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VALENSI
Published by Universitas Islam Negeri Syarif Hidayatullah Jakarta
ISSN : 24606065     EISSN : 25483013     DOI : 10.15408/jkv
Core Subject : Science,
Chemistry
Jurnal Kimia Valensi is a biannual and peer-reviewed open access journal published by Department of Chemistry, Faculty of Science and Technology UIN Syarif Hidayatullah Jakarta. This journal covering all aspect of chemistry.
Arjuna Subject : Umum - Umum
Articles 328 Documents
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The Potency of Alkaloid Derivates as Anti-Breast Cancer Candidates: In Silico Study Sedin Renadi; Anindita Tri Kusuma Pratita; Richa Mardianingrum; Ruswanto Ruswanto
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 9, No. 1, May 2023
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v9i1.31481

Abstract

Breast cancer is the most frequent malignancy in women worldwide. One of the target receptors for the treatment of breast cancer are estrogen, progesterone, and HER2 receptors. An alternative treatment using natural ingredients has been developed, one of which is alkaloid compounds. This study aims to determine the activity of alkaloid compounds as anti-breast cancer agents through an in-silico method. Virtual screening (AutoDock Vina), molecular docking (AutoDock Tools), molecular dynamics (Desmond), scanning Lipinski's rule of five, as well as pharmacokinetic and toxicity parameters, were performed. The results of virtual screening, molecular docking, and molecular dynamics show that the compounds daurisoline, solasodine, and sambutoxin have stable interactions with the HER2 receptor, with the lowest values of RMSD (Root Mean Square Deviation) and RMSF (Root Mean Square Fluctuation) compared to other compounds. Based on the results of the study conducted, it was shown that daurisoline, solasodine, and sambutoxin were predicted to be used as anti-HER2 candidates for the treatment of breast cancer.
Synthesis of Iron Oxide (Fe2O3)-Xanthan Gum Nanoparticle Composites Its Potential as a Chemical Flooding Media in Enhanced Oil Recovery (EOR) Yong Richard Sriwijaya; Paramita Jaya Ratri; Tirta Rona Mayangsari; Azis Adharis; Shabrina Sri Riswati
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 9, No. 1, May 2023
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v9i1.29468

Abstract

Increasing oil consumption in Indonesia encourages an improvement of production using chemical flooding of Enhanced Oil Recovery (EOR) technology. Chemical flooding is an injection method of materials based on polymer and nanoparticles such as α-Fe2O3-xanthan gum nanocomposite into the reservoir. In this study, α-Fe2O3 nanoparticles were synthesised and then blended to xanthan gum by sonochemical method through an ex-situ process. The α-Fe2O3-xanthan gum nanocomposite X-ray diffraction (XRD) shows that there are no additional peaks. Only the α-Fe2O3 and the xanthan gum peaks are detected with the crystallite size of around 16-20 nm. The particle size of α-Fe2O3-xanthan gum (1:1) nanocomposite as measured by Particle Size Analyzer (PSA) was 228.43 nm with the type of polydisperse. The functional group of the nanocomposite is a combination of the α-Fe2O3 and xanthan gum functional groups which shows there are no other compounds detected in IR spectra. The EOR test showed that xanthan gum had a significant effect on increasing the viscosity of the α-Fe2O3-xanthan gum nanofluid to 1.964 cP at a 1:2 composition. Based on these results, α-Fe2O3-xanthan gum nanofluid is the potential material used in the chemical flooding process in the reservoir.
Screening and Optimization Consortium Technique of the Bacillus megatherium and Saccharomyces cerevisiae Microbial Consortium for Ethanol Detection Nurdiani Nurdiani; Dyah Iswantini; Novik Nurhidayat; Wulan Tri Wahyuni; Agus Kartono
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 9, No. 1, May 2023
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v9i1.31506

Abstract

Determination of alcohol content is very important in the food and beverage industry. Biosensor is an alternative to measuring ethanol content. Alcohol biosensors with a single microbe still have a narrow measurement area at ethanol concentrations, so a microbial consortium is needed to widen the range of measured ethanol concentrations. Therefore, it is necessary to screen the microbes from Bacillus sp and S. cerevisiae which have the potential to produce alcohol dehydrogenase (ADH) enzymes and optimize the consortium technique that can provide the best response to oxidation currents. In the yeast microbial screening of 14 S. cerevisiae isolates and 5 Bacillus sp isolates, it can be concluded that for the 14 yeast S. cerevisiae isolates that have the potential to produce ADH enzymes, there is one isolate with the SCRF code. For the 5 bacterial isolates of Bacillus sp that have the potential to produce ADH enzymes, all Bacillus isolates with the code Bacillus megatherium 29/9/14, Bacillus megatherium 23/6/22, Bacillus 6, Bacillus 53, and Bacillus 55. Based on the oxidation current data, Bacillus megatherium 23 /6/22 produces the highest current compared to other Bacillus isolates. The consortium technique that provides the highest current is the method of mixing 1:1 (µL) microbial suspension in an Eppendorf container. Optimization of the consortium's biofilms using the Response Surface Method was produced at 10 days of age, pH 7.5, and 75 µL of microbial suspension dripping volume.
Zeolite from Zirconium-Modified Fly Ash Waste for Absorption of Phosphate Compounds in Waters Mu'izzah Irsyadi Putri; Asep Saefumillah; Ridla Bakri
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 9, No. 1, May 2023
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v9i1.26951

Abstract

Eutrophication is a phenomenon of decreasing air quality caused by the very high amount of phosphate ions in the aquatic system. Thus, an effective and efficient adsorbent is needed for phosphate absorption in aquatic systems. In this study, zeolit from fly ash waste was modified with zirconium (Zr) as an adsorbent for phosphate absorption in aquatic systems. Fly ash was pretreated with acid and then synthesised using the hydrothermal method. And then, the results of the fly ash zeolit synthesis were continued using zirconium. The adsorption capacity was tested through several parameters, including the adsorbent concentration test, variations in pH,and contact time. Zirconium-modified zeolite (ZrMZ) adsorbent was the most effective adsorbent for phosphate adsorption, with an adsorption capacity of 3.015 mg-P/g at a 3 g/L adsorbent dosage and pH 7. The adsorption kinetics for the ZrMZ adsorbent followed pseudo-second-order kinetics. The best result of ZrMZ adsorbent to absorb phosphate in lake water was an adsorption capacity value of 0.186 mg-P/g and an adsorption efficiency of 81.137%.
The Potential of Nanocellulose Acetate as Surfactant for Water-Vegetable Oil Systems Ikhsan Ibrahim; Mia Ledyastuti
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 9, No. 1, May 2023
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v9i1.29467

Abstract

Indonesia, as an agricultural country, has a variety of abundant plants. Cellulose is a component in plants that can be modified to increase its economic value. Resizing cellulose to nanocellulose and modification of nanocellulose to nanocellulose acetate can increase its potential as a surfactant. Resizing cellulose can be done using the strong acid hydrolysis method. An acetic anhydride reagent was utilized to convert the surface hydroxyl functional group into acetyl. The successful production and modification of nanocellulose were confirmed using fourier transform infrared and particle size analysis characterization. The infrared absorption spectrum of cellulose and nanocellulose showed no difference in peaks. Particle size distribution showed that nanocellulose I (CNC I) and nanocellulose II (CNC II) has sizes of 142 nm and 319 nm, respectively. The property of nanocellulose molecules in an oil-water system was simulated using molecular dynamics with GROMACS 2020.6 software. Appropriate trends can be seen in the interfacial tension of water-vegetable oil systems. The value of interfacial tension decreases with the addition of nanocellulose acetate compared to the addition of nanocellulose. With the agreement between the experimental and computational results, nanocellulose acetate can act as a surfactant.
Structure Prediction and Ultrasonic Assisted Synthesis of Coordination Compound Cadmium (II) Bromide with N,N’-diethylthiourea Ligand Yuni Susanti; Fariati Fariati; Effendy Effendy; Yulyani Nur Azizah
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 9, No. 1, May 2023
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v9i1.30868

Abstract

Cadmium (II) halides with N,N'-diethylthiourea (detu) ligands at a stoichiometry of 1: 2 tend to form molecular complexes [Cd(detu)2X2] with a distorted tetrahedral geometry at the central atom. Generally, these complex compounds are prepared by the conventional method of reflux for 4 hour. The use of ultrasonic waves for complex synthesis can be an alternative to make the reaction time more efficient and environmentally friendly. The aim of this study was to synthesize and characterize complex compounds from CdBr2 and detu ligands using the ultrasonication method that have not previously reported. The synthesis of complex compounds was carried out by reacting CdBr2 and detu (1:2) in methanol solvent. In the synthesized compounds, a melting point test, electrical conductivity test, Fourier Transform Infrared (FTIR), Scanning Electron Microscope-Energy Dispersive Xray (SEM-EDX), qualitative test of bromide ion and calculation of free energy using Spartan'14 software were carried out for the complex structure prediction. The complex compound resulted has colorless needle crystals with a melting point of 93-94°C. The results of the EDX analysis provide the empirical formula C10H24CdBr2N4S2. The electrical conductivity test data and the bromide ion qualitative test proved that the synthesized complex compound was a molecular complex compound with the molecular formula [Cd(detu)2Br2]. The complex compound has two possible structures, namely a distorted tetrahedral and a square planar. Free energy calculations showed that complex compounds with a distorted tetrahedral structure and a square  planar have free energies of -527.5574 kJ/mol and -408.7424 kJ/mol, respectively.
Exploring The Potential of Mango Seed as A Bioadsorbent for Pb(II) Removal in Aqueous Solution Ahmad Zakaria; Aynuddin Aynuddin; Wittri Djasmasari
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 9, No. 1, May 2023
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v9i1.31733

Abstract

Various industrial activities produce heavy metals as by-products or wastes. Lead is a metal trace element from sewage disposal, vehicle fumes, and atmospheric emissions from industrial activities. Mango seeds are composed of cellulose, lignin, and hemicellulose, which have many potential binding groups. Mango seeds, which are often considered waste, can be utilized as a low-cost biosorbent due to their various functional groups, such as hydroxyl, carboxyl, carbonyl, alcohol, amide, and aromatic groups. Mango seed are organic waste with potential as low-cost biosorbent for heavy metals removal. The purposes of the study are: (1) to explore the optimum condition of biosorbent in absorbing heavy metal species (Pb (II)), and (2) to analyze the adsorption model of synthetic waste containing Pb(II). Mango seeds have a considerable potential to be used as a biosorbent to absorb heavy metal ions. The optimum conditions for Pb2+ ion adsorption is at pH 6 with contact time 70 minutes, and concentration of biosorbent 2.0 g/L. Adsorbate adsorption follows the Freundlich model, and adsorption occurs only in a few surface layers. The kinetic parameters of adsorbent satisfied pseudo-second-order reaction. The optimum adsorption capacity (qm) of mango seed biosorbent in absorbing Pb ions is 43.86 mg/g.
The Virtual Screening of Flavonoid Derivatives on Progesterone, Estrogen, and HER-2 Receptor for Breast Cancer Treatment Candidate Ade Dwi Septian; Gatut Ari Wardani; Richa Mardianingrum; Ruswanto Ruswanto
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 9, No. 1, May 2023
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v9i1.31482

Abstract

Cancer is defined as a disease caused by progressive and abnormal cell proliferation in the body. This condition is caused by deoxyribonucleic acid (DNA) changes, which causes cells to lose their normal function. The aim of this study is to find that flavonoid compounds have a more stable interaction than tamoxifen as anti-cancer candidates. Research has been conducted in silico with molecular docking (AutodockTools-1.5.7) and molecular dynamics of 200 flavonoid compounds. Furthermore, pharmacokinetic parameters, toxicity, and the application of the Lipinski Rule of Five were investigated. Based on molecular docking results, the compounds eriocotrin, glabrol, kaempferitrin, linarin, and narirutin have more stable interactions with lower binding energy (∆G) than tamoxifen. From the results of molecular docking, molecular dynamics, and pharmacokinetic studies, it is predicted that the kaempferitrin compound can be used as an anti-cancer candidate and does not cause toxicity through further research.

Page 33 of 33 | Total Record : 328

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