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Bencoolen Journal of Pharmacy
Published by Universitas Bengkulu
ISSN : -     EISSN : 28085663     DOI : 10.33369/bjp.v4i1.34258
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Bencoolen Journal of Pharmacy accepts original research papers in the field of Pharmacy and Health. The field of Pharmacy includes Science Pharmacy, Clinical Pharmacy and Community. In the field of pharmaceutical science, the research articles received include Pharmaceutical Biology and Pharmacognosy, Pharmaceutical Chemistry, Pharmacy, Pharmacology and Toxicology, and also Biotechnology. The Community and Clinical Pharmacy areas include Hospital Pharmacy, Clinical Pharmacy, Pharmacy Management, and Social Pharmacy. In the field of Health, it includes Public Health, Nutrition, Biomedicine, Biotechnology, Biochemistry, Epidemiology and Nursing.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 6 Documents
 1 
Search results for , issue "Vol. 2 No. 2 (2022): Oktober" : 6 Documents clear
SGOT/SGPT levels in blood serum on rats (Rattus norvegicus) that CCl4 induced then its treatment by ethanol extract of Curcuma xanthorrhiza rhizome as hepatoprotector Hamida Nurlaila; Aulanni’am AULANNI’AM; Fahmi Dimas Abdul Azis; Sasangka PRASETYAWAN
BENCOOLEN JOURNAL OF PHARMACY Vol. 2 No. 2 (2022): Oktober
Publisher : UNIB PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/bjp.v2i2.24343

Abstract

CCl4 is a xenobiotic compound that could be entered into body by digestion and ingestion system. It trigger to produce ROS until lipid peroxydation which can increase SGOT/SGPT levels on blood serum. Both SGOT and SGPT are transaminase enzymes that activated on blood serum and they were produced in hepatocyte. If there are radicals in hepatocyte as final product of lipid peroxydation, then they are exit from cytoplasm on hepatocyte to intravenous so theirs levels is increase in blood. Producing of radicals from ROS in lipid peroxydation can be scavenged by antioxidant compounds on ethanol extract of Curcuma xanthorrhiza rhizome. This research are aimed to determine of SGOT/SGPT levels on blood serum in each of groups. This research used male rats that divided into five groups, that were negative control (A group), positive control (CCl4 10% induced (B group)) and therapy groups (200, 400, and 800 mg/kg BW of Curcuma xanthorrhiza rhizome ethanol extracts (C, D, E groups respectively)). SGOT/SGPT levels was analyzed, its result was 165/92, 264/141, 161/64, 130/59 and 135/55 U/L respectively. Based on the Tukey’s HSD test (p = 0.1), SGOT/SGPT levels in positive control was significance different (p < 0.1) to negative control, but theirs levels in 400 and 800 mg/kg BW of Curcuma xanthorrhiza rhizome ethanol extract therapy groups were not significance different (p > 0.1) to negative control. Thereby, 400 and 800 mg/kg BW of Curcuma xanthorrhiza rhizome ethanol extracts was more effective as hepatoprotector which known from decreasing of SGOT/SGPT levels.
Spatial Distribution of COVID-19 Related to the Potential for Spreading Outbreaks and Vulnerability of a Region in Bengkulu Province on 2020 Naurah Shafa Putri Cahyangi; Dessy Triana; Liya Agustin Umar; Nikki Aldi Massardi; Utari Hartati Suryani; Riry Ambarsari
BENCOOLEN JOURNAL OF PHARMACY Vol. 2 No. 2 (2022): Oktober
Publisher : UNIB PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/bjp.v2i2.24359

Abstract

Coronavirus disease 2019 (COVID-19) was declared a pandemic on March 11, 2020, by the World Health Organization (WHO). The spread of COVID-19 increases with different conditions and situations in each region. Spatial distribution plays a role in identifying the vulnerability of an area. This study aimed to determine the differences in COVID-19 cases from one area to another in 10 regions in Bengkulu Province in 2020. This study is a descriptive study with an observational study through a cross-sectional approach using an epidemiological investigation form as a data source. Sampling was carried out from July to December 2020 and obtained from 3044 respondents who met the inclusion criteria. The total sampling technique did sampling. The relationship between the population density of an area and the severity of COVID-19 cases was statistically analyzed using the Spearman rank test. The results showed that areas with higher density levels, such as Bengkulu City, caused a wider spread of cases, causing the number of COVID-19 cases to increase compared to other areas with lower population densities in Bengkulu Province. There is no significant relationship between population density and the severity of COVID-19
Testing the Effectiveness of Anti-Mosque Lotion from the Formulation of Male Breadfruit (Artocarpus altilis) and Lemon (Cymbopogon citratus) Flower Extract Nurasia; Ilmiati Illing; Riska Nurhayati
BENCOOLEN JOURNAL OF PHARMACY Vol. 2 No. 2 (2022): Oktober
Publisher : UNIB PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/bjp.v2i2.24360

Abstract

This study aims to compare the concentration of extracts of male Breadfruit and Lemongrass stalks which are effective as mosquito repellent lotions. Male Breadfruit (Artocarpus altilis) and Lemongrass (Cymbopogon citratus) stems can be used as natural mosquito repellents because they contain active ingredients (compounds) that do not liked by mosquitoes. The research method used in this study includes sample preparation, maceration using 96% ethanol, the distillation process to separate the filtrate and residue, making lotion formulations using the oil phase and water phase with different sample concentrations, then carried out three stages of testing, namely organoleptic test. , pH test and effectiveness test to determine the effectiveness of the male flower repellent lotion of Breadfruit (Artocarpus altilis) and Lemongrass (Cymbopogon citratus) stems. The results obtained showed that the effective concentrations used as mosquito repellent lotions for male Breadfruit (Artocarpus altilis) and Serai (Cymbopogon citratus) flowers were 15 mL and 20 mL of male flower extract of Breadfruit and Serai stems.
Cloning and Characterization of Gene Encoding Thermostable Enzyme from Domas Crater Siti Julia Asyifa; Akhmaloka; Suharti
BENCOOLEN JOURNAL OF PHARMACY Vol. 2 No. 2 (2022): Oktober
Publisher : UNIB PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/bjp.v2i2.24361

Abstract

This research has been carried out an analysis of the gene encoding thermostable enzymes from natural samples of Domas Crater by using a metagenomic approach. The purpose of this study was to identify the gene encoded thermostable enzyme from natural samples of the Domas Crater. In this study, genes were amplified through random PCR technique from a collection of community DNA that had been isolated previously using a metagenomic approach. Random PCR of total community DNA produced DNA fragments with a size of about 1 kb, and then ligated to the pJET1.2/blunt vector and inserted into E. coli TOP10 for cloning process. The recombinant plasmid was then analysed using restriction enzymes BamHI and EcoRI to confirm the presence of the gene inserted in the cloning vector. Homology analysis of the DNA sequences of the cloned genes showed five groups of proteins that were similar to the ABC Transporter permease protein from archaea with an identity of about 76 – 96%. The grouping of these proteins is shown by the constructed phylogenetic tree.
The Correlation Between Adult Age Factors toward The Clinical Manifestation and The Severity Level of COVID-19 in Bengkulu Province in 2020 Begumratu VOCA; Dia Triyani Putri; Dessy Triana; Riry Ambarsari; Nikki Aldi Massardi; Utari Hartati Suryani
BENCOOLEN JOURNAL OF PHARMACY Vol. 2 No. 2 (2022): Oktober
Publisher : UNIB PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/bjp.v2i2.24362

Abstract

Coronavirus Disease-19 (COVID-19) is an acute respiratory disease in Wuhan, China, and was discovered discovered in 2019. The things that need to be considered in COVID-19 patients include their clinical manifestation and the severity level of COVID-19. The severity level of COVID-19 patients is associated with age. Each age has a different proportion of severity. The study aimed to determine the correlations among adult age with clinical manifestation and severity of COVID-19 in Bengkulu Province 2020. This study used an observational analytic study. The sample was 108 patients 19 - ≥65 years old and confirmed positive for COVID-19 in 2020. The assessment used the epidemiological investigation form and medical record from Dr. M.Yunus Hospital. At the same time, the severity level of COVID-19 was obtained from the measurement based on the COVID-19 Prevention and Control Guidelines by the Indonesian Ministry of Health. The results showed that the subjects in 19 – 23 years old mostly have asymptomatic severity, 24 – 64 years old mostly have mild severity, and ≥65 years old have moderate severity. It was concluded that there was a significant correlation between the severity of COVID-19 in Bengkulu Province in 2020.
The correlation between Children’s Age Factors toward the clinical manifestation and the severity level of COVID-19 in Bengkulu Province in 2020 Dia Triyani Putri; Begumratu VOCA; Diah Ayu Aguspa Dita; Dessy Triana; Riry Ambarsari; Utari Hartati Suryani
BENCOOLEN JOURNAL OF PHARMACY Vol. 2 No. 2 (2022): Oktober
Publisher : UNIB PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/bjp.v2i2.24363

Abstract

Coronavirus Disease 2019 (COVID-19) is a disease that can infect people of all ages. Symptoms can range from asymptomatic to severe in certain age groups. It can occur due to differences in the innate immune response, comorbidities and the function, distribution, maturation of the SARS-CoV-2 receptor. This study aimed to determine the correlation between children’s age factors toward the clinical manifestation and the severity level of COVID-19 in Bengkulu Province in 2020. An observational analytic study with cross-sectional design was used in this study. This study included 86 children aged 0-18 years old who were confirmed positive for COVID-19 and lived in Bengkulu Province from March to December 2020. The clinical manifestation was assessed using the COVID-19 epidemiological investigation form and medical records from M.Yunus Hospital. The degree of severity is determined using Ministry of Health of Indonesia’s Guidelines for COVID-19 Prevention and Control. The result showed that of the majority of children aged 0-1 years old, 5-11 years old, and 12-18 years old have asymptomatic severity illness. While children are between the ages of two and four, the majority of their illnesses are of a mild severity. There was no significant correlation between children age factors and the severity of COVID-19 in Bengkulu Province in 2020.

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