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INDONESIA
Indonesian Archives of Biomedical Research (InABR)
Published by Konsorsium Ilmu Biomedis Indonesia
ISSN : -     EISSN : 27988236     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
InABR publishes three categories of papers: Original research papers, Case report articles, and Literature review articles on applied or scientific research relevant to biomedical sciences. The scope of this journal covers biomedicine, molecular biology, stem cell, herbal medicine, anti-aging, reproduction, and genetics.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 6 Documents
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Search results for , issue "Vol 1 No 2 (2021): Indonesian Archives of Biomedical Research (InABR). 1(2): 2021" : 6 Documents clear
The role and regulation of FOXO1 in carbohydrate metabolism and its targeting in metabolic diseases Ani Retno Prijanti; Ni Made Wiasty Sukanty
Indonesian Archives and Biomedical Sciences Vol 1 No 2 (2021): Indonesian Archives of Biomedical Research (InABR). 1(2): 2021
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (145.708 KB) | DOI: 10.55392/indarcbiores.v1i2.8

Abstract

Carbohydrate is the first energy source used in metabolic processes. Failure in carbohydrate metabolism can cause metabolic diseases, and many studies are focused on its therapy. Until now, there is no specific therapy approved. Despite that, one of the main alternatives is regarding the involvement of FOXO1 protein in metabolic disease progress. As a transcription factor for gluconeogenesis genes, FOXO1 can increase blood glucose levels. It also involves various signaling pathways in carbohydrate metabolisms such as PI3K/Akt and PKA in which many proteins act as FOXO1 regulators through posttranslational modification. The vital role of FOXO1 in carbohydrate metabolism provides an opportunity to make FOXO1 the main target of metabolic disease therapy. Various proteins and natural compounds can either directly or indirectly regulate FOXO1 activity. It can be an option to be used to control blood glucose levels by targeting FOXO1
Smoking habit affects the qualities of stored leukodepleted red blood cells Aulia Eka Sari Sari; Mohammad Sadikin; Ni Ken Ritchie
Indonesian Archives and Biomedical Sciences Vol 1 No 2 (2021): Indonesian Archives of Biomedical Research (InABR). 1(2): 2021
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (288.238 KB) | DOI: 10.55392/indarcbiores.v1i2.9

Abstract

Background: Pack Red Cell (PRC) is one of the most widely used blood products. Indonesia has a high number of smokers who are potential donors. Smoking is a habit that can cause radicals, triggers oxidative stress so that transfusion becomes ineffective. Objective: This study aimed to determine the relationship between smoking habits and methemoglobin, glutathione, and glucose 6 phosphate dehydrogenase (G6PD) in leukodepleted PRC (PRC-LD) blood bags during storage. Methods: PRC-LD from the Jakarta Red Cross Transfusion Unit were grouped into non-smoker donors (NP), light smoker donors (PR), and moderate smoking donors (PS).  Analysis for methemoglobin, glutathione, and G6PD was performed on days 0, 14, 21, and 35h. The analysis was done spectrophotometrically. Results:  Statistical analysis indicates that methemoglobin was increased on days 21 and 35, glutathione levels decreased progressively on days 0, 14, 21, and 35. The G6PD activities decreased markedly on day 35 in all groups. A significant relationship was found between methemoglobin and glutathione, as well as G6PD and glutathione. Conclusion: Smoking habits make the storage blood condition worse. 
Medication Adherence in Type 2 Diabetes Mellitus Patients with Diabetic Ulcer: Systematic Literature Review: English Safira Raissa Dwi Putri; Sony Wibisono Mudjanarko; Bambang Hermanto
Indonesian Archives and Biomedical Sciences Vol 1 No 2 (2021): Indonesian Archives of Biomedical Research (InABR). 1(2): 2021
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (133.293 KB) | DOI: 10.55392/indarcbiores.v1i2.13

Abstract

Background: Patient non-adherence to diabetes medication can worsen the patient's condition and increase the risk of diabetes complications such as diabetic ulcers. A sufficient level of medication adherence can prevent diabetic complications. This study aimed to determine the level of medication adherence of type 2 DM patients with diabetic ulcers. Review: This research uses a systematic literature review with a PRISMA chart as a research design guideline. Researchers searched three databases, namely PubMed, Google Scholar, and ScienceDirect, using predefined keywords. The search resulted in 2,763 literatures then 11 literatures that met the criteria were taken. The number of respondents obtained amounted to 1,082 people. Characteristics of type 2 DM patients with diabetic ulcers: respondents were female, aged under 60 years, had diabetes for more than five years, used oral medication, insulin, or combination, could have normal or excess BMI, and possibly had hypertension or neuropathy. The result from systematic literature review obtained seven pieces of literature that had a low medication adherence level, two pieces of literature showed no correlation between medication adherence and the incidence of diabetic ulcers in type 2 DM patients, and two pieces of literature had a sufficient level of medication adherence. Summary: The level of medication adherence in type 2 DM patients with diabetic ulcers varies. However, more literature contains results in low medication adherence of type 2 Diabetes Mellitus patients with diabetic ulcers, so it needs to be improved in the future. Keywords: diabetic ulcer, medication adherence, type 2 diabetes mellitus
Neratinib a MST 1 inhibitor coated with Chitosan-alginate nanocarrier as a promising oral drug to inhibit pancreas cell apoptosis, stimulate insulin secretion, and restore Glycemia in type 1 Diabetes Mellitus Nabila Anisa Harum; Zumara Ma'rifah Azzahra; Faizah Sugiarto; Arifa Mustika
Indonesian Archives and Biomedical Sciences Vol 1 No 2 (2021): Indonesian Archives of Biomedical Research (InABR). 1(2): 2021
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (210.789 KB) | DOI: 10.55392/indarcbiores.v1i2.17

Abstract

Type 1 Diabetes Mellitus (T1DM) is a polygenic disorder in which autoimmunity destroys pancreatic beta cells, culminating in an absolute insulin secretion deficiency. Neratinib is an MST1 inhibitor to improve β-cell survival cells coated with alginate calcium nanocarrier encapsulated with chitosan that allows the retention of the packaged oral drug until it reaches specific target cells. This review aims to determine the potential of Neratinib as a Mammalian sterile 20-like kinase 1 Inhibitor, which is carried by nanocarrier chitosan-alginate as an alternative cutting edge oral drug for T1DM by preventing the apoptosis of beta cells.. Neratinib coated with chitosan-alginate nanocarrier and packaged in the form of an oral drug can be used as an advanced T1DM therapy. Future perspective needs further experimental and clinical trials to obtain concrete scientific evidence.
Biosensor development as an alternative test for Leptospirosis diagnosis: a systematic review Susanti Susanti; Radiana Dhewayani Antarianto
Indonesian Archives and Biomedical Sciences Vol 1 No 2 (2021): Indonesian Archives of Biomedical Research (InABR). 1(2): 2021
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (818.951 KB) | DOI: 10.55392/indarcbiores.v1i2.22

Abstract

Leptospirosis is a zoonotic disease caused by pathogenic bacteria from the genus Leptospira that can attack livestock, wild animals, and humans. The diagnosis of leptospirosis is currently carried out by Leptospira culture, Microscopic Agglutination Test (MAT), Enzyme Linkage Immunosorbent Assay (ELISA), and Polymerase Chain Reaction (PCR). This test requires a specific laboratory, long test time, experienced personnel, a lot of equipment and is expensive and difficult to apply in the field. Biosensor technology is a necessary method of disease diagnosis to detect biomolecules such as protein and bacteria biomarkers. The purpose of this article is to provide information on the development of biosensors as an alternative test for the diagnosis of leptospirosis. The method used is a systematic review using the PRISMA protocol. The results showed that the electrochemical biosensor with monoclonal anti-LipL32 and ssDNA probe specific to the LipL32 gene of Leptospira had advantages for leptospirosis diagnosis because it was cheap, accurate, portable, small test equipment, and capable of detecting leptospirosis. Optical biosensors (specifically lateral flow systems, magnetogenosensors and paper fluidic devices) can detect Leptospira bacteria with sensitive, specific, easy manipulation, and users can get fast visual test results within minutes. This biosensor technology can be used as a promising alternative diagnostic method for the diagnosis of leptospirosis with simplicity, high sensitivity, fast detection time, low cost, and portable so that it is easy to apply in the field.
Sulforaphane as a potential therapy for multiple sclerosis: a review article Gede Febby Pratama Kusuma, Pratama Kusuma; Kadek Dede Frisky Wiyanjana; Sri Maliawan
Indonesian Archives and Biomedical Sciences Vol 1 No 2 (2021): Indonesian Archives of Biomedical Research (InABR). 1(2): 2021
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (370.969 KB) | DOI: 10.55392/indarcbiores.v1i2.24

Abstract

Multiple Sclerosis (MS) is a chronic immune-mediated Neuroinflammatory disease that attacks the Central Nervous System (CNS). It creates serious physical disabilities characterized by neuronal injury, demyelination, and axonal loss. Several mechanisms are responsible for the progression of MS, including the infiltration of T-cells from the peripheral to the CNS, the autoreactivity of B-cells that contribute to abnormal regulation of antibodies and antigen presentation, and the assault of Macrophage that lead to inflammation and neuron damage. Additionally, oxidative stress plays a more important role in chronic inflammation of MS. Sulforaphane (SFN) is an isothiocyanate derived from glucoraphanin (GRA) that is found mostly in broccoli. SFN can act as an anti-inflammatory and anti-oxidant agent by activating the Nuclear factor-erythroid 2-(NF-E2-) Related Factor 2 (Nrf2). Nrf2 is expressed in the central nervous system and upregulated in response to inflammation and cerebral insults. Nrf2 binds to the antioxidant response element (ARE) which is a DNA promoter region of genes codifying antioxidant enzymes, which in turn can reduce oxidative stress. Several in vitro and in vivo studies show that SFN can increase the anti-inflammatory and anti-oxidant genes. Thus, SFN is very promising as a potential therapy for MS.

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