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Biomolecular and Health Science Journal

BHSJ
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Published by Universitas Airlangga

ISSN : - EISSN : 26208636 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Bimolecular and Health Science Journal (BHSJ) is a scientific peer-reviewed medical doctor which relevant to a medical doctor and other health-related professions by the Faculty of Medicine Universitas Airlangga, Indonesia. BHSJ provides a forum for original article, review article, editorial, case report(s), letter(s) to the editor, short communication and it will be published two times a year. Studies that focus on evaluating and understanding the complex medical importance are welcomed in BHSJ.

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Articles 16 Documents

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Search results for , issue "Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal" : 16 Documents clear

Palliative Therapy of Esophageal Stent Installation with Shim Modified Fixation Techniques on An Esophageal Adenocarsinoma Patients Yudith Annisa Ayu Rezkita
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Esophageal carcinoma is a progeny disease that often results in significant disruption to the ability to ingest solid foods and liquid foods at an advanced stage. Reported case of a 27-year-old man with a diagnosis of an intestinal type of adenocarcinoma gastroesophageal junction stage III with a dysphagia score 4. Diagnosis based on anamnesis, endoscopy and anatomical pathology. Patients have undergone chemotherapy and palliative therapy with esophageal dilatation. Patients experienced improvement in dysphagia score from initial score 3 (unable to swallow solid or liquid food), to 2 (able to swallow semisolid food) after the installation of esophageal stent. The patient planned to continue therapy his chemotherapy.

Age as the Risk Factor that Affected the Increased Degree of Uterine Prolapse Shervil Kagayaita Sayko; Eighty Mardiyan Kurniawati; Pudji Lestari
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Uterine prolapse is a gynecological problem that women often experience with a prevalence of 50% and is predicted that the next 30 years will increase by 45% as life expectancy increases. Increased degrees of uterine prolapse have an impact on the deterioration of women's quality of life. The uterine prolapse is influenced by several mutually supportive factors. The purpose of this study was to analyze the relationship between these factors to the degree of uterine prolapse.Methods: This research is an observational analytic research with cross sectional approach. The number of samples were 65 patients with uterine prolapse at Policlinic Gynecology RSUD Dr. Soetomo Surabaya from 2015-2017. Sampling was done by consecutive sampling. To find out the significant level, the collected data will be tested with Fisher Exact Test statistic at significance level α = 0,05.Results: The result showed that there was significant difference between degree of uterine prolapse with age factor (p = 0,016) and obesity (p = 0,041). As for the parity factor (p = 0.508) there was no significant difference between the parity factor and the degree of uterine prolapse.Discussion: Age is a major factor affecting the degree of uterine prolapse, weakening of pelvic floor tissue and muscle in elderly women is the main cause. While on the obesity factor, there is no data to support that obesity is related to the degree of uterine prolapse because the trend indicates that the majority of patients are not obese. In contrast the parity factor, although according to the statistical test there is no difference to the degree of uterine prolapse, the trend shows that parity leads to increased incidence of uterine prolapse itself.Conclusion: Age is a factor that affects the degree of uterine prolapse.

Characteristic of Referral Patients With Severe Preeclampsia In Surabaya Myrna Evanda Adeline; Muhammad Ardian Cahya Laksana; Atika Atika
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introductions: Pre-eclampsia is a hypertensive disorder of a pregnancy that remains major maternal mortality in developing country. Severe pre-eclampsia needed an advanced medical treatment since it could cause life treathening condition for both mother and fetus. The purpose of this research was to understand and got the picture of the age, parity, complication, delivery method, referral pathway, age of pregnancy, birth weight, and Apgar score of baby from pre-eclamptic mother in dr. Soetomo General Hospital during 2011.Methods: This research is a retrospective-descriptive research which observed the age, parity, complication, delivery method, referral pathway, age of pregnancy, birth weight, and Apgar score of baby from pre-eclampsia mother This research used medical record then the data was recorded and analyzed descriptively.Result: The number of patients who met the inclusion criteria were 239 patients. Patient’s age were distributed unimodally with a peak at productive age. Most of patients had previous history of pregnancy. Pulmonary edema was the most common cause of maternal complication and intra uterine fetal death was the most common cause of fetal complication. Most delivery were performed in Sectio Caesaria method. Almost all cases was direct refferal cases from other medical services. Then most of cases was reaching aterm periode. Most of babies were born with body weight ≥ 2500 gram. And based on Apgar score the babies were well adapted.Conclusions: Most of the patients with severe preeclampsia referrals were referred from a health care setting, only a small percentage of women were referred to relay. Most of severe preeclampsia occured in women with their gestational age has reached 37 weeks.

Hematemesis on Hepatic Cirrhosis Patients in Area with Limited Facilities Yudha Klahan; Firas Farisi Alkaff
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Esophageal variceal haemorrhage is one of the more dangerous complications of hepatic cirrhosis. Initial treatment can determine patient mortality and morbidity. But not all hospitals have adequate facilities and medicines to handle it. The 53-year-old woman came with a diagnosis of ascites and hematemesis. At the initial examination found hypotension. Laboratory results show anemia, thrombocytopenia, and leukocytosis. The next morning the patient's condition worsened and was transferred to ICU. During the ICU patients receive 10 lpm oxygen support, cefobactam, pantoprazole, PRC transfusion, and dopamine. Patients begin conscious on the 5th day of treatment. Then the patient started getting diuretics on day 6 and propranolol on day 9. On day 13 the patient's condition improved and the patient was discharged for outpatient treatment. Limitations of the endoscopic tool cause not every hospital in Indonesia can perform emergency endoscopy for therapy. However, with rapid and appropriate pharmacological therapy, patients can be helped not to fall into mortality and prevent recurrent bleeding.

Altered Ghrelin Secretion Pattern and Sense of Hunger by Providing Low and High Density Breakfast in Obese Female Adolescents Ni Luh Putu Ayu Putrisari Putri; Elyana Asnar; Purwo Sri Rejeki
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Ghrelin has been recognized to have a major influence on energy balance. Hence, the discovery of various regulatory factors that control ghrelin secretion may have major implications for the development of drugs and diet control. This study aims to analyze differences in ghrelin secretion pattern and prevention of hunger in the provision of breakfast in low-calorie breakfast, low energy density and high energy density in obese female adolescents.Methods: Subjects were female students aged 18-22 years with a BMI=25 kg/m², receiving low-calorie breakfast with low (n=8) and high energy density (n=8). Before the breakfast, subjects fasted for 12 hours and were subjected to plasma ghrelin level and hunger measurement using visual analog scale (VAS). Breakfast was done at 08.00, divided into three parts and each was taken for 5 minutes. Measurement of plasma ghrelin was carried out again post prandial (PP) at 2 hours and 4 hours. VAS filling was done 1 hour PP, 2 hours PP, 3 hours PP, and 4 hours PP.Result: There were differences in plasma ghrelin level, but not significant. VAS 1 analysis of hunger (p=0.040) at 4 hours PP and VAS 3 of satiety (p=0.025) was significantly different at 3 hours PP. Conclusion: Food density did not affect the plasma ghrelin levels. Low density foods are more effective to prevent hunger in 4 hours PP and increases satiety in 3 hours PP.

The Effect of Hypertension on Hearing Sense A.C Romdhoni
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Hypertension is an important health problem because it has a high prevalence and can cause damage to target organs. The relationship between hypertension and hearing loss is not difficult to understand, when blood pressure becomes high blood vessel damage occurs. Hearing loss cases caused by hypertension are considerable, in America 64 million people aged 18 to 75 years suffer from hypertension, 40% with hearing loss. This damage is not centered on one area of the body, but the whole body is also affected, including the ears. The incidence of hearing loss in hypertension is due to the occurrence of inner ear damage due to high pressure in the vascular system, changes in microcirculation and the occurrence of ionic changes.

Role of Bariatric Surgery for Reducing Glycated Hemoglobin (Hba1c) in Type 2 Diabetes Mellitus Compared to Current Medicaments Therapy Firas Farisi Alkaff; Ricardo Adrian Nugraha; Michael Jonatan; Sulistia wati
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Type II is the most common type of Diabetes Mellitus, and one of the most common non-communicable diseases globally. In Indonesia, diabetes contributes to 6% of total deaths. Current medicaments therapy available can only control the disease, not to cure it. Recently, there has been new treatment that has been recommended into standard care for type II Diabetes Mellitus. It was in September 2015 at the second Diabetes Surgery Summit that the introduction of bariatric surgery has been put into standard care for type II Diabetes Mellitus.Objective: To draw a comparison of the effectiveness between bariatric surgery and current medicaments therapy in reducing HbA1c to achieve remission.Methods: Literature study was conducted to identify relevant literature showing comparison study between bariatric surgery and medicaments therapy, and comparison study between types of bariatric surgery. 16 Studies are included in this article from 230 studies found.Results: HbA1c remission in bariatric surgery is significantly higher than medicaments therapy in all studies, ranging from 66.7% vs 0% to 57.1% vs 9.5% during 6-24 months after therapy. Between all types of bariatric surgery, most of the studies shows that Roux-en-Y Gastric Bypass achieves HbA1c remission higher than other types of surgery.Conclusion: Bariatric surgery is better than current medicaments therapy in achieving HbA1c remission.

Comparison of High-sensitivity C-reactive Protein Level between Chronic Kidney Disease Stages Mochammad Thaha; Tri Asih Imroati; Aditia Wardana; Widodo Widodo; Pranawa Pranawa; chandra irwanadi
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

ABSTRACTAim : This research is to evaluate the hs-CRP level comparison between CKD stages in Dr. Soetomo General Hospital Surabaya.Methods: An analytic observational cross-sectional study, evaluating the differences of hs-CRP level between CKD stages in 72 patients (mean age 55.49±7.62 years, the ratio between male:female was 1:1.48, mean BMI 24.18±3.64 kg/m2, 36.11% diabetics, 43.05% on ACEI/ARB, 29.16% on statin), recruited from Nephrology Outpatient Clinic, Dr Soetomo General Hospital, Surabaya, from January to May 2014. The stages were stratified according to the MDRD formula.Results: The mean hs-CRP of CKD stage 3 was 2.29±2.86, stage 4 was 2.48 ± 2.19, and non-dialysis stage 5 was 2.09 ± 2.54. The analysis using Kruskal-Wallis test showed no significant differences among patients with CKD stage 3, stage 4, and non-dialysis stage 5 (median 1.25 vs 1.80 vs 1.05 mg/L; p=0.430). No significant differences of the serum hs-CRP level were detected between diabetics and non diabetics in stage 3, 4, and non-dialysis stage 5 (p=0.673 vs 0.666 vs 0.138); between patients with and without ACEI/ARB treatment (p=0.610 vs 0.649 vs 0.671); and between patients with and without statin treatment (p=0.852 vs 0.341 vs 0.309).Conclusion: The elevation of serum hs-CRP level can not indicate the decline of kidney function, but it still needs further investigations.

Keratosis Obturans Management A.C Romdhoni
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Keratosis obturans is a large accumulation of plaque from desquamated keratin distributed in the ear. The etiology of keratosis obturans remains unclear. Keratosis obturans generally occurs in young patients between the ages of 5-20 years and can attack one or both ears. Patients suffering from keratosis obturans and have a history of bronchiectasis or sinusitis reported 77% of adolescent cases, only 20% of adult cases. The diagnosis of keratosis obturance is made on the basis of anamnesis and clinical examination, while CT scan is performed to determine whether or not bone erosion is present. This disease can be controlled by performing clearance of the ear canal periodically every one to three months to reduce debris accumulation. Ear dropping of mixtures of alcohol or glycerin in 3% peroxide, three times a week can often be helpful.

The Effect of Sapodilla Leaves (Achras Zapota) Infusum towards Mice (Mus Muculus) Diarrheal Activity Induced by Oleum Ricini Glabela Christiana Pandango; Ramadhani R. B; Irfiansyah Irwadi
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Diarrhea is a significant health problem, especially in countries with low income. In many cases, diarrhea even can cause death. Treatment for diarrhea has been done both pharmacologically (including the usage of herbal remedies) and non-pharmacologically. Decoction of the sapodilla’s leaves is often used to treat diarrhea, but no studies directly demonstrates the effects of sapodilla’s leaves’ decoction towards living creatures. The purpose of this study was to determine the effect of sapodilla leaves’ (Achras zapota) infusum towards diarrheal activity of mice (Mus musculus) which can be seen through the onset and frequency of diarrhea, and the consistency and quantity / weight of feces.Methods: 30 mice were divided into five groups. Negative controls (group I) were administered with oleum Ricini, positive controls (group II) were administered with oleum Ricini and Loperamide HCl after half-an hour, and group III, IV, and V, were administered with oleum Ricini and sapodilla leaves’ (Achras zapota) infusum ( with the concentration of 5 g %, 10 g %, and 20 g %) after half-an hour. Then, those mice were observed for 3 hours for their diarrheal activity (diarrheal onset, frequency, fecal consistency, and fecal weights).Results: Analysis by Kruskal-Wallis method showed significant differences of diarrheal activities among the five groups (p = 0.023). Whilst, analysis by Mann-Whitney method showed significant differences between group I and II (p = 0.04), group I and III (p = 0.012), and group I and IV (p = 0.006).Conclusions: Based on the result showed sapodilla leaves’ (Achras zapota) infusum could reduce diarrheal activity of mice (Mus musculus).

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Home Page

OAI Link

Editorial Team

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Reviewer

Google Scholar

Contact Name Muhammad Miftahussurur

Contact Email bhsj@journal.unair.ac.id

Phone -

Journal Mail Official bhsj@journal.unair.ac.id

Editorial Address -

Location Kota surabaya, Jawa timur INDONESIA

Abstract

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Abstract

Abstract

Abstract

Abstract

Contact Name
Muhammad Miftahussurur

Contact Email
bhsj@journal.unair.ac.id

Phone
-

Journal Mail Official
bhsj@journal.unair.ac.id

Editorial Address
-

Location
Kota surabaya,

Jawa timur

INDONESIA