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Indonesian Archives of Biomedical Research (InABR)

InABR
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Published by Konsorsium Ilmu Biomedis Indonesia

ISSN : - EISSN : 27988236 DOI : -

Core Subject : Health, Science,

Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

InABR publishes three categories of papers: Original research papers, Case report articles, and Literature review articles on applied or scientific research relevant to biomedical sciences. The scope of this journal covers biomedicine, molecular biology, stem cell, herbal medicine, anti-aging, reproduction, and genetics.

Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)

Articles 17 Documents

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Correlation between Nephrin expression, tubular injury, and serum Creatinine level in kidney failure model with 5/6 subtotal Nephrectomy in mice M. Mansyur Romi; Dwi Cahyani Ratna Sari; Riky Setyawan; Fauziyatul Munawaroh; Nur Arfian
Indonesian Archives and Biomedical Sciences Vol 1 No 1 (2021): Indonesian Archives and Biomedical Sciences Vol 1(1): 2021
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

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Background: Chronic kidney diseases (CKD) is characterized by glomerulosclerosis, tubular injury, and proteinuria. Neprin is the one of the most important protein involved in glomerular filtration but the mechanism of nephrin expression in chronic kidney failure is not well understood. Objective: We aims to elucidate the correlation between nephrin expression with tubular injury and serum creatinine level. Methods: We performed 5/6 subtotal nephrectomy (SN) in male strain Swiss mice to induce CKD. Sham operation was performed to control group (SO) (n=8). Mice were sacrificed in day 7 (SN7; n=8) and day 28 (SN28; n=8) after operation. We measure creatinine serum level to assess renal function. Tubular injury score was quantified using Periodic Acid Schiff (PAS) staining. Reverse transcriptase PCR (RT-PCR) was carried out to examine Nephrin mRNA expression. Results: 5/6 subtotal nephrectomy induced an increased of serum creatinine level in SN7 and SN28 (p<0,01 vs SO), followed by an increased of tubular injury score in SN7 and SN28 (p<0,01 vs SO). We confirmed reduction of nephrin expression in SN28 (p<0.01 vs SO). There was a negative correlation between nephrin and tubular injury (r=0.719, p<0.01) and the positive correlation between tubular injury and serum creatinine level (r=0.891, p<0.01). However, we did not find any significant correlation between nephrin expression and serum creatinine level. Conclusion: Nephrin expression downregulation might represent renal function disturbtion in CKD.

Administration of Bajakah (Spatholobus littoralis hassk) stem ethanol extract cream inhibited the increasing of mmp-1 expression and the reducing of collagen in male wistar rats (Rattus norvegicus) exposed to ultraviolet b Milhanah Milhanah; Wimpie Pangkahila; Anak Agung Gde Putra Wiraguna; IGA Wiwiek Indrayani; IM Agus Eka Darwinata; I Wayan Weta
Indonesian Archives and Biomedical Sciences Vol 1 No 1 (2021): Indonesian Archives and Biomedical Sciences Vol 1(1): 2021
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Background: Exposure to ultraviolet B (UV-B) rays causes skin aging characterized through increased free radical damaged. To prevent skin aging due to UV-B exposure, it is necessary to additionally provide antioxidants as a measure to inhibit the skin aging process. Bajakah tree (Spatholobus littoralis hassk) is one antioxidants sourche such as phenols, flavonoids, and tannins. The aim was to prove that the administration of Bajakah stem ethanol extract cream inhibits increasing MMP-1 expression and reduction of collagen number in male Wistar rats exposed to UV-B. Methods: A posttest control group study design was coducted in male rats (Rattus norvegicus), Wistar strain, aged 2-3 months, weigh 180-200gram which was divided randomly into two groups. The control group (n = 18) was exposed to UV-B rays and placebo cream (0.2 mg/cm2), while the treatment group (n = 18) was exposed to UV-B rays and Bajakah stem ethanol extract cream 15 % (0.2 mg/cm2). Both creams have aplied twice before and after exposure to UV-B rays (3 times a week, with 840 mJ/cm2) for 4 weeks. Twenty-four hours after the last day intervention, a punch biopsy of skin tissue was prepared for histological examination followed by immunohistochemical assay (for MMP-1) and Sirius red (for collagen) staining. Results: The expression of MMP-1 was significantly higher in the control group (24.3 ± 6.20%) compared to the treatment group (11.5 ± 3.21%), p<0.001. Furthermore, the number of collagen was statistically lower in the control group (63.1 ± 3.94%) compared to the treatment group (82.0 ± 3.02%), p<0.001. Conclusion: The administration of bajakah (Spatholobus littoralis hassk) stem ethanol extract cream inhibited the increasing of MMP-1 expression and the reducing of collagen cells in male Wistar rats (Rattus norvegicus) those were exposed to UV- B.

The Role of artificial intelligence in designing antibody-based therapy for Covid-19 Wahyu Hidayati; Radiana Dhewayani Antarianto
Indonesian Archives and Biomedical Sciences Vol 1 No 1 (2021): Indonesian Archives and Biomedical Sciences Vol 1(1): 2021
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

For several decades ago, passive immunization has already proven its ability to treat some diseases, especially pandemic diseases. On the contrary, after antibiotics discovery, the usage of passive immunization becomes neglected. Nowadays, we face a pandemic situation, COVID-19, which needs the possible treatment to save patients lives while medicines and vaccines are under development. By learning from history, passive immunization seems to be the best choice to save patient lives. As a kind of passive immunization, antibody-based therapy successfully treats diseases, including infectious diseases. Several antibody-based therapies are developed, as vast as the technology development, especially after the genetic codes announced. This article highlighted the influence of genomics tools, which helps researchers develop various platforms in developing monoclonal antibodies with high safety and efficiency in production and application.

GLUT1: structure, function, and biomedical significances Ika Yustisia; Mutmainah Arif
Indonesian Archives and Biomedical Sciences Vol 1 No 1 (2021): Indonesian Archives and Biomedical Sciences Vol 1(1): 2021
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Background; Glucose is the main energy source for cells. To be utilized by cells, glucose enters the intracellular space facilitated by transporters. GLUT1 is one of the glucose transporters and is the most widely expressed by various tissues in the body. Not only that, cancer cells, which are known to have very high glucose requirements compared to healthy cells, have a high expression of GLUT1 as well. Reviews; This paper reviews the structure, function, and biomedical importance of GLUT1 and specifically describes recent developments regarding GLUT1 inhibition as a novel therapeutic approach in both metabolic diseases and cancers. Conclusion; Inhibition of GLUT1 has also been shown to increase cancer cells' sensitivity to chemotherapy agents such as cisplatin and adriamycin. GLUT1 inhibition also increases the sensitivity of cancer cells to radiotherapy.

Biofilm forming potential of Streptococcus suis: focusing on luxs/ai-2-mediated quorum sensing system Tjokorda Istri Pramitasuri; Ni Made Adi Tarini; Ni Made Susilawathi; Anak Agung Raka Sudewi
Indonesian Archives and Biomedical Sciences Vol 1 No 1 (2021): Indonesian Archives and Biomedical Sciences Vol 1(1): 2021
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Because of its virulence and ability to survive, the incidence of infection caused by Streptococcus suis (S. suis), an emerging zoonotic pathogen, is expected to increase significantly. A biofilm-forming process, which is a cornerstone of chronic infection, influences the survival rate of S. suis. The mechanism helps bacteria to live longer in host tissues, form colonies, escape immune clearance, and share genetic information. At this moment, the most studied regulatory mechanism of S. suis biofilm formation is Quorum Sensing (QS), mainly on LuxS/AI-2-mediated QS system, in which AI-2 is the most closely related molecule to biofilm formation. In this system, LuxS acts as the key player in the process. The understanding of biofilm formation in S. suis, especially the LuxS/AI-2-mediated QS system, is a valuable contribution to future therapeutic research frameworks.

Seahorse (Hippocampus sp): opportunities in assisted reproduction with nanotechnology approach Trisnawati Mundijo; Yurnadi Hanafi Midoen; Radiana Dhewayani Antarianto
Indonesian Archives and Biomedical Sciences Vol 1 No 1 (2021): Indonesian Archives and Biomedical Sciences Vol 1(1): 2021
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Seahorse (Hippocampus sp) is the unique fish, because the male is pregnancy. The seahorse not only given an economic value but also have a potential drug for medical use, which is have a steroid an aphrodisiac for fertility. The previous studies have reported the function seahorse extract and have been studied both in vitro and in vivo to know the effects from the natural product. Nowadays, infertility caused many factors, such as a factor from the male including spermatogenesis and testis disorder. In decade, there is the treatment for infertility used GnRH therapy, but it still controversy between the impact in reproductive system and needed the study. GnRH in vertebrate has a G receptor from kisspeptin gene to transcription promote and suggested a key regulator reproductive with a kiss 1 gene, which is the same function in mammals and fishes. In this condition, it is suggested a bioactive compound in seahorse can be investigated to replace a treatment infertility in male with GnRH therapy. It can be done through drug delivery systems with several carrier systems, such as nanoparticles. In the future, bioactive compound from seahorse needed the study to explore a potential drug in medical use including the efficiency and efficacy for fertility in human with nanotechnology approach.

The role and regulation of FOXO1 in carbohydrate metabolism and its targeting in metabolic diseases Ani Retno Prijanti; Ni Made Wiasty Sukanty
Indonesian Archives and Biomedical Sciences Vol 1 No 2 (2021): Indonesian Archives of Biomedical Research (InABR). 1(2): 2021
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Carbohydrate is the first energy source used in metabolic processes. Failure in carbohydrate metabolism can cause metabolic diseases, and many studies are focused on its therapy. Until now, there is no specific therapy approved. Despite that, one of the main alternatives is regarding the involvement of FOXO1 protein in metabolic disease progress. As a transcription factor for gluconeogenesis genes, FOXO1 can increase blood glucose levels. It also involves various signaling pathways in carbohydrate metabolisms such as PI3K/Akt and PKA in which many proteins act as FOXO1 regulators through posttranslational modification. The vital role of FOXO1 in carbohydrate metabolism provides an opportunity to make FOXO1 the main target of metabolic disease therapy. Various proteins and natural compounds can either directly or indirectly regulate FOXO1 activity. It can be an option to be used to control blood glucose levels by targeting FOXO1

Smoking habit affects the qualities of stored leukodepleted red blood cells Aulia Eka Sari Sari; Mohammad Sadikin; Ni Ken Ritchie
Indonesian Archives and Biomedical Sciences Vol 1 No 2 (2021): Indonesian Archives of Biomedical Research (InABR). 1(2): 2021
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Background: Pack Red Cell (PRC) is one of the most widely used blood products. Indonesia has a high number of smokers who are potential donors. Smoking is a habit that can cause radicals, triggers oxidative stress so that transfusion becomes ineffective. Objective: This study aimed to determine the relationship between smoking habits and methemoglobin, glutathione, and glucose 6 phosphate dehydrogenase (G6PD) in leukodepleted PRC (PRC-LD) blood bags during storage. Methods: PRC-LD from the Jakarta Red Cross Transfusion Unit were grouped into non-smoker donors (NP), light smoker donors (PR), and moderate smoking donors (PS). Analysis for methemoglobin, glutathione, and G6PD was performed on days 0, 14, 21, and 35h. The analysis was done spectrophotometrically. Results: Statistical analysis indicates that methemoglobin was increased on days 21 and 35, glutathione levels decreased progressively on days 0, 14, 21, and 35. The G6PD activities decreased markedly on day 35 in all groups. A significant relationship was found between methemoglobin and glutathione, as well as G6PD and glutathione. Conclusion: Smoking habits make the storage blood condition worse.

Medication Adherence in Type 2 Diabetes Mellitus Patients with Diabetic Ulcer: Systematic Literature Review: English Safira Raissa Dwi Putri; Sony Wibisono Mudjanarko; Bambang Hermanto
Indonesian Archives and Biomedical Sciences Vol 1 No 2 (2021): Indonesian Archives of Biomedical Research (InABR). 1(2): 2021
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Background: Patient non-adherence to diabetes medication can worsen the patient's condition and increase the risk of diabetes complications such as diabetic ulcers. A sufficient level of medication adherence can prevent diabetic complications. This study aimed to determine the level of medication adherence of type 2 DM patients with diabetic ulcers. Review: This research uses a systematic literature review with a PRISMA chart as a research design guideline. Researchers searched three databases, namely PubMed, Google Scholar, and ScienceDirect, using predefined keywords. The search resulted in 2,763 literatures then 11 literatures that met the criteria were taken. The number of respondents obtained amounted to 1,082 people. Characteristics of type 2 DM patients with diabetic ulcers: respondents were female, aged under 60 years, had diabetes for more than five years, used oral medication, insulin, or combination, could have normal or excess BMI, and possibly had hypertension or neuropathy. The result from systematic literature review obtained seven pieces of literature that had a low medication adherence level, two pieces of literature showed no correlation between medication adherence and the incidence of diabetic ulcers in type 2 DM patients, and two pieces of literature had a sufficient level of medication adherence. Summary: The level of medication adherence in type 2 DM patients with diabetic ulcers varies. However, more literature contains results in low medication adherence of type 2 Diabetes Mellitus patients with diabetic ulcers, so it needs to be improved in the future. Keywords: diabetic ulcer, medication adherence, type 2 diabetes mellitus

Neratinib a MST 1 inhibitor coated with Chitosan-alginate nanocarrier as a promising oral drug to inhibit pancreas cell apoptosis, stimulate insulin secretion, and restore Glycemia in type 1 Diabetes Mellitus Nabila Anisa Harum; Zumara Ma'rifah Azzahra; Faizah Sugiarto; Arifa Mustika
Indonesian Archives and Biomedical Sciences Vol 1 No 2 (2021): Indonesian Archives of Biomedical Research (InABR). 1(2): 2021
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Type 1 Diabetes Mellitus (T1DM) is a polygenic disorder in which autoimmunity destroys pancreatic beta cells, culminating in an absolute insulin secretion deficiency. Neratinib is an MST1 inhibitor to improve β-cell survival cells coated with alginate calcium nanocarrier encapsulated with chitosan that allows the retention of the packaged oral drug until it reaches specific target cells. This review aims to determine the potential of Neratinib as a Mammalian sterile 20-like kinase 1 Inhibitor, which is carried by nanocarrier chitosan-alginate as an alternative cutting edge oral drug for T1DM by preventing the apoptosis of beta cells.. Neratinib coated with chitosan-alginate nanocarrier and packaged in the form of an oral drug can be used as an advanced T1DM therapy. Future perspective needs further experimental and clinical trials to obtain concrete scientific evidence.

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Renny I'tishom

Contact Email inabrjournal@gmail.com

Phone +628121644432

Journal Mail Official inabrjournal@gmail.com

Editorial Address Redaksi Indonesian Archives of Biomedical Research (InABR), Gedung Konsorsium Ilmu Biomedik Indonesia, Salemba Raya No. 4, Jakarta Pusat, 10430

Location Kota adm. jakarta pusat, Dki jakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Renny I'tishom

Contact Email
inabrjournal@gmail.com

Phone
+628121644432

Journal Mail Official
inabrjournal@gmail.com

Editorial Address
Redaksi Indonesian Archives of Biomedical Research (InABR), Gedung Konsorsium Ilmu Biomedik Indonesia, Salemba Raya No. 4, Jakarta Pusat, 10430

Location
Kota adm. jakarta pusat,

Dki jakarta

INDONESIA