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Ilhami Romus
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Jurnal Ilmu Kedokteran (Journal of Medical Science)
Published by Universitas Riau
ISSN : 1978662X     EISSN : 27154467     DOI : https://doi.org/10.26891/JIK
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Public Health
Journal of Medical Science receives a script from health and medical lecturer, undergraduate, residents, hospital staff and those who interested in writing scientific papers. The scientific articles posted on JIK include: literature reviews, research article, case report and EBCR (Evidence Based Case Report). Article preferably basic science of medicine and health.
Arjuna Subject : Kedokteran - Review dan Referensi, Kedokteran
Articles 208 Documents
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Comparations Of Glycated Albumin Among Type 2 Diabetes Mellitus Patient With Normoalbuminuria, Microalbuminuria And Macroalbuminuria Raja Iqbal Mulya Harahap; Nina Tristina; Ruri Rizki Anriani
Jurnal Ilmu Kedokteran Vol 17, No 1 (2023): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v17i1.2023.53-58

Abstract

Diabetic nephropathy is the most often complication of diabetes mellitus (DM). Complications of diabetic nephropathy can occur through several pathways, one of which is the formation of Advanced Glycation End Products (AGEs) through the formation of Glycated Albumin (GA). Glycated albumin (GA) is a medium-term glycemic control (2-3 weeks), shorter duration than HbA1c (2-3 months). The aim of this study was to compare the levels of GA in T2DM patients with normoalbuminuria, microalbuminuria, and macroalbuminuria. This is a cross-sectional study with subjects were 105 outpatients who had been diagnosed with T2DM by clinicians at Hasan Sadikin Hospital’s Endocrinology Clinic. We examined urinary albumin per Creatinine (u-ACR) and blood GA Increased GA level was found in 75.24% subjects. Kruskal Wallis test in GA serum levels of patients with T2DM normoalbuminuria group, microalbuminuria and macroalbuminuria revealed statistically significant (p <0.001), with median and range of GA in normoalbuminuria 15,9% (12,1-21,89)%; microalbuminuria 20,9% (12,9-47,2)%; dan macroalbuminuria 23,1% (13,6-46,1)%. Statistical analysis showed that the GA serum level was significantly different between T2DM patients with normoalbuminuria and macroalbuminuria, but not between those with microalbuminuria and macroalbuminuria (p=0.001 and p=0.137, respectively).  The result showed that the extensive kidney damage at the subject, the higher result of Glycated Albumin level in serum.
Efek Inhibitor Proteasom Terhadap Gambaran Histopatologi Jantung pada Tikus yang diinduksi Aterosklerosis Ilhami Romus; Ismawati Ismawati; Indah Putri Arwandi
Jurnal Ilmu Kedokteran Vol 17, No 1 (2023): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v17i1.2023.66-70

Abstract

Proteasome inhibitors are compounds that can inhibit the proteasome pathway in carrying out its functions. Proteasome inhibitors have a beneficial effect due to their anti-inflammatory properties. The proteasome inhibitor used in this study was bortezomib. This study aimed to analyze the effect of proteasome inhibitors on cardiac histopathology in atherosclerosis-induced rats. This study used male Rattus novergicus Wistar strain which was divided into 3 groups, namely the control group, the atherosclerosis-induced group and the atherosclerosis-induced group and given bortezomib. The results obtained the mean scores of edema, inflammation and necrosis in the atherosclerosis group were given bortezomib at a dose of 50 g/kgBW were less than the atherosclerosis group. Theese difference were statistically significant  (p<0.05). This study concluded that the administration of bortezomib can reduce the Impact of atherosclerotic lesions on the heart muscle.
Faktor - faktor yang mempengaruhi kunjungan ibu balita ke Posyandu Desa Melayu Besar Kabupaten Rokan Hilir Yusdiana Yusdiana; Armoni Suci Dewi; Fathiya Azka Putri; Ria Permata Sari
Jurnal Ilmu Kedokteran Vol 17, No 1 (2023): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v17i1.2023.24-31

Abstract

Integrated Healthcare Center (Posyandu) provides access to the community for basic health access, especially for children under five. Indonesian Ministry of Health targeting children under five visit coverage at Posyandu by 90%. Children under five visit coverage to Posyandu at Tanah Putih Tj. Melawan public health center in 2019 only 37.2% of children under five visit coverage at Posyandu Melayu Besar by 42.8%. It is far from the expected target. The objective of this study is to determine factors influencing mother visitation to posyandu Melayu Besar, Rokan Hilir district. Fifty five mothers who have children between 1 – 5 years old were included in this study with accidental sampling. This observational study using a cross-sectional design. This study was conducted from August-October 2022. Collecting data using questionnaire and registration book for posyandu for visitation data. We analyze with univariate for distribution frequencies and bivariate using chi-square for relations. Most of the mothers who bring their children to posyandu are not working and high school graduates, with distance from home to posyandu not being a significant variable. Knowledge level about posyandu mostly in the “good” category by 60%. Number of children under five visit in the “routine” category by 61.8%. There is a correlation with mother visitation. Chi-Square (X2) analysis earned p-value = 0,004 compare to α = 5% mean p < 0,05. In conclusion, there is a correlation between the mother’s knowledge with number of children under five visitation to posyandu.
Perbandingan Mikroorganisme Pada Kultur Urin Pre-Operasi Dan Kultur Batu Pasca Operasi Pada Pasien Batu Saluran Kemih Indra Jaya; Gatot Aji Prihartomo; Fathiyah afaf
Jurnal Ilmu Kedokteran Vol 17, No 1 (2023): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v17i1.2023.59-65

Abstract

Urinary tract infection (UTI) and urinary tract calculi (UTC) still causes significant health problem and present as a dominant case in urology. Urine culture is a standard examination prior to UTC surgery which provide information on microorganism and its sensitivity to antibiotics. Despite of appropriate preoperative antibiotic therapy, we still found post operative infections among those patients. This study aims to determine if there any difference between urine and calculi culture in patients underwent UTC surgery. This is a comparative observational study in patients underwent urinary stone removal procedures from April 2022 to August 2022. Urinary culture attained 5-7 days prior to procedure and crushed calculi culture directly after procedure. The comparison between two examinations was performed. Total of 50 cases consisting of 33 (66%) males and 17 (34%) females was included. Patient with positive urine culture and calculi culture was 15 (30%) and 14 (28%) respectively. Only 3 (6%) patients positive for both, and only one patient with same pathogen. In 11 (22%) patients, we found positive calculi culture with previously sterile urine culture. Most common pathogen in urine culture was Escherichia coli, and Klebsiella pneumoniae found mostly in calculi culture. This study showed 21% accuracy, 66,67% specificity, 20% positive prediction value, 68,57% negative prediction value and 54% diagnostic accuracy. Low positive prediction value and diagnostic accuracy for microorganism of preoperative urine cultured was shown in this study. As a consequences, calculi culture is required  as a routine examination during stone removal procedures.
Aktifitas Antibiotik Ceftazidime-Avibactam Dan Ceftaroline Secara In Vitro Terhadap Isolat Klinis Di Pekanbaru Chandra Wijaya
Jurnal Ilmu Kedokteran Vol 17, No 1 (2023): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v17i1.2023.71-83

Abstract

Ceftaroline and Ceftazidime–avibactam are relatively new antibiotics that show good effectiveness against antibiotic-resistant pathogens. Both of these antibiotics are now available worldwide, but reports of resistance to them are also starting to emerge. This study aimed to evaluate the in vitro activity of the antibiotic Ceftazidime-avibactam combination of 100 clinical isolates consisting of Enterobacteriaceae and Pseudomonas aeruginosa bacteria and to evaluate the antibiotic effect of Ceftaroline against 100 clinical isolates of Enterobacteriaceae and Staphylococcus sp. This study is observational with cross-sectional study design. The study was conducted at the microbiology laboratory of a private hospital at Pekanbaru Riau in Januari-June 2021. There were 100 clinical isolates tested with Ceftaroline and Ceftazidime-avibactam. The sensitivity to Ceftaroline and Ceftazidime-avibactam were reported as a number isolate and percentage. The results showed the sensitivity of bacteria K. pneumoniae, E. coli, Enterobacter sp, and P. aeruginosa, to Ceftazidime-Avibactam were 87%, 90%, 66%, and 82%, respectively. The sensitivity of the antibiotic Ceftaroline to the bacteria K. pneumoniae, E. coli, Enterobacter sp and Staphylococcus sp. were 39%, 54%, 36.4%, 67% and 75%, respectively. Based on these results, the antibiotic ceftazidime avibactam can be used for the treatment of suitable pathogenic infections because of its fairly good sensitivity (>80%) to Enterobacteriaceae and P. aeruginosa bacteria. Ceftaroline antibiotics are not recommended to be used as a therapeutic option, because of the high resistance to Enterobacteriaceae and Staphylococcus sp. Further research is needed to determine the molecular mechanism of resistance to Ceftaroline antibiotics
Karakterisasi Peptida Nterm-34 kDa Protein Saliva Nyamuk Aedes aegypti sebagai Kandidat Antigen Biomarker Risiko Transmisi Virus Dengue Secara In Silico Yunita Armiyanti; Nizar Fiska Bayu Agustian; Sheilla Rachmania
Jurnal Ilmu Kedokteran Vol 17, No 1 (2023): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v17i1.2023.32-40

Abstract

Recently, a new biomarker of mosquito bite has been developed using human antibody response to mosquito salivary protein. One of the proteins that has been tested is salivary protein 34-kDa which has been refined to Nterm-34 kDa peptide. This study aimed to characterize Nterm-34 kDa salivary peptide as a potential antigen biomarker to asses Dengue virus transmission risk. The sequence Nterm-34 kDa was analyzed using several software to predict the characteristic of the peptide. BLASTP from Vectorbase and NCBI wa used to check the specificity of the peptide. IBIVU Praline was used to do multiple sequence alignment. IEDB (Bepipred and Kolaskar & Tongaonkar antigenicity prediction) was used to predict epitopes and antigenic properties, and lastly, ProtParam was used to predict physicochemical properties. The result showed that Nterm-34 kDa salivary peptide is specific to the  Aedes aegypti mosquito at the species level and has low conservation compared to other proteins in Aedes aegypti 34-kDa salivary protein family. Nterm-34 kDa is predicted to be antigenic and one of the epitopes. Nterm-34 kDa salivary peptide is predicted to have a molecular weight of 2,092 kDa, unstable, and hydrophilic. In conclusion, Nterm-34 kDa salivary peptide is predicted to have potential as an antigen biomarker for Dengue virus transmission.
Hemokonsentrasi dan Trombositopenia pada COVID-19, Pembelajaran dari Ruang Instalasi Gawat Darurat Dani Rosdiana; Marlina Tasril; M Firdaus J Karimi
Jurnal Ilmu Kedokteran Vol 17, No 1 (2023): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v17i1.2023.84-89

Abstract

Coronavirus disease 2019 (COVID-19) has become a pandemic since January 2020 and caused the death of 6 million people by April 2022. Exponential human-to-human transmission and the wide variety of clinical and laboratory manifestations of COVID-19 were challenging. Hematological abnormalities such as thrombocytopenia and hemoconcentration in COVID-19 are difficult to distinguish from dengue fever in the ER. Misdiagnosis would impact patient outcomes, health workers, and community safety as well as its transmission. We report a suspected case of dengue fever in admission in X Pekanbaru hospital, Riau which is confirmed as COVID-19. The patient was observed in the isolation ward and treated accordingly to the COVID-19 protocol and heparin due to coagulopathy related to COVID-19. The Proper initial assessment of acute febrile, especially Dengue fever at the emergency room, and the availability of modalities in diagnosing COVID-19 are of paramount importance in the era of the COVID-19 pandemic, even more, it become endemic status.
Pengaruh Ekstrak Buah Bakau (Rhizophora sp) terhadap Ekspresi Monocyte Chemoattractant Protein-1 pada Aorta Tikus Aterosklerosis Muhammad Yulis Hamidy; Huriatul Masdar; Ayu Trisya Arti
Jurnal Ilmu Kedokteran Vol 17, No 1 (2023): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v17i1.2023.41-45

Abstract

Atherosclerosis is an atheromatous plaque that protrudes into and clogs blood vessels. This study aimed to analyze the effect of Rhizophora sp extract on the expression of Monocyte Chemoattractant Protein-1 (MCP-1) in the early stages of atherosclerosis in rats fed an atherogenic diet. Eighteen abdominal aortic paraffin blocks of white rats were used, consisting of 3 groups: normal diet (K1), atherogenic diet (K2), and atherogenic diet and Rhizophora sp extract (K3). The effect of Rhizophora sp extract was assessed by immunohistochemical examination. MCP-1 expression was calculated in 5 fields of view, then analyzed using Photoshop Image Analysis. The results of this study indicated that administration of Rhizophora sp extract reduced MCP-1 expression in K3 compared to K2 (0.155±0.075 vs 0.246±0.097) although this result was not statistically significant. In conclusion, Rhizophora sp extract has the ability to inhibit MCP-1 expression in the aorta of rats fed an atherogenic diet.

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