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INDONESIA
ISM (Intisari Sains Medis) : Jurnal Kedokteran
Published by Universitas Udayana
ISSN : 25033638     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Intisari Sains Medis is published by Medical Scientific Community, Indonesia. Intisari Sains Medis is an international, multidisciplinary, peer-reviewed, open access journal accepts papers for publication in all aspects of Science Digest, Medical Research Development, Research Medical Field and Theory. We also publish cases from third world country, that is considered very rare and special cases.
Arjuna Subject : -
Articles 17 Documents
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Search results for , issue "Vol. 9 No. 2 (2018): (Available online: 1 August 2018)" : 17 Documents clear
The accuracy of automated oscillometry compared to manual doppler in measuring ankle brachial index in suspected peripheral arterial disease patients: a systematic review Achmad Ismail Sampurna Putra
Intisari Sains Medis Vol. 9 No. 2 (2018): (Available online: 1 August 2018)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (555.051 KB) | DOI: 10.15562/ism.v9i2.152

Abstract

Background: Golden standard to diagnose Peripheral Artery Disease (PAD) is angiography. A more common and practical alternative technique is by calculating Ankle Brachial Index (ABI) using Oscillometry as systolic blood pressure measurement. Though, its accuracy remains obscure.Methods: A systematic search was performed using PubMed and Google Scholar database.  There were 11 articles were found after reviewed for the title and abstract by inclusion and exclusion criteria. However, only 6 articles were relevant and used by the authors.Results: Based on the six journals appraised, the sensitivity of automated oscillometry in detecting PAD (ABI <0.9) ranged from 0.4-0.7. The specificity, however, showed better result around 0.75-1. It shows that those patients who scored negative for PAD with oscillometry are not likely to have the disease. Automated oscillometry in studies appraised was also seen to have moderate positive and negative predictive value, which may indicate the possibility of this simpler diagnostic tool to be used to screen PAD. Most of the studies demonstrated good likelihood ratio for oscillometry, which even adds more power to oscillometry as a PAD diagnostic tool.Conclusion: Automated oscillometry was comparable with manual Doppler due to its high specificity. Several advantages were identified such as; oscillometry required less reliant on the specialized skills, commonly available, reliable, and simple to use which can be performed by primary care physicians even in their primitive set up. Thus, the oscillometric method can be utilized as an alternative in diagnosing patients suspected with PAD.
Gambaran evaluasi tingkat nyeri pasien pasca operasi radang usus buntu dengan bedah terbuka dan laparoskopi di Rumah Sakit Umum Pusat Sanglah Denpasar tahun 2016 Dewa Ayu Wahyu Diantari; IGL Ngr Agung Artha Wiguna; I Wayan Niryana
Intisari Sains Medis Vol. 9 No. 2 (2018): (Available online: 1 August 2018)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (239.109 KB) | DOI: 10.15562/ism.v9i2.158

Abstract

Radang pada usus buntu merupakan peradangan dari apendiks vermiformis. Pasien pasca operasi radang usus buntu yang ditangani dengan bedah terbuka atau laparoskopi akan merasakan suatu sensasi nyeri dari tindakan pembedahan yang dilakukan. Tujuan: Mengetahui gambaran evaluasi tingkat nyeri secara umum dan berdasarkan karakteristik data sampel. Metode: Penelitian ini menggunakan desain retrospektif observasional. Sampel ialah pasien pasca operasi radang usus buntu dengan bedah terbuka dan laparoskopi di Rumah Sakit Umum Pusat Sanglah Denpasar dari tahun 2016 dari hari pertama hingga hari ketiga pasca operasi. Pengambilan data menggunakan data sekunder, meliputi: skor VAS (visual analog scale) yang telah tertera pada rekam medis pasien. Tingkat nyeri dilihat dari hari pertama hingga hari ketiga pasien pasca operasi radang usus buntu dengan bedah terbuka dan laparoskopi. Hasil: Terdapat sebanyak 44 orang pasien bedah terbuka memberikan gambaran tingkat nyeri yang terdata pada hari pertama 75% nyeri ringan dan 25% nyeri sedang, hari kedua 2,3% tanpa nyeri, 86,4% nyeri sedang, dan 11,4 nyeri berat, serta pada hari ketiga 9,1% tanpa nyeri, 88,6 nyeri ringan, 2,3% nyeri sedang. Terdapat pula 6 orang pasien dengan laparoskopi yang terdata pada hari pertama 50% tanpa nyeri dan  50% nyeri ringan, pada hari kedua 66,7% tanpa nyeri dan 33,3% nyeri ringan, serta pada hari ketiga 83,3% tanpa nyeri dan 16,7% nyeri ringan. Simpulan: Gambaran evaluasi tingkat nyeri pasien pasca operasi radang usus buntu dengan bedah terbuka adalah nyeri ringan, sedangkan untuk laparoskopi adalah tanpa nyeri. 
Prevalence, characteristics and risk factors of suicides in Denpasar from 2014-2016 Pravinthiran Manokaran; Luh Nyoman Alit Aryani; Ni Ketut Putri Ariani
Intisari Sains Medis Vol. 9 No. 2 (2018): (Available online: 1 August 2018)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (814.847 KB) | DOI: 10.15562/ism.v9i2.159

Abstract

Suicide is an important health issue worldwide which is generally on the rise from annually. It has no known pathophysiology; it interlinks psychological, biological, societal and environmental factors. Aim: This study was conducted to identify the prevalence and various variables, such as characteristics, methods and risk factors of attempted and completed suicides. Methods: This is a cross-sectional descriptive study which was conducted in Denpasar from 2014-2016 and the subjects of study are those attempted and died from suicides. Data were collected from resident’s log book and medical records from Psychiatric and Forensic departments in RSUP Sanglah and police reports from Polresta Denpasar. Data collected from Polresta has also included those from Forensic. Results: Age group 15-29 years (121), females (118), married people (82), private sector employees (109), and Balinese (108) have highest numbers of suicide attempts in their respective character groups. Poisoning (145) and problems with a partner (99) are the most typical methods of choice and risk factor respectively among the 176 cases of attempted suicides. Age group 30-49 years (11), males (17), married people (16), private sector employees (16), and Balinese (13) have highest numbers of completed suicides. Hanging (22) and economy crisis (13) are the most prevalent method and risk factor among the 23 cases of completed suicides. Conclusion: Findings of this study show that there were 176 suicide attempts and 23 suicide deaths in Denpasar from 2014-2016.
The relationship between the decrease in Glomerulus Filtration Rate (GFR) and the increase in amount of coronary artery lesions on coronary heart disease patients in Sanglah General Hospital, Denpasar-Indonesia I Nyoman Triaditya Kresna Putra; I Kadek Susila Dharma; Ida Bagus Rangga Wibhuti
Intisari Sains Medis Vol. 9 No. 2 (2018): (Available online: 1 August 2018)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (214.389 KB) | DOI: 10.15562/ism.v9i2.160

Abstract

Coronary heart disease or coronary artery disease is caused by the atherosclerosis process in the coronary blood vessels. The high number of patients with this condition is significantly due to the influence of modern and all instant lifestyle. Among the factors suspected to be capable of influencing the increase in the number of coronary artery lesions in coronary heart patients is the Glomerulus Filtration Rate (GFR). This result is related to the high mortality and morbidity of coronary heart patients. Aim: The purpose of this research is to determine the relationship between the decrease in glomerulus filtration rate (GFR), the disturbance variables (age, gender, hypertension history, diabetes mellitus history, smoking history) and the increase in the number of coronary artery lesions in Sanglah General Hospital. Methods: This research is an analytical observational design with the cross-sectional design using secondary data from the medical records in Sanglah General Hospital Denpasar. This study attains 196 sample. Results: A significant relationship is attained between GFR (<60 ml/ minute) and the increase in the total vessel score (p = 0.017) with an OR 2.47 (CI95% 1.014-6.041). Furthermore, there is a significant relationship between risky age (male >45, female >55) and the increase in total vessel score (p = 0.015) with an OR 3.54 (CI 95% 1.217-10.307). Diabetes mellitus and the increase in the total vessel score also shows a significant relationship  (p = 0.016) with an OR 2.99 (CI 95% 1.189-7.539). While other risk factors such as gender, hypertension, and smoking have an insignificant relationship (p > 0.05). In the multivariate analysis, GFR (<60 ml/ minute) is a predictor of the vessel score (p=0,050) with an adjusted value of OR 1.86 (CI 95% 0.735-4.725). There are some other variables in which are significant predictors of the increase in vessel score. Risky age (male >45, female >55) (p=0,048) with an adjusted OR value of 3.08 (CI 95% 1.012- 9.407) and also diabetes mellitus (p=0.044) with an adjusted OR value of 2.65 (CI 95% 0.145-0.973) are those predictors. Conclusion: Hence, it appears that GFR (<60 ml/ minute), risky age (male >45, female >55) and diabetes mellitus have a significant relationship with the increase in vessel score and are predictors of the increase in vessel score. While gender, hypertension, and smoking do not have significant relationships with the increase in the amount of vessel score.
Risk factors of preeclampsia and eclampsia in Sanglah General Hospital from March 2016 to March 2017 Ng Teng Fung Vincent; I Made Darmayasa; Anom Suardika
Intisari Sains Medis Vol. 9 No. 2 (2018): (Available online: 1 August 2018)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (230.343 KB) | DOI: 10.15562/ism.v9i2.162

Abstract

Background: Preeclampsia and eclampsia have been increasing at an alarming rate. It is a challenging task for doctors and pregnant mothers. Preeclampsia defined as new onset of hypertension (≥140mmHg systolic or ≥90mm Hg diastolic on at least two occasions 6 hours apart) and proteinuria (at least 1+ on dipstick or ≥300mg in a 24-hour urine collection) after 20 weeks of gestation. Eclampsia defined as neurologic involvement in the form of generalized tonic-clonic convulsions in women with preeclampsia is termed eclampsia if the seizures cannot be attributed to any other cause such as epilepsy, cerebral infection, tumor or ruptured aneurysm. Aim: This study aims to find the association of risk factors for preeclampsia and eclampsia. The risk factors for preeclampsia and eclampsia are obesity, primigravida, multiple pregnancies, diabetes, pre-existing hypertension, family history, expecting mother’s age, nutritional status, and socioeconomic status. The study was carried out by using descriptive research and data were collected from medical records in Sanglah hospital which has 140 cases. Results: The results for preeclampsia are highest in expecting the age of 20-35 years old, primigravida women with gestational age > 37 weeks, overweight and overnourished women, a middle socioeconomic status and also without risk factors. The results for eclampsia are dominant in expecting age of 20-35 years old, primigravida women with gestational age > 37 weeks, women with middle socioeconomic status and majority without risk factors, and women who are overweight and overnourished. Conclusion: Preeclampsia and eclampsia cases are highest in expecting age of 20-35 years old, primigravida women with gestational age >37 weeks, overweight and overnourished women, majority women without risk factors and from middle socioeconomic status.
Hubungan antara bayi berat lahir rendah dengan asfiksia neonatarum di RSUD Wangaya Kota Denpasar Ida Bagus Wiadnyana; I Wayan Bikin Suryawan; A.A Made Sucipta
Intisari Sains Medis Vol. 9 No. 2 (2018): (Available online: 1 August 2018)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (208.28 KB) | DOI: 10.15562/ism.v9i2.167

Abstract

Latar Belakang: Bayi Berat Lahir Rendah (BBLR) pada bayi masih merupakan masalah di bidang kesehatan terutama kesehatan perinatal. Prevalensi bayi dengan berat badan lahir rendah (BBLR) diperkirakan 15% dari seluruh kelahiran di dunia dengan batasan 3,3%-38% dan lebih sering terjadi di negara berkembang atau negara dengan sosio-ekonomi rendah. Komplikasi yang sering terjadi pada BBLR seperti hipotermi, gangguan pernafasan, gangguan alat pencernaan, gangguan immunologi, immatur hati, immatur ginjal serta perdarahan. Pada BBLR dapat terjadi kekurangan surfaktan dan belum sempurna pertumbuhan dan perkembangan paru sehingga kesulitan memulai pernafasan yang berakibat untuk terjadi asfiksia neonatorum. Tujuan dari penelitian ini adalah untuk mengetahui hubungan derajat BBLR dengan derajat asfiksia neonatorum.Metode: Jenis penelitian yang digunakan adalah observasional analitik dengan rancangan penelitian cross sectional. Pada penelitian ini, pengambilan sampel dilakukan pada BBLR di RSUD Wangaya periode April 2016 - April 2017 di ruang Nicu dan Perinatologi sampai jumlah sampel penelitian yang memenuhi kriteria inklusi dan eksklusi dengan jumlah sample total 87 sampel. Sampel diperoleh melalui metode consecutive sampling, selanjutnya dilakukan pengumpulan data yang diperlukan. Data yang diperoleh dianalisis secara analitik, selanjutnya disajikan dalam tabulasi data serta dijabarkan menggunakan tabel dan narasi.Hasil: Terdapat hubungan yang signifikan antara derajat BBLR dengan derajat Asfiksia Neonatarum (p=0,03), BBLR merupakan factor resiko terhadap derajat asfiksia dengan nilai resiko prevalensi (RP)=2,08 (IK 95%=1,08 – 1,30).Simpulan: Terdapat hubungan yang signifikan antara derajat BBLR dengan derajat Asfiksia Neonatarum.
Gambaran pengetahuan, sikap, dan praktik ibu balita terhadap penatalaksanaan diare pada anak balita di wilayah kerja Puskesmas Abang 1 Made Rahayu Suryapramita Dusak; Yetty Sukmayani; Stephanie Apriliana Hardika; Luh Putu Ariastuti
Intisari Sains Medis Vol. 9 No. 2 (2018): (Available online: 1 August 2018)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (265.358 KB) | DOI: 10.15562/ism.v9i2.168

Abstract

Latar Belakang: Diare merupakan salah satu permasalahan kesehatan dunia yang menjadi penyebab utama kedua kematian anak dibawah lima tahun. Diare dan gastroenteritis dengan penyebab infeksi juga ditemukan masih termasuk ke dalam 10 besar penyakit dengan kunjungan terbanyak di Puskesmas Abang I, Karangasem. Edukasi kesehatan mengenai diare pada balita serta penanganannya penting untuk keefektifan penatalaksanaan kasus diare. Berdasarkan survei singkat yang dilakukan pada 10 orang ibu balita terkait dengan penanganan diare di rumah didapatkan bahwa sebagian besar (70%) ibu balita memberikan penanganan yang kurang tepat. Hal ini menunjukkan kecenderungan perilaku yang kurang tepat dalam penatalaksanaan diare di rumah.Metode:  Penelitian ini merupakan studi deskriptif cross sectional dengan melibatkan 62 subjek penelitian yang merupakan ibu balita di wilayah kerja Puskesmas Abang I. Penelitian ini dilakukan bertujuan untuk mengetahui gambaran pengetahuan, sikap, dan praktik ibu balita dalam penatalaksanaan diare pada anak balita di wilayah kerja Puskesmas Abang I. Penelitian ini menggunakan metode purposive sampling untuk memilih tiga desa yang berada di wilayah kerja Puskesmas Abang I dan pengambilan sampel dilakukan dengan snowballing method. Cara pengumpulan data pada penelitian ini dengan melakukan wawancara berbasis kuesioner.Hasil: Pada penelitian ini didapatkan gambaran pengetahuan mengenai diare pada balita mayoritas dalam kategori kurang (91,9%).Simpulan: ibu balita memiliki pengetahuan kurang terkait penatalaksanaan diare pada balita, dimana sebagian besar ibu balita masih merespon negatif dalam penanganan awal saat anak mengalami buang air besar lebih encer dari biasanya serta penanganan diare cukup dengan oralit saja. Selain itu, sebagian besar ibu balita juga masih memiliki praktik yang kurang tepat terkait penggunaan obat tradisional dan pemberian teh manis pada balita dengan diare.
Pemberian ekstrak etanol Cordyceps militaris dapat menurunkan kadar glukosa darah dan menghambat penurunan massa sel beta pankreas pada tikus diabetes mellitus yang diinduksi dengan Streptozotocin dan Nikotinamid Jopy Wikana
Intisari Sains Medis Vol. 9 No. 2 (2018): (Available online: 1 August 2018)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (746.024 KB) | DOI: 10.15562/ism.v9i2.174

Abstract

Background: The antioxidant and anti-inflammatory effects of Cordyceps militaris extracts can neutralize the increased production of Reactive Oxygen Species (ROS) due to hyperglycemia conditions, as well as neutralize NO produced through inducible Nitric Oxide Synthase (iNOS). Thus, the antioxidant effects of C. militaris extract are expected to decrease DNA damage and ER stress leading to intrinsic apoptosis of pancreatic beta cells. Another positive effect of C. militaris which is expected to suppress glucotoxicity is its hypoglycemic effect.Methods: The design of this study was Randomized Post-test Only Control Group Design. The study was conducted on mice divided into three groups: negative control group (DM + placebo), treatment 1 group and treatment 2 group.Results: Based on study on 15 rats, each 5 rats per group, it was found that the mean blood glucose level in control group was 399,20 ± 28,07 mg/dl, mean of blood glucose level of treatment 1group  (extraction 50% ethanol Cordyceps militaris) was 198.60 ± 30.42 mg/dl, and, the mean blood glucose levels of the treatment 1 group  (extract ethanol Cordyceps militaris 100%) was 141.00 ± 17.03 mg/dl. With One Way ANOVA test found that p-value = 0,001. Immunohistochemical examination result shows that beta cell mass is more prominent in either treatment group 1 and treatment group 2 compare to the control group.Conclusions: There were significant differences in blood glucose levels after extracted ethanol Cordyceps militaris. It is further known that ethanol extract of Cordyceps militaris can decrease blood glucose level by 50,25% at 50% concentration and 64,68% at 100% concentration. Immunohistochemical examination result shows that ethanol extract of C. militaris seem could inhibit the decrease of beta cell mass especially at 100% concentration.
Metilasi DNA dalam Perkembangan Kanker Kolorektal Ni Nyoman Ayu Dewi; Ni Made Pramita Widya Suksmarini
Intisari Sains Medis Vol. 9 No. 2 (2018): (Available online: 1 August 2018)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (348.292 KB) | DOI: 10.15562/ism.v9i2.176

Abstract

Kanker kolorektal adalah kanker yang terjadi pada kolon (usus besar) dan rektum. Kanker kolorektal menempati urutan kedua sebagai penyebab kanker di negara-negara berkembang dengan angka kematian yang tinggi. Selama ini perubahan genetik dipandang sebagai faktor paling penting dalam inisiasi dan progresivitas kanker. Namun beberapa tahun terakhir diketahui bahwa perubahan epigenetik juga memiliki peran yang sama pentingnya dengan perubahan genetik dalam perkembangan kanker. Perubahan epigenetik meliputi metilasi DNA, modifikasi histon, dan non-coding RNA. Diantara ketiga mekanisme ini, metilasi DNA adalah yang paling banyak dipelajari. Dalam artikel ini dibahas mengenai proses metilasi DNA pada sel normal dan sel kanker, khususnya kanker kolorektal. Pengetahuan dan pemahaman mengenai mekanisme epigenetik sangat diperlukan untuk kepentingan pencegahan maupun pengobatan kanker.
Laporan Kasus: Perimortem Sectio Caesarean pada Ibu Hamil dengan Henti Jantung Yanti Permatasari; Willy Yant Kartolo
Intisari Sains Medis Vol. 9 No. 2 (2018): (Available online: 1 August 2018)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (664.238 KB) | DOI: 10.15562/ism.v9i2.196

Abstract

Background Perimortem caesarean section (PMCS) was done in pregnant women with no hope for survival, and not responding to initial resuscitative maneuver. The primary aim of PMCS procedure is to empty the uterus to aid maternal resuscitation.Case Presentation We performed a PMCS after no response of cardiopulmonary resuscitation (CPR) in a 19 years old woman with severe preeclampsia, severe anemia, and acute lung edema.ConclusionThis is a case report of PMSC procedure performed in maternal cardiac arrest. The PMCS was done after no response of CPR with left uterine displacement (LUD). However, the outcome of maternal and neonatal deaths was unavoidable.

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