. Daerah D-loop merupakan bagian dari mtDNA yang memiliki dua daerah yaitu HV1 dan HV2 dengan laju mutasi paling tinggi. Maka, dilakukan penelitian untuk mengidentifikasi mutasi d-loop daerah HV1 dan HV2 untuk mencari mutasi baru yang berkaitan dengan DMT2. Tahapan yang dilakukan meliputi isolasi mtDNA, amplifikasi fragmen HV1 dan HV2 dengan teknik Polymerase Chain Reaction (PCR), visualisasi hasil PCR dengan elektroforesis gel agarosa, penentuan urutan nukleotida daerah HV1 dan HV2 mtDNA, dan analisis hasil sekuensing. Berdasarkan hasil analisis dari perbandingan antara urutan nukleotida sampel dengan revised Cambridge Reference Sequence (rCRS), ditemukan mutasi 16189T>C pada sampel DM02; DM03, dan mutasi 16223C>T pada sampel DM02; DM03; DM04 daerah HV1 D-loop mtDNA, juga mutasi 73A>G pada sampel DM02; DM03; DM04 daerah HV2 D-loop mtDNA. Hasil analisis pada MITOMAP menunjukkan bahwa mutasi 16189T>C tercatat sebagai mutasi yang terdapat pada diabetes, mutasi 16223C>T tidak terkait dengan penyakit apapun, dan mutasi 73A>G terdapat pada penuaan sel otak. Kata Kunci: Diabetes mellitus tipe 2 (T2DM), mitokondria DNA, D-loop, mutasi, MITOMAP.

Ultrafiltration Membrane Of Polysulfone/ TiO2 (Psf/TiO2) For Diesel Fuel Polluted Water Filtration Alfian Yulia Rahmat; Intan Syahbanu; Rudiyansyah Rudiyansyah
Jurnal Kartika Kimia Vol 3 No 1 (2020): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, Jenderal Achmad Yani University

Membrane is an important part in ultrafiltration process to split up water from its impurities. Commonly membranes are made of polymer which has adequate resistance in filtration process. One type of them is polysulfone. Good physical endurance is its supremacy as material in the manufacture of membranes. Nevertheless, the hydrophobic nature of polysulfone makes membrane performance less efficient. Blending process using TiO2 can lessen the hydrophobicity of polysulfone, but still maintain membrane primacy. The blending process was carried out by the phase inversion method. Membrane physical structure was observed by SEM and XRD analysis. The pore arrangement on both membranes looks asymmetric. However, the PSF/TiO2 membrane has more systematic pore disposition. Good crystallinity was noticed on PSF/TiO2 membranes with crystal size of 27 nm whereas pure polysulfone looks more amorphous. Membrane performance can be discerned by considering various parameters after performance tests by using diesel fuel emulsion in water. Some of these parameters include flux, rejection, and total fouling after the emulsion filtration process. PSF/ TiO2 membrane flux values showed better results at 21.05 L/m2 hour. Rejection of the PSF/TiO2membrane looked better as well, spesifically 70,857%. Total fouling showed preferable result on the PSF/TiO2 membrane, which was 42.34%. The insertion of TiO2 by a composition of 10% of the total PSF used can improve membrane performance and morphology. Keywords: Filtration, Flux, Membrane, polysulfone, TiO2

Analysis Of Phytochemical Profile And Antioxidant Activities From Ethanol Extract Of Leaf, Stem Bark And Wood Clausena lansium L. Fajar Fauzi Abdullah; Ruchiyat Ruchiyat; Iqbal Musthapa
Jurnal Kartika Kimia Vol 3 No 1 (2020): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, Jenderal Achmad Yani University

Wampi belongs to Rutaceae family. The shape of this plant is kind of bush or small tree and its fruits are similar to grapples or oranges. C. lansium was reported has the main biological activity as radical scavenger. The aim of this study to identify the content of secondary metabolites found in bark, woody stems and leaves of C. lansium plants, and to determine antioxidant activity through IC50 values. This research method begins with sample preparation, plant determination, simplicia characteristic examination, extraction, characterization with infrared spectroscopy, thin layer chromatography (TLC), then proceed with antioxidant activity assay using DPPH method (2.2 -Diphenyl-1-picrylhidrazyl) with a comparison of vitamin C. The results of this study showed that C. lansium contains alkaloids and kumarin. Furthermore, antioxidant activity assay measured absorption at a wavelength of 517 nm, obtained IC50 values of vitamin C 6.22 ppm; bark 231.54 ppm (weak), wood stem 131.49 ppm (weak), and leaves 22,60 ppm (strong). Keywords: Clausena lansium, Antioxidant, phytochemical profile.

The Activity of Marine Microalgae Extract Chlorella vulgaris Against Propionibacterium acnes and Formulated As Emulgel Aris Suhadirman; Sinta Purnamasari; Dewi Kurnia
Jurnal Kartika Kimia Vol 3 No 1 (2020): Jurnal Kartika Kimia
Publisher : Department of Chemistry, Faculty of Sciences and Informatics, Jenderal Achmad Yani University

Chlorella vulgaris merupakan salah satu jenis mikroalga yang mempunyai potensi untuk dimanfaatkan sebagai antibakteri. Aktivitas antibakteri tersebut diketahui karena adanya kandungan asam lemak. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri dari mikroalga Chlorella vulgaris terhadap bakteri Propionibacterium acnes. Chlorella vulgaris ditumbuhkan dalam medium Walne dan dikultivasi dengan kondisi suhu ruang (±25-27°C), fotoperiod 12:12 (gelap:terang), intensitas cahaya 10.000 lux dan aerasi selama 24 jam. Ekstraksi Chlorella vulgaris dilakukan dengan metode maserasi bertingkat menggunakan pelarut n-heksana, kloroform dan etanol. Uji aktivitas antibakteri dilakukan dengan metode Broth Microdillution pada konsentrasi 65.536 µg/mL hingga diperoleh konsentrasi terkecil 64 µg/mL dengan pengenceran. Berdasarkan hasil diperoleh nilai KHM pada konsentrasi 8.192 µg/mL dan KBM pada konsentrasi 16.384 µg/mL pada ekstrak n-heksana. Kemudian dilanjutkan dengan uji bioautografi yang menunjukan senyawa aktif antibakteri berasal dari asam lemak galaktolipid. Aktivitas antibakteri Chlorella vulgaris terhadap bakteri P. acnes berpotensi untuk dikembangkan dalam bentuk sediaan emulgel. Hasil uji aktivitas sediaan emulgel pada konsentrasi 8% diperoleh diameter zona hambat 12,63 mm. Berdasarkan hasil yang diperoleh, dapat disimpulkan bahwa ekstrak dan sediaan emulgel dari mikrolaga Chlorella vulgaris mempunyai aktivitas antibakteri terhadap bakteri Propionibacterium acnes. Kata Kunci : Antijerawat, Propionibacterium acnes, Chlorella vulgaris, Emulgel

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