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Jurnal Sains dan Kesehatan
Published by Universitas Mulawarman
ISSN : 23030267     EISSN : 24076082     DOI : https://doi.org/10.25026/jsk
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology
Jurnal Sains dan Kesehatan (J. Sains. Kes) (e-ISSN 2407-6082, p-ISSN 2303-0267), is a national journal with ISSN and published four times a year in 2015. In 2016 the publishing frequency changed to twice a year. In 2021 the frequency increased to six times a year. Jurnal Sains dan Kesehatan is published online by the Faculty of Pharmacy, Mulawarman University, Samarinda City, East Kalimantan. Since 2019, the Jurnal Sains dan Kesehatan has been accredited to SINTA. Jurnal Sains dan Kesehatan publishes manuscripts (Original research Article, review articles, and Short communication) on original work, either experimental or theoretical in the following areas: Pharmaceutics, Pharmaceutical Chemistry, Pharmacology & Toxicology, Pharmaceutical Biotechnology & Microbiology, Pharmacy practice & Hospital Pharmacy, Case Study & Full clinical trials, Clinical Pharmacy, Medicine, and other related fields. The purpose of publishing the Jurnal Sains dan Kesehatan is to provide scientific information about the development of science and technology in the field of Science and Health. Lingkup naskah Jurnal Sains dan Kesehatan mencakup bidang ilmu: Kimia Farmasi Biologi Farmasi Farmakologi Teknologi Farmasi dan Farmasetika Farmasi Klinik dan Komunitas Kedokteran dan Bidang ilmu lain yang terkait Tujuan penerbitan Jurnal Sains dan Kesehatan adalah memberikan informasi ilmiah tentang perkembangan ilmu pengetahuan dan teknologi bidang Farmasi dan yang terkait
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 23 Documents
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Search results for , issue "Vol. 5 No. 2 (2023): J. Sains Kes." : 23 Documents clear
In Silico Study of Bajakah Compounds (Spatholobus suberectus) to Protease SARS-CoV-2 Inhibitor Norhayati Norhayati; Andika Andika; Aris Purwanto
Jurnal Sains dan Kesehatan Vol. 5 No. 2 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i2.950

Abstract

Coronavirus Disease 2019 or COVID-19 is caused by a virus called Severe Acute Respiratory Syndrome Coronavirus 2. Until now, there is no specific treatment guide in dealing with COVID-19 in Indonesia. The curative pharmacological therapy for COVID-19 used is antiviral such as lopinavir, ritonavir, and oseltamivir, currently based on trial and error. This study carried out a Molecular Docking Analysis of 16 compounds owned by the Bajakah plant (Spatholobus suberectus). Oseltamivir was used as a control, and validation was carried out on a natural ligand, namely boceprevir against the main protease CoV or Mpro, 7C6S and the result was 1.47 Å using Toshiba hardware and AutoDock Tools, ChemSketch, Discovery Studio, Avogadro, UCSF Chimera software. Lipinski Rules of Five (RO5) analysis and ADMET analysis using SWISSADME and admetSAR. Licochalcone A compound had the best binding energy and inhibition constant values of -7.98 kcal/mol and 1.42 ?M. In contrast, the 6-Methoxyeriodictyol compound had fewer binding energy and inhibition constants, namely -5.24 kcal/mol and 143.04 ?M, respectively. In addition to the licochalcone A compound, the afrormosin compound, 3'4'7'-trihydroxyflavone, formononetin, cajanin, and dihydrokaempferol showed good binding energy values and inhibition constants compared to oseltamivir (control), so that these compounds have the potential to inhibit Mpro SARS-COV-2 or the virus that causes COVID-19. Analysis of Lipinski Rules of Five and ADMET is used to determine the properties of a molecule on the pharmacokinetics of drugs in the human body, and the results obtained to meet the requirements so that it is potentially effective for oral consumption.
Literatur Review: Plant Efficacy as Biolarvicide for Anopheles Mosquito Vector Control: Literatur Review: Efikasi Tanaman Sebagai Biolarvasida Untuk Pengendalian Vektor Nyamuk Anopheles Asrianto Asrianto; Suarna Samai; Muhamad Sahidin; Indra Taufik Sahli; Risda Hartati; Wiwiek Mulyani
Jurnal Sains dan Kesehatan Vol. 5 No. 2 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i2.1172

Abstract

Mosquito vectors are a severe threat to the prevalence and incidence of malaria, dengue fever, yellow fever, and filariasis. Malaria is a Plasmodium infection that is transmitted by the female Anopheles mosquito. Malaria cases in tropical and subtropical countries have social and economic impacts. Mosquito vector control has been using chemical and synthetic compounds. This method can reduce malaria cases, but it creates new problems that also slow down the elimination of malaria in the long run. Vector control in the larval phase using bioactive compounds of various plants is an alternative to eradicating vectors; besides that, utilizing these bioactive compounds is relatively safer, cheaper, and more accessible. Plants contain several compounds that are toxic to Anopheles mosquito larvae. This literature study summarizes research on extracts of various plants that function as larvicides of the Anopheles mosquito. The research method uses a literature study. The literature related to the research topic was obtained from the databases of Google Scholar, Semantic Sholar, Garuda, PubMed, and Science Direct. The primary literature is a publication of the last ten years. The literature study results showed that the plants Vitex negundo Linn., Lawsonia inermisLinn., Stachys byzantina K.Koch., Pithecellobium dulce Bth., Olax dissitiora Oliv., Ipomea cairica Linn., Ricinnus communis Linn., Carica papaya Linn., Paederia foetida Linn., Glycosmis pentaphylla Retz., Terminalia chebula Retz., Annona squamosa Linn., Tagetes erecta Linn. and Azadiracha indica Juss. against mosquito vectors. This study concludes that secondary plant metabolites can be used as candidates and alternatives for controlling Anopheles mosquito larvae.
Penggunaan Aplikasi Edukasi Seksual dalam Mendukung Sustainable Development Goals 2030: Usage of Sexual Education Applications for Sustainable Development Goals, 2030 Dhani Wijaya; Humaira Ramzi; Azian Firman Saputra; Ilmiyatul Muhimmah
Jurnal Sains dan Kesehatan Vol. 5 No. 2 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i2.1186

Abstract

Increasing sexual reproductive health information and knowledge about Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome in adolescents is one of the targets of the Sustainable Development Goals, 2030. The use of sexual education applications helps educate adolescents that supports the achievement of these targets. This study describes the effect of sexual health education applications on adolescent knowledge and decreases the prevalence of Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome to support the 2030 Sustainable Development Goals. This research is a literature study of articles published in NCBI, Google Scholar, and PubMed. The keywords used in the article search were: sex education, android application, Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome, and reproduction health. Inclusion criteria were articles published in 2016-2020, using English or Indonesian, original article, can be accessed in full text, free of charge and the manuscript content’s were relevant to the study. Review articles and duplicate journals were excluded. In this study, only ten of the 1250 articles met the inclusion criteria. Study shows that sexual education applications can increase adolescents' understanding of reproductive health, good and healthy sexuality, improve sexual attitudes and behavior, and also reduce the prevalence of Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome that supports the 2030 Sustainable Development Goals. Keywords: Sexual Education Applications, Reproductive Health, HIV/AIDS Abstrak Peningkatan informasi kesehatan reproduksi dan seksual serta pengetahuan mengenai Human Immunodeficiency Virus dan Acquired Immune Deficiency Syndrome pada remaja merupakan salah satu target Sustainable Development Goals 2030. Penggunaan aplikasi edukasi seksual membantu edukasi terkait kesehatan seksual dan reproduksi yang mendukung pencapaian target tersebut. Tujuan penelitian ini untuk mendeskripsikan pengaruh aplikasi edukasi kesehatan seksual terhadap pengetahuan remaja dan penurunan prevalensi Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome dalam kaitannya untuk mendukung Sustainable Development Goals 2030. Penelitian ini merupakan studi literatur atas artikel yang terbit NCBI, Google Scholar dan PubMed. Kata kunci yang digunakan dalam pencarian artikel adalah: sex education, application android, Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome dan reproduction health. Kriteria inklusi meliputi artikel terbitan 2016-2020, berbahasa Inggris atau Indonesia, original article, dapat diakses secara lengkap, gratis dan isi naskah relevan dengan topik penelitian. Review article dan duplikasi jurnal dikeluarkan dari penelitian. Dalam penelitian ini, sepuluh dari 1250 artikel yang memenuhi kriteria inklusi. Berdasarkan tinjauan artikel diketahui bahwa aplikasi edukasi seksual dapat meningkatkan pemahaman remaja terkait kesehatan reproduksi, seksualitas yang sehat, memperbaiki sikap dan perilaku seksual serta menurunkan prevalensi Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome. Hal ini mendukung tercapainya Sustainable Development Goals 2030. Kata Kunci: Aplikasi Edukasi Seksual, Kesehatan Reproduksi, HIV/AIDS
High Calcium Boba from Egg Shells to Prevent Stunting and Boost the Immune System Laillatul Mas’udah; Dhani Wijaya; Nabila Asha Rahmita; Ulva Nur Rahmawati
Jurnal Sains dan Kesehatan Vol. 5 No. 2 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i2.1187

Abstract

Nutritional status and stunting are problems in several countries, including Indonesia. Calcium is one of the important micronutrients to prevent stunting, and the immune system can act as a second messenger of lymphocytes to maintain the body's immune response. Calcium in eggshells can be processed into boba which is popular in the community. This study aims to examine eggshells as a high-calcium food source to prevent stunting and help increase immunity. This research is a Literature Review of open access articles published in 2016 - 2021 on Google Scholar, PubMed, and Science Direct. Duplicate reports were excluded from the study. The keywords used in searching the journal in the database are eggshells, calcium, stunting, immune system, and popular foods. Research shows that every gram of eggshell contains 381 mg of calcium. Adequate calcium intake supports increasing height, maintaining bone health, and preventing stunting. Increased intracellular calcium is essential for the steps of intracellular signaling that induce proliferation, cytokine production, and regulation of several transcription factors. Eggshells can be safely consumed if they are kept for 20 minutes and finely ground with the high calcium content. High calcium boba from eggshell flour can prevent stunting and boost the immune system.
Flavonoid dalam Penyembuhan Luka Bakar pada Kulit: Flavonoids in Healing Burns on the Skin Gede Reynaldi Wahyu Sanjaya; Ni Made Linawati; I Gusti Kamasan Nyoman Arijana; Ida Ayu Ika Wahyuniari; I Gusti Nyoman Sri Wiryawan
Jurnal Sains dan Kesehatan Vol. 5 No. 2 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i2.1247

Abstract

Burns can be caused by heat or other acute trauma, currently the number of cases is still high in Indonesia and the world. The advances of burns treatment are made through research on possible natural ingredients. Flavonoids are polyphenolic compounds that are most commonly found in plants and as well as possible in burn healing. The aims of this literature review are decribed burns, histological structure of skin, and the effectiveness of flavoinoids in burns healing. The method used in this literature review is by searching data through the Science Direct, PubMed, and Google chrome databases. The search results of 19 appropriate journals, it was found that the flavonoid compounds can heal burns through their ability to inhibit prostanoid biosynthesis, inhibition of phosphodiesterase, and various other important mechanisms. Keywords: burns, histological structure of skin, flavonoids, burns healing Abstrak Luka bakar dapat sebabkan oleh panas atau trauma akut lain, saat ini jumlah kasusnya masih tinggi di Indonesia maupun dunia. Kemajuan pengobatan luka bakar dilakukan melalui penelitian bahan alami yang berpotensi. Flavonoid adalah senyawa polifenolik yang paling banyak ditemukan pada tumbuh-tumbuhan serta berpotensi dalam penyembuhan luka bakar. Literature review ini bertujuan mengulas tentang luka bakar, struktur histologi kulit serta potensi flavonoid pada penyembuhan luka bakar. Metode yang digunakan dalam pembuatan literature review ini dengan pencarian data melalui database pada Science Direct, PubMed, dan Google chrome. Dari hasil pencarian ditemukan 19 jurnal yang sesuai, diperoleh hasil bahwa senyawa jenis flavonoid yang terkandung pada beberapa tumbuhan berpotensi menyembuhkan luka bakar melalui kemampuannya dalam penghambatan biosintesis prostanoid, penghambatan fosfodiesterase, serta berbagai mekanisme penting lainnya. Kata Kunci: luka bakar, struktur histologi kulit, flavonoid, penyembuhan luka bakar
Pengaruh Ekstrak Etanol Daun Asam Jawa (Tamarindus indica L.) terhadap Jantung Tikus Putih (Rattus norvegicus L.) yang Diinduksi Minyak Jelantah: Effect of Java Acid Leaf (Tamarindus indica L.) Ethanol Extract on Heart of White Rats (Rattus norvegicus L.) Induced Used Cooking Oil Nurkhaida Siregar; Husnarika Febriani; Syukriah Syukriah
Jurnal Sains dan Kesehatan Vol. 5 No. 2 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i2.1619

Abstract

This study aims to determine the effect of ethanol tamarind leaves (Tamarindus indica L.) om histology and levels of the enzyme lactate dehydrogenase (LDH) in rat hearts induced by used cooking oil.This study used a completely randomized design with 25 male white rats devided into 5 groups: negetive control, positive control, 1, 2 and 3 doses treatment (150 mg/kg BW, 200 mg/kg BW, and 250 mg/kg BW), where each group consisted of 5 replications. The stages of this research were phytochemical screening, total flavonoid test, antioxidant test, oil quality test, measurement of lactate dehydrogenase (LDH) enzyme levels and cardiac histological observations. The data analysis used was one way ANOVA followed by Duncan’s test. The results showed that the dose of ethanol extract of tamarind leaves (Tamarindus indica L.) 250 mg/kg BW was the most optimal dose to reduce histological damage in the form of pycnotic percentage with an average of 30.40% and thickness of the myocardium of the heart with an average of 852.8 um and decreased cardiac lactate dehydrogenase (LDH) levels by an average of 152 U/L. The ethanol extract of tamarind leaves (Tamarindus indica L.) had an effect on the hearts of white rats (Rattus norvegicus L.) induced by used cooking oil. Keywords: Used Cooking Oil, Tamarindus indica, Heart Abstrak Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak etanol daun asam jawa (Tamarindus indica L.) terhadap histologi dan kadar enzim lactat dehidrogenase (LDH) jantung tikus yang diinduksi minyak jelantah. Penelitian ini menggunakan rancangan acak lengkap dengan 25 tikus putih jantan yang dibagi 5 kelompok yaitu kelompok kontrol negatif, kontrol positif, perlakuan 1, 2 dan 3 dosis (150 mg/kg BB, 200 mg/kg BB, dan 250 mg/kg BB), dimana masing-masing kelompok terdiri dari 5 ulangan. Tahapan penelitian ini adalah skrining fitokimia, uji flavonoid total, uji antioksidan, uji kualitas minyak, pengukuran kadar enzim lactat dehidrogenase (LDH) dan pengamatan histologi jantung. Analisis data yang digunakan adalah one way ANOVA dilanjutkan dengan uji Duncan. Hasil penelitian menunjukkan bahwa dosis ekstrak etanol daun asam jawa (Tamarindus indica L.) 250 mg/kg BB merupakan dosis paling optimal menurunkan kerusakan histologi berupa persentase piknotik dengan rata-rata 30,40 % dan ketebalan miokardium jantung dengan rata-rata 852,8 um serta menurunkan kadar enzim lactat dehidrogenase (LDH) jantung dengan rata-rata 152 U/L. Ekstrak etanol daun asam jawa (Tamarindus indica L.) berpengaruh terhadap jantung tikus putih (Rattus norvegicus L.) yang diinduksi minyak jelantah. Kata Kunci: Minyak Jelantah, Tamarindus indica, Jantung
Karakterisasi Pati Bonggol Pisang Kepok Kuning (Musa paradisiaca L.) sebagai Bahan Tambahan Sediaan Farmasi: Characterization of Sucker Starch of Yellow Kepok Banana (Musa paradisiaca L.) as Pharmaceutical Excipient Tias Eka Rahmawati; Intan Martha Cahyani; Siti Munisih
Jurnal Sains dan Kesehatan Vol. 5 No. 2 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i2.1658

Abstract

Banana sucker is the part of banana plant which is rarely used and is considered trash after harvesting. The banana sucker composition is 76% starch and 20% water. Starch content in banana sucker has the potential to developed in the pharmaceutical industry. The aim of this study was to find a new source of starch and determine the characterization of starch sucker of yellow kepok  banana as an alternative excipient in pharmaceutical. The sucker starch of yellow kepok banna isolation uses bleaching method whith sulfite solution. Results showed that sucker starch of yellow kepok banan from Plamongansari and Ambarawa powder form, brownish white, odorless, and tasteless. Kepok banana sucker strach has a pH of 6.51 and 6.60; moisture content 11.74% and 13.29%; ash content 0.74% - 0.83%; moisture content 12.28% and 13.50%; flow rate of 0.86 grams/second and 1.04 grams/second; resting angle 39.89° and 39.91° so that banana sucker starch includes a fairly good flow properties; development power 80.36% and 93.65%; solubility 18.28% and 22.96%; particle size 32.984 μm – 91.466μm, starch content 45.07% and 51.48%.. Starch producted further characterized using FT-IR to know functional groups is OH, C-H, C-O-C and C-O which is the same as the chemical structure of starch. Keywords: banana sucker, characterization, starch Abstrak Bonggol pisang merupakan bagian bawah tanaman pisang yang jarang dimanfaatkan dan dianggap sampah setelah pemanenan buah pisang. Komposisi bonggol pisang meliputi 76% pati, 20% air. Kandungan pati yang tinggi dalam bonggol pisang berpotensi untuk dikembangkan dalam industri farmasi sebagai bahan penghancur, pengisi, dan pengikat. Tujuan dari penelitian ini adalah mencari sumber pati baru dan mengetahui karakterisasi pati bonggol pisang kepok kuning (Musa paradisiaca L.) sebagai alternatif bahan tambahan dalam sediaan farmasi. Metode isolasi pati bonggol pisang kepok kuning menggunakan metode bleaching dengan larutan bisulfit. Hasil penelitian uji karakterisasi pati bonggol pisang kepok kuning daerah Plamongansari dan Ambarawa putih kecoklatan, tidak berbau, dan tidak berasa. Pati bonggol pisang kepok kuning memiliki pH 6,51 dan 6,60; kadar air 11,74% dan 13,29%; kadar abu 0,74% dan 0,83%; kandungan lembap 12,28% dan13,50%; kecepatan alir 0,86 gram/detik dan 1,04 gram/detik; sudut istirahat 39,91° dan 39,89° sehingga pati bonggol pisang termasuk memiliki sifat alir yang cukup baik; daya pengembangan 80,36% dan 93,65%; kelarutan 18,28% dan 22,96%; ukuran partikel 32.984μm – 91.466μm, kadar pati 45,07% dan 51,48%. Pati yang dihasilkan selanjutnya di karakteristik gugus fungsinya dengan menggunakan FTIR terdapat gugus OH, C-H, C-O-C dan C-O yang sama dengan struktur kimia amilum. Kata Kunci: bonggol pisang, karakterisasi, pati
Formulasi dan Evaluasi Sediaan Nanoemulsi Ekstrak Umbi Bawang Putih (Allium sativum L.): Formulation and Evaluation of Nanoemulsion of Garlic (Allium sativum L.) Extract Alvira Intan Widyastuti; Dwi Saryanti
Jurnal Sains dan Kesehatan Vol. 5 No. 2 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i2.1677

Abstract

Garlic bulbs (Allium sativum L.) has an active substance in the form of allicin which is thermolabil, allicin as the main antioxidant that can prevent free radicals. Nanoemulsion has a particle size of 20-500 nm which is an oil and water dispersion system stabilized by a combination of surfactant and cosurfactant. The purpose of this study was to obtain the best formula from the variation of VCO concentration 3%, 5%, 8% and determine the stability of nanoemulsion preparations. Nanoemulsions are formulated in oil phase VCO, surfactant Tween 80, and cosurfactant PEG 400. Nanoemulsion preparation performed organoleptic test, pH, viscosity , transmittance%, stability. The best Formula continued particle size test, and zeta potential. This study used laboratory experimental method, the results of the study were analyzed by one way ANOVA test. Obtained the best formula of nanoemulsion preparation of garlic bulb extract at a concentration of 8% VCO, the best formula physical results with clear yellow organoleptic characteristics, distinctive odor, and does not separate, pH value 4.9, viscosity value 7.0 d'pas, transmitan % value 96.11, nanoemulsion preparation of garlic bulb stable after stability test. The best Formula in Continue particle size test is the average value obtained 607.0, 53.4 and the average value of the potential Zeta test obtained -5.7, 0.86. The higher the concentration of VCO, the stability of smakin good preparation, nanoemulsion preparation that has good stability in formula 3 with a concentration of 8% VCO. Keywords: Nanoemulsion, Antioxidants, VCO, PEG 400, Tween 80 Abstrak Umbi bawang putih (Allium sativum L.) memiliki zat aktif berupa allicin yang bersifat termolabil, allicin sebagai antioksidan utama yang dapat mencegah radikal bebas. Nanoemulsi memiliki ukuran partikel 20-500 nm yang merupakan suatu sistem dispersi minyak dan air yang distabilkan oleh kombinasi surfaktan dan kosurfaktan. Tujuan penelitian ini untuk mendapatkan formula terbaik dari variasi konsentrasi VCO 3%, 5%, 8% dan mengetahui kestabilan sediaan nanoemulsi. Nanoemulsi diformulasikan dalam fase minyak VCO, surfaktan Tween 80, dan kosurfaktan PEG 400. Sediaan nanoemulsi dilakukan uji organoleptis, pH, viskositas, % transmitan, stabilitas. Formula terbaik dilanjutkan uji ukuran partikel, dan zeta potensial. Hasil penelitian dianalisis dengan uji one way anova. Berdasarkan % transmitan tertinggi didapatkan formula terbaik sediaan nanoemulsi ekstrak umbi bawang putih pada konsentrasi VCO 8%, dengan karakteristik organoleptis kuning bening, bau khas, dan tidak memisah, pH 4,9, viskositas 7,0 d’Pas, % transmitan 96,11%. Sediaan nanoemulsi umbi bawang putih stabil setelah dilakukan uji stabilitas. Formula terbaik mempunyai ukuran partikel yaitu 607,0±53,4 nm dan nilai zeta potensial sebesar -5,7±0,86 mV. Semakin tinggi konsentrasi VCO maka stabilitas sediaan semakin baik, sediaan nanoemulsi yang memiliki stabilitas yang baik yaitu pada formula 3 dengan konsentrasi VCO 8%. Kata Kunci: Nanoemulsi, Antioksidan, VCO, PEG 400, Tween 80
Potensi Interaksi Polifarmasi Pasien Jantung Koroner (PJK) di Rumah Sakit I.A. Moeis Samarinda: Polypharmacy Potential Interactions in Coronary Heart (CHD) Patients at I.A. Moeis Hospital, Samarinda Melenia Saputri; Sinta Ratna Dewi
Jurnal Sains dan Kesehatan Vol. 5 No. 2 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i2.1709

Abstract

The condition of the heart experiencing changes is called Coronary Heart Disease namely, changes in body cells that encourage organ work. According to the 2018 Basic Health Research, coronary heart disease in Indonesia is 1.5% or is estimated to be 883,447 people and for East Kalimantan it is 1.9% or as many as 13,977 people. The use of a lot of drugs, often occurs in coronary heart patients with additional comorbiditiens that require doctors to prescribe more than one drug to overcome the complaints suffered by the patient. The purpose of this study was to determine the interaction of the use of drug in patients with coronary heart disease and additional comorbidities. The concept was carried out using a random sampling data collection method in the form of taking outpatient prescription data at the cardiac polyclinic for 1 year, from January to December 2021. There were 242 patients, 59.1% male and 40.9% female. The highest comorbidities, of the 7 comorbidities with the most patients being hypertension, amounted to 122 and followed by diabetes mellitus 40 patients. The highest drug interactions were found in 108 clopidogrel and lansoprazole drugs, 31 spironolactone and furosemide drugs, and 26 simvastatin and amlodipine. With the incidence of drug interactions as many as 218 of 242 samples. Keywords: Heart, Polyclinic, Drug Interactions, Additional Disease, Polypharmacy Abstrak Kondisi jantung mengalami perubahan disebut Penyakit Jantung Koroner yaitu, terjadinya perubahan sel-sel tubuh yang mendorong kerja organ. Menurut Riset Kesehatan Dasar 2018, penyakit jantung koroner di Indonesia sebesar 1,5% atau diperkirakan menjadi 883.447 orang dan untuk Kalimantan Timur sebesar 1,9% atau sebanyak 13.977 orang. Penggunaan obat yang banyak, sering terjadi pada pasien jantung koroner dengan tambahan penyakit penyerta yang mengharuskan dokter meresepkan obat lebih dari satu untuk mengatasi keluhan yang dialami pasien. Tujuan dari penelitian ini untuk mengetahui interaksi dari penggunaan obat pasien penyakit jantung koroner dan tambahan penyakit penyerta dengan adanya penelitian ini agar menjadi sumber informasi agar dapat meningkatkan profil pengobatan pada peresepan obat. Konsep dilakukan dengan metode pengumpulan data random sampling berupa pengambilan data resep pasien rawat jalan yang ada di poliklinik jantung selama 1 tahun yaitu pada bulan Januari – Desember 2021. Ditemukan 242 pasien, 59,1% laki-laki dan 40,9% perempuan. Penyakit penyerta tertinggi, dari 7 penyakit penyerta dengan pasien terbanyak adalah hipertensi berjumlah 122 dan disusul diabetes melitus 40 pasien. Interaksi obat terbanyak ditemukan pada obat clopidogrel dengan lansoprazole sebanyak 108, spironolakton dengan furosemide sebanyak 31, dan pada obat simvastatin dengan amlodipine sebanyak 26. Dengan kejadian interaksi obat sebanyak 218 dari 242 sampel. Kata Kunci: Jantung, Poliklinik, Interaksi Obat, Penyakit Penyerta, Polifarmasi
Hubungan Mutu Pelayanan Kefarmasian dengan Kepuasan Pasien di Apotek Wilayah Kecamatan X Kota Surakarta Tahun 2022: Correlation of Quality of Pharmaceutical Services and Patient Satisfaction in Pharmacy of X District Surakarta in 2022 Zorathea Benita; Tri Wijayanti; Ganet Eko Pramukantoro
Jurnal Sains dan Kesehatan Vol. 5 No. 2 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i2.1711

Abstract

Pharmaceutical service quality refers to degree of service perfection that increases patient satisfaction. Pharmacies are required to review several aspects in order to improve quality of pharmaceutical services which include tangibles, empathy, assurance, responsiveness and reliability. The research objective was to determine the correlation between quality of pharmaceutical services and degree of patient satisfaction with pharmaceutical services in pharmacy of X District Surakarta in 2022. This study is a descriptive involved 225 patients and 8 pharmacies in a survey. Pharmaceutical service data is concluded based on quality category of pharmaceutical services in pharmacies. Patient satisfaction was analyzed by comparing the weight of reality and expectations based on variables that affect patient satisfaction. Additionally, it was examined using the SPSS 23 Spearsman's Rho test to see if there was a correlation between caliber of pharmaceutical services and degree of patient satisfaction. In pharmacies of X District Surakarta, the quality of pharmaceutical services received an average score of 63,62% (sufficient) and an average percentage of patient satisfaction levels of 79.55% (satisfied) in 2022. The results of the Spearman's rho correlation test of 0.994 indicate that there is a correlation between quality of pharmaceutical services and level of patient satisfaction. Keywords: pharmaceutical services, patient satisfaction, pharmacy X district, Surakarta Abstrak Mutu pelayanan kefarmasian mengacu pada tingkat kesempurnaan suatu pelayanan untuk meningkatkan kepuasan pasien. Pihak apotek wajib meninjau aspek meliputi bukti fisik, empati, jaminan, daya tanggap dan reliabilitas. Tujuan penelitian ini adalah untuk mengetahui hubungan mutu pelayanan kefarmasian dengan tingkat kepuasan pasien terhadap pelayanan kefarmasian di apotek wilayah Kecamatan X Kota Surakarta tahun 2022. Penelitian ini merupakan penelitian deskriptif dengan metode survei menggunakan kuesioner terhadap 8 apotek dan 225 pasien. Data pelayanan kefarmasian disimpulkan berdasarkan kategori mutu pelayanan kefarmasian di apotek. Kepuasan pasien dianalisis dengan membandingkan bobot realita dan ekspektasi berdasarkan variabel yang mempengaruhi kepuasan pasien. Selanjutnya dianalisis untuk mengetahui ada atau tidaknya hubungan antara mutu pelayanan kefarmasian dengan tingkat kepuasan pasien menggunakan SPSS 23 uji spearsman’s rho. Mutu pelayanan kefarmasian di apotek wilayah Kecamatan X Kota Surakarta tahun 2022 memperoleh skor rata-rata sebesar 63,62% (cukup) dan rata- rata persentase tingkat kepuasan pasien sebesar 79,55 % (puas). Hasil uji korelasi spearman’s rho sebesar 0,994 hal tersebut menunjukkan bahwa terdapat hubungan antara mutu pelayanan kefarmasian dengan tingkat kepuasan pasien. Kata Kunci: pelayanan kefarmasian, kepuasan pasien, apotek Kecamatan X Surakarta

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