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Muammar Fawwaz
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Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy Universitas Muslim Indonesia, Jl. Urip Sumohardjo KM 5 Kampus II, Makassar 90231, Indonesia
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INDONESIA
Pharmaceutical Reports
Published by Universitas Muslim Indonesia
ISSN : 28286030     EISSN : 28288734     DOI : https://doi.org/10.33096/pharm%20rep.v1i2
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology
Pharmaceutical Reports is a peer-reviewed journal published by the Pharmaceutical Chemistry Laboratory of the Faculty of Pharmacy, Universitas Muslim Indonesia, which was first published in 2022. We published two times a year in January-June and July-December. Our mission is to advance the science and practice of pharmaceutical research by working to develop and maintain competence, ethics, and integrity, and the highest professional standards in the specialty for the benefit of the public. Pharmaceutical Reports publishes studies that contribute to an understanding of some specific areas in pharmaceutical sciences including the following: - Analytical chemistry of organic and natural product compounds using instrumental analysis in pharmaceutical sciences including spectroscopy and chromatography method. - Design, synthesis, and biological evaluation of biologically active compounds, diagnostic agents, or labeled ligands employed as pharmacological tools. - Molecular modifications of reported series that lead to a significantly improved understanding of their structure-activity relationships (SAR). - Structural biological studies (X-ray, NMR, etc.) of relevant ligands and targets with the aim of investigating molecular recognition processes in the action of biologically active compounds. - Pharmaceutics & Biopharmaceutics - Novel & Targeted Drug Delivery - Pharmacology & Toxicology - Pharmaceutical Biotechnology & Microbiology - Pharmacy Practice & Hospital Pharmacy - Drug Regulatory Affairs
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 18 Documents
 1   2 
Radiolabeled Peptide as Diagnostic, Therapeutic, and Theranostic agents for Prostate Cancer: Systematic Literature Review Syabrina Salsabilah Gili; Muzakkir Baitz; Nurmaya Effendi
Pharmaceutical Reports Vol 1, No 1 (2022): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharm rep.v1i1.174

Abstract

Prostate cancer (PCa) is the most common sex-related malignancy and the second most common cause of mortality after lung cancer for men. Around 61.8% of Indonesian people undergo cancer treatment with surgery. This study aimed to figure out the use of radiolabeled peptides for diagnosis, therapy, and theranostics of prostate cancer. This study performed a literature review by searching the web databases such as PubMed, MDPI, Elsevier (Science Direct), and ACS Publications. The result showed that peptide compounds such RM2, VCN (Vicrostatin), DB15, and BBN7-14 were utilized as radionuclide-carriers for diagnostic imaging, meanwhile, peptides such as NeoBOMB1, PSMA-617, and [RGD-Glu-[DO3A]-6-Ahx-RM2] containing alpha or beta-emitted radionuclide were used as therapeutic and theranostic agents. They were tagged using 68Ga, 161Tb, 177Lu, 64Cu, 124I, 99mTc, 90Y, and 86Y radionuclides. Great efforts have been conducted in developing peptide-based radiopharmaceuticals for diagnosis and therapy of prostate cancer. Research groups focusing in nuclear medicine will continue to develop radiopharmaceuticals in the future, especially radiopeptide compounds for the diagnosis and therapy of prostate cancer.
Analysis of Rhodamine B Levels in Cotton Candy Circulated in Makassar City Dhela Ainun Qalbi Ahsyaf; Aminah Aminah; Andi Trihadi Kusuma Kisra
Pharmaceutical Reports Vol 2, No 1 (2023): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharm rep.v2i1.228

Abstract

Rhodamine B is a synthetic dye used as a textile dye. It is prohibited as a Food Additive because it can irritate the digestive tract, poison, and even cause cancer and death. The research was to see if there were any Rhodamine B deposits of cotton candy in Makassar. This test used five samples. The methods used in testing are TLC and spectrophotometry UV-Vis. All five samples' test results show no stain was formed (negative). UV-Vis spectrophotometry test on a 553 nm length acquired data of Rhodamine B levels in a row as follows: first sample of cotton candy = 0.005%, sample 2 of cotton candy = 0.001%, sample 3 of cotton candy = 0.0008%, sample 4 of cotton candy = 0.003%, and sample 5 of cotton candy = 0.0009%. They concluded that all five samples identified contained Rhodamine B synthesized dye to a minimal degree of the cotton candy sample distributed in Makassar.
Analysis of Formaldehyde in Circulating Grapes in Makassar Nurfathiyatul Izza; Aminah Aminah; Rais Razak
Pharmaceutical Reports Vol 2, No 1 (2023): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharm rep.v2i1.229

Abstract

Formalin or formaldehyde is a chemical compound whose use is prohibited as a preservative in food additives. This study aims to analyze the content of formalin in red grapes (Vitis vinifera) circulating in the city of Makassar. The method used in this test is by using Schiff reagent and UV-Vis spectrophotometry. The results of the Schiff reagent test showed that two of the 10 grape samples were positive for formalin. Test results on UV-Vis Spectrophotometry at a wavelength of 556 nm, that all red grape samples obtained contained formalin with formalin levels as follows: Sample Tamalanrea 1 TD = 0.778%, Tamalanrea 2 TD = 0.483%, Manggala TD= 0.452%, Tamalate TD= 0.734%, Biringkanaya TD= 0.552%, Tamalanrea 1 SD= 0.452%.
Acute Oral Toxicity Evaluation of Extract Bajakah (Spatholobus littoralis Hassk) in Mice Imran Firman; Safaruddin Safaruddin; Nurisrah Nurisrah; Besse Yuliana
Pharmaceutical Reports Vol 2, No 1 (2023): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharm rep.v2i1.225

Abstract

One potential biodiversity as traditional medicine is bajakah (Spatholobus littoralis Hassk.). Bajakah is an herbal plant that has been used in the Borneo region, Indonesia. However, there are not enough data regarding the toxicity of this plant. Therefore, in this study, we aimed to determine acute toxicity in the form of a lethal dose value of 50% (LD50) and the effect on behaviour and organ macroscopic after administration of S. littoralis methanol extract. The LD50 test used 50 male mice divided into five groups of 5 mice each. The treatment groups were divided based on the concentration of the given extract, namely; 0, 1, 10, 100, and 1000 mg/g BW. Observations were made for 14 days after treatment, and then surgery and macroscopic observations were made on the organs of mice. The results showed that the LD50 value for replication A and B was 17.78 and 68.13 mg/Kg BW, respectively. Macroscopic observations found damage to the liver, heart, and stomach. The macroscopic assessment by ANOVA and Kruskal Wallis test showed that in the replication A there was a toxic effect on the stomach, which was marked by a significant difference in weight compared to the control at the test level of p 0.05. These data revealed that the methanol extract of S. littoralis lignum is categorized as very toxic, and therefore, it requires special attention in its use. However, further research needs to be done to support the results of this study.
Antibacterial Activity of Actinomycetes Isolates from The Rhizosphere of The Turate Kasumba Plant (Carthamus Tinctorius L.) Against Bacteria Causing Skin Infections Safira Brigeeta Kinanti; Rachmat Kosman; Rusli Rusli
Pharmaceutical Reports Vol 2, No 1 (2023): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharm rep.v2i1.226

Abstract

Actinomycetes is one group of microorganisms capable of producing secondary metabolites that function as antibacterials. Actinomycetes isolates used were isolated from the rhizosphere of the kasumba turate plant (Carthamus tinctorius L.). The purpose of this study was to determine the antibacterial activity of Actinomycetes isolates from the rhizosphere of kasumba turate (Carthamus tinctorius L.) which is the largest and most against skin infection bacteria. The results of the study obtained 2 isolates that are most active. IARK-6 obtained spot with Rf value = 0.70 for Staphylococcus aureus bacteria, Rf1 = 0.70 and Rf2 = 0.38 for Staphylococcus epidermidis bacteria, Rf = 0.70 for Pseudomonas aeruginosa bacteria. While the results of KLT-Bioautography testing for isolate IARK-7 obtained spots with a value of Rf = 0.38 for Staphylococcus aureus bacteria, Rf = 0.70 for Staphylococcus epidermidis bacteria, Rf = 0.38 for Pseudomonas aeruginosa bacteria.
Analysis of Rhodamine B Levels in Cotton Candy Circulated in Makassar City Dhela Ainun Qalbi Ahsyaf; Aminah Aminah; Andi Trihadi Kusuma Kisra
Pharmaceutical Reports Vol 2, No 1 (2023): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharm rep.v2i1.227

Abstract

Rhodamine B is a synthetic dye used as a textile dye. It is prohibited as a Food Additive because it can irritate the digestive tract, poison, and even cause cancer and death. The research was to see if there were any Rhodamine B deposits of cotton candy in Makassar. This test used five samples. The methods used in testing are TLC and spectrophotometry UV-Vis. All five samples' test results show no stain was formed (negative). UV-Vis spectrophotometry test on a 553 nm length acquired data of Rhodamine B levels in a row as follows: first sample of cotton candy = 0.005%, sample 2 of cotton candy = 0.001%, sample 3 of cotton candy = 0.0008%, sample 4 of cotton candy = 0.003%, and sample 5 of cotton candy = 0.0009%. They concluded that all five samples identified contained Rhodamine B synthesized dye to a minimal degree of the cotton candy sample distributed in Makassar.
The Neutralizing Effect of Squeezed Juice, Infusion and Ethanol Extract of Miana Leaves Isnayanti Isnayanti; Ira Asmaliani; Nurlina Nurlina; Mirawati Mirawati
Pharmaceutical Reports Vol 2, No 1 (2023): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharm rep.v2i1.230

Abstract

The traditional use of miana leaves as a remedy for various ailments, including stomach acid, is well-documented. The utilization of traditional treatments is prevalent due to the absence of side effects associated with synthetic chemical treatments. The consumption of miana leaves by communities is typically achieved through the ingestion of the juice extracted from fresh leaves or by boiling the leaves in water. The purpose of this study is to investigate the mechanism of action of miana leaves as a stomach acid remedy, specifically, its neutralizing effect on stomach acid. The study was conducted on water extracts using squeezed juice and infusion methods, as well as ethanol extracts using the maceration method. The dosage used was obtained by converting the commonly used dosage by the community, which is 3 medium-sized leaves. The average weight of 1 fresh leaf is 1g and the volume of medicine consumed is 1 tablespoon or 15 mL. The concentration for squeezed juice is 20%, infusion 2.08% and ethanol extract 0.28%. The results obtained from maceration, infusion, and miana leaf extract demonstrate a neutralization capacity of 26.617 ± 0.236; 26.7 ± 0.05 and 26.633 ± 0.07 respectively. In conclusion, this study demonstrates that miana leaves possess a neutralizing effect on stomach acid, and may be used as a remedy for stomach acid.
Determination of UV-Vis Spectrophotometry with Differential pH on Total Anthocyanin Levels of Ethanol Extract of Cordyline fruticosa (L.) A. Cheval Leaves Yuri Pratiwi Utami; Ainun Jariah; Rahmah Mustarin
Pharmaceutical Reports Vol 2, No 1 (2023): (March) Pharmaceutical Reports
Publisher : Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/pharm rep.v2i1.232

Abstract

Cordyline fruticosa (L.) A. Cheval is a traditional medicinal plant contains several chemical compounds including saponins, tannins, flavonoids, polyphenols, steroids, and anthocyanins. The purpose of this study was to determine the total anthocyanin levels of red andong leaf extract. In this study, red andong leaf was extracted using the maceration method with 70% ethanol solvent. Furthermore, qualitative testing was carried out by screening the phytochemicals of red andong leaf extract and continued with qualitative-specific testing for anthocyanins. Then the anthocyanin levels were measured using UV-Vis spectrophotometry with differential pH. The results showed that anthocyanins were of cyanidin type. Furthermore, the measurement of total anthocyanin levels was carried out using the differential pH method. Based on these results it can be concluded that the totalanthocyanin levels of andong red leaf extract (Cordyline fruticosa (L.) A. Cheval) 17.76mg/L.

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