JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
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<![CDATA[Pengembangan Need Assesment Pada Penentu Kebijakan Dan Stakeholder Dalam Program Kawasan Tanpa Rokok (KTR) Di Kantor Kecamatan Dukun Kabupaten Magelang ]]>
<![CDATA[Punik Mumpuni Wijayanti]]>;
<![CDATA[Arif Rahmat Kurnia]]>;
<![CDATA[Edi Soeharso]]>
<![CDATA[ JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 1, (2020) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Islam Indonesia ]]>
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DOI: 10.20885/JKKI.Vol11.Iss1.art9
<![CDATA[Background: A smoking habit mostly has spread to almost groups of societies in Indonesia. This habit tends to increase among children and adolescents. Rights to access fresh air free from smoking have been widely discussed at various world meetings. Therefore, it is necessary to have an in-depth study to increase non-smoking areas in public areas.Objective: This study is to develop a need assessment on policy makers and related stakeholders applying a non-smoking area program (in Indonesia it is called KTR/Kawasan Tanpa Rokok) at District Office of Dukun, Magelang Regency, Central Java.Methods: This study was an observational study with a qualitative approach. Its respondents were determined purposively focusing on the Head of Dukun District, some officials of the District, and its visitors.Results: This study found that a majority of respondents understood effects and impacts of smoking to their health. They requested an issuance of official letter for a non-smoking area. The Head of the District has issued a smoking ban for its officials and employees. This issuance was important to increase comfort of its visitors, employees, and officials. In addition, it could make the Head easier to develop derivative regulations.Conclusion: A defined regulation is necessary to apply the non-smoking area program. A regulation from the Regent is highly suggested, but decisions from related agencies can be considered sufficient. The government and related stakeholders should immediately make a local regulation so that the program can be widely applied in the Dukun District.]]>
<![CDATA[Kidney tubular injury of rats caused by unripe green betel nuts (Areca catechu) ]]>
<![CDATA[Ave Olivia Rahman]]>;
<![CDATA[Anati Purwakanthi]]>
<![CDATA[ JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 1, (2020) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Islam Indonesia ]]>
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DOI: 10.20885/JKKI.Vol11.Iss1.art5
<![CDATA[Background: Unripe green betel nuts (Areca catechu) are usually consumed as herbal medicines by some inhabitants in several regions of Indonesia. It is considered that the nuts contain Arecoline hydrobromide that can cause damages in a kidney tubule, although it needs further studies about effects of the nuts.Objective: This study aims to determine the effects of the unripe green betel nuts on kidney tissues of rats in a long-term treatment.Methods: Twenty rats used in this study were Sprague-Dawley strain, male, 2-3 months old, and 150-200 gram of weight. They were randomly divided into four groups. Group I was control group, given distilled water once a day; group II, III, and IV were served by juice of the unripe green betel nuts with a dose of 250 mg/kgBW, 1,000 mg/kgBW, and 10,000 mg/kgBW, respectively. Histopathology examination by staining of Haematoxylin Eosin was conducted by an anatomic pathologist using blind methods including glomerulus, tubulus, and interstitial tissues.Result: The tested kidney tissues showed mild interstitial congestion, tubular cast, and tubular degeneration in groups that received unripe green betel nuts. There were no glomerulus abnormality and interstitial inflammation. The highest percentage of rats suffering injury in their kidney was the group IV, with p value <0.05 when compared to the control group.Conclusion: Long-term consumption of unripe green betel nuts could cause kidney tubular injury.]]>
<![CDATA[Penghambatan Ekstrak Metabolit Sekunder Streptomyces sp. dari Sedimen Tanah Kawasan Hutan Mangrove Hamadi terhadap Plasmodium falciparum Secara in vitro ]]>
<![CDATA[Semuel Sandy]]>;
<![CDATA[Iman Harisma Saleh Sasto]]>
<![CDATA[ JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 1, (2020) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Islam Indonesia ]]>
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DOI: 10.20885/JKKI.Vol11.Iss1.art6
<![CDATA[Background: Reports about the resistance of antimalarial drugs demand exploration and development of new drugs. Indonesia's vast maritime area and abundance of mangrove forests have the potential for the development and discovery of active anti-cancer substances, antibiotics and antiplasmodial. Studies on the potential of new drugs from this sector are still limited. Objective: The purpose of this study was to see the potential of Actinomycetes genus Streptomyces sp. as an antiplasmodial in the Hamadi Coast of Papua.Methods: Retrieval of mangrove soil sediments to isolate Streptomyces was located in the Hamadi-Jayapura mangrove forest. Selective isolation was conducted by SCA (Starch Casein Agar) selective media. Identification of Streptomyces sp was examined microscopically through observation of colony morphology and gram staining. The results of isolation of Streptomyces were then fermented on FM3 media until finally secondary metabolite extract of Streptomyces was obtained. The secondary metabolite extract of Streptomyces was tested for its inhibition on the development of Plasmodium falciparum.Result: Analysis of inhibition of the secondary metabolite extract of Streptomyces sp on the development of Plasmodium falciparum showed good results because the extract of Streptomyces sp with a concentration of 100 µg/mL could suppress average growth values of Plasmodium falciparum to only 0.66% with an average inhibitory value of 95.20%. This value followed levels of extract concentration by the lowest concentration of 0.01 µg/mL, the average value of Plasmodium falciparum growth which increased to 10.89% with an average inhibition value of 20.83%. IC50 analysis of Plasmodium falciparum in culture for 48 hours was 0.12 µg/mL, and this value was very good because a test of substance has very good inhibitory activity when the IC50 value is = 10 µg/mL.Conclusion: Streptomyces’ secondary metabolite extract from mangrove sediments showed a very good ability to inhibit the growth of Plasmodium falciparum so that it could have potential as a source of antiplasmodial.]]>
<![CDATA[Regional pericarditis with reciprocal ECG changes mimicking inferior ST-elevation myocardial infarction (STEMI): A case report ]]>
<![CDATA[Gilang Mauladi Rahman]]>;
<![CDATA[Mochammad Yusuf Alsagaff]]>
<![CDATA[ JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 1, (2020) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Islam Indonesia ]]>
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DOI: 10.20885/JKKI.Vol11.Iss1.art13
<![CDATA[Acute pericarditis is generally presented with a chest pain and a diffuse ST-segment elevation in ECG. Focal ST-segment elevation due to localised inflammation of pericardium in regional pericarditis could resemble ST-elevation myocardial infarction (STEMI). A case in this study was a 30-year-old man in emergency room as a surgery resident experiencing recently acute typical chest pain. He had a history of smoking without other cardiovascular disease risk factors. ECG immediately was conducted, and it revealed ST-segment elevation in an inferior lead with reciprocal ST-segment depression in aVL, which was typical for an inferior STEMI. Primary PCI was conducted, and it surprisingly revealed a normal coronary artery. Serial serum cardiac biomarkers found a normal cardiac troponin-I level (<0.001 mcg/L) and did not significantly change after serial examinations. We treated the patient as a suspect of coronary spasm with calcium-channel blockers and nitrates. After three days of hospitalization, the patient was discharged from the hospital, and he planned to get cardiac magnetic resonance (CMR). The CMR was conducted after seven days of the discharge, and it revealed a loculated pericardial effusion leading to regional pericarditis. The patient was treated with empirical NSAIDs for three weeks. Clinical and echocardiographic evaluation after the treatment showed an excellent result. A presence of focal ST-segment elevation with reciprocal ST-segment depression was generally consistent with the STEMI, but this case was an exception. Although rare, regional pericarditis can be a differential diagnosis in a patient with acute chest pain with a focal ST-segment elevation.]]>
<![CDATA[KORELASI KARAKTERISTIIK PASIEN DENGAN DRUG RELATED PROBLEMS PASIEN STROKE ISKEMIK GERIATRI DI RS X KABUPATEN TULUNGAGUNG ]]>
<![CDATA[Dhanang Prawira Nugraha]]>;
<![CDATA[Antonius Adji Prayitno Setiadi]]>;
<![CDATA[Yosi Irawati Wibowo]]>
<![CDATA[ JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 1, (2020) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Islam Indonesia ]]>
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DOI: 10.20885/JKKI.Vol11.Iss1.art8
<![CDATA[Background: Drug related problems (DRP) can cause problems in treatments of patients with ischemic stroke.Objective: This study was to determine the correlation between the characteristics of patients with ischemic stroke and the DRP.Methods: A population in this study was 53 patients at dr Iskak Public Hospital in Tulungagung. Inclusion criteria were patients who were = 60 years old and were diagnosed as acute ischemic stroke patients. The DRP was classified based on Pharmaceutical Care Network Europe version 6.2, especially problem and cause domain. Correlation between age, duration of treatment, number of comorbidities and number of drugs and the DRP was analysed by Spearman Rho or by Pearson analysis. The relationship between gender, guaranteed care and the DRP was analysed by using Eta analysis.Results: This study revealed that patients with 60-69 years were 24 patients (45.28%), men were 30 patients (57%), 1 comorbidity was 26 patients (49.06%), duration of 5 days was 14 patients (26.42%), BPJS patients were 23 patients (35.94%), using 6 types of drug was 11 patients (20.75%). Age, sex and care guarantee did not correlate with the DRP (p-values > 0.05). Duration of treatment, number of comorbidities and number of drugs correlated with the DRP (p-value <0.05) with consecutive correlation strength: weak (R = 0.32), moderate (R = 0.45), strong (R = 0.56).Conclusion: Duration of treatment, number of comorbidities and number of drugs correlated with increasing incidences of the DRP in geriatric ischemic stroke patients.]]>
<![CDATA[GLYCATED ALBUMIN SEBAGAI KONTROL GLIKEMIK ALTERNATIF PADA DIABETES MELITUS TIPE 2 DENGAN HEMODIALISA ]]>
<![CDATA[Clara Elitha]]>;
<![CDATA[Pusparini Pusparini]]>
<![CDATA[ JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 1, (2020) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Islam Indonesia ]]>
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DOI: 10.20885/JKKI.Vol11.Iss1.art7
<![CDATA[Background: Uses of HbA1c compared with glycated albumin as an indicator of glycemic control for hemodialysis patients(HD) needs to be evaluated. HbA1c has some limitations when used for HD because its results can falsely low or falsely high. It can be missunderstood if clinicians use HbA1c as glycemic control. Objective: This study aimed to evaluate correlation between HbA1c and GA in HD patients with Diabetes Mellitus (DM).Methods: This study was a cross sectional study conducted on November 2016 until January 2017. Its samples were obtained from 43 patients in HD with DM, fullfilling inclusion and exclusion criteria, located in a private hospital at east Jakarta. The HbA1c was measured by using a turbidimetric inhibition immunoassay method, and the GA was measured by using an enzimatic colorimetric method. In addition, a test of Pearson correlation was used to determine the correlation between HbA1c and GA with a significance of p<0.05.Results: Averages of patients age in this study was 57.16 ± 9.0 years old, including 24 men (55.8%) and 19 women (44.2%). The mean values of HbA1C were 8 ± 2.30%, and the mean values of GA were 30.02 ± 13.3%. The mean duration of the HD was 4.5 ± 1.3 years. The glycemic control based on GA was significantly better than the HbA1c with p = 0.028 (Chi-Square test). Pearson correlation showed that there were a significant correlation between HbA1c and GA with r = 0.759 and p = 0.000.Conclusion: There were a significant correlation between HbA1c with GA in HD patients with DM. Glycemic control based on GA was better than HbA1c.]]>
<![CDATA[Diagnostic challenge in parathyroid carcinoma with multiple pathological bone fracture: A case report ]]>
<![CDATA[Hermin Aminah Usman]]>;
<![CDATA[Hasrayati Agustina]]>;
<![CDATA[Zahra Nurusshofa]]>;
<![CDATA[Siska Dwiyantie Wahyuni]]>
<![CDATA[ JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 1, (2020) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Islam Indonesia ]]>
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DOI: 10.20885/JKKI.Vol11.Iss1.art14
<![CDATA[Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. It often presents with unspecified clinical manifestation that leads to misdiagnosis. We report a case of a 36-year-old woman who suffered from multiple bone tumours and recurrent bone fracture for 3 years ago, and misdiagnosis as only a giant cell tumours of the bone. Then, the patient continued to develop another mass in the neck that kept growing and the mass move on swallowing. The clinician diagnosed her as a colloid goitre based on cytological examination from fine-needle aspiration biopsy. Elevated parathyroid hormone level, hypercalcemia, and suspected parathyroid adenoma in the Sestamibi Parathyroid scan led the clinician to perform a frozen section in this patient with subsequent histopathological of diagnosis as parathyroid carcinoma. The diagnosis of parathyroid carcinoma continues to be a challenge. Understanding the pathogenesis and multidisciplinary collaboration is important to define an accurate diagnosis and treatment. ]]>
<![CDATA[Comparing tools of balance tests in assessing balance of middle-aged women with or without exercises ]]>
<![CDATA[Nawanto Agung Prastowo]]>;
<![CDATA[Michelle Olivia Budiarta]]>;
<![CDATA[Kidyarto Suryawinata]]>;
<![CDATA[Ignatio Rika Haryono]]>
<![CDATA[ JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 1, (2020) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Islam Indonesia ]]>
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DOI: 10.20885/JKKI.Vol11.Iss1.art4
<![CDATA[Background: Fall risks among middle-aged women are relatively high. However, there is a lack of studies on tools of balance tests and their accuracy among middle-aged women. Objective: The aim of this study is to compare three tools of balance tests to predict falls of middle-aged women who exercise regularly and who do not. Methods: Eighty-five middle-aged women (50-64 years old) were included in this study, and 40 women of them (47.1%) exercised regularly. The Berg Balance Scale (BBS), Timed Up and Go Test (TUG), and 30-second Chair Stand Test (30-s CST) were the tools examined in this study. The numerical data of this study were analyzed by using a Mann-Whitney test. Those were significant if p<0.05. Accuracy of the tools of balance tests was evaluated by using Receiver Operating Characteristic (ROC) curve. Area under the curve (AUC) was significant if =0.70.Results: Based on this study, the middle-aged women (EG) indicated lower score of TU than sedentary (SG) test (6.9 ± 0.9 vs 8.3 ± 1.7, p = <0.000), and higher score of 30-s than sedentary (SG) test (20.1 ± 3.6 vs 17.2 ± 5.6, p = 0.026). Three participants (3.53%) reported history of falls. The TUG test had better accuracy to predict the falls (AUC 0.922, 95% CI 0.840 - 1.005, sensitivity 1.00, specificity 0.84, p=0.013). Mostly, the participants (˜70%) preferred to practice Tai Chi and Yoga. Conclusion: The middle-aged women who exercised could have a better score of the balance tests, and the TUG test could predict falls of them.]]>
<![CDATA[Risks of preterm birth and low Apgar score among preeclamptic women ]]>
<![CDATA[Chiquita Febby Pragitara]]>;
<![CDATA[Risa Etika]]>;
<![CDATA[Lilik Herawati]]>;
<![CDATA[Aditiawarman Aditiawarman]]>
<![CDATA[ JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 1, (2020) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Islam Indonesia ]]>
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DOI: 10.20885/JKKI.Vol11.Iss1.art3
<![CDATA[Background: Preeclampsia has been a major problem for obstetric care in Indonesia due to risks of preterm birth and lower Apgar score. Objective: This study is to examine relationships of preeclampsia, preterm births, and Apgar Score.Methods: This used an analytic study with retrospective case-control design in Dr. Soetomo Academic Hospital. A case group was taken by total sampling from medical records of all patients who had preterm delivery in 2017, and a control group of term deliveries was taken by random sampling. Then the data were analysed by using Chi-square test and Fisher’s Exact Test.Results: There were 80 samples for each group. 63.75% of patients by age of 20-35 years were who delivered preterm birth, 40.00% had normal BMI, 40.00% were nulliparous, 92.50% did not have history of preterm labour, 50.00% had preeclampsia with severe features, and 46.25% had spontaneous vaginal delivery. Around 47.14% neonates from preeclamptic women were born at 32-<37 weeks gestation, 50.00% were born with low birth weight, 52.86% had the first minute Apgar score <7, and 72.86% had the fifth minutes Apgar score =7. The statistical analysis showed a significant relationship between the preeclampsia and the preterm birth (p<0.007; OR=2.54, 95% CI 1.34-4.83). The preeclampsia was also related to lower Apgar score at 1st minute (p<0.042; OR=2.03, 95% CI 1.07-3.85) and 5th minute (p<0.046; OR=2.42, 95% CI 1.08-5.41). Preterm neonates born from preeclamptic mothers were related to lower Apgar score at 1st minute (p<0.002; OR=5.82, 95% CI 1.99-17.02) and 5th minute (p<0.001; OR 17.31, 95% CI 2.15-139.54).Conclusion: Preeclampsia could make pregnant women at risks of delivering preterm birth and neonates with low Apgar score.]]>
<![CDATA[Moxibustion for nausea and vomiting in pregnancy ]]>
<![CDATA[Siti Raihanah]]>;
<![CDATA[Masrifan Djamil]]>;
<![CDATA[Sutopo Patria Jati]]>
<![CDATA[ JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 1, (2020) ]]>
Publisher : <![CDATA[Faculty of Medicine, Universitas Islam Indonesia ]]>
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DOI: 10.20885/JKKI.Vol11.Iss1.art10
<![CDATA[Background: Nausea and vomiting are common symptoms that occur for 70-80% of pregnant women. Alternative treatments such as herbal medicine, acupressure and moxibustion have been suggested to control pregnancy-induced nausea-vomiting.Objective: This study is to observe effects of moxibustion at P6 and ST36 point on nausea and vomiting in pregnancy. Methods: This study applied a queasy experimental study by pretest-posttest design on two groups of study. Moxibustion in this study was a heat stimulation technique at P6 and ST36 points for 5 days (7 minutes per day). The P6 point was located on the inner wrist, 2-3 fingers above the wrist between the tendons and the ST36 point was located on 4 fingers below the lower limit of the patella. A random sampling was conducted for 30 pregnant women with gestational age<16 weeks of pregnancy that randomly was divided into 2 groups, or 15 women for each group. Instruments used to measure the nausea and vomiting applied Pregnancy Unique-Quantification of Emesis (PUQE) and B-endorphin.Results: Moxibustion at the P6 point could reduce symptoms of nausea and vomiting (p<0.05). However, Moxibustion at the ST36 point was not effective in reducing symptoms of nausea and vomiting in pregnancy (p>0.05). Conclusion: Moxibustion can more effective at P6 point than at ST36 point in reducing symptoms of nausea and vomiting in pregnancy.]]>
