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Muammar Fawwaz
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muammar.fawwaz@umi.ac.id
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+6282125556303
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pharmaceutical.reports@umi.ac.id
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Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy Universitas Muslim Indonesia, Jl. Urip Sumohardjo KM 5 Kampus II, Makassar 90231, Indonesia
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Kota makassar,
Sulawesi selatan
INDONESIA
Pharmaceutical Reports
Published by Universitas Muslim Indonesia
ISSN : 28286030     EISSN : 28288734     DOI : https://doi.org/10.33096/pharm%20rep.v1i2
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Pharmaceutical Reports is a peer-reviewed journal published by the Pharmaceutical Chemistry Laboratory of the Faculty of Pharmacy, Universitas Muslim Indonesia, which was first published in 2022. We published two times a year in January-June and July-December. Our mission is to advance the science and practice of pharmaceutical research by working to develop and maintain competence, ethics, and integrity, and the highest professional standards in the specialty for the benefit of the public. Pharmaceutical Reports publishes studies that contribute to an understanding of some specific areas in pharmaceutical sciences including the following: - Analytical chemistry of organic and natural product compounds using instrumental analysis in pharmaceutical sciences including spectroscopy and chromatography method. - Design, synthesis, and biological evaluation of biologically active compounds, diagnostic agents, or labeled ligands employed as pharmacological tools. - Molecular modifications of reported series that lead to a significantly improved understanding of their structure-activity relationships (SAR). - Structural biological studies (X-ray, NMR, etc.) of relevant ligands and targets with the aim of investigating molecular recognition processes in the action of biologically active compounds. - Pharmaceutics & Biopharmaceutics - Novel & Targeted Drug Delivery - Pharmacology & Toxicology - Pharmaceutical Biotechnology & Microbiology - Pharmacy Practice & Hospital Pharmacy - Drug Regulatory Affairs
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 6 Documents
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Search results for , issue "Vol 1, No 1 (2022): (March) Pharmaceutical Reports" : 6 Documents clear
Chromatogram Profile of Vigna radiata and Phaseolus vulgaris Related to Chemical Hydrolysis Muammar Fawwaz
Pharmaceutical Reports Vol 1, No 1 (2022): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (330.176 KB) | DOI: 10.33096/pharm rep.v1i1.153

Abstract

Mungbean (Vigna radiate) and red bean (Phaseolus vulgaris) is a type of food containing isoflavone in the form of glycoside (genistin, daidzin, glycitin). Isoflavones are one type of phytoestrogen which have similar chemical structure with estradiol. Therefore, it can be used not only to inhibit but also to prevent many symptoms related to estrogen deficiency. Human body cannot adsorb isoflavone in the glycoside form. In order to make it absorbable, isoflavone should be hydrolyzed to defuse its glycoside chain to be aglycon (genistein, daidzein, glycitein). The aim of this study was to determine the influence of hydrolysis on chromatogram profile of mungbean and red bean. Hydrolysis was conducted by chemical method using hydrochloride acid (HCl). The chromatogram profile was determined by High Performance Liquid Chromatography method (HPLC) using C18 reverse phase column, the mobile phase was methanol : water (7:3), the sample injected automatically as much as 10 ml, the flow rate of 1 ml/min with a temperature of 28°C, at a wavelength of 254 nm. This study showed that chemical hydrolysis successes to remove the glycoside chain in both mungbean and red bean extract.
Determination of Acetaminophen in Jamu Pegal Linu by High Performance Liquid Chromatography Mamat Pratama; Dian Harisman; Lukman Labasy; Seniwati Seniwati; Muammar Fawwaz
Pharmaceutical Reports Vol 1, No 1 (2022): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (357.555 KB) | DOI: 10.33096/pharm rep.v1i1.154

Abstract

Traditional medicine is very popular in Indonesia, so it is necessary to do this research to analyze the presence or absence of chemical substances contained in traditional medicine. This research aims to determine acetaminophen content on jamu pegal linu circulating in Makassar city by High Performance Liquid Chromatography (HPLC). The jamu were obtained from several drugs stores near Terong traditional market. Five brands of jamu pegal linu detected their acetaminophen content by HPLC method using a UV-Visible SPD 20A detector with a wavelength of 254 nm. The result showed that chromatogram on jamu pegal linu is the same as the acetaminophen at the retention time of 5.28 minutes. The whole of jamu pegal linu analyzed positively contain acetaminophen and prohibited for consumption in accordance with the regulations of National Agency of Drug and Food Control (POM) Republic Indonesia No.KH.00.01.43.2773/2008.
In Vitro Activity Test of A-Glucosidase Enzyme Inhibition of Moringa oleifera L. Leaves Extract Irma Pattola; St. Maryam; Rais Razak
Pharmaceutical Reports Vol 1, No 1 (2022): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (184.834 KB) | DOI: 10.33096/pharm rep.v1i1.155

Abstract

Diabetes Mellitus (DM) is a group of disease characterized by an increase in insulin. Moringa oleifera leaves contain chemical properties such as tannins, steroids, triterpenes, flavonoids, saponins, anthraquinones and alkaloids. These chemical compounds can affect a variety of biological activities and one of the is antidiabetic. The research aimed to study the potential of Moringa oleifera extract in relation to the a-glucosidase enzyme which is one of the transitions of antidiabetic drugs based on IC50 values. In this study moringa leaves were extracted by maceration method using 96% ethanol solvent. The inhibitory activity testing uses an ELISA (Enzyme-linked Immunosorbent Assay) reader measured at 405 nm wavelength with a comparator of the acarbose because it is an antidiabetic drug of the glucosidase enzyme inhibitor group. The results of the a-glucosidase enzyme showed that the a-glucosidase enzyme activity was inhibited by the ethanol extract of Moringa oleifera L. with C50 value 84,238 µg/mL included in the less active category.
The Effect of Heating on Ascorbic Acid Levels of Brassica oleracea L. Determined by UV-Visible Spectrophotometry Muzakkir Baits; Riski Mentari Jahri; Asriani Suhaenah; Aminah Aminah; Tadjuddin Naid; Muammar Fawwaz
Pharmaceutical Reports Vol 1, No 1 (2022): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (179.042 KB) | DOI: 10.33096/pharm rep.v1i1.156

Abstract

Vitamin C is one of the nutrients that act as antioxidants derived from fruits and green vegetables, such as the broccoli (Brassica oleracea L.). This study aims to warming influence on levels of vitamin C in broccoli (Brassica oleracea L.) with qualitative and quantitative analysis. Qualitative analysis was performed using specific reagents that ammonium molybdate, Fehling Fehling's A and B which have indicated a positive sample containing vitamin C, and vitamin C were analyzed quantitatively using UV- Vis spectrophotometry at a wavelength of 570 nm. The results showed levels of vitamin C in raw broccoli 0.62915 mg/g and steamed broccoli 0.45449 mg/g.
Comparative Study of Nutritional Content and Amino Acid Profile on Rono Poso Fish (Adrianichthys oophorus) and Rono Lindu Fish (Oryzias sarasinorum) Endemic of Central Sulawesi Jamaluddin Jamaluddin; Meita Meita; Syariful Anam; Agustinus Widodo; Pitriani Pitriani
Pharmaceutical Reports Vol 1, No 1 (2022): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (483.147 KB) | DOI: 10.33096/pharm rep.v1i1.152

Abstract

Rono Poso fish (Adrianichthys oophorus) originating from Lake Poso and  Rono Lindu fish (Oryzias sarasinorum) from Lake Lindu, is central Sulawesi endemic fish that consumed the communities around the lake, but it is not known nutritional content. This study aims to determine the nutrient content and amino acid profile in Rono Poso and Rono fish Lindu. Ash content analysis testing using the dry ashing method, testing the moisture content using the oven method, using soxhlet fat, and protein content using the method and the testing Kjeldhal amino acid profile using Chromatography Hight Performance Liquid (HPLC). The results showed that several nutrients and amino acid profiles differ between the two samples. In Rono Poso fish containing ash 11:00%, water 6:11%, 58.88% protein,  fat, and carbohydrates 22.68% 1:33%. In Rono Lindu containing ash 18.84%, water 9.77%, 58.97% protein, fat, and carbohydrate 10:35% 2:07%.
Radiolabeled Peptide as Diagnostic, Therapeutic, and Theranostic agents for Prostate Cancer: Systematic Literature Review Syabrina Salsabilah Gili; Muzakkir Baitz; Nurmaya Effendi
Pharmaceutical Reports Vol 1, No 1 (2022): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharm rep.v1i1.174

Abstract

Prostate cancer (PCa) is the most common sex-related malignancy and the second most common cause of mortality after lung cancer for men. Around 61.8% of Indonesian people undergo cancer treatment with surgery. This study aimed to figure out the use of radiolabeled peptides for diagnosis, therapy, and theranostics of prostate cancer. This study performed a literature review by searching the web databases such as PubMed, MDPI, Elsevier (Science Direct), and ACS Publications. The result showed that peptide compounds such RM2, VCN (Vicrostatin), DB15, and BBN7-14 were utilized as radionuclide-carriers for diagnostic imaging, meanwhile, peptides such as NeoBOMB1, PSMA-617, and [RGD-Glu-[DO3A]-6-Ahx-RM2] containing alpha or beta-emitted radionuclide were used as therapeutic and theranostic agents. They were tagged using 68Ga, 161Tb, 177Lu, 64Cu, 124I, 99mTc, 90Y, and 86Y radionuclides. Great efforts have been conducted in developing peptide-based radiopharmaceuticals for diagnosis and therapy of prostate cancer. Research groups focusing in nuclear medicine will continue to develop radiopharmaceuticals in the future, especially radiopeptide compounds for the diagnosis and therapy of prostate cancer.

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