Molekul: Jurnal Ilmiah Kimia
The MOLEKUL is dedicated to fostering advancements in all branches of chemistry and its diverse sub-disciplines. It aims to publish high-quality research encompassing a wide range of topics, including but not limited to Pharmaceutical Chemistry, Biological Activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry. By providing a platform for rigorous scientific inquiry and dissemination of knowledge, the journal strives to contribute to the understanding, innovation, and practical applications of chemistry in various fields. We encourage submissions that explore new methodologies, elucidate fundamental principles, address pressing challenges, and demonstrate the potential for real-world impact. Our journal welcomes original research articles, reviews, and perspectives from researchers, scholars, and professionals across the global scientific community, promoting interdisciplinary collaboration and the advancement of chemical sciences. The scope of this journal encompasses a wide range of topics within the field of chemistry, with a particular focus on advancing knowledge and innovation in the following areas: 1. Theoretical Chemistry and Environmental Chemistry: This includes theoretical studies, computational modeling, and experimental investigations related to chemical reactivity, molecular structures, spectroscopy, and the environmental fate and impact of chemicals. 2. Materials Synthesis for Energy and Environmental Applications: The journal welcomes research on the synthesis, characterization, and application of materials for energy storage, catalysis, solar energy conversion, pollution mitigation, and sustainable environmental technologies. 3. Isolation, Purification, and Modification of Biomolecules: Manuscripts addressing the isolation, purification, and modification of biomolecules, such as proteins, nucleic acids, carbohydrates, and lipids, along with their applications in areas such as biotechnology, drug discovery, and diagnostics, are of particular interest. 4. Fabrication, Development, and Validation of Analytical Methods: The journal encourages submissions focusing on the development and optimization of analytical techniques, including chromatography, spectroscopy, electrochemistry, and mass spectrometry. Topics may include method validation, sample preparation, quality control, and applications in diverse fields.
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<![CDATA[Gas-Liquid Separator Modified on CV-AAS System for Determination of Total Hg in the Industrial Wastewater Samples ]]>
<![CDATA[Sujito Sujito]]>;
<![CDATA[Subur P Pasaribu]]>;
<![CDATA[Teguh Wirawan]]>;
<![CDATA[Aman Sentosa Panggabean]]>
<![CDATA[ Molekul Vol 17 No 3 (2022) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2022.17.3.5039
<![CDATA[The research about the utilization of modified gas-liquid separators in the determination of Hg ions by using the Cold Vapor Atomic Absorption Spectrophotometer (CV-AAS) method has been done. To optimize the measurement results, several parameters that affect the hydride generator have been studied. Some specified essential parameters are the type and concentration of acid, the level of SnCl2 as a reducing agent, sample volume and the analytical performance such as linearity (r), detection limit (LOD) and quantitation limit (LOQ), repeatability (% RSD), and accuracy have been studied. The results of the research showed the gas-liquid separator modified can be used instead of commercial gas- liquid separators. It was showed by the repeatability value as % RSD < 2/3 CV Horwitz values, the LOD was 0.2530 μg/mL, and the LOQ was 0.8432 μg/mL. The accuracy of this method was good shown by a recovery percentage of 101.6%. Based on the result of this research, the modified of gas-liquid separator can be used for the determination of Hg ions by using the CV-AAS method with valid results]]>
<![CDATA[Moringa Seed Powder Biocoagulant (Moringa oleifera) for Improving Laboratory Wastewater Quality ]]>
<![CDATA[Peni Pujiastuti]]>;
<![CDATA[Yari Mukti Wibowo]]>;
<![CDATA[Narimo Narimo]]>
<![CDATA[ Molekul Vol 17 No 3 (2022) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2022.17.3.5461
<![CDATA[The purpose of the study was to examine the ability of 100 mesh size moringa seed powder as a biocoagulant in improving the quality of laboratory wastewater, in terms of parameters: color, TSS, Cu, Fe, COD, P-PO4, and antibacterial. The variable that changed was the concentration of Moringa seed powder solution of 0 mg/L, 40 mg/L, 80 mg/L, 120 mg/L, and 160 mg/L, with fast stirring of 150 rpm for 15 minutes and slow stirring of 50 rpm for 15 minutes. Analysis of test parameters was carried out using standardized methods of wastewater samples before and after the addition of biocoagulants. Characteristics of 100 mesh Moringa seed powder were that with the SEM-EDX test at 5000x magnification. While with the BET-BJH test it had a surface area of 14.519 m2/g, a total pore volume of 0.026 cm2/g, and an average pore size of 7.055. Moringa seed powder could improve the quality of laboratory wastewater and it had good effectiveness. Optimal TSS reduction was at a concentration of 80 % with effectiveness of 81.01 %. The reduction of COD and P-PO4 at a concentration of 160 % biocoagulants had an effectiveness of 96.36 % and 79.36 %. Whilst the decrease in heavy metal Cu was 67.7 %, Fe was 89.33 % and color was 52.96 % with the addition of 120 % biocoagulants. It had antibacterial properties of E-coli and Bacillus at the addition of 200 mg/L biocoagulant as well.]]>
<![CDATA[Effect of pH and Ozone Dosage on Characteristic of Ozonated Rice Bran Oil ]]>
<![CDATA[E. Enjarlis]]>;
<![CDATA[Marcelinus Christwardana]]>;
<![CDATA[Sri Handayani]]>;
<![CDATA[Sofa Fajriah]]>;
<![CDATA[Setijo Bismo]]>;
<![CDATA[Jehuda Reinhard Rahmani]]>;
<![CDATA[Muhammad Tama Hazadin]]>
<![CDATA[ Molekul Vol 17 No 3 (2022) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2022.17.3.5474
<![CDATA[The influence of pH and ozone dose, as well as ascorbic acid addition during the ozonation process, on the properties of Rice Bran Oil (RBO), was examined. The spectroscopic characteristic of RBO before and after ozonation was analysis directly, while the physicochemical property was assessed by density, viscosity, pH, iodine number, peroxide number, and acid number. With an increase in ozone dose, the carbon double bond in the RBO reduced. The primary product of the ozonation process is ozonide, and one of its by-products is 1,2,4-trioxolane, which contains a carbon single bond as a result of the ozonation reaction. According to this study, the pH 4 and ozone dose of 440 mg O3/L are the optimum parameters utilized in the RBO ozonation process. RBO's density and viscosity were 0.918 g/mL and 0.042 cP, respectively, at these conditions. Its iodine number, acid number, and peroxide number were also 3.173 g/g RBO, 2.3 mg NaOH/g RBO, and 55 mgeq/kg, respectively. Analyses of gas chromatography and nuclear magnetic resonance spectroscopy revealed the presence of 1,2,4-trioxolane. Ozone dosage is critical because greater ozone concentrations place RBO in a saturated state, making the 1,2,4-trioxolane unstable and readily destroyed, whereas lower temperatures can avoid this.]]>
<![CDATA[Easy Handling Preparation of Cubic Sulfur in Aqueous Extract of Sapindus rarak rinds ]]>
<![CDATA[Charles Banon]]>;
<![CDATA[Nesbah Nesbah]]>;
<![CDATA[Bambang Trihadi]]>;
<![CDATA[Aswin Falahudin]]>;
<![CDATA[Salprima Yudha S]]>
<![CDATA[ Molekul Vol 17 No 3 (2022) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2022.17.3.5719
<![CDATA[The aqueous extract of Sapindus rarak (S. rarak) was produced by heating its rinds in demineralized water at 80 °C. The main experiment was conducted at room temperature by mixing a solution of sodium thiosulfate with the extract obtained previously. After adding dilute hydrochloric acid (10%), fine granules gradually formed in the solution and precipitated when the reaction was stopped and allowed to stand for 24 h. The analysis results showed the consistency of the X-ray diffraction (XRD) peak of the obtained material with sulfur standards. When looked at the surface using scanning electron microscopy (SEM), sulfur was found to be cube-shaped. The formation of cuboidal elemental sulfur possibly occurs due to the covering of thiosulfate ions and elemental sulfur during and after the reaction. Organic compounds were found covering sulfur through elemental and functional group analyses using energy-dispersive X-ray (EDX) and Fourier-transform infrared (FTIR) spectroscopy, respectively]]>
<![CDATA[Toxicity and Antimicrobial Activity of Zerumbon from Zingiber zerumbet Rhizome ]]>
<![CDATA[Hartiwi Diastuti]]>;
<![CDATA[Ari Asnani]]>;
<![CDATA[Eva Vaulina Yulistia Delsy]]>;
<![CDATA[Restu Pamukasari]]>;
<![CDATA[Sri Indriani]]>
<![CDATA[ Molekul Vol 17 No 3 (2022) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2022.17.3.5808
<![CDATA[Zingiber zerumbet is a medicinal plant that has the potential as a source of bioactive compounds. Zerumbone is a major compound of the essential oil fraction of Z. zerumbet. Research on antimicrobial activity and toxicity of zerumbone is still very limited. In this study, the zerumbone was isolated from Z. zerumbet rhizome and then studied for its potential as an antimicrobial agent and toxicity properties. The isolation of the zerumbone compound was carried out through extraction, fractionation, and purification. The structure of zerumbone was determined by an NMR spectrophotometer (1D and 2D) and GCMS. The toxicity assay was carried out using the Brine Shrimp Lethality Test (BSLT) method, while the antimicrobial activity assay was carried out using the microdilution method against, Escherichia coli, Propionibacterium acnes, Staphylococcus aureus, Bacillus ceureus, Candida albicans, Malasezia furfur, and Aspergillus sp. The isolation of zerumbone from the n-hexane fraction of Z. zerumbet rhizome obtained a pure compound in the form of white crystals, with a melting point of 65.5 ºC. Toxicity assay of zerumbone was obtained LC50 values of 21.29 µg/mL. The activity assays on the seven test microbes showed potential activities with a range of MIC values of 15.62–250 µg/mL. Zerumbone has the highest activity against Aspergillus sp with the MIC value of 15.62 µg/mL.]]>
<![CDATA[Anti-inflammatory and immunosuppressant activity of Coprinus comatus ethanol extract in carrageenan-induced rats (Rattus norvegicus) ]]>
<![CDATA[Nuniek Ina Ratnaningtyas]]>;
<![CDATA[Fajar Husen]]>;
<![CDATA[Hernayanti Hernayanti]]>;
<![CDATA[Nuraeni Ekowati]]>;
<![CDATA[Bambang Heru Budianto]]>
<![CDATA[ Molekul Vol 17 No 3 (2022) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2022.17.3.5815
<![CDATA[oprinus comatus (O.F. Mull.) is an edible mushroom that is used as an anti-inflammatory agent. Therefore, this study aims to determine the effect of inflammation treatment on symptoms alleviating, function maintenance, and inhibiting the process of tissue damage due to an increase in free radicals using drug formulations with high antioxidant compounds. This is a true experiment conducted using a Completely Randomized Design (CRD) with a post-test and a control group. The rats were divided into 6 categories, which include 1 healthy and 5 groups induced with 1% carrageenan. Out of the treatment groups, 3 were treated with ethanol extract of C. comatus fruiting body at doses of 250 (T1), 500 (T2), and 750 mg/kg BW (T3), 1 received diclofenac sodium (PC) and the other as a negative control (NC), were given extract for 14 days and induced with 0.5 mL carrageenan in paw of rats at day 15. The qualitative identification showed the extracts contains flavonoid, polyphenol, alkaloid, triterpenoid, steroids and saponins, and GC-MS analysis showed 10 putative metabolites compound. T2 group significantly decreased the levels of IL-1β (70.63%), IgE (59.04%), total leukocyte count (31.24%), plantar thickness (12.5%), edema volume (33.3%), and increased endothelial NO levels (48.2%).]]>
<![CDATA[Preliminary Phytochemical Studies, GC-MS Analysis, and Anti-Nephrototic Activity of Ethanol Extract of Phoenix dactylifera L ]]>
<![CDATA[Warsinah Warsinah]]>;
<![CDATA[Eka Prasasti Nur Rachmani]]>;
<![CDATA[Hartiwi Diastuti]]>
<![CDATA[ Molekul Vol 17 No 3 (2022) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2022.17.3.5881
<![CDATA[Date palm seeds (Phoenix dactylifera L.) are known to contain phenolic compounds that have the potential as natural nephroprotective agents. Phenolics with solvents suitable for polarity and compounds identified by phytochemical screening, GC-MS analysis, and activity assays. This research went through 3 stages, screening with exploration and qualitative analysis of GCMS. The anti-nephrotoxic activity test used a pre-posttest controlled group design. In this study, rats have divided into six groups, namely Healthy control, negative control, and three treatment groups with ethanol extract of dates 150, 300, and 600 mg/kg. Mice were induced with 1% carrageenan twice a week. On macroscopic observation, date palm seeds are oval with indentations and light brown with a hard texture. Microscopic profile, endosperm, parenchyma, endocarp, stone cells, collenchyma, starch, oil cells, and carrier bundles. Physicochemical analysis, water content (8%), ash content (1.15%), fiber content (14.96%), and ethanol soluble extract content (10.3%). GC-MS analysis showed phenol,2,6-bis(1,1-dimethyl ethyl)-4-methyl, 1,2-benzene dicarboxylic, and dihydromethyl jasmonate. A dose extract ethanol of 600 mg/kg BW reduces urea and creatinine levels up to 8,3 mg/dl and 0.132 mg/dl. The conclusion of the phytochemical study obtained a pharmacognostic profile. The GCMS analysis obtained the compound. The activity of the ethanol extract of date palm seeds can reduce urea and creatinine levels so that it developed as an anti-nephrotoxic alternative from natural ingredients.]]>
<![CDATA[Kinetic Parameters Investigation for The Esterification of Free Fatty Acid from Coconut Oil Mill Waste using Montmorillonite-Sulfonated Carbon from Glucose Composite Catalyst ]]>
<![CDATA[Hasanudin Hasanudin]]>;
<![CDATA[Wan Ryan Asri]]>;
<![CDATA[Widia Purwaningrum]]>;
<![CDATA[Fahma Riyanti]]>;
<![CDATA[Novia Novia]]>;
<![CDATA[Roni Maryana]]>;
<![CDATA[Muhammad Al Muttaqii]]>
<![CDATA[ Molekul Vol 17 No 3 (2022) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2022.17.3.5925
<![CDATA[Coconut oil mill waste (CMW) contained high free fatty acid (FFA) content which potentially could be converted into a value-added product such as fatty acid methyl ester (FAME). In this study, a montmorillonite-sulfonated carbon catalyst was used to evaluate the kinetic parameter of FFA conversion from CMW into FAME. The characterization of FTIR and SEM-EDX confirmed that the -SO3H groups were successfully incorporated into montmorillonite- carbon catalyst. The highest catalyst acidity (9.4 mmol/g) was achieved by a ratio of montmorillonite to sulfonated carbon of 1:3 % w/w. The kinetic study using montmorillonite-sulfonated carbon 1:3 % w/w showed that the reaction temperature and molar ratio of methanol to FFA (% v/v) were positively correlated to the reaction rate. The highest rate constant of esterification towards the product (k1), reactant (k2), and equilibrium were 0.1187, 0.0595, and 1.995, achieved by a temperature of 80 ˚C, respectively. The Arrhenius constant and activation energy towards the product were 3.3085×106 and 50.3 J/mole, respectively. The reaction temperature was positively correlated to the equilibrium constant, which indicated that the reaction was endothermic. The kinetic model validation revealed that the predicted value from the model was adequately in accordance with the experimental value, as indicated by a high coefficient of determination.]]>
<![CDATA[Preparation of Atorvastatin Calcium-Dipicolinic Acid Multicomponent Solids by Liquid-Assisted Grinding Method to Increase Solubility ]]>
<![CDATA[Yudi Wicaksono]]>;
<![CDATA[Shafira Faradiba Tsaniyah]]>;
<![CDATA[Budipratiwi Wisudyaningsih]]>;
<![CDATA[Kuni Zu''aimah Barikah]]>;
<![CDATA[Lusia Oktora Ruma Kumala Sari]]>
<![CDATA[ Molekul Vol 17 No 3 (2022) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2022.17.3.5946
<![CDATA[Atorvastatin calcium is a cholesterol-lowering drug that is very potent but difficult to dissolve in water, so its bioavailability is low. In this study, atorvastatin calcium-dipicolinic acid multicomponent solids were prepared using the liquid-assisted grinding method to improve atorvastatin calcium's solubility. Characterization of multicomponent solids was carried out using powder x-ray diffraction (PXRD), differential scanning calorimetry (DSC), fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Solubility test was carried out by shaking method using distilled water media. The results showed that the particles of atorvastatin calcium - dipicolinic acid multicomponent solids had an irregular shape with rough and porous surface topography. The multicomponent solids have a diffractogram with specific peaks of 2θ at 8.8, 9.9, 11.5, 16.7, 19.1, 21.2, 22.4, 23.4, and 27.7°. The DSC thermogram of multicomponent solids showed a sharp endothermic peak at 181.9 °C (∆H=17.69 J/g), indicating its melting point. The FTIR spectra of atorvastatin calcium-dipicolinic acid multicomponent solids indicated an intermolecular interaction that was thought to be a hydrogen bond between the molecules of atorvastatin calcium and dipicolinic acid. The results of the solubility test showed that the atorvastatin calcium-dipicolinic acid multicomponent solids had a significantly increased solubility (p<0.05) compared to the solubility of pure atorvastatin calcium.]]>
<![CDATA[Synthesis Glycine-Modulated Metal Organic Framework Cr-PTC-Gly for Synergetic Methylene Blue Adsorption and Photodegradation under Visible Light Irradiation ]]>
<![CDATA[ Molekul Vol 17 No 3 (2022) ]]>
Publisher : <![CDATA[Universitas Jenderal Soedirman ]]>
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DOI: 10.20884/1.jm.2022.17.3.6126
<![CDATA[The glycine-modulated metal-organic framework (MOF) Cr-PTC-Gly was successfully synthesized for methylene blue elimination application. The Fourier Transform Infra-Red (FTIR) characterization showed the stretching vibration N-H at 2034 cm-1. The bands at 1506 and 1406 cm-1 are asymmetric and symmetric stretching vibrations (-COO) bound to Cr3+ ions and 3118 cm-1 of the hydroxyl (OH) functional group of H2O bound to the Cr3+ ion. The band gap energy of MOF Cr- PTC-Gly is 1.9 eV. The XRD analysis showed that MOF Cr-PTC-Gly has good crystallinity with a crystal size of 17.79 nm. MOF Cr-PTC-Gly with 50% glycine gave the most optimum elimination activity with an elimination capacity of 87.95 mg/gram via adsorption and photocatalytic degradation. The adsorption mechanisms were carried out via electrostatic interaction, hydrogen bonding, and π-π interaction. In contrast, photocatalytic degradation was carried out by forming free radical species with hydroxyl radicals (•OH) as a dominant species that contributed to the methylene blue degradation.]]>
