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All Journal Buletin Udayana Mengabdi E-Jurnal Medika Udayana Jurnal Veteriner ISM (Intisari Sains Medis) : Jurnal Kedokteran Neurologico Spinale Medico Chirurgico Jurnal Kefarmasian Indonesia Bali Anatomy Journal Jurnal Sains dan Kesehatan
I Gusti Nyoman Sri Wiryawan
Departemen Histologi, Fakultas Kedokteran, Universitas Udayana, Denpasar, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Veterinary

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PENGEMBANGAN POLA HIDUP BERSIH DAN SEHAT (PHBS) PADA ANAK SEKOLAH MELALUI METODE PENYULUHAN I. W. Sugiritama; I. G. N. S. Wiryawan; I. G. A. D. Ratnayanthi; I. G. K. K. Arijana; N. M. Linawati; I. A. I. Wahyuniari
Buletin Udayana Mengabdi Vol 20 No 1 (2021): Buletin Udayana Mengabdi
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4650.153 KB) | DOI: 10.24843/BUM.2021.v20.i01.p11

Abstract

Perilaku hidup bersih dan sehat (PHBS) merupakan salah satu strategi penting untuk meningkatkan derajat kesehatan, karena banyak penyakit yang bisa dicegah jika masyarakat menerapkan perilaku hidup sehat. Anak sekolah merupakan kelompok usia yang rentan untuk mengalami masalah kesehatan karena sebagian waktunya dihabiskan diluar lingkungan rumah dan diluar pengawasan orang tua. Saat anak berada di lingkungan sekolah bisa mengalami penularan penyakit dari teman sebaya, dari lingkungan sekolah atau bisa saja mengkonsumsi makanan yang tidak memenuhi syarat kesehatan. Anak sekolah juga merupakan kelompok usia yang mudah untuk diberikan pengetahuan tentang PHBS untuk membentuk perilaku yang sehat. Sekolah Dasar 2 Demulih berlokasi dilingkungan padat penduduk dan belum tersedia kantin yang memenuhi syarat kesehatan. Karena hal tersebut maka sangat tepat jika dilakukan pemberian pengetahuan tentang PHBS melalui metode ceramah yang menarik dengan media gambar dan video yang kemudian dilanjutkan dengan tanya jawab. Pelaksanaan penyuluhan berlangsung dengan baik, anak-anak sekolah sangat antusias saat mendengarkan paparan dan sangat aktif saat diskusi. Anak-anak sekolah terlihat sudah memahami konsep PHBS dan sudah mengerti bagaimana cara melaksanakannya.
DETEKSI DINI DAN PENANGANAN FAKTOR RISIKO PENYAKIT KARDIOVASKULAR PADA PENDUDUK USIA 45 TAHUN KE ATAS DI DESA PEGAYAMAN BULELENG Ika Wahyuniari I.A; Dewi Ratnayanti I.G.A; Mayun G.N; Sri Wiryawan G.N; Linawati N.M; Sugiritama W
Buletin Udayana Mengabdi Vol 9 No 2 (2010): Volume 9 No.2 – September 2010
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

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Abstract

Cardiovascular diseases such as heart attacks and strokes, are the main cause of death in Indonesia. Information about risk factors of these disease (like hypertension, diabetes mellitus, obesity) are required in order to control and prevent the disorders. The aim of this program was at early detection and managing the relevant risk factors. The program commenced by providing information about risk factors of cardiovascular disease and by examining the level of blood pressure, blood sugar, body weight, body height, and waist circumference. Participants that have risk factors of cardiovascular disease in Pagayaman were 52,94%. Most of them had abnormal waist circumference (59,26%), particularly in woman. The next and most prevalent risk factors were Body Mass Index (40,74%), hypertension (18,52%), and hyperglycemia (3,70%).
THE ROLE OF ESTROGEN IN WOMEN WITH ANDROGENETIC ALOPECIA Putu Diah Pratiwi; IGN Sri Wiryawan; Ni Made Linawati; Ni Luh Mas Rusyati
E-Jurnal Medika Udayana vol 2 no 8 (2013):e-jurnal medika udayana
Publisher : Universitas Udayana

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Abstract

Hair loss may accured in both male and female population. Hair loss usually accured in Telogenic phase, meanwhile in Anagenic phase hair loss due to chemotherapy or radiation. Female pattern hair loss (FPHL) is regarded as hair fall type which is accured in women in common and known as female androgenetic alopecia. Almost 40%, 50 years old female shown hair fall sign, which is developed progressive fibrosing alopecia of central scalp, especially in frontal and parietal area. There are two common treatment for Female pattern Hair Loss are Minoxidil for topical use, and Fenesteride by oral. However, it has long been known that estrogens also profoundly alter hair follicle growth and cycling by binding to locally expressed high-affinity estrogen receptors (ERs), in turn increase anagenic phase and represed telogenic phase.
EKSTRAK ETANOL UBI JALAR UNGU (IPOMOEA BATATAS L.) MENURUNKAN DEGENERASI LEMAK JARINGAN HATI TIKUS YANG DI https://ojs.unud.ac.id/index.php/eum OVARIEKTOMI Ni Putu Candra Paramita; I Wayan Sugiritama; Ni Made Linawati; IGA Dewi Ratnayanti; Ida Ayu Ika Wahyuniari; IGK Nyoman Arijana; IGN Sri Wiryawan
E-Jurnal Medika Udayana Vol 8 No 5 (2019): Vol 8 No 5 (2019): Vol 8 No 5 (2019): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

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Abstract

Menopause didefinisikan sebagai 1 tahun tanpa menstruasi. Wanita menopausekemungkinan berisiko mengalami Nonalcoholic Fatty Liver Disease(NAFLD). Efekmenguntungkan dari antosianin telah dibuktikan dalam penelitian hewan,sehubungan denganstres oksidatif dan steatosis hati. Ubi jalar ungu mengandung antosianin yang berfungsi sebagaiantioksidan. Penelitian ini dilakukan dengan menggunakan sampel tikus yang sudah diovariektomi, kemudian diberikan ekstrak etanol ubi jalar ungu pada tikus secara oral selama 30hari. Pada hari pertama dilakukan randomisasi dibagi menjadi empat kelompok yaitu kelompokkontrol negatif (P0), kelompok perlakuan pemberian ekstrak etanol ubi jalar ungu dosis 1ml(P1), dosis 2 ml (P2), dan dosis 4ml (P3). Pada hari ke-31 dilakukan terminasi untuk di ambiljaringan hati dan pembuatan preparat histologi, kemudian dilakukan pengamatan pada preparatdengan pembesaran 10x10 pada 2 lapang pandang. Dari 28 sampel hati tikus yang diperiksa,didapatkan semua sel hati tikus mengalami degenerasi lemak atau steatosis sebanyak >5% yangmerupakan kunci dari penyakit hati berlemak nonalkohol (NAFLD), namun jumlahnya berbedabeda. Rerata perlemakan kelompok kontrol negatif didapatkan hasil perlemakan paling tinggiyaitu 49,1%, kelompok perlakuan pemberian dosis 1ml, 2ml, dan 4ml didapatkan hasil 39,48%,31,62%, dan 29,14%. Setelah diuji secara statistik didapatkan perbedaan yang signifikan(p<0,05) terhadap pengaruh pemberian ekstrak etanol ubi jalar ungu.Berdasarkan hasilpenelitian yang telah dilakukan, maka dapat disimpulkan bahwa pemberianekstrak etanol ubijalar ungu selama 30 hari dapat menurunkan degenerasi lemak pada hati tikus yang mengalamipenyakit hati berlemak nonalkohol (NAFLD). Kata Kunci: Ekstrak etanol ubi jalar ungu, menopause, fatty liver
ROLE OF OLIVE OIL IN CANCER PREVENTION GAP Ratih Pradnyandari; IGN Sri Wiryawan
E-Jurnal Medika Udayana vol 3 no 2 (2014):e-jurnal medika udayana
Publisher : Universitas Udayana

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Abstract

Cancer is the second leading cause of death in the United States. From this fact showshow ferociously the disease if not treated well. The emergence of this disease is causedby various factors, but often caused by damage to the structure of DNA and othermolecular structures by a reactive oxygen species (ROS). Early prevention that can beimplemented, is to improve the lifestyle and diet that contains a substance that canprotect our body cells from damage caused by ROS. These molecules calledantioxidants. Therefore, antioxidants are often called reducing agents (thiol orpolyphenols). Olive oil is the one of the exogenous antioxidants have many benefitsespecially polyphenols that have chemo preventive effects on several types of cancer,and can inhibit the process of carcinogenesis by several mechanisms such as inhibitionof DNA synthesis in the process, reducing the production of ROS, regulate cell cycle,regulate proliferation and survival mechanisms of cells.
KORELASI TINGKAT PENGETAHUAN DAN SIKAP MASYARAKAT USIA 17-30 TAHUN DESA TIGAWASA KECAMATAN BANJAR KABUPATEN BULELENG TERHADAP PEROKOK PASIF I Made Perdana; IGN Sri Wiryawan
E-Jurnal Medika Udayana Vol 9 No 9 (2020): Vol 9 No 09(2020): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2020.V09.i9.P08

Abstract

ABSTRAK Merokok menjadi gaya hidup sebagian orang dikarenakan zat adiktif yang terkandung didalamnya membawa efek kecanduan. Asap rokok dihirup oleh perokok pasif. Kurang pengetahuan masyarakat di pedesaan mengakibatkan sikap terhadap perokok masih kurang. Adapun tujuan dari penelitian ini adalah untuk mengetahui tingkat pengetahuan warga Desa Tigawasa Kecamatan Banjar Kabupaten Buleleng terhadap perokok pasif dan untuk mengetahui korelasi tingkat pengetahuan dan sikap warga terhadap perokok pasif. Perokok pasif adalah yang terpapar asap rokok secara tidak sadar. Secara teori orang dengan tingkat pengetahuan yang lebih akan mengambil keputusan dengan logika dalam pengambilan sikap. Penelitian ini merupakan cross-sectional dengan populasi warga Desa Tigawasa. Dengan menggunakan simple random sampling, didapatkan 96 sampel. Teknik pengumpulan data dilakukan dengan kuisioner dan analisis data dengan SPSS. Berdasarkan hasil penelitian didapatkan bahwa 69 (62,5%) warga memiliki tingkat pengetahuan berada pada kategori baik, meskipun sikapnya dikategorikan kurang (50,0%). Terdapat korelasi antara tingkat pengetahuan dan sikap warga (r= -0,306; p=0,002). Dapat disimpulkan bahwa tingkat pengetahuan masyarakat usia 17-30 tahun Desa Tigawasa Kecamatan Banjar Kabupaten Buleleng terhadap perokok pasif termasuk kategori baik meskipun dengan sikap yang kurang. Terdapat korelasi negatif lemah antara tingkat pengetahuan dan sikap masyarakat terhadap perokok pasif. Disarankan agar penelitian selanjutnya membandingkan populasi di pedesaan dengan perkotaan. Kata kunci: Perokok pasif, tingkat pengetahuan, sikap
PHARMACOTHERAPY ALOPECIA ANDROGENETIC IN MEN Riezky Januar Pramitha; I.G.N Sri Wiryawan; Ni Made Linawati
E-Jurnal Medika Udayana vol 2 no3 (2013):e-jurnal medika udayana
Publisher : Universitas Udayana

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Abstract

Androgenetic alopecia is hair thinning due to the stimulation of hair follicles to androgens. Incidence in men is higher than in women, it is because men have a degree higher 5? reductase. This condition can cause both physical and psychological effects to the patient. Physical effects due to baldness cause hair loss as a function of protection against heat, cold and trauma. While psychologically can affect self-esteem and self-perception of the patient. Androgenetic alopecia in men influenced by the androgen dihydrotestosterone and genetic predisposition, although the physiology remains unclear. Modality in the management of androgenetic alopecia in males patients including pharmacotherapy, hair transplants and cosmetic approach. According to the Food and Drug Administration (FDA), there are two main drugs are safe and effective in the long term given to men with androgenetic alopecia are minoxidil and finasteride. Although the mechanism of action and route of administration are different, but both drugs have similar effectiveness in stopping the progression of androgenetic alopecia in men.
Minyak Buah Merah Meningkatkan Aktivitas Proliferasi Limfosit Limpa Mencit Setelah Infeksi Listeria Monocytogenes Ika Wahyuniari; Marsetyawan HNE Soesatyo; Muhammad Ghufron; Yustina -; Andwi Ari Sumiwi; Sri Wiryawan
Jurnal Veteriner Vol 10 No 3 (2009)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

The success of individual in keeping healthy from infectious disease is closely related to the ability oftheir body immune responses againts infectious agents. It is reported that one way to increase the immuneresponses is by system to antioxidant. Red fruit oil contains carotenoid and tocoferol that function asantioxidant. This study was aimed at investigating the effect of red fruit oil on spleen lymphocyteproliferation in mice infected with Listeria monocytogenes. Sixty female Balb/c mice were used in thisstudy. The animals were randomly selected and divided into five groups, each group were 12 mice. The firstand second groups received aquadest only, whereas the third, fourth, and fifth groups received red fruit oilwith different doses, ie. 0.3, 0.6, and 1.2 mL/kbBW/day, respectively. Lymphocyte proliferation activitieswere tested by using 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay method.Lymphocyte proliferation assay demonstrated that there was significant difference between the groupswith red fruit oil and aquadest, started at day 2 post-infection. The optical density (OD) values recorded atday 3 in groups I, II, III, IV, and V were 0.769 ± 0.025, 0.904 ± 0.048, 1.110 ± 0.020, 1.021 ± 0.033, 0.979 ±0.002, respectively. The highest optical density (OD), ie. 1.194 ± 0.032, occurred at day 6 after receiving 0,3mL/kgBW/day. In conclusion, red fruit oil could increase lymphocyte proliferation.
Ekstrak Biji Klabet Menurunkan Jumlah Sel Spermatozoa pada Kelinci I Gusti Nyoman Sri Wiryawan; Ida Ayu Ika Wahyuniari
Jurnal Veteriner Vol 10 No 2 (2009)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

Fenugreek seed (Trigonella foenum-graecum) contains saponin diosgenin, wich has an antifertility effect on spermatozoa so it can be used as an oral contraceptive drug. This study was aimedto investigate the effect of fenugreek seed extract to spermatogenic process of rabbit, especially onviability spermatozoa. “Completely randomized control group post-test only design” was used inthis study. The animals were divided into four groups; one control group and three treatmentgroups with six replicates (P0 = control group; P1 = group were given 10 % fenugreek seed extract,1 cc/day; P2 = group were given 20 % fenugreek seed extract, 1 cc/day; P3 = group were given 30 %fenugreek seed extract, 1 cc/day). The extract was given orally once a day in 50 days. After treatment,testicles were sectioned and stained with Hematoxylin Eosin; for qualitative and quantitativemicroscopic analysis. The result of this study showed that the number of spermatozoa were decreasedsignificantly (p<0,05) after receiving 10% fenugreek seed extract 1 cc per day. In conclusion,fenugreek seed extract could reduce the number of spermatozoa.
Growth Hormone Menurunkan Ekspresi Protein p53 dan p21 Sel Endotel Tikus Jantan (GROWTH HORMONE REDUCES P53 AND P21 ENDOTHELIAL PROTEIN EXPRESSION IN MALE RATS) I Gusti Ayu Dewi Ratnayanti; Ni Putu Sriwidyani; I Dewa Ayu Inten Primayanti; I Gusti Kamasan; Nyoman Arijana; I Gusti Nyoman Sri Wiryawan; Ida Ayu Ika Wahyuniari; I Wayan Sugiritama; I Gusti Ngurah Mayun
Jurnal Veteriner Vol 17 No 3 (2016)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

The use of growth hormone (GH) treatment in aging related condition such as atherosclerosis is stillcontroversial. Previous study showed GH reduce atherosclerotic plaque and prevent endothelial cellsenescence. This study was aimed to understand the mechanism of GH effect to endothelial senescencethrough p53/p21 pathway. A randomized posttest only control group design study was conducted. Twentymale Wistar rats were randomized into five groups; negative control (P0), positive control (P1), and GHtreated group (P2, P3, P4). Negative control group was fed with standard diet, and others were fed withatherogenic diet for 20 weeks. After 10 weeks, subjects were injected subcutaneously (0,1 mL) with aquadest(P0 and P1) and increasing dose of GH (0,02 IU, 0,04 IU, and 0,08 IU) for P2, P3, P4 once a day respectivelyfor 10 weeks. In the end of the study all subjects were examined for p53 and p21 endothelial proteinexpressions. Immunohistochemistry of endothelial p53 showed reduce expression in treated groups (P0:7.28 ± 0.36; P1: 39.51 ± 1.18; P2: 32.70 ± 1.10; P3: 16.98 ± 0.78; and P4: 14.29 ± 0.38). The reduction was also observed in p21 expression (P0: 5.38 ± 0.49; P1: 37.81 ± 0.76; P2: 26.02 ± 1.54; P3: 16.37 ± 1.24; andP4: 4.82 ± 0.61. One way analysis of variance and post hoc test (LSD) analysis showed significant differencesbetween all groups (p<0.05). In conclusion, GH reduces endothelial expression of p53 and p21 and thispathway may contribute to GH effect on atherosclerotic plaque and endothelial senescence.
Co-Authors Andwi Ari Sumiwi Dewa Ayu Agus Sri Laksmi Dinesh Tanabbal Dyta Putri Aryo Eswariy Chandramogan Fedik Abdul Ratam GAP Ratih Pradnyandari Gede Reynaldi Wahyu Sanjaya Gede Wirata I Dewa Ayu Inten Primayanti I Gusti Ayu Dewi Ratnayanthi I Gusti Ayu Dewi Ratnayanti I Gusti Kamasan I Gusti Kamasan Arijana I Gusti Kamasan Nyoman Arijana I Gusti Ngurah Mayun I Made Perdana I Nyoman Wande I Wayan Sugiritama I. G. A. D. Ratnayanthi Ida Ayu Ika Wahyuniari Linawati N.M Luh Made Mas Rusyati Marsetyawan HNE Soesatyo Mayun G.N Melita Soares Cristovao Muhammad Ghufron N. Ary Laksmi Purnamasari N. M. Linawati Ni Made Linawati Ni Made Linawati Ni Made Mertaniasih Ni Nyoman Sri Budayanti Ni Putu Candra Paramita Ni Putu Sriwidyani Putu Diah Pratiwi Raditya Pradipta Raymond Elbert Budianto Riezky Januar Pramitha Ruthirar Kalaichelvam Yustina -