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Biomolecular and Health Science Journal

BHSJ
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Published by Universitas Airlangga

ISSN : - EISSN : 26208636 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Bimolecular and Health Science Journal (BHSJ) is a scientific peer-reviewed medical doctor which relevant to a medical doctor and other health-related professions by the Faculty of Medicine Universitas Airlangga, Indonesia. BHSJ provides a forum for original article, review article, editorial, case report(s), letter(s) to the editor, short communication and it will be published two times a year. Studies that focus on evaluating and understanding the complex medical importance are welcomed in BHSJ.

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Articles 140 Documents

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Correlation Between Nutritional Status Of Children Aged 12 – 36 Months And Mother’s Working Status In Taman, Sidoarjo Nur Annisa Nugraheningtyasari; Ninik Asmaningsih Soemayarso; Dwi Susanti
Biomolecular and Health Science Journal Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: The correlation between child’s nutritional status and mother’s working status in Indonesia is still unclear. Some research report a high prevalence of low-nourished children whose mother is working, while others report a non significant correlation between child’s nutritional status and mother’s working status.Methods: This study was case-control study, sample of low-nourished children (treatment group) & well-nourished children (control) are taken from 21 Posyandu in Taman, Sidoarjo in 2015. All data were analyzed using Chi Square test.Results: There are 72 samples which are suitable with the inclusion criteria, consisted of 36 low-nourished children and 36 well-nourished children. From 72 samples, 28 children have a working mother and 44 children have a non working mother. There were no correlation between Mother’s working status (p=0,486), Number of children in the family (p=0,468), History of chronic disease (p=0,054) with child’s nutritional status. Level of family income, Mother’s education level, History of exclusive breastfeeding, Energy consumption level, Protein consumption level were correlated with child’s nutritional status with value (p=0,000), (p=0,002), (p=0,002), (p=0,000), (p=0,001) respectively.Conclusion: Mother’s working status is proved that is not correlated with child’s nutritional status. But, level of family income, mother’s education level, energy & protein consumption level, and history of exclusive breastfeeding are significantly correlated with child’s nutritional status.

Primary Pulmonary Lymphoma with Superior Vena Cava Syndrome Alfian Nur Rosyid; Resti Yudhawati Meliana
Biomolecular and Health Science Journal Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Primary Pulmonary Lymphoma (PPL) is a clonal proliferation of lymphoid cells that involve one or two lungs (parenchyma and or bronchi. PPL is found in approximately 0.4% of all lymphoma cases and 3.6% of NHL cases. Five years survival rate at stage I and II is 90%, and 80% in stage III and IV. A 63-year-old male farmer presented with chief complaint of shortness of breath for one week before admission and preceded by coughing for a month, loss of appetite and night sweating. There was an abnormal physical examination on the right side of the chest with non-tender lymph node enlargements in the right supraclavicular and neck region and superior vena cava syndrome. CT guided FNAB suggesting NHL. Patient was treated with CHOP chemotherapy regiment. However, with high grade lymphoma, patient did not respond well.

Bactericidal Effects of Extract Basil Leaves in In-vitro Study of Pseudomonas aeruginosa Deny Febriwijaya Romadhani; Achmad Hilman Fahmy; Ilham Putera Alam; Hotimah Masdan Salim
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.22090

Introduction: Pseudomonas aeruginosa is the most common bacterial cause of nosocomial infections. Bacteria become resistant to antibiotics by various mechanisms, including producing enzymes that can damage antibiotics, change intracellular targets from antibiotics, and efflux pumps. Basil (Ocimum sanctum L.) is a traditional plant that is usually used as ingredients that contain antibacterial compounds including flavonoids, tannins, alkaloids, and eugenol. The aim was to determine the effectiveness of extract basil leaves for inhibiting and killing the growth of Pseudomonas aeruginosa.Methods: We administrated extract basil leaves with a concentration of 100%, 50%, and 25% in the plate contained bacterium Pseudomonas aeruginosa. The result showed that there was no inhibition of bacterial growth in broth dilution for 8 hours and 24 hours. We continued to culture bacteria for 24 hours.Results: The analysis showed extract basil leaves has bactericidal effects in 8 hours and 24 hours incubation significantly (p < 0.05). However, in 24 hours more effective as a bactericidal in 100% of concentration significantly (p < 0.05).Conclusion: From this result, eugenol (a phenol derivative found in the ethanol extract of basil leaves) has the effect of damaging cell membranes. Phenol bonding with bacterial cell walls can disrupt the permeability of transport cell membranes, thus the bacteria will be disrupted and die.

Palliative Therapy of Esophageal Stent Installation with Shim Modified Fixation Techniques on An Esophageal Adenocarsinoma Patients Yudith Annisa Ayu Rezkita
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Esophageal carcinoma is a progeny disease that often results in significant disruption to the ability to ingest solid foods and liquid foods at an advanced stage. Reported case of a 27-year-old man with a diagnosis of an intestinal type of adenocarcinoma gastroesophageal junction stage III with a dysphagia score 4. Diagnosis based on anamnesis, endoscopy and anatomical pathology. Patients have undergone chemotherapy and palliative therapy with esophageal dilatation. Patients experienced improvement in dysphagia score from initial score 3 (unable to swallow solid or liquid food), to 2 (able to swallow semisolid food) after the installation of esophageal stent. The patient planned to continue therapy his chemotherapy.

Etiology Based on Clinical Manifestation of Acute Diarrhea Incidence of Children Hospitalized in Dr. Soetomo General Hospital Surabaya Period 2011-2013 Ashfahani Imanadhia; IGM Reza Gunadi Ranuh; Djohar Nuswantoro
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Diarrhea is one of the most common causes of morbidity and mortality of children worldwide, especially in developing countries. Acute diarrhea can occur from a large number of causes. We aim to describe the clinical manifestation characteristics of acute diarrhea on pediatric patients that are presented to the hospital.Methods: A cross-sectional study from all pediatric patients treated in Dr. Soetomo General Hospital Surabaya in 2011-2013.Age, gender, nutritional status, length of hospital stay, duration of breastfeeding, clinical signs and symptoms, as well as laboratory results collected and analyzed descriptively.Results: One hundred and fifty patients were included with characteristics of male(54%), infant (55.3%)with a mean age of 6-7 month. History of being exclusively breastfed(54%) and lack of nutrition(48%). Vomiting is mostly present (72.7%) and commonly come with a combination of two symptoms (42%) which were vomiting and fever. Mild to severe dehydration degree could be found on the patient who had vomiting, seizure, and fever. The most length of stay was frequently >72 hours. The occurrence of acute diarrhea on a child who was treated in Dr. Soetomo General Hospital Surabaya is dominated by vomiting and it could be inferred that the most acute diarrhea has a tendency of being caused by a virus, where liquid acute diarrhea without blood, mucus, or fever is found.Conclusion: The etiology of acute diarrhea is mostly caused by viruses and symptoms dominated by a combination of vomiting, fever, and diarrhea without blood caused by villi damage.

Back Matter Volume 4 No.1 2021 Back Matter
Biomolecular and Health Science Journal Vol. 4 No. 1 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i1.28337

Antibacterial Effects of Fluoride in Streptococcus mutans Growth in Vitro Yura Pradiptama; Marijam Purwanta; Harianto Notopuro
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Streptococcus mutans is a gram-positive coccus commonly found in the human oral cavity and is a pathogen of dental caries. S. mutans known to form biofilm in infective endocarditis heart-valve. Fluoride usage known to reduce the risk of dental caries. This study aims to analyze how usage of fluoride in inhibiting S. mutans growth.Methods: This study was an experimental study. Antibacterial activity test was performed to evaluate the minimum inhibitory concentration (MIC) using dilution method of sodium fluoride. The minimum bactericidal concentration (MBC) was determined by culturing from the previous dilution test into Chocolate Agar Plate.Results: MIC for sodium fluoride is 4,8 mg/ml and the MBC for sodium fluoride to S. mutans is 4,8 mg/ml. We found S. mutans growth in higher concentration than 19,2 mg/ml. Conclusion: S. mutans was inhibited in dilution test. Growth of the bacteria in higher concentration of sodium fluoride is explained with quasi-irreversible inhibtior effects of fluorida.

Analgesic Effect of Dayak Onion (Eleutherine americana (Aubl.) Merr.) on Mice (Mus musculus) by Hot Plate Test Method Muhammad Hafizh; Danti Nur Indiastuti; Indri Safitri Mukono
Biomolecular and Health Science Journal Vol. 4 No. 1 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i1.26915

Introduction: Pain is an unpleasant experience that reduces a person's quality of life. Pain related complain can be treated by administering analgesic drugs. Several studies show that the availability of analgesics is still low, especially opioid analgesics. Dayak onion (Eleutherine americana (Aubl.) Merr.) are used by the Dayaks to relieve pain. Several empirical studies have shown that Dayak onion contain compounds including quercetin as a potential analgesic. This research aimed to investigate the potential analgesic effect of Dayak onion using hot plate method.Methods: The research was conducted experimentally on 36 BALB/c male mice which randomly divided into 6 different treatment groups of Dayak onion exctract, aspirin, codein and aquadest. Each group were thermally pain-induced for latency period measurement by the hot plate test method. Obtained data were processed using Analysis of Variance (ANOVA) followed by Dunnett test.Results: There was a difference in the latency period between the baseline response time and the response time after being treated in each group. ANOVA test results showed significant results (p<0.05) so that the resulting latency period was significant. Dunnett test results showed significant results (p<0.05) in negative control group. Based on these results, Dayak onion are proven to have an analgesic effect on heat stimulation.Conclusion: Dayak onion possess significant analgesic effect on thermally pain-induced mice. Dayak onion extract 90 mg/kg mouse produced better analgesic effects than aspirin 65 mg/kg mouse.

Bacteria Pattern, Results of Antibiotic Sensitivity Test, and Complications of Deep Neck Abscess Patients in Dr. Soetomo General Hospital Syaiful Rijal; Achmad C. Romdhoni
Biomolecular and Health Science Journal Vol. 1 No. 2 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Deep Neck Abscess is the accumulation of pus inside the potential space between the deep neck fasciae. The incidence has decreased dramatically since the antibiotic era. Empirical antibiotics are administered before the sensitivity test results out, so it is important to know the map of bacteria and its resistance.Methods: This study was conducted retrospectively using medical records of patients with deep neck abscess in Dr. Soetomo General Hospital Surabaya during January 2014-December 2017. Data recorded included gender, age, location, results of bacteria culture examination, antibiotic sensitivity test, and complications that occurred. Data is processed descriptively. Results: Of the 162 patients, 102 (62.96%) were males, followed by 60 females (37.04%). The 46-60 years old group has the largest percentage (33.95%). Whereas the most common location of abscess was in the submandibular (42.59%). Pus culture test, most bacteria is Klebsiella pneumonia (13.04%). While the sensitivity test shows that meropenem has the highest sensitivity number (73.58). Most complications were sepsis, in 48 patients (29.63%). Conclusion: Klebsiella pneumonia, Staphylococcus aureus, and Streptococcus anginosus are the most common etiologies in deep neck abscess. Meropenem, cefoperazone-sulbactam, and oxacillin are the most sensitive antibiotics.

Age as the Risk Factor that Affected the Increased Degree of Uterine Prolapse Shervil Kagayaita Sayko; Eighty Mardiyan Kurniawati; Pudji Lestari
Biomolecular and Health Science Journal Vol. 1 No. 1 (2018): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Uterine prolapse is a gynecological problem that women often experience with a prevalence of 50% and is predicted that the next 30 years will increase by 45% as life expectancy increases. Increased degrees of uterine prolapse have an impact on the deterioration of women's quality of life. The uterine prolapse is influenced by several mutually supportive factors. The purpose of this study was to analyze the relationship between these factors to the degree of uterine prolapse.Methods: This research is an observational analytic research with cross sectional approach. The number of samples were 65 patients with uterine prolapse at Policlinic Gynecology RSUD Dr. Soetomo Surabaya from 2015-2017. Sampling was done by consecutive sampling. To find out the significant level, the collected data will be tested with Fisher Exact Test statistic at significance level α = 0,05.Results: The result showed that there was significant difference between degree of uterine prolapse with age factor (p = 0,016) and obesity (p = 0,041). As for the parity factor (p = 0.508) there was no significant difference between the parity factor and the degree of uterine prolapse.Discussion: Age is a major factor affecting the degree of uterine prolapse, weakening of pelvic floor tissue and muscle in elderly women is the main cause. While on the obesity factor, there is no data to support that obesity is related to the degree of uterine prolapse because the trend indicates that the majority of patients are not obese. In contrast the parity factor, although according to the statistical test there is no difference to the degree of uterine prolapse, the trend shows that parity leads to increased incidence of uterine prolapse itself.Conclusion: Age is a factor that affects the degree of uterine prolapse.

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Muhammad Miftahussurur

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Jawa timur

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Home Page

OAI Link

Editorial Team

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Reviewer

Google Scholar

Contact Name Muhammad Miftahussurur

Contact Email bhsj@journal.unair.ac.id

Phone -

Journal Mail Official bhsj@journal.unair.ac.id

Editorial Address -

Location Kota surabaya, Jawa timur INDONESIA

Abstract

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Contact Name
Muhammad Miftahussurur

Contact Email
bhsj@journal.unair.ac.id

Phone
-

Journal Mail Official
bhsj@journal.unair.ac.id

Editorial Address
-

Location
Kota surabaya,

Jawa timur

INDONESIA