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CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Published by Universitas Airlangga
ISSN : -     EISSN : 2721544X     DOI : http://dx.doi.org/10.20473/cimrj.v1i2.21472
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
The scope for CIMRJ includes: Allergy, Endocrinology, Gastroenterology, Geriatrics, Hematology, Hepatology, Nephology, Rheumatology, Tropic.
Arjuna Subject : Kedokteran - Kedokteran Internal
Articles 50 Documents
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Diagnosis and Management of Patients with Radiation Colitis Made Bayu Agastia Rakateja; Budi Widodo
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 1 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i1.42417

Abstract

Radiation colitis (Radiation Proctitis or Proctopathy) is a condition in which injury to the rectal mucosa is induced by radiation therapy to the pelvic organs. Radiation colitis is a condition that progresses and is becoming more common and dangerous—usually occurring 6 months to 5 years following regional radiation. This paper presented the diagnosis and management of patients with radiation colitis. There was a patient who had cervical cancer and was hospitalized every 2-3 months because of red blood chapters and weakness. She did chemotherapy and radiation for one year. The patient also received medical therapy, including rectal administration of sucralfate and oral sulfasalazine. Management of patients with radiation colitis is still a problem. There are no definite and consistent guidelines for the treatment of radiation colitis In this patient's case, medical therapy was recently carried out, including rectal administration of sucralfate and oral sulfasalazine. The patient was planning to undergo surgical therapy, but the patient and family refused. It is necessary to think about endoscopic therapy in patients. Argon plasma coagulation (APC) has become the most widely used first-line endoscopic therapy.
The Frequency of Multidrug-Resistant Tuberculosis Patient who have History of Tuberculosis, HIV, and Diabetes Mellitus at Dr. Soetomo General Academic Hospital Marsha Zahrani; Rebekah J. Setiabudi; Helmia Hasan; Manik Retno Wahyunitisari
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 1 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i1.42603

Abstract

Introduction: The main causes of MDR TB include interperson transmission and TB treatment failure. In addition to TB, HIV and diabetes mellitus may raise the risk of TB MDR. To determine the TB MDR risk factors, it's critical to understand the prevalence of TB MDR patients with TB, HIV, and diabetes mellitus histories.Methods: This study is an observational descriptive study with a retrospective design. The sample for this study was all patients from the TB and MDR-TB polyclinic at Dr. Soetomo General Academic Hospital, Surabaya, in January 2020–December 2020 who met the inclusion criteria. The data obtained were analyzed descriptively.Results: There were 72 patients who met the criteria: there were 26 patients who have a history of TB, 15 patients who only have a history of diabetes mellitus, 2 patients who only have a history of HIV, 27 patients who have a history of TB with diabetes mellitus, and 2 patients who have a history of TB with HIV.Conclusion: The data could support the theory of an association between MDR-TB with TB, HIV, and diabetes mellitus and increase the awareness of primary MDR TB cases with history of HIV and diabetes mellitus.
CD4 Association with Mortality in HIV Patients with Dyspnea in Dr Seotomo General Academic Hospital Surabaya Moh. Hamzah Raka Pratama; Muhammad Vitanata Arfijanto; Maria Lucia Inge Lusida
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 1 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i1.42609

Abstract

Introduction: HIV AIDS patients who have a CD4 count < 200 cells/uL often complain of respiratory symptoms (Wallace, 1993). The complaint was shortness of breath (62%). Opportunistic infections (IO) in HIV patients are also brought on by a decreased CD4 count of 200 cells/uL (Peters, 2007). HIV/AIDS patients with CD4 < 200 cells/uL have a risk of death of 10.399 (Kusumaadhi, 2021). This study aims to determine the association between CD4 cell count with mortality in HIV patients with shortness of breath at Cendana, Dr. Soetomo General Academic Hospital Surabaya, during the period of January–December 2020.Methods: This study used a cross-sectional retrospective design. The population in this study were patients diagnosed with HIV at Cendana, Dr. Soetomo General Academic Hospital, using a total sampling technique. The variables studied were the CD4 counts as the independent variable, and the mortality of HIV patients with dyspnea as the dependent variable. The sample in this study must meet the inclusion criteria, namely, the sample must have a history of CD4 counts in their medical record in the last 2 to 3 months while in Cendana, Dr. Soetomo General Academic Hospital. Secondary data from medical record data in Cendana, Dr. Soetomo General Academic Hospital, was used for the research from January to December 2020. Results: A total of 128 HIV patients with dyspnea and a history of CD4 counts in the previous 3 to 4 months were included in the study: 79 (61.7%) males and 49 (38.3%) females. The most common age groups were 31–40 years (33.6%), 20–30 years (32.0%), 41–50 years (23.4%), and > 60 years (2.4%), with no patients under the age of 20. The distribution of the most opportunistic infections were: pneumocystis pneumonia (n = 62), tuberculosis (n = 49), and bacterial pneumonia (n = 17). Patients lived (n = 79) and died (n = 49) in total.Conclusion: There was no significant association between CD4 count and mortality in HIV patients with dyspnea (p-value 0.084 > 0.05).
Omega-3 Polyunsaturate Fatty Acid Supplementation Potential to Improve Activity Components of Rheumatoid Arthritis: A Systematic Review Nadia Hidayat; Awalia Awalia; Betty Agustina Tambunan; Hermina Novida
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 2 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i2.32613

Abstract

Introduction: Rheumatoid arthritis (RA) is a chronic disease that causes deformity in most productive age and can lead to death as disease activity increases. Omega-3 polyunsaturated fatty acids have the potential to complement available therapies in reducing disease activity. Currently, the effect of omega-3 PUFAs on disease activity components is still unclear. The current systematic reviews determine the effect of omega-3 PUFAs’ supplementation on the components of RA disease activity. Methods: This research is guided by the PRISMA guidelines systematically. Literature was searched in the databases: PubMed, MDPI, and Clinicaltrials.gov. The inclusion criteria used were: giving omega-3 PUFAs, free full-text, RCT, in English or Indonesian, assessing disease activity and its components; while the exclusion criteria were: unpublished, comparisons were inappropriate. Assessment of literature quality with the Cochrane Collaboration's tool. The study included six studies from 1994 to 2017. Results: The effect of omega-3 PUFAs is diversity in changes of disease activity in 4 of 5 studies. There are significant reductions in the number of joint pains in the literature by daily doses above 2.9 grams or at lower doses taking longer; and swollen joints in 2 studies that were only affected in doses above 2.9 grams. There are significant reductions in pain severity in the studies. Change increases with higher doses. There are variable LED and CRP changes. Conclusion: Depending on their dose and administration duration, omega-3 PUFAs can directly and indirectly affect disease activity through the influence of most of its components, namely: the number of joints affected and the degree of pain.
Lung Abnormalities in Liver Cirrhosis Muli Yaman
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 2 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i2.45201

Abstract

Regardless of preexisting lung illness, patients suffering from liver cirrhosis, especially decompensated liver cirrhosis, can develop distinct pulmonary complications. Liver cirrhosis patients should be assessed for hepatopulmonary syndrome (HPS), portopulmonary hypertension (PoPH), hepatic hydrothorax (HH) and spontaneous bacterial empyema (SBEM) which are the most clinically significant pulmonary consequences, in particular when dyspnea develops in conjunction with hepatic cirrhosis. These entities differ in terms of pathophysiology, clinical characteristics, diagnosis and suitable treatment options. This emphasize the need of specific diagnostic algorithm in liver cirrhosis patients presenting with dyspnea or other pulmonary symptoms. These pulmonary complications might be rare in patients with liver cirrhosis and portal hypertension, but these complications might carry significant morbidity and mortality risks and, therefore, strong clinical suspicion is required to make an early accurate diagnosis. There are several medical therapies available for each condition in the multiple studies but most of the treatments and procedures does not have significant benefit or have short lived benefit. The only treatment that changes the clinical prognosis of decompensated cirrhosis effectively in long term is liver transplantation. However, liver transplantation also needs careful considerations as on some cases it might increase the risk of morbidity and mortality.
Correlation between Serum High-Sensitivity C-Reactive Protein Level and Severity of Albuminuria Measured by Urine Albumin-to-Creatinine Ratio in Type 2 Diabetic Patients Dicky Febrianto; Soebagijo Adi Soelistijo; Artaria Tjempakasari
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 2 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i2.49152

Abstract

Introduction: One of complications in type 2 diabetes mellitus (DM) that require high treatment cost is diabetic kidney disease (DKD), which is characterized by the presence of albuminuria, decrease in glomerular filtration rate, or both. Researches show a positive correlation between type 2 DM and serum high-sensitivity C-reactive protein (hs-CRP) level, a sensitive marker of subclinical inflammation. This study aimed to analyze the correlation between serum hs-CRP level and severity of albuminuria measured by urine albumin-to-creatinine ratio (ACR).Methods: The study was conducted at the Endocrinology Outpatient Clinic of Dr. Soetomo General Academic Hospital, Surabaya, on June-July 2020.Results: The study included 50 patients with type 2 DM, consisting of 25 (50%) men and 25 (50%) women, with median age of 58.0 (42-68) years and mean body mass index (BMI) of 21.91 ± 1.310 kg/m2. Median duration of DM was 12.0 (6-22) years, median HbA1c level was 7.20% (5.7%-12.3%), mean serum crEatinine level was 0.83 ± 0.180 mg/dL, and median estimated glomerular filtration rate (eGFR) value was 92.85 (61.6-121.2) mL/minute/1.73 m2. Median serum hs-CRP level was 1.20 (0.1-4.0) mg/L and median urine ACR value was 49.570 (7.78-426.00) mg/g. Normoalbuminuria was detected in 28% of subjects, microalbuminuria in 66% of subjects, and macroalbuminuria in 6% of subjects. This study showed positive and significant correlation between serum hs-CRP level and severity of albuminuria (r = 0.701; p = <0.001).Conclusion: There was positive and significant correlation betweeen serum hs-CRP level and severity of albuminuria in type 2 diabetic patients.
N-Acetylcysteine Improves Renal Function and Reduces Tissue Malondialdehyde Levels in Glycerol-Induced Acute Kidney Injury Nurina Hasanatuludhhiyah; Arifian Hardi Putri Ratnani; Suhartati
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 2 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i2.49153

Abstract

Introduction: The etiology of myoglobinuric acute kidney injury involves oxidative injury brought on by the Fenton reaction and myoglobin redox cycle. Renal tubules may be harmed, and lipid peroxidation compounds with vasoconstrictor characteristics may be produced. N-acetylcysteine (NAC) is an antioxidant shown to improve renal microcirculation and have protective effects in various models of renal damage. The aim of the study was to demonstrate the protective impact of NAC in glycerol-induced rats by measuring tissue malondialdehyde (MDA) level and renal function test (RFT), and to determine the correlation between the protective effect and NAC dose.Methods: This study measured tissue malondialdehyde (MDA) and renal function to examine any protective effect of NAC in a glycerol-induced rat model and to determine whether the effect was dose-related. Five groups of male Wistar rats were used: 1) saline control group, (2) glycerol (50%, 8mL/kg, i.m) plus saline i.v group, 3) glycerol plus NAC (100 mg/kg)-treated group, 4) glycerol plus NAC (200 mg/kg)-treated group, 5) glycerol plus NAC (400 mg/kg)-treated group. At 24 hrs, after glycerol injection, rats were sacrificed, cardiac blood was taken for renal function measurement, and renal tissues were removed for thiobarbituric acid MDA level assessment.Results: Our study revealed that glycerol administration significantly amplified renal tissue MDA, serum creatinine, and BUN (blood urea nitrogen) levels. However, NAC administration dampened the MDA increment and renal function deterioration (p<0.05). Moreover, tissue MDA, BUN, and serum creatinine levels were significantly correlated to NAC dose (r=0.485; r=0.491; rs=0.544, respectively; all p<0.05), indicating that NAC protection declines by dose increments.Conclusion: In this glycerol-induced acute kidney injury rat model, the administration of intravenous NAC 100 mg/kg reduced lipid peroxidation and improved renal function. Nevertheless, the protective effect was diminished in higher doses.
Correlation between Skinfold Thickness and Total Daily Dose of Insulin in Patient with Type 2 Diabetes Mellitus in Dr Soetomo General Hospital Amilia Putri Larasati; Jongky Hendro Prajitno; Bambang Purwanto
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 2 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i2.49154

Abstract

Introduction: Type 2 diabetes mellitus (T2DM) is a non-communicable disease with a high prevalence in Indonesia. T2DM is caused by insulin resistance and relative insulin deficiency. One of the therapy for T2DM is insulin administration which is injected into the subcutaneous tissue. The absorption of insulin in the subcutaneous tissue is influenced by many factors, one of which is the thickness of subcutaneous fat. This study aimed to determine the correlation between the skinfold thickness of T2DM patients with the total daily dose of insulin needed every day. Methods: This was an observational analytic study using a cross-sectional design to analyze the correlation between subcutaneous fat thickness represented by skinfold thickness and the total daily dose of insulin of T2DM patients. Measurement of skinfold thickness was carried out on the triceps using a skinfold caliper. Data on the patient's total daily dose of insulin were obtained from medical records.Results: A total of 53 patients were included in this study. The patient's mean triceps skinfold thickness was 26.29±8.72 mm. The mean total daily dose of insulin was 40.96±18.01 IU. The results of the Spearman Rank correlation test showed a significant correlation between skinfold thickness on the triceps and the patient's total daily dose of insulin (p<0.05). Conclusion: The higher the skinfold thickness, the greater the dose of insulin needed by the patient.
Association between Albuminuria and Serum Phosphate Levels in Non-Dialysis Stage 3-5 Chronic Kidney Disease Patients Ernesto Everald Baibelino Harfonso; Nunuk Mardiana; Atika
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 2 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i2.49184

Abstract

Introduction: Chronic kidney disease (CKD) remains a global burden and catastrophic disease as about 697.5 million people suffering from it in 2017. About 42% of CKD mortality in Indonesia is related to cardiovascular complications. Hyperphosphatemia, a manifestation of chronic kidney disease-mineral bone disorder, could increase the risk of cardiovascular mortality. Albuminuria has been proven to inhibit the compensatory mechanisms for hyperphosphatemia, thereby aggravating this condition. This study was conducted to analyze the association between albuminuria and serum phosphate levels among CKD patients in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.Methods: This cross-sectional study used medical records of 129 non-dialysis stage 3-5 CKD patients at the outpatient clinic of Dr. Soetomo General Academic Hospital from March-November 2021. Descriptive analysis was performed on albuminuria, serum phosphate, age, sex, body mass index, comorbid, blood chemistry tests, and CKD stages data. Correlational analysis was conducted using the Spearman Rank test on albuminuria and serum phosphate levels.Results: The majority of the subjects in this study were male (55.81%); mean age was 55.21±11.99 years; mean BMI was 22.39±2.27 kg/m2; hypertension was found in 65.89% of the patients; mean eGFR was 25.01±16.1 ml/min/1.73 m2 and dominated by CKD stage 3-5. The distribution of albuminuria grade was dominated by heavy albuminuria (>300 mg/g) and the mean serum phosphate level was 4.81±1.9 mg/dl. Spearman Rank analysis found a significant positive correlation with weak association strength (p<0.001; rs=0.277) between albuminuria and serum phosphate levels.Conclusion: There was a significant positive correlation with weak association strength between albuminuria and serum phosphate levels.  
Association Between Hemoglobin Levels and Quality of Life in Patients Undergoing Chronic Hemodialysis Naufal Daffa Uzzuhdi
Current Internal Medicine Research and Practice Surabaya Journal Vol. 4 No. 2 (2023): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v4i2.49190

Abstract

Introduction: Anemia is a global problem that can be found almost all over the world. Anemia is the most common complication in patients undergoing chronic hemodialysis which can affect quality of life. Health-related quality of life is a factor that correlates with morbidity, mortality, and patient care costs. This study aimed to assess the correlation between hemoglobin levels and quality of life in patients undergoing chronic hemodialysis. Methods: This study was a cross-sectional study with consecutive sampling of 92 research subjects conducted in November-December 2022 at the hemodialysis installation at Dr. Soetomo General Academic Hospital. This study used the SF-36 questionnaire instrument which was divided into 8 quality of life domains.Results: Of the 92 samples that have been collected, 54 were male patients (58.7%) while 42 were female (41.3%). The average age of the subjects in this study was 47.55 years old. The highest level of education was senior high school graduates with a total of 40 people (43.5%). Hemoglobin levels in 92 research subjects were in the range of 7–3.9 g/dl with an average of 9.70±1.63. Fifty subjects (54.4%) had a poor quality of life and 42 subjects (45.6%) had a good quality of life. The range of total quality of life values was 22.98–89.75 with an average of 59.87±14.16. Conclusion: There was a significant relationship between hemoglobin levels with quality of life of the patients at Dr. Soetomo General Academic Hospital. The higher the hemoglobin level, the higher the total quality of life of the patients. It is recommended to the hemodialysis unit at Dr. Soetomo General Academic Hospital to increase hemoglobin level in hemodialysis patients.

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