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Lembaga Penelitian dan Pengabdian Masyarakat (LPPM) Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Jl.Pajajaran No 1. Kelurahan Pamulang Barat, Kecamatan Pamulang, Kota Tangerang Selatan, Banten, 15417 No. Telp : (021) 7471628
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Pharmaceutical Science Journal
Published by Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang
ISSN : 28078535     EISSN : 29861993     DOI : 10.52031/Phrase
Core Subject : Health,
Medicine & Pharmacology
Pharmaceutical Science Journal is a periodical scientific journal published by Pharmacy Major in STIKes Widya Dharma Husada. Pharmaceutical Science Journal accepts scientific papers in the form of research reports (original article research papers), systematic review, and meta analysis with focus and scope: Pharmaceutical Technology Pharmacology and Toxicology Pharmaceutical Chemistry Pharmaceutical Biology Clinical and Community of Pharmacy Management of Pharmacy Biopharmaceutics Pharmaceutical Microbiology and Biotechnology Pharmacocinetics Alternative Medicines Cosmetic Technology
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 10 Documents
 1 
Search results for , issue "Vol 2, No 2 (2022): PHRASE (PHARMACEUTICAL SCIENCE) JOURNAL VOL 2 NO 2 (2022)" : 10 Documents clear
HUBUNGAN TINGKAT PENGETAHUAN TERHADAP PERILAKU SWAMEDIKASI OBAT ANALGESIK, MASYARAKAT RW 04 DESA TREMBULREJO BLORA PERIODE APRIL TAHUN 2021 Melizsa - Melizsa; Siti Novy Romlah; Istikholul Laiman
PHRASE (Pharmaceutical Science) Journal Vol 2, No 2 (2022): PHRASE (PHARMACEUTICAL SCIENCE) JOURNAL VOL 2 NO 2 (2022)
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v2i2.391

Abstract

Self-medication or self-medication is a community effort in dealing with complaints of illness. In practice, self- medication will cause drug-related problems, this is due to a lack of understanding about drugs and functions. The level of knowledge is one of the factors that facilitate proper self-medication behavior. Analgesics area a class of drugs to treat mild to severe pain. This study aims to determine the relationship between the level of knowledge on self-medication behavior of analgesic drugs in RW 04 Trembulrejo village. This research is an analytical survey research with cross sectional technique. Sampling used non-random sampling with purposive sampling technique. The sample used in this study was 163 respondents. The result of this study indicate that respondents have less knowledge of 11,04%, 72,40% of respondents are classified as good enough, and 16,56% are classified as good. Then the behavior of self-medication showed that 2,45% pf respondents had self-medication behavior classified as lacking, 67,49% of respondentswere classified as moderate, and29,45% were classified as good. Based on the Spearman rank correlation test, there was a significant correlation with the calculated r value of 0,516 and the p value of 0,000 which showed that there was a fairly strong and significant relationship between the level of knpwledge on self-medication behavior of analgesic drugs and the direction of the positive relationship.
REVIEW ARTIKEL: TINJAUAN AKTIVITAS FARMAKOLOGI KULIT BAWANG MERAH (Allium cepa aggregatum group) nurihardiyanti nurihardiyanti; Tania Rizki Amalia; Andriyani Rahmah Fahriati
PHRASE (Pharmaceutical Science) Journal Vol 2, No 2 (2022): PHRASE (PHARMACEUTICAL SCIENCE) JOURNAL VOL 2 NO 2 (2022)
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v2i2.413

Abstract

Herbal medicine is widely used and trusted by the community . and trusted by the public to treat various diseases.One of the plants that is often used is onion. Shallots are widely used or often consumed by the public as a kitchen spice, which is widely known by the public. In addition, red onion is often used by the community for alternative medicine because this plant is widely available in the community and is easy to obtain, only the skin is discarded because it is considered useless and is only used as waste. Shallot skin has many pharmacological activities, especially if it is in the form of an extract. The pharmacological activities of bay leaves include antibacterial, anti-inflammatory, antidiabetic, antioxidant, hepatoprotector and hyperuricemia. The content of onion skin is allicin, aliin, phenolic acid, flavonoids, quercetin, saponins, flavonoids, polyphenols, saponins, terpenoids and alkaloids, onion skin also contains various chemical compounds, namely proteins, minerals, sulfur anthocyanins, kaemferol, carbohydrates, and fiber. . In this review, primary data searches are conducted online, in the form of national and international journals, books and ebooks. The results obtained from several journals and other sources can be known various kinds of pharmacological activities of onion peel extract.
REVIEW ARTIKEL AKTIVITAS ANTIBAKTERI EKSTRAK RIMPANG KUNYIT (Curcuma domestica Val) TERHADAP BEBERAPA SAMPEL BAKTERI Sheila Meitania Utami; Diah Permata Sari; Nurwulan Adi Ismaya; Erwin Herdiawan
PHRASE (Pharmaceutical Science) Journal Vol 2, No 2 (2022): PHRASE (PHARMACEUTICAL SCIENCE) JOURNAL VOL 2 NO 2 (2022)
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v2i2.415

Abstract

The increase in antibiotic resistance is very fast throughout the world, this is a problem because it threatens human health globally. The increase in antibiotic resistance is due to overprescribing of antibiotics, as well as poor infection prevention and control. The use of traditional medicine can be used as an alternative treatment in overcoming health problems, prevention, and healing. Traditional medicine is considered safer than synthetic medicine, one of the plants that has antibacterial benefits is turmeric rhizome (Curcuma domestica Val). Turmeric rhizome has an antibacterial effect against gram negative and gram positive bacteria. This study aims to determine the antibacterial activity and active compounds contained in turmeric rhizome extract that can produce an antibacterial effect. The type of research used is descriptive using the Literature Review method by collecting various sources from 8 research journals that have been published and come from the internet. Turmeric rhizome extract is known to contain curcumin, alkaloids, flavonoids, essential oils, phenols, saponins, tannins, and terpenoids compounds that have antibacterial properties. The results of the literature review of the antibacterial activity test of turmeric rhizome extract showed that the antibacterial activity was classified as moderate to very strong against Escherichia coli (9 mm), Pseudomonas aeroginosa (7,8 mm), Bacillus cereus (11,1 mm), Salmonella typhi (12.1 mm), Staphylococcus aereus (10 mm), and Propionibacterium acnes (20.8 mm), while Bacillus subtilis (1.03 mm) was classified as weak.
GAMBARAN TINGKAT KEPATUHAN MINUM OBAT PADA PASIEN HIPERTENSI DI WILAYAH KERJA PUSKESMAS MUKA KABUPATEN CIANJUR PERIODE JANUARI – FEBRUARI 2022 Lia Zia Ulhaq; Usi Yusnitaswari; Gina Aulia; Tania Rizki Amalia; Amelia Nurul Hakim; Intan Tsamrotul Fu’adah; Sayyidah Sayyidah
PHRASE (Pharmaceutical Science) Journal Vol 2, No 2 (2022): PHRASE (PHARMACEUTICAL SCIENCE) JOURNAL VOL 2 NO 2 (2022)
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v2i2.414

Abstract

Kepatuhan minum obat merupakan penentu utama keberhasilan pengobatan. Ketidakpatuhan minum obat dapat menyebabkan perburukan penyakit, kematian, dan peningkatan biaya kesehatan. Di negara maju, tingkat kepatuhan minum obat jangka panjang pada populasi umum adalah sekitar 50%, sedangkan di negara berkembang, angka tersebut lebih rendah. Tujuan dari penelitian ini untuk mengetahui tingkat kepatuhan minum obat pada pasien hipertensi di wilayah kerja Puskesmas Muka Kabupaten Cianjur. Metode yang digunakan adalah metode deskriptif dengan menyebarkan kuesioner Morisky Medication Adherence Scale-8 (MMAS-8). Populasi yang digunakan dalam penelitian ini yaitu 64 responden pasien hipertensi yang memenuhi kriteria inklusi dan ekslusi. Berdasarkan hasil penelitian dapat disimpulkan bahwa tingkat kepatuhan penggunaan obat pada pasien hipertensi di wilayah kerja Puskesmas Muka Kabupaten Cianjur Periode Januari – Februari 2022 tergolong rendah, yaitu sebanyak 50,25%.
EVALUASI PENGGUNAAN OBAT PENYAKIT INFEKSI SALURAN PERNAFASAN AKUT (ISPA) PADA ANAK DI INSTALASI RAWAT INAP RSIA CITRA INSANI Humaira Fadhilah; Gina Aulia; Erika Suci Delia
PHRASE (Pharmaceutical Science) Journal Vol 2, No 2 (2022): PHRASE (PHARMACEUTICAL SCIENCE) JOURNAL VOL 2 NO 2 (2022)
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v2i2.416

Abstract

Acute Respiratory Infection (ARI) is a disease that many people suffer from, and is still a major health problem in Indonesia. ARI is a disease caused by various kinds of microorganisms and can cause infection. Deaths caused by infection are 2-6 times higher in developing countries. The purpose of this study was to determine the evaluation of the use of drugs for acute respiratory infections (ARI) in children at the Inpatient Installation of RSIA Citra Insani . This study used a descriptive design with retrospective data collection. The data used in this study were ARI medical record sheets in pediatric patients at the RSIA Citra Insani Inpatient Installation. This study used a total sampling technique and obtained 80 patients who met the inclusion criteria. Based on the results of the study, it was known that the characteristics of pediatric ARI patients based on age <5 years were 50 patients (62.50%), and based on gender, 45 patients (56.52%) were female. The use of ARI drugs based on the most common class was antipyretic as many as 78 (31.45%), and based on the type the most was paracetamol as many as 78  (31.45%). Evaluation of drug use on each criterion, namely the right indication (100%), the right drug (100%), the right dose (93.75%), and the right patient (100%).
UJI AKTIVITAS ANTIBAKTERI DARI EKSTRAK METANOL BUNGA MELATI (Jasminum sambac L.) TERHADAP Staphylococcus aureus DAN FORMULASI DALAM SEDIAAN GEL ANTI JERAWAT Tyssa Mariyana; Ratna Rosdiana
PHRASE (Pharmaceutical Science) Journal Vol 2, No 2 (2022): PHRASE (PHARMACEUTICAL SCIENCE) JOURNAL VOL 2 NO 2 (2022)
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v2i2.389

Abstract

ABSTRAKJerawat merupakan masalah kulit wajah yang paling sering dijumpai. Peradangan yang terjadi pada jerawat salah satunya dipicu oleh bakteri Staphylococcus aureus. Bunga melati (Jasminum sambac L.) memiliki kandungan minyak atsiri z-jasmon, nerol idol, metil salisilat, linalol, benzil alkohol, benzil asetat dan indol, serta kandungan metabolit sekunder lainnya yang memperlihatkan daya mencegah pertumbuhan bakteri. Pada penelitian ini bunga melati diekstraksi dengan menggunakan pelarut metanol. Aktivitas antibakteri diuji dengan menggunakan metode difusi sumur dengan konsentrasi ekstrak 5, 10, dan 15 %. Gel dibuat dengan mencampurkan 5% konsentrasi ekstrak dengan 2% karbomer 934 sebagai gelling agent. Evaluasi fisik sediaan gel meliputi organoleptis, uji pH, viskositas, daya sebar dan homogenitas. Data hasil pengukuran diameter zona hambat dan data hasil uji daya sebar dianalisis dengan metode One Way Anova. Hasil pengukuran diameter zona hambat menunjukkan bahwa ekstrak metanol bunga melati dengan konsentrasi 5, 10 dan 15% memiliki daya antibakteri yang lemah. Hasil evaluasi fisik gel menunjukkan organoleptis dan homogenitas yang baik, namun belum memenuhi persyaratan pH, viskositas dan daya sebar. Hasil analisis Anova menunjukkan bahwa tidak ada perbedaan yang bermakna pada daya antibakteri ekstrak metanol bunga melati dengan konsentrasi 5, 10 dan 15 % , ketiga konsentrasi tersebut memiliki daya antibakteri lemah.
GAMBARAN PERESEPAN OBAT PADA PASIEN COVID-19 DI APOTEK BERKAT CILEDUG PERIODE DESEMBER 2021- FEBRUARI 2022 Anis Dwi Kristiyowati; Nurhasanah Nurhasanah; Sunny Koswara R
PHRASE (Pharmaceutical Science) Journal Vol 2, No 2 (2022): PHRASE (PHARMACEUTICAL SCIENCE) JOURNAL VOL 2 NO 2 (2022)
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v2i2.362

Abstract

COVID-19 merupakan virus SARS COV-2 keluarga besar dari coronavirus, dalam perkembangannya virus ini menyebabkan penyakit infeksi saluran pernapasan seperti Flu, MERS ( Midlle Respiratory Syndrome ), dan SARS ( Serverse Acute Respiratory Syndrome ). Gejala umum pada pasien terindikasi infeksi COVID-19 antara lain gangguan pernapasan akut seperti demam, batuk dan sesak napas, pada kasus COVID-19 yang berat dapat menyebabkan pneumonia, sindrom pernapasan akut, gagal ginjal, dan kematian. Penelitian ini bertujuan untuk mengetahui gambaran peresepan obat pada pasien COVID-19 di Apotek Berkat Ciledug periode Desember 2021 - Februari 2022 berdasarkan usia pasien, jenis kelamin, golongan obat, jenis obat dan jumlah obat. Penelitian ini merupakan penelitian Deskriptif dengan data Retrospektif, data diperoleh dari resep pasien terkonfirmasi COVID-19 menggunakan metode Purposive Sampling, lalu disajikan dalam bentuk presentase dan tabel. Hasil penelitian menunjukkan resep pasien terkonfirmasi COVID-19 didominasi rentang usia 26 - 45 tahun sebanyak 39 pasien (40,6%) dan jumlah pasien laki-laki lebih banyak dibandingkan perempuan sebanyak 59 pasien (61,5%). Berdasarkan golongan obat paling banyak yaitu golongan Antiviral sebanyak 93 resep pasien (34,4%), denga jenis obat paling banyak yaitu obat Favipiravir 200 mg sebanyak 57 resep pasien (21,1%) dengan jenis terapi terbanyak yaitu monoterapi atau obat tunggal dengan jenis obat Fapivirapir 200 mg (29,1%).
FORMULASI SEDIAAN MIKROEMULSI TRANSDERMAL PIROKSIKAM DENGAN MENGGUNAKAN VIRGIN COCONUT OIL (VCO) SEBAGAI FASE MINYAK Yola Desnera Putri; Haruman Kartamihadrja; Lusi Fauziah
PHRASE (Pharmaceutical Science) Journal Vol 2, No 2 (2022): PHRASE (PHARMACEUTICAL SCIENCE) JOURNAL VOL 2 NO 2 (2022)
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v2i2.399

Abstract

Piroxicam is a non-steroidal anti-inflammatory drug thus in the oral dosage of piroxicam often can irritate the stomach, thus piroxicam was made be of a transdermal microemulsion  preparation. The research was conducted in the preparation of transdermal piroxicam microemulsions by used Virgin Coconut Oil (VCO) as oil phase and tween 80 as a surfactant. The formula was varied into 5 formulas with distinguished tween 80 concentrations of 40%, 45%, 50%, 55%, 60% and propylene glycol as cosurfactants with 15% concentration, and emulsion preparations without the addition of propylene glycol as cosurfactants. This study aimsed to created a stable and transparent physically microemulsion preparation and determined piroxicam the ratio of diffusion rate in piroxicam microemulsions and  piroxicam emulsions. The test was performed by using Franz diffusion test by using Whatman membrane. In the microemulsion formula, the percentage of diffused piroxicam content obtained was greatest at F5 (24.35%) at 180 minutes and compared to emulsion (2,66%). The diffusion test resultsed show that the effect of addition of cosurfactant at the diffusion rate of the microemulsion preparation is compared to the emulsion preparation without the addition of cosurfactant. This cosurfactant can help surfactants to penetrate skin membranes.
EVALUASI PENGGUNAAN OBAT ANTIHIPERTENSI PADA PASIEN HIPERTENSI RAWAT INAP DI RUMAH SAKIT HERMINA SERPONG TAHUN 2019 Suny Koswara Rahajeng; Setianti Haryani; Anis Dwi Kristiowati; Rachma Fitriana
PHRASE (Pharmaceutical Science) Journal Vol 2, No 2 (2022): PHRASE (PHARMACEUTICAL SCIENCE) JOURNAL VOL 2 NO 2 (2022)
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v2i2.390

Abstract

The study aims to evaluate the use of antihypertensive drugs which include patient accuracy, indications, drugs, and doses in inpatients with hypertensive patients from January to December at Hermina Hospital in 2019 based on JNC 8 guidelines. This study is a descriptive study with retrospective data collection based on medical records. The sampling technique used is the total sampling technique. The results obtained from 78 samples based on patient characteristics for gender were 43 female patients (55,13%) and 35 male patients (44,87%). Characteristics of patients based on age obtained the most at the age of 45-≥65 years as many as 64 patients (82,05%). Characteristics of patients based on the pattern of drug use, the most widely used antihypertensive drug therapy was combination of ACEI + CCB as many as 47 patients (60, 26%). Evaluation of the use of antihypertensive drugs was obtained based on the right patient as many as 78 patients (100%), the right indication as many as 78 patients (100%), the right drug as many as 69 patients (88.46%), and the right dose as many as 69 patients (88.46% ). 
TINGKAT KEPATUHAN PASIEN TUBERKULOSIS PARU PADA PENGGUNAAN OBAT ANTI TUBERKULOSIS DI PUSKESMAS CIPAYUNG KOTA DEPOK Agung Dewantoro; Aulia Nadya Rizki Imansari; Ahmad Fadhila
PHRASE (Pharmaceutical Science) Journal Vol 2, No 2 (2022): PHRASE (PHARMACEUTICAL SCIENCE) JOURNAL VOL 2 NO 2 (2022)
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v2i2.400

Abstract

Tuberculosis is a contagious infectious disease caused by Mycobacterium tuberculosis, which can attack the lungs and other organs. Transmission occurs when a person inhales droplet nuclei that enter through the mouth or nose, upper respiratory tract and bronchi until they reach the lungs. One of the determinants of success in the treatment of pulmonary TB is that the patient must improve compliance in taking anti-tuberculosis drugs obediently and regularly until complete. There are several factors that influence the level of adherence to the use of anti-tuberculosis drugs in patients with pulmonary TB, namely motivation, family support, supervision from PMO, education level and occupation. This study aims to determine the level of adherence to the use of anti-tuberculosis drugs in pulmonary TB patients at the Cipayung Health Center. The type of research used is descriptive by using the total sampling method and the sample used is 28 respondents. Data were collected using a validated questionnaire based on the MMAS-8 (Morisky Medication Adherence Scale). The results of this study were (57%) male samples, (36%) were early adults between 26-35 years old, (57%) had high school education, (53.5%) worked as private employees. And the results obtained (82%) have a high level of compliance, (14%) have a moderate level of compliance, and (4%) have a low level of compliance. The conclusion from the level of adherence to the use of anti-tuberculosis drugs in pulmonary TB patients at the Cipayung Health Center with a value (82%) has a high level of adherence as many as 23 respondents.

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