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Sainstech Farma: Jurnal Ilmu Kefarmasian
Published by Institut Sains dan Teknologi Nasional
ISSN : 20867816     EISSN : 27761878     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal ini memuat artikel penelitian kefarmasian meliputi kimia farmasi, biologi farmasi, bahan alam farmasi, teknologi farmasi, farmasi komunitas dan klinis, serta bioteknologi farmasi.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 129 Documents
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ANALISIS PROTEIN, KARBOHIDRAT, LEMAK, DAN PIGMEN FIKOBILIPROTEIN MIKROALGA Spirulina platensis YANG DIKULTIVASI PADA MEDIA LIMBAH CAIR PEMBUATAN TEMPE Mellova Amir; Wayan Sri Agustini; Qste Fatimah Caesar
SAINSTECH FARMA Vol 6 No 2 (2013): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : FAKULTAS FARMASI, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

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Abstract

Spirulina platensis merupakan mikroalga yang banyak mengandung protein yang berfungsi sebagai sumber makanan tambahan dan mengandung pigmen utama fikosianin berwarna biru yang dapat digunakan sebagai antioksidan. Penelitian ini bertujuan untuk menganalisis kandungan protein, karbohidrat, lemak, dan pigmen fikobiliprotein dari mikroalga Spirulina platensis yang dikultivasi pada media limbah cair tempe. Biomassa Spirulina platensis merupakan sampel dari hasil sentrifugasi kultur menggunakan limbah cair tempe dengan konsentrasi 0%(kontrol), 25%, 50%, dan 75% yang diambil pada fase logaritmik dan fase stasioner. Analisis kandungan protein dilakukan menggunakan metode biuret, analisis kandungan karbohidrat dengan menggunakan metode fenol–sulfat, metode Bligh and Drier untuk analisis total lemak, serta analisis kandungan fikobiliprotein dengan menggunakan Bennet and Bogorad. Hasil penelitian menunjukkan bahwa adanya variasi konsentrasi limbah cair tempe sebagai media kultivasi mempengaruhi kandungan protein, karbohidrat, lemak, dan pigmen fikobiliprotein. Hasil analisis kandungan protein, karbohidrat, dan lemak paling tinggi dihasilkan pada Spirulina platensis yang dikultivasi dengan media limbah cair tempe 50% dengan kadar protein sebesar 58,11%, karbohidrat sebesar 31,22% dan lemak sebesar 4,00%. Hasil analisis kandungan fikobiliprotein paling tinggi dihasilkan pada kontrol dengan kadar fikosianin sebesar 3.69% dan allofikosianin sebesar 4.59%..
ANALISIS FIKOBILIPROTEIN DAN POLISAKARIDA DARI MIKROALGA MERAH (Porphyridium cruentum) YANG DIKULTIVASI PADA MEDIA LIMBAH CAIR NATA DE COCO Mellova Amir; Atikah Nurjanah; Ni Wayan Sri Agustini
SAINSTECH FARMA Vol 7 No 1 (2014): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : FAKULTAS FARMASI, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

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Abstract

Porphyridium cruentum adalah mikroalga merah yang mampu memproduksi fikobiliprotein dan polisakarida berupa ekso- dan endopolisakarida. Telah dilakukan penelitian analisis kandungan fikobiliprotein dan polisakarida dari P. cruentum yang dikultivasi pada media limbah cair nata de coco. P. cruentum dikultivasi pada media limbah cair nata de coco dengan konsentrasi 25%, 50%, 75%, dan 0% sebagai kontrol. Biomassa dan supernatan P. cruentum merupakan sampel uji dari hasil sentrifugasi P. cruentum media limbah cair nata de coco. Analisis kandungan fikobiliprotein dilakukan dengan menggunakan metode Bennet and Bogorad, dan ekso- dan endopolisakarida dengan presipitasi etanol. Hasil penelitian menunjukan bahwa perbedaan konsentrasi limbah cair nata de coco mempengaruhi nilai kandungan fikobiliprotein, dan ekso- dan endopolisakarida. Kandungan fikosianin terbesar ditunjukkan pada P. cruentum media limbah cair nata de coco 25% sebesar 2,44%, allofikosianin pada P. cruentum media limbah cair nata de coco 50% sebesar 6,17%, dan fikoeritrin terbesar yaitu pada P. cruentum media limbah cair nata de coco 50% sebesar 12,63%. Kandugan ekso- dan endopolisakarida terbesar yaitu pada P. cruentum media limbah cair nata de coco 50% dengan nilai 29,53% (eksopolisakarida) dan 3,68% (endopolisakarida). Kandungan glukosa terbesar yaitu pada P. cruentum media limbah cair nata de coco 50% dengan nilai 38,45% untuk kandungan glukosa pada eksopolisakarida dan 44,08% untuk kandungan glukosa pada endopolisakarida.
ANALISIS VITAMIN B1, VITAMIN B6 DAN VITAMIN E PADA DAGING TOPBLADE SAPI BERBEDA RAS (LOKAL, IMPOR) DAN KERBAU Mellova Amir
SAINSTECH FARMA Vol 4 No 2 (2012): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : FAKULTAS FARMASI, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

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Abstract

A study were conducted to analize the vitamins B1, B6 and vitamin E concentrations of top-blade steak from Indonesian local beef, swamp buffalo and imported wagyu beef. Animals were slaughtered at ± 2 year old, top-blade were removed, aged at 10C for seven days, then stored at-800C, thawed to 50C before analyzed. Vitamins B1, B6, and vitamin E content from different breeding meat and buffalo (P<0.05) were significantly different. The content of vitamins B1, B6 and vitamin E local cattle Indonesia is not different from imported beef, and from buffalo meat even contain the highest vitamin E
Uji Aktivitas Penghambatan Enzim Tirosinase Oleh Ekstrak Etanol Daun Keladi Tikus (Typhonium flagelliforme (Lodd.) Blume) Secara In Vitro Munawarohthus Sholikha; Wahyuningtyas Wahyuningtyas; Lia Puspitasari
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 1 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

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Abstract

Hyperpigmentation is an event that occurs due to excessive production of skin pigment. Skin color is strongly influenced by the presence of melanin, where the presence of melanin is strongly influenced by the enzyme tyrosinase. Taro leaf (Typhonium flagelliforme (Lodd.) Blume) are one of the plants have flavonoid compounds used as antioxidants and tyrosinase inhibitors. The aim of this study was to test the ethanol extract of taro leaf as a tyrosinase inhibitor. Taro leaf in this study were obtained through an extraction process using 96% ethanol solvent by maceration method. The thick ethanol extract of taro leaf was tested for phytochemical screening, total flavonoid levels, and tyrosinase inhibition test. The method used for tyrosinase inhibition test was enzymatic method in vitro. The results of this study indicated that there was a total flavonoid compound content of 0.7378% (b/b) and the inhibitor activity can be seen from the IC50 value for the diphenolation reaction (L-DOPA substrate) which was 13.307 mg/mL. This value was greater when compared with 0.093 mg/mL of phenolic acid, so that the ethanol extract of taro leaf has the potential to inhibit tyrosinase activity.
Perbedaan Kualitas Hidup antara Terapi Hemodialisis dengan Terapi Continuous Ambulatory Peritoneal Dialysis (CAPD) pada Pasien Gagal Ginjal Kronik Lili Musnelina; Ditha Kurniati; Del Ferdinal
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 1 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

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Abstract

Chronic Kidney Disease (CKD) is a progressive and irreversible disorder of kidney function. CKD patients who enter the final stage must immediately get renal replacement therapy to maintain their life. The most widely used kidney replacement therapy hemodialysis (HD) and peritonial dialysis (CAPD). Therapies performed either HD or CAPD cause various side effects such as physical fatigue, impaired concentration, disruption of social life and risk of infection. Side effects affect the quality of life of CKD patients. The purpose of this study was to the determine the differences quality of life chronic kidney failure patients between HD and CAPD. This research was an analytic observational research using the SF- 36 questionnaire. The results have shown that the average value of quality of life was significally different, the average score in the CAPD therapy group was 71.06 ± 13.92 and the HD therapy group the average score was 48.08 ± 14.37. The study found a that the majority of the CAPD therapy group have a good quality of life than the HD therapy group.
Potensi Larvasida Ekstrak Daun Alpukat (Persea americana) terhadap Larva Nyamuk Aedes aegypti Desy Muliana Wenas; Muhammad Nur Fajrin; Subaryanti Subaryanti
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 1 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

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Abstract

Avocado (Persea americana Mill.) leaves contain saponins, tannins, flavonoids and alkaloids that have potential as larvicides. The purpose of this study was to determine the larvicidal activity of ethanol extract of avocado (Persea americana) leaves against Aedes aegypti larvae. The test was carried out on 210 larvae which were divided intro 7 groups, namely group I, II, III, IV, V which were ethanol extract of avocado leaves with concentration of 0,1%; 0,5%; 1%; 1,5%; and 2%. Positive control (group VI) was given Temephos 0,01% solution and group VII as negative control was only given Aquadest. Each treatment groups were observed for larvae death and counted every hour for 24 hours. LC50 and LT50 values were calculated using probit analysis. The results showed that ethanol extract of avocado leaf had larvicidal activity against Aedes aegypti larvae with LC50 = 0,03% at 3 hours and LT50 = at 1 hour 42 minutes. The ethanol extract of avocado leaf had a potential as larvicidal against Aedes aegypti larvae.
Evaluasi Penggunaan Antibiotik Profilaksis pada Pasien Sectio Caesarea di RSUD Budhi Asih Periode Juni-Desember 2020 Ritha Widya Pratiwi; Yenny Yosalina Simanjuntak; Putu Rika Veriyanti
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 1 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

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Abstract

Sectio Caesarea (SC) surgical patients are given prophylactic antibiotics to prevent surgical wound infections (SWIs). This study aimed to determine the pattern of use of prophylactic antibiotics in SC surgical patients at Budhi Asih Hospital. This research used a descriptive research type with a cross sectional approach. Number of samples 201 medical records with retrospective data collection. The patient inclusion criteria used were patients delivered by Sectio Caesarea and the patients who had a complete medical record. The results showed that the characteristics of Sectio Caesarea surgical patients at were based on age ≤ 20 years were 14 people (7%), were based on age of 21–34 years there were 133 people (66.2%), and were based on age ≥ 35 years old as much as 54 peoples (26.9%). Based on parity 1-2 people as 114 peoples (56.7%) and parity ≥ 3 people as 87 peoples (43.3%). Based on the history of SC 1-2 times as many as 193 people (96%) and ≥ 3 times as many as 8 people (4%). Based on the prescription pattern using ceftriaxone as many as 200 people (99.5%) and those using amoxicilin as many as 1 person (0.5%). Based on the route of prophylactic antibiotics intravenously, it was 200 people (99.5%) and orally 1 person (0.5%). Based on the time and frequency of prophylactic antibiotics, 201 people (100%) were given. Based on the duration of antibiotics, 201 people (100%) were not added prophylactic antibiotics. Based on the duration of surgery ≤ 60 minutes is 201 people (100%). Based on the Surgical Site Infection(SSI), those who experienced the SSI were 2 people (1%) and those who did not experience the SSI were 199 people (99%). The prophylactic antibiotics used were ceftriaxone with a dose of 1-2 grams/day, the time for drug administration was appropriate 30-60 minutes before surgery, appropriate antibiotics were given intravenously.
Analisis Rhodamin B pada Lip Tint Menggunakan Metode Kromatografi Cair Kinerja Tinggi (KCKT) Lia Puspitasari; Kholipia Azizah; Amlius Thalib
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 1 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

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Rhodamine B is a dangerous colorant and is prohibited for use in various cosmetic products. The aim of this study was to analyze Rhodamine B in lip tint cosmetics, using the High Performance Liquid Chromatography (HPLC) system. Quantitative determination of Rhodamine B was carried out on 8 samples consisting of 4 BPOM registered samples and 4 non BPOM registered samples. The samples were taken at the Cakung traditional market with a randomized sampling method. The quantitative analysis of Rhodamine B by HPLC was carried out with a C18 stationary phase and a mobile phase of a mixture of acetonitrile and diammonium hydrogen phosphate (80:20); the sample injection volume was 20 µl and the eluent flow rate was 0.71 mL/minute. The results showed that Rhodamine B was not detected in the 8 lip tint samples tested.
Antioxidant Cream Formulation Type W/O Ethyl Acetate Extract of Rambutan Fruit Peel (Nephelium lappaceum L .) Waste with the DPPH Method Amelia Febriani; Ika Maruya Kusuma; Nada Zahra
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 1 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

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Abstract

Kulit buah rambutan memiliki kandungan kimia fenolik antara lain berupa geraniin dan corilagin yang merupakan golongan flavonoid, serta asam elagat dari golongan tanin sebagai antioksidan penangkap radikal bebas. Penelitian ini bertujuan memformulasi krim tipe Air dalam Minyak (A/M) yang mengandung ekstrak etil asetat limbah kulit buah rambutan dan diuji aktivitas antioksidannya. Ekstraksi kulit buah rambutan dilakukan secara maserasi dengan pelarut etil asetat. Krim tipe A/M dibuat dengan konsentrasi 5% ekstrak limbah kulit buah rambutan dan kemudian diuji aktivitas antioksidannya dengan metode DPPH menggunakan spektofotometer UV-Vis. Pengujian aktivitas antioksidan pada krim ekstrak etil asetat kulit buah rambutan 5% dilakukan pada konsentrasi sebesar 200, 100, 50, 25 dan 12,5 ppm. Hasil penelitian menunjukkan krim ekstrak etil asetat kulit buah rambutan 5% secara organoleptik memiliki warna kuning kecokelatan, berbau kulit rambutan lemah, karakteristik tidak mudah dicuci dengan air, berbentuk kental dan memiliki nilai pH ±5 yang memenuhi syarat kriteria pH kulit dengan tipe krim air dalam minyak (A/M). Hasil uji aktivitas antioksidan krim ekstrak etil asetat kulit buah rambutan memiliki nilai IC50 sebesar 124, 92 μg/mL yang merupakan kategori antioksidan sedang.
The Effect of Fever Medicine Advertising on Television onPurchase Decisions Fever Medicine in RW 01 Cipedak Jagakarsa South of Jakarta Ainun Wulandari; Afifah Fiandani
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 1 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

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Abstract

Advertising is a form of non-personal communication activity delivered through the media by paying for the space it uses to convey messages that are persuasive, reminding, and offering a product to consumers by companies, non- commercial institutions, and interested individuals. Advertising can affect the feelings of someone who sees it, so that it can influence purchasing decisions. The purpose of this study was to determine the effect of fever medicine advertisements on television on purchasing decisions for fever medicine in the community of RW 01 Cipedak, Jagakarsa, South of Jakarta. This research was an observational study with a quantitative descriptive cross sectional method. The number of respondents obtained was 120 people. The sampling technique in this study used cluster random sampling. Data obtained through questionnaire. The research results obtained that the advertising variable has a positive effect on people's attitudes with sig. 0.000 (p value <0.05), the public attitudes variabel has a positive affect on purchasing decisions with sig. 0.000 (p value <0.05). The results showed that advertisements for fever medicine on television indirectly influenced the purchasing decisions of fever medicine for the people of RW 01 Cipedak Village, Jagakarsa Distrik, South Jakarta.

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