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INDONESIA
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Published by Perhimpunan Dokter Spesialis Patologi Klinik Indonesia
ISSN : 08544263     EISSN : 24774685     DOI : https://dx.doi.org/10.24293
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) is a journal published by “Association of Clinical Pathologist” professional association. This journal displays articles in the Clinical Pathology and Medical Laboratory scope. Clinical Pathology has a couple of subdivisions, namely: Clinical Chemistry, Hematology, Immunology and Serology, Microbiology and Infectious Disease, Hepatology, Cardiovascular, Endocrinology, Blood Transfusion, Nephrology, and Molecular Biology. Scientific articles of these topics, mainly emphasize on the laboratory examinations, pathophysiology, and pathogenesis in a disease.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 26 Documents
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Search results for , issue "Vol 25, No 1 (2018)" : 26 Documents clear
THE CORRELATION BETWEEN THE MEAN PLATELET VOLUME VALUES WITH THROMBOCYTE AGGREGATION IN NEPHROPATHY DIABETIC PATIENTS Agus Sunardi; Nadjwa Zamalek Dalimoenthe; Coriejati Rita; Adhi Kristianto Sugianli
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 1 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i1.1510

Abstract

     Diabetic nephropathy is the most important cause of end-stage renal failure. Chronic hyperglycemia will cause glomerular endothelial damage, and this damage will stimulate hemostasis activation including platelets so that platelet aggregation will increase. The increase of platelet aggregation will increase platelet consumption, which further stimulates thrombopoiesis which will lead to immature platelets of large size to be released into the circulation. This research aimed to determine the positive correlation between MPV with platelet aggregation in patients with diabetic nephropathy. This study was an analytic observational study with a cross-sectional study design. The research was conducted in the Dr. Hasan Sadikin Hospital Bandung from July 2016 to October 2017. A total of 52 subjects who met the inclusion criteria were included in the study. Mean platelet volume and platelet aggregation were performed with venous examination with EDTA and sodium citrate 3.2% anticoagulants. The result of platelet aggregation examination showing platelet hyper-aggregation was found in 44.2% of subjects, 50% normal-aggregation, 5.8% hypo-aggregation. While the median value of MPV in this study was 9.2 fL with the range of 8.00 – 11.80 fL. A positive correlation was found  between MPV value with platelet aggregation with r= 0.067, p= 0.634. The conclusion was that there was no correlation between MPV values with platelet aggregation in diabetic nephropathy patients. This small and insignificant r-value might be due to several factors that also affect platelet aggregation in diabetic nephropathy patients, requiring further investigation.
ANALYSIS OF RED BLOOD CELL DISTRIBUTION WIDTH COEFFICIENT OF VARIATION ON STROKE PATIENT Kartika Paramita; Agus Alim Abdullah; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 1 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i1.1482

Abstract

 Stroke is a functional disorder attributed to acute focal or global brain injury by vascular cause and persists more than 24 hours. Stroke is divided into ischemic and hemorrhagic strokes. Red Blood Cell Distribution Width (RDW) is a measurement of erythrocyte volume variation in blood circulation. Increased RDW reflects the inflammation that plays a role in the development of atherosclerosis in stroke. This study aims to analyze differences in RDW-CV values in patients with stroke. The design was cross-sectional with a retrospective approach, secondary data from medical records of inpatients with stroke from January to December 2016 at the Dr. Wahidin Sudirohusodo Hospital. The study population consisted of 490 patients aged ≥ 18 years old. The Kruskal-Wallis, Mann-Whitney, and Anova one way tests were used to analyze differences in RDW-CV values in patients with ischemic and hemorrhagic stroke. Mann-Whitney test results showed no significant difference in RDW-CV values between groups of ischemic and hemorrhagic stroke (p 0.96). Kruskal-Wallis and Anova one way tests showed no significant difference in RDW-CV values between four groups of patient outcomes in ischemic and hemorrhagic stroke (p 0.13 and p 0.35 consecutively). There were no significant RDW-CV values between ischemic and hemorrhagic stroke. There was no significant difference between RDW-CV values of four groups of patient outcomes in ischemic and hemorrhagic stroke. RDW-CV values cannot be used to distinguish both ischemic and hemorrhagic stroke, including the prediction of stroke mortality
THE CORRELATION BETWEEN GALECTIN-3, CREATININE AND URIC ACID ON STAGE V CHRONIC RENAL FAILURE Indranila K S; Guruh A I; Meita H
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 1 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i1.1516

Abstract

Chronic Renal Failure (CRF) is structural damage and function of the kidneys that cannot excrete toxins and waste products from the blood, characterized by the presence of protein in the urine and decreased glomerulus filtration rate. This study aimed to determine the correlation between Galectin-3 and markers of kidney function which are creatinine and uric acid. This study was being concluded on 33 CRF patients who were doing hemodialysis therapy. This study was conducted in the Dr. Kariadi Semarang Hospital and GAKI Laboratory of Diponegoro Medical Faculty from April to June 2018. The research method was analytical descriptive with cross-sectional approach. Galectin-3 was analyzed using ELISA method with an automatic analyzer, creatinine and uric acid using the colorimetric method with an automatic spectrophotometer. Statistical analysis used Shaphiro-Wilk normality test and Spearman correlation test. There is a weak positive correlation test of galectin-3 with creatinine (r = 0.381; p = 0.029) and galectin-3 with uric acid (r = 0.374; p = 0.048) in CRF – HD. It is concluded galectin-3 can be used as a marker of kidney function.
PLATELET INDICES FOR PREDICTING LIVER FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS B INFECTION Shendy Sherly Soeliauwan; Darwati Muhadi; Mutmainnah Mutmainnah
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 1 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i1.1487

Abstract

Chronic Hepatitis B involves liver parenchymal destruction leading to fibrosis. Decreased serum thrombopoietin associated with liver cell failure is thought as the leading cause of thrombocytopenia. Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) describe platelet size and degree of variation in platelet size respectively. The researchers intended to investigate whether platelet count, MPV, and PDW were variables to determine the severity of liver fibrosis in chronic hepatitis B patients. An observational study was carried out at the Dr. Wahidin Sudirohusodo Hospital Makassar from January 2015 until December 2016. A total of 100 chronic hepatitis B patients with negative HBeAg who underwent Fibroscan and complete blood count test were included in this study. A total of 100 chronic hepatitis B patients comprising, 11 with severe liver fibrosis, 16 with moderate liver fibrosis, 46 with mild liver fibrosis, and 27 with normal liver. There were significant differences in platelet count and MPV among liver fibrosis groups with p-value <0.001 and 0.046 respectively. No significant difference was observed for PDW among liver fibrosis groups (p=0.131). This study showed that platelet count and MPV were significantly different among the normal group, mild liver fibrosis group, moderate liver fibrosis group and severe liver fibrosis group in chronic hepatitis B patients. The researchers recommend to carry out studies with larger samples in number and distributed more evenly.
LEUKEMIC PHASE OF MALIGNANT LYMPHOMA IN CHILDREN Sahriany S; Agus Alim Abdulah; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 1 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i1.1519

Abstract

Leukemic phase of malignant lymphoma is a group of lymphoid malignancies typically localized in lymph node and present typical clinical features such as lymphadenopathy with irregular distribution. It can manifest as an extranodal disorder infiltrates the bloodstream (leukemic phase). Lymphomas are differentiated into Hodgkin and non-Hodgkin. The presentation of Reed-Sternberg (RS) cells in histological evaluation establishes Hodgkin lymphoma. A number of classification systems have been used before the publication of Revised European American Lymphoma (REAL) classification in 1994 which includes all lymphoid and lymphoma malignancies according to typical histology, morphology, immunophenotype, genetic, and clinical manifestation. A highly proliferative and fatal malignant lymphoma with leukemic phase case in 13 years and a one-month-old male was reported. The diagnosis was established based on marble-sized lymph nodes enlargement that increased in size, two weeks after initial identification on the neck, head, and inguinal regions and followed by lymphadenopathies in submental, right submandibular, preauricular and right inguinal region. No fever history of this patient or malignant history among his family was found. Laboratory findings included WBC of 26,050/µL, Hb 9.6 g/dL, and PLT 16,000/µL. Peripheral blood smear results indicated suspected leukemic phase of malignant lymphoma DD/ALL. Bone marrow aspiration showed leukemic-phase of malignant lymphoma with bone marrow infiltration. Cytological evaluation of Fine Needle Aspiration (FNA) identified atypical round nucleated cells with nucleus size mostly larger than the mature lymphocytes, minimum cytoplasm, diffuse erythrocyte as background, a conclusion was malignant lymphoma.
MICROORGANISM PATTERN ON NASAL CAVITY OF END STAGE RENAL DISEASE PATIENTS WITH REGULAR HEMODIALYSIS AND STAFFS IN HEMODIALYSIS INSTALLATION ADAM MALIK GENERAL HOSPITAL MEDAN Imelda Damayanti; Ricke Loesnihari; Syafrizal Nasution
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 1 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i1.1509

Abstract

Colonization is the presence and growth of microorganism on the skin or mucous membrane of the body without any sign of infection. Commonly colonized microorganisms are normal flora within a person's body, but can also be microorganism in the hospital that colonizes within the body a few days after they enter the hospital. The longer a person is hospitalized the more likely to be colonized with the microorganism in the hospital. The objective is to determine microorganism pattern and antimicrobial sensitivity in the nasal cavity of regular hemodialysis patients and staff in Hemodialysis Installation of Adam Malik Hospital Medan. The study was analytic observational with a cross-sectional method, conducted in the Department of Clinical Pathology of Adam Malik Hospital Medan together with Hemodialysis Installation of Adam Malik Hospital Medan from August 2016 - October 2016. The sample was anterior nasal cavity swab which went through identification and sensitivity test. A total number of participants following the study were 46 people where patients and staffs were equal to 23 people. Most bacterial colonization of the nasal cavity of patients and staffs: Staphylococcus epidermidis 9 (39.13%) and 12 (52.17%); Staphylococcus aureus 4 (17.39%) and 3 (13.04%); Staphylococcus saprophyticus 2 (8.70%) and 2 (8.70%). There were 3 MRSA from a total of 23 bacteria (13.04%) in regular hemodialysis patients. MRSA colonization was found in regular hemodialysis patients with 50% sensitivity level of Vancomycin.
IgA ANTI-DENGUE PROFILE IN SAMPLES WITH POSITIVE DENGUE PCR OR NS1 M Thohirin Ramadhani; Aryati Aryati; M Vitanata Arfijanto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 1 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i1.1483

Abstract

Dengue Virus Infection (DVI) causes several clinical manifestations and requires varied diagnostic instruments. IgA anti-dengue as one of the diagnostic markers of DVI is suspected to have a shorter lifespan and greater sensitivity in detecting secondary infections compared to IgM anti-dengue. This study was conducted using 34 sera with positive RT-PCR or NS1 dengue virus. Samples were examined by a reverse flowimmunochromatographic method using AIM Dengue IgA Assure Rapid Test and will be analyzed its profile toward the day of fever, serotype, severity, platelet count, and type of infection. The overall sensitivity of IgA anti-dengue was 61.76% (n=34); in which IgA anti-dengue detected 14.29% primary and 66.67% secondary cases. IgA anti-dengue detected DEN1, DEN2, DEN3, and Mixed DEN1 – DEN3 virus serotype respectively 55.56%, 22.22%, 16.67%, and 5.56% (n=20). The day of fever was dominated by day-4 and day-5 respectively 28.57% (n=21). IgA anti-dengue was detected in DD, DHF grade I, II, and III 42,86%, 28.57%, 19.05%, and 9.52% (n=21) respectively. IgA anti-dengue detected in all levels of platelet count, it detected 60% in < 50,000 cell/mm3, 30% in 50,000 - 100.000 cell/mm3 and 10% in > 100,000 cell/mm3 platelet count sample (n=20). In conclusion, IgA anti-dengue showed a good performance, applicable as a diagnostic marker of DVI.
CORRELATION OF SERUM HIGH-DENSITY LIPOPROTEIN CHOLESTEROL AND HOMOCYSTEINE LEVEL IN PATIENT WITH ACUTE MYOCARDIAL INFARCTION Yayie Dwina Putri; Tuty Prihandani; Lillah Lillah; Rismawati Yaswir
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 1 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i1.1515

Abstract

Acute Myocardial Infarction (AMI), one of the primary manifestation of coronary heart disease, is a significat cause of death worldwide. Hyperhomocysteinemia, a risk factor for cardiovascular disease, is caused by nutritional or genetic disturbances in homocysteine metabolism. The role of hyperhomocysteinemia in altered lipid metabolism presumed holds the key to an increased risk of cardiovascular disease. Hyperhomocysteinemia causes the reduction of serum High-Density Lipoprotein (HDL) cholesterol level by inhibiting hepatic synthesis of apo-A1 (significant apolipoprotein HDL). The aim of this study was to know the correlation between hyperhomocysteinemia and decreased HDL cholesterol levels for the management of cardiovascular disease risk factors. This research was an analytical study with cross-sectional design in 40 patients AMI who meet the inclusion and exclusion criteria and conduct blood test at the Central Laboratory of Hospital Dr. M. Djamil Padang and Biomedical Laboratory Faculty of Medicine Andalas University. The study was conducted in May 2016-Agustus 2017. Homocysteine level was measured by ELISA method. High-Density Lipoprotein level was performed by enzymatic colorimetric method. Data were analyzed by Spearman’s correlation test. Research subjects were 40 people with male gender 30 (75%) and female 10 (25%), mean age 61.08 (11.09) year. The mean level of HDL cholesterol in patients with AMI is 41.93 ± 13.12 mg/dL. The mean level of homocysteine in patients with AMI is 25.36 ± 22.2 µmol/L. Spearman’s correlation test showed a strong correlation between the levels of homocysteine and HDL cholesterol with r=-0.603 and p<0.01.
ANALYSIS OF RED BLOOD CELL DISTRIBUTION WIDTH VALUE TOWARDS FIBROTIC STAGE IN CHRONIC HEPATITIS B Fatma Idris; Darwati Muhadi; Mutmainah Mutmainah
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 1 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i1.1514

Abstract

Chronic hepatitis-B is a liver disease caused by hepatitis B virus infection lasting for more than 6 months since the first appearance of signs and symptoms. Red Blood Cell Distribution Width (RDW) is more related to an inflammation process compared to the fibrotic stage. Increase in RDW value results from an increase in erythrocyte destruction or ineffective erythrocyte production caused by the inflammation process. The inflammation can suppress erythrocyte maturation and enable new reticulocytes to be released into blood circulation. Liver inflammation is the characteristic of chronic hepatitis B virus infection. This study aimed to know the RDW value towards the fibrotic stage in chronic hepatitis B patients. This study was a retrospective study conducted in the Dr. Wahidin Sudirohusodo Hospital Makassar. The data were taken from medical records of chronic hepatitis B patients in January 2015-July 2016. The research subjects were chronic hepatitis B patients who underwent routine blood examination for the first time when the patients had just hospitalized. The investigated was continued with fibroscan examination in Gastroenterohepathology Department of the Dr. Wahidin Sudirohusodo General Hospital. Statistical analysis was analyzed with Kruskal-Wallis test using SPSS ver.22. One hundred data of chronic hepatitis B patient consisted of 27 patients without fibrosis, 16 with moderate fibrosis and 11 with severe fibrosis were obtained in this study. Kruskal-Wallis test results showed no significant difference between RDW value with a fibrotic stage in chronic hepatitis B patient (p = 0.255). This study results showed no significant difference between RDW value and fibrotic stage in chronic hepatitis B patients. Red blood cell distribution width value cannot be used as a predictor of liver fibrosis. It is suggested to conduct further studies using larger sample size and more equally distributed sample based on fibrotic stage.
THE RELATIONSHIP BETWEEN THE LEVEL OF INTERLEUKIN-6 AND PROCALCITONIN IN SEVERE SEPSIS PATIENTS AT THE ADAM MALIK HOSPITAL Sesily C Nainggolan; Adi Koesoema Aman; Achsanudin Hanafie
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 25, No 1 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v25i1.1488

Abstract

Severe sepsis is defined as sepsis that is accompanied by one or more organ dysfunctions, hypotension or hypoperfusion (decreased renal function, hypoxemia, lactic acidosis, oliguria, mental status changes). Macrophages and monocytes produced Procalcitonin (PCT) in serious bacterial infections and sepsis. Interleukin-6 (IL-6) is an interleukin that acts as proinflammatory cytokines. The high IL-6 level is due to chronic inflammation and sepsis. IL-6 is found increased more rapidly in the acute phase, so it can be used to evaluate early phase infection and sepsis. The purpose of this study was to find out IL-6 and PCT levels in severe sepsis patients. This study was a cross-sectional observational study. The subjects were sepsis patients treated in Adam Malik Hospital on Jan-Mar 2016. Statistical data was analyzed using SPSS and the Spearman rank correlation, with significant p-value < 0.05. IL-6 was tested using Chem Well 9210 series. Procalcitonin examination was done by mini VIDAS BRAHMS PCT. There were 40 people observed as subjects in this study, 26 males (65%) and 14 females (35%). The average age of male was 49.42 ± 18.19 years old, the youngest 18 years old, and the oldest 79 years old. The average age of females 57.35 ± 20.73, the youngest 18 years old, and the oldest 87 years old. The average of IL-6  was 10862.12 ± 25489.16 and PCT was 9666.73 ± 10540.13. Spearman rank test was also used, the value of r = 0.176 and p = 0.277. The conclusion is there is no significant correlation between IL-6 and PCT. There is no significant correlation between IL-6 and PCT levels in severe sepsis patients.

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