Garuda - Garba Rujukan Digital

All

Pharmaceutical Reports

PharmRep
Website

Published by Universitas Muslim Indonesia

ISSN : 28286030 EISSN : 28288734 DOI : https://doi.org/10.33096/pharm%20rep.v1i2

Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

Pharmaceutical Reports is a peer-reviewed journal published by the Pharmaceutical Chemistry Laboratory of the Faculty of Pharmacy, Universitas Muslim Indonesia, which was first published in 2022. We published two times a year in January-June and July-December. Our mission is to advance the science and practice of pharmaceutical research by working to develop and maintain competence, ethics, and integrity, and the highest professional standards in the specialty for the benefit of the public. Pharmaceutical Reports publishes studies that contribute to an understanding of some specific areas in pharmaceutical sciences including the following: - Analytical chemistry of organic and natural product compounds using instrumental analysis in pharmaceutical sciences including spectroscopy and chromatography method. - Design, synthesis, and biological evaluation of biologically active compounds, diagnostic agents, or labeled ligands employed as pharmacological tools. - Molecular modifications of reported series that lead to a significantly improved understanding of their structure-activity relationships (SAR). - Structural biological studies (X-ray, NMR, etc.) of relevant ligands and targets with the aim of investigating molecular recognition processes in the action of biologically active compounds. - Pharmaceutics & Biopharmaceutics - Novel & Targeted Drug Delivery - Pharmacology & Toxicology - Pharmaceutical Biotechnology & Microbiology - Pharmacy Practice & Hospital Pharmacy - Drug Regulatory Affairs

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi

Articles 18 Documents

1 2

Total Flavonoid Content of the Bark Extract of Salacca edulis Reinw Nisradhiyah Caesarika Ardin; Mamat Pratama; Harti Widiastuti; Muammar Fawwaz
Pharmaceutical Reports Vol 1, No 2 (2022): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Salak fruit (Salacca edulis Reinw) is one of the fruits whose bark is not used but contains chemical components in the form of secondary metabolites that are beneficial to health. A previous study reported that the bark of salak fruit has potential as an anti-diabetic, antioxidant. The bark of Salak fruit is traditionally beneficial for the treatment of diabetes mellitus by drying then boiling and drinking the boiled water. Therefore, this study aims to determine the total flavonoid content of the bark extract of the pondoh and honey varieties of salak fruit. A sample of 30 g was dissolved with ethanol in a 10 mL volumetric flask, then 1 mL was pipette and added with 0.2 ml AlCl3 and 0.2 mL potassium acetate then allowed to stand for 30 min at 25°C. After being allowed to stand, it was measured on a UV-Vis spectrophotometer with a wavelength of 442 nm. In the measurement with UV-Vis spectrophotometer, the total flavonoid content of the salak bark extract of pondoh and honey varieties were 5.18 mg QE/g and 5.77, respectively.

Chromatogram Profile of Vigna radiata and Phaseolus vulgaris Related to Chemical Hydrolysis Muammar Fawwaz
Pharmaceutical Reports Vol 1, No 1 (2022): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Mungbean (Vigna radiate) and red bean (Phaseolus vulgaris) is a type of food containing isoflavone in the form of glycoside (genistin, daidzin, glycitin). Isoflavones are one type of phytoestrogen which have similar chemical structure with estradiol. Therefore, it can be used not only to inhibit but also to prevent many symptoms related to estrogen deficiency. Human body cannot adsorb isoflavone in the glycoside form. In order to make it absorbable, isoflavone should be hydrolyzed to defuse its glycoside chain to be aglycon (genistein, daidzein, glycitein). The aim of this study was to determine the influence of hydrolysis on chromatogram profile of mungbean and red bean. Hydrolysis was conducted by chemical method using hydrochloride acid (HCl). The chromatogram profile was determined by High Performance Liquid Chromatography method (HPLC) using C18 reverse phase column, the mobile phase was methanol : water (7:3), the sample injected automatically as much as 10 ml, the flow rate of 1 ml/min with a temperature of 28°C, at a wavelength of 254 nm. This study showed that chemical hydrolysis successes to remove the glycoside chain in both mungbean and red bean extract.

Sulfonamide Residue in the Broiler Chicken Circulating in Makassar Muammar Fawwaz; Rais Razak; Masdiana Tahir; Andi Permatasari; Andi Tenri Amula; Seniwati Seniwati
Pharmaceutical Reports Vol 1, No 2 (2022): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

The use of sulfonamide related to drug residual in the product of broiler chicken, like meat and egg. This research aimed to determine the sulfonamides (sulfamerazine, sulfanilamide, and sulfadiazine) on the broiler chicken meat, breast, and egg from the three different slaughterhouses circulating in the City of Makassar. The sample was extracted by acetonitrile and acetone then concentrated. The extract and sulfonamides then analyzed by HPLC method using C18 reverse phased column, UV-Visible detector in the wavelength of 270 nm. The result of study shows that the chromatogram of sample breast and egg has similar retention time with sulfonamides as a standard reference. The breast sample contains sulfamerazine residues, sample B and C contains 0.014 and 0.005 % (w/w), respectively. The egg sample A and D contains sulfadiazine 0.045 and 0.108 % (w/w), respectively. Sample B contains sulfanilamide 0.053 % (w/w). Sample A and B is egg yolk, while sample D is egg whites. Based on the results obtained, this is not suitable for the rules set by JECFA of 0.1 mg/kg (10-5 % w/w) as well as the standard of SNI. It can be concluded that generally broiler chicken breast and egg circulating in the City of Makassar was contaminated by sulfonamide with high concentration.

Determination of Acetaminophen in Jamu Pegal Linu by High Performance Liquid Chromatography Mamat Pratama; Dian Harisman; Lukman Labasy; Seniwati Seniwati; Muammar Fawwaz
Pharmaceutical Reports Vol 1, No 1 (2022): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Traditional medicine is very popular in Indonesia, so it is necessary to do this research to analyze the presence or absence of chemical substances contained in traditional medicine. This research aims to determine acetaminophen content on jamu pegal linu circulating in Makassar city by High Performance Liquid Chromatography (HPLC). The jamu were obtained from several drugs stores near Terong traditional market. Five brands of jamu pegal linu detected their acetaminophen content by HPLC method using a UV-Visible SPD 20A detector with a wavelength of 254 nm. The result showed that chromatogram on jamu pegal linu is the same as the acetaminophen at the retention time of 5.28 minutes. The whole of jamu pegal linu analyzed positively contain acetaminophen and prohibited for consumption in accordance with the regulations of National Agency of Drug and Food Control (POM) Republic Indonesia No.KH.00.01.43.2773/2008.

UV-Visible Spectrophotometric Determination of Formalin Contamination in Tofu Circulated in Maros City - Indonesia Seniwati Seniwati; Haqi Romadhona Qawiy; Aminah Aminah; Tadjuddin Naid
Pharmaceutical Reports Vol 1, No 2 (2022): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Tofu is one of the healthiest foods because of its high protein content and the quality is equivalent to the quality of animal protein. Formaldehyde has a function as an antibacterial agent that can slow down the activity of bacteria in foods that contain a lot of protein, so formaldehyde reacts with proteins in food and makes food durable, but when it enters the human body, formaldehyde itself is mutagenic and carcinogenic which can trigger the growth of cancer cells. and gene defects in the body. Thus, in this study, we aim to determine the formalin contamination in tofu circulated in Maros City – Indonesia. This research was conducted from December 2014 to June 2015. The analysis of formalin contamination in tofu was conducted in qualitative and quantitative analysis. The qualitative analysis was performed using the specific reagent, and the quantitative analysis was measured by UV-Vis spectrophotometric method. The result showed that sample codes RMD1 and RMD2 with formalin contaminants because the color of the solution produced after the test was red correspond to the positive result. As for the tofu sample with sample code RMD3, the results were negative because it gave a yellow color after adding potassium permanganate reagent. In the quantitative analysis, samples were measured using a UV-Vis spectrophotometer at a wavelength of 571.5 nm. From the measurement process, the result exhibited that the samples RMD1 and RMD2 contain formalin of 5.92 and 3.34 g/gram, respectively.

In Vitro Activity Test of A-Glucosidase Enzyme Inhibition of Moringa oleifera L. Leaves Extract Irma Pattola; St. Maryam; Rais Razak
Pharmaceutical Reports Vol 1, No 1 (2022): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Diabetes Mellitus (DM) is a group of disease characterized by an increase in insulin. Moringa oleifera leaves contain chemical properties such as tannins, steroids, triterpenes, flavonoids, saponins, anthraquinones and alkaloids. These chemical compounds can affect a variety of biological activities and one of the is antidiabetic. The research aimed to study the potential of Moringa oleifera extract in relation to the a-glucosidase enzyme which is one of the transitions of antidiabetic drugs based on IC50 values. In this study moringa leaves were extracted by maceration method using 96% ethanol solvent. The inhibitory activity testing uses an ELISA (Enzyme-linked Immunosorbent Assay) reader measured at 405 nm wavelength with a comparator of the acarbose because it is an antidiabetic drug of the glucosidase enzyme inhibitor group. The results of the a-glucosidase enzyme showed that the a-glucosidase enzyme activity was inhibited by the ethanol extract of Moringa oleifera L. with C50 value 84,238 µg/mL included in the less active category.

Criminal Responsibility of the Pharmacist in the Pharmaceutical Services in Indonesia Saparuddin Latu; Aswanto K; Marthen Arie; Alimuddin Alimuddin
Pharmaceutical Reports Vol 1, No 2 (2022): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Medical malpractice has a long history in Indonesia, with fatal consequences for patients due to negligence from the health practitioner. This study aims to ensure legal certainty in pharmaceutical practice according to laws and regulations. Also, to provide criminal law sanctions for pharmacists in pharmaceutical practices that lead to criminal acts. The method used was qualitative empirical normative research with a literature study. This research was conducted qualitatively based on data triangulation which resulted from three ways: interview, participant to observation, and review of organizational records (document records). Data collection usually uses qualitative research observation, documentation, and interview methods. This study discusses legal provisions related to health and pharmaceutical services and interviews with ten people at Dr. Wahidin Sudirohusodo Regional General Hospital, Makassar, and five people from Wamena Regional General Hospital, Jayawijaya Regency, Papua. Our study exhibited that implementing a pharmacist's practice was based on the prevailing laws and regulations. The pharmaceutical practice in question starts from planning, procurement, storage, distribution, evaluation, and provision of drug information and monitoring of drug side effects. These practices are based on Government Regulation No. 51 of 2009 article 4. This regulation is stated to protect patients and the public in obtaining and stipulating pharmaceutical preparations and pharmaceutical services. In addition, to maintain and improve the quality of implementation of pharmaceutical work by using developments in science and technology as well as laws and regulations; and provide legal certainty for patients, communities, and pharmaceutical workers. In the criminal responsibility of pharmacists in pharmaceutical services that have resulted in illegal acts, there have not been cases that have reached court proceedings. Nevertheless, there are cases where actions that have resulted in criminal acts have occurred in the field. Still, mediation can resolve them to reach a consensus with unique mediation.

The Effect of Heating on Ascorbic Acid Levels of Brassica oleracea L. Determined by UV-Visible Spectrophotometry Muzakkir Baits; Riski Mentari Jahri; Asriani Suhaenah; Aminah Aminah; Tadjuddin Naid; Muammar Fawwaz
Pharmaceutical Reports Vol 1, No 1 (2022): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Vitamin C is one of the nutrients that act as antioxidants derived from fruits and green vegetables, such as the broccoli (Brassica oleracea L.). This study aims to warming influence on levels of vitamin C in broccoli (Brassica oleracea L.) with qualitative and quantitative analysis. Qualitative analysis was performed using specific reagents that ammonium molybdate, Fehling Fehling's A and B which have indicated a positive sample containing vitamin C, and vitamin C were analyzed quantitatively using UV- Vis spectrophotometry at a wavelength of 570 nm. The results showed levels of vitamin C in raw broccoli 0.62915 mg/g and steamed broccoli 0.45449 mg/g.

Determination of Total Phenolic Levels of Ethyl Acetate Fraction of Clove Leaves (Syzygium aromaticum (L) Merr) Arniati Arniati; Mamat Pratama; Muzakkir Baits; Masdiana Tahir
Pharmaceutical Reports Vol 1, No 2 (2022): (October) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Clove is a spice plant used in the kretek cigarette industry, food, beverage, and medicine. Clove leaves contain chemical compounds, namely saponins, flavonoids, tannins, and essential oils. The exploration of clove leaves has not been maximally carried out. Therefore, this study aims to determine the total phenolic content in the ethyl acetate fraction of clove leaves by using gallic acid as a comparison. Clove leaves were powdered and then macerated by ethanol. The ethanol extract was dissolved in distilled water and it was fractionated with ethyl acetate on a separating funnel. The method used in this assay is the UV-Vis spectrophotometry technique. The qualitative analysis was performed by adding the FeCl3 reagent. The results showed that the ethyl acetate fraction of clove leaves contained a total phenolic compound of 65.52 mg gallic acid equivalent per gram of extract (GAE/g). Thus, the ethyl acetate fraction of clove leaves is feasible to be developed as a source of phenolic compound.

Comparative Study of Nutritional Content and Amino Acid Profile on Rono Poso Fish (Adrianichthys oophorus) and Rono Lindu Fish (Oryzias sarasinorum) Endemic of Central Sulawesi Jamaluddin Jamaluddin; Meita Meita; Syariful Anam; Agustinus Widodo; Pitriani Pitriani
Pharmaceutical Reports Vol 1, No 1 (2022): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Rono Poso fish (Adrianichthys oophorus) originating from Lake Poso and Rono Lindu fish (Oryzias sarasinorum) from Lake Lindu, is central Sulawesi endemic fish that consumed the communities around the lake, but it is not known nutritional content. This study aims to determine the nutrient content and amino acid profile in Rono Poso and Rono fish Lindu. Ash content analysis testing using the dry ashing method, testing the moisture content using the oven method, using soxhlet fat, and protein content using the method and the testing Kjeldhal amino acid profile using Chromatography Hight Performance Liquid (HPLC). The results showed that several nutrients and amino acid profiles differ between the two samples. In Rono Poso fish containing ash 11:00%, water 6:11%, 58.88% protein, fat, and carbohydrates 22.68% 1:33%. In Rono Lindu containing ash 18.84%, water 9.77%, 58.97% protein, fat, and carbohydrate 10:35% 2:07%.

Page 1 of 2 | Total Record : 18

1 2

Filter by Year

2022 2023

Filter By Issues

All Issue Vol 2, No 1 (2023): (March) Pharmaceutical Reports Vol 1, No 2 (2022): (October) Pharmaceutical Reports Vol 1, No 1 (2022): (March) Pharmaceutical Reports

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Muammar Fawwaz

Contact Email
muammar.fawwaz@umi.ac.id

Phone
+6282125556303

Journal Mail Official
pharmaceutical.reports@umi.ac.id

Editorial Address
Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy Universitas Muslim Indonesia, Jl. Urip Sumohardjo KM 5 Kampus II, Makassar 90231, Indonesia

Location
Kota makassar,

Sulawesi selatan

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Muammar Fawwaz

Contact Email muammar.fawwaz@umi.ac.id

Phone +6282125556303

Journal Mail Official pharmaceutical.reports@umi.ac.id

Editorial Address Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy Universitas Muslim Indonesia, Jl. Urip Sumohardjo KM 5 Kampus II, Makassar 90231, Indonesia

Location Kota makassar, Sulawesi selatan INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Muammar Fawwaz

Contact Email
muammar.fawwaz@umi.ac.id

Phone
+6282125556303

Journal Mail Official
pharmaceutical.reports@umi.ac.id

Editorial Address
Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy Universitas Muslim Indonesia, Jl. Urip Sumohardjo KM 5 Kampus II, Makassar 90231, Indonesia

Location
Kota makassar,

Sulawesi selatan

INDONESIA