cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Armeida Dwi Ridhowati Madjid
Contact Email
armeida@uin-malang.ac.id
Phone
+6281233402334
Journal Mail Official
alchemy@uin-malang.ac.id
Editorial Address
Fakultas Sains dan Teknologi Universitas Islam Negeri (UIN) Maulana Malik Ibrahim Malang Gedung BJ Habibie Lt 2 Jl. Gajayana 50 Malang 65144 Indonesia
Location
Kota malang,
Jawa timur
INDONESIA
Alchemy : Journal of Chemistry
Published by Universitas Islam Negeri Maulana Malik Ibrahim Malang
ISSN : 20861710     EISSN : 24606871     DOI : http://dx.doi.org/10.18860/al
Core Subject : Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Materials Science & Nanotechnology
ALCHEMY: Journal of Chemistry (eISSN 2460-6871) is a scientific journal that focus on chemistry. This journal publishes a scientific article that cover research and review articles. Research topics for this journal such as natural science, physical chemistry, inorganic chemistry, organic chemistry, environment, biochemistry, marine, energy and other related-sciences. ALCHEMY: Journal of Chemistry also accepts article about halal products and chemistry on Islamic perspectives.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 7 Documents
 1 
Search results for , issue "Vol 8, No 1 (2020): ALCHEMY: Journal of Chemistry" : 7 Documents clear
Analisis Kuat Tarik dan Elongasi Film Gelatin – Khitosan Abdul Wafi; Lukman Atmaja; Yatim Lailun Ni’mah
ALCHEMY:Journal of Chemistry Vol 8, No 1 (2020): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (590.944 KB) | DOI: 10.18860/al.v8i1.9097

Abstract

Gelatin and chitosan have been widely used in various industries such as pharmaceuticals, textiles, cosmetics, food processings, and others. Gelatin has different mechanical properties compared to chitosan, especially its tensile strength and elongation. In this study, gelatin (Ge) was obtained commercially, while chitosan (Ch) was obtained from the skin of windu shrimp via deproteination, demineralization, and deacetylation of chitin into chitosan. The results of this study indicated that the degree of deacetylation of chitosan was 52.06%. Afterward, various films including Ge, Ch, Ge 4%-Ch 1.5%, Ge 4%-Ch 3%, Ge 4%-Ch 4% were prepared by the casting method. The film of Ge 4%-Ch 4% exhibited the best tensile strength and elongation with values of 0.6 MPa and 21.53%, respectively. Gelatin dan kitosan merupakan biopolimer alam yang selama ini banyak digunakan di berbagai industri seperti farmasi, tekstil, kosmetik, pengolahan pangan dan lain sebagainya. Gelatin memiliki sifat mekanik yang berbeda dibandingkan dengan kitosan terutama kuat tarik dan elongasinya. Pada penelitian ini, gelatin (Ge) diperoleh secara komersial, sedangkan kitosan (Ch) diperoleh dari kulit udang windu melalui proses deproteinasi, demineralisasi, dan deasetilasi kitin menjadi kitosan. Hasil penelitian ini menunjukkan derajat deasetilasi kitosan sebesar 52,06%.  Selanjutnya, dilakukan proses pembuatan film Ge, Ch, Ge 4%-Ch 1,5%; Ge 4%-Ch 3%, Ge 4%-Ch 4% dengan menggunakan metode casting. Film Ge 4%-Ch 4% memiliki kuat tarik dan elongasi yang paling baik yaitu 0,6 MPa dan 21,53%, berturut-turut. 
Profil FTIR Minyak Ikan dan Lemak Babi serta Perbandingannya sebagai Dasar Penentuan Autentifikasi Halal Dewi Sinta Megawati; Begum Fauziyah; Siti Maimunah; Abdul Wafi
ALCHEMY:Journal of Chemistry Vol 8, No 1 (2020): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (592.043 KB) | DOI: 10.18860/al.v8i1.9818

Abstract

Research has been conducted on the determination of tuna oil and lard spectra using FTIR. This research aims to determine the IR spectra profile of lard and tuna oil and to compare both spectra profiles. Profile and comparison of lard and tuna oil IR spectra useful to determine whether an ingredient or a product contaminated with lard. The fatty acid profile of lard by FTIR analysis showed a significant difference in the absorption patterns of the spectra, especially at 3010-3000, 1680- 1600, and 968-966 cm-1 wavenumbers which represented the different composition and type of fatty acids in the lard and tuna oil. The absorption patterns at 3007 and 1653 cm-1 regions (double bond C=C cis) for tuna oil showed relatively high peaks if it is compared to lard samples because of the percentage of MUFA fatty acids (oleic acid) in tuna oil was much higher.  Telah dilakukan penelitian mengenai penentuan spektra minyak ikan tuna dan lemak babi dengan menggunakan FTIR. Penelitian ini bertujuan untuk mengetahui profil spektra IR dari lemak babi dan minyak ikan tuna serta membandingkan kedua profil spektranya. Profil dan perbandingan spektra IR lemak babi dan minyak ikan tuna dapat digunakan sebagai dasar penentuan apakah suatu bahan atau produk terkontaminasi lemak babi. Profil asam lemak babi hasil analisis FTIR menunjukkan adanya perbedaan yang cukup signifikan pada pola-pola penyerapan spektra, khususnya pada bilangan gelombang 3010-3000, 1680-1600 dan 968-966 cm-1 yang merepresentasikan perbedaan komposisi dan jenis asam lemak pada sampel lemak babi dan minyak ikan tuna. Pola serapan pada bilangan gelombang 3007 dan 1653 cm-1 (ikatan rangkap C=C cis) untuk sampel minyak ikan tuna menunjukkan puncak yang relatif tinggi jika dibandingkan dengan sampel lemak babi karena persentase asam lemak MUFA (asam oleat) pada minyak ikan tuna jauh lebih tinggi. 
Potential Use of Compounds from Neem Leaves (Azadirachta indica Juss) as PPARg and ERa Inhibitors to Control Breast Cancer Cell Growth In Silico Model Supriyanto Supriyanto; Muhaimin Rifa'i; Yunianta Yunianta; Simon Bambang Widjanarko
ALCHEMY:Journal of Chemistry Vol 8, No 1 (2020): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (430.121 KB) | DOI: 10.18860/al.v8i1.9863

Abstract

Treatment using herbs is currently growing rapidly. Compounds in herbal plants can cure various degenerative diseases. The study aims to analyze the potency of nimbin, deacetylnimbin, salanin, and deacetylsalanin compounds in the neem leaves extract to inhibit target proteins namely PPARg and ERa. PPARg is the main regulator of the function of adipose tissue microvascular endothelial cells (aMVECs) while ERa is a protein that mediates all estrogen effects and it is important in the growth of prostate and breast cancer. Inhibition of ERa can prevent the proliferation and growth of breast cancer cells by affecting the performance of estrogen which binds to hormonal receptors and causes inhibition of breast cancer cell proliferation. The results of in silico analysis show that deacetylnimbin can inhibit ERa protein. The docking analysis shows that deacetylnimbin has the potential to replace tamoxifen as a breast cancer drug. The other studies such in vitro and in vivo are needed to validate in silico study.
Potential Use of Compounds from Neem Leaves (Azadirachta indica Juss) as PPARg and ERa Inhibitors to Control Breast Cancer Cell Growth In Silico Model Supriyanto, Supriyanto; Rifa'i, Muhaimin; Yunianta, Yunianta; Widjanarko, Simon Bambang
ALCHEMY Vol 8, No 1 (2020): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (430.121 KB) | DOI: 10.18860/al.v8i1.9863

Abstract

Treatment using herbs is currently growing rapidly. Compounds in herbal plants can cure various degenerative diseases. The study aims to analyze the potency of nimbin, deacetylnimbin, salanin, and deacetylsalanin compounds in the neem leaves extract to inhibit target proteins namely PPARg and ERa. PPARg is the main regulator of the function of adipose tissue microvascular endothelial cells (aMVECs) while ERa is a protein that mediates all estrogen effects and it is important in the growth of prostate and breast cancer. Inhibition of ERa can prevent the proliferation and growth of breast cancer cells by affecting the performance of estrogen which binds to hormonal receptors and causes inhibition of breast cancer cell proliferation. The results of in silico analysis show that deacetylnimbin can inhibit ERa protein. The docking analysis shows that deacetylnimbin has the potential to replace tamoxifen as a breast cancer drug. The other studies such in vitro and in vivo are needed to validate in silico study.
Aktivitas Antioksidan Isolat Steroid Hasil Kromatografi Lapis Tipis dari Fraksi n-Heksana Hydrilla verticillata Ahmad Ghanaim Fasya; Bagas Purwantoro; Lulu'atul Hamidatu Ulya; Mujahidin Ahmad
ALCHEMY:Journal of Chemistry Vol 8, No 1 (2020): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (732.05 KB) | DOI: 10.18860/al.v8i1.9936

Abstract

 Hydrilla verticillata is one of Allah SWT creations that potential as an antioxidant. This study’s objectives were to determine antioxidant activity and identify steroid isolates of n-hexane fraction of H. verticillata. The steroid compounds were extracted using methanol solvent. The methanol extract was hydrolyzed with HCl 2 N and partitioned using n-hexane. The n-hexane fraction was tested phytochemically and separated using thin-layer chromatography (TLC). The steroids compounds were identified using UV-Vis spectrophotometer, FTIR, and LC-MS/MS. The result showed that maceration extraction produced 5.14% yield, whereas n-hexane fraction produce 47.95% yield. Steroid separation through analytical TLC revealed that n-hexane: ethyl acetate (4:1) as the best eluant with 12 spots, while separation using preparative TLC yielded 19 spots. Steroid isolate from TLC preparative has antioxidant activity with EC50 of 5.109 ppm. Identification of steroid compounds using UV-Vis produced maximum wavelengths at 203.9 and 276 nm, while using FTIR indicated the presence of O-H group, geminal dimethyl, C=O, C=C, secondary C-OH, and =C-H (alkene) which might contain steroid compounds. The result of LC-MS/MS showed the presence of β-sitosterol. Hydrilla verticillata merupakan salah satu ciptaan Allah SWT yang memiliki potensi sebagai antioksidan. Penelitian ini bertujuan mengetahui aktivitas antioksidan dan mengidentifikasi senyawa steroid pada isolat hasil pemisahan fraksi n-heksana H. verticillata. Senyawa steroid diekstraksi menggunakan pelarut metanol. Ekstrak pekat metanol dihidrolisis dengan HCl 2 N dan dipartisi dengan n-heksana. Fraksi n-heksana hasil partisi diuji fitokimia dan dipisahkan senyawanya menggunakan KLT (Kromatografi Lapis Tipis). Identifikasi dilakukan menggunakan UV-Vis, FTIR, dan LC-MS/MS. Hasil penelitian menunjukkan ekstraksi maserasi menghasilkan rendemen 5,14%, sedangkan rendemen partisi n-heksana sebesar 47,95%. Pemisahan steroid menggunakan KLT analitik menunjukkan bahwa variasi eluen terbaik adalah n-heksana: etil asetat (4:1) dengan 12 noda, sedangkan pemisahan KLT preparatif menghasilkan 19 noda. Isolat steroid hasil KLT preparatif memiliki aktivitas antioksidan dengan EC50 5,109 ppm. Identifikasi senyawa steroid menggunakan UV-Vis menunjukkan bahwa panjang gelombang maksimum sebesar 203,9 dan 276 nm, sedangkan untuk identifikasi isolat steroid menggunakan FTIR menunjukkan gugus fungsi O-H, geminal dimetil, C=O, C=C, C-OH sekunder dan =C-H (alkena) yang diduga merupakan senyawa steroid. Hasil LC-MS/MS menunjukkan adanya senyawa steroid β-sitosterol.   
Aktivitas Antioksidan Isolat Steroid Hasil Kromatografi Lapis Tipis dari Fraksi n-Heksana Hydrilla verticillata Fasya, Ahmad Ghanaim; Purwantoro, Bagas; Ulya, Lulu'atul Hamidatu; Ahmad, Mujahidin
ALCHEMY Vol 8, No 1 (2020): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (732.05 KB) | DOI: 10.18860/al.v8i1.9936

Abstract

 Hydrilla verticillata is one of Allah SWT creations that potential as an antioxidant. This study’s objectives were to determine antioxidant activity and identify steroid isolates of n-hexane fraction of H. verticillata. The steroid compounds were extracted using methanol solvent. The methanol extract was hydrolyzed with HCl 2 N and partitioned using n-hexane. The n-hexane fraction was tested phytochemically and separated using thin-layer chromatography (TLC). The steroids compounds were identified using UV-Vis spectrophotometer, FTIR, and LC-MS/MS. The result showed that maceration extraction produced 5.14% yield, whereas n-hexane fraction produce 47.95% yield. Steroid separation through analytical TLC revealed that n-hexane: ethyl acetate (4:1) as the best eluant with 12 spots, while separation using preparative TLC yielded 19 spots. Steroid isolate from TLC preparative has antioxidant activity with EC50 of 5.109 ppm. Identification of steroid compounds using UV-Vis produced maximum wavelengths at 203.9 and 276 nm, while using FTIR indicated the presence of O-H group, geminal dimethyl, C=O, C=C, secondary C-OH, and =C-H (alkene) which might contain steroid compounds. The result of LC-MS/MS showed the presence of β-sitosterol. Hydrilla verticillata merupakan salah satu ciptaan Allah SWT yang memiliki potensi sebagai antioksidan. Penelitian ini bertujuan mengetahui aktivitas antioksidan dan mengidentifikasi senyawa steroid pada isolat hasil pemisahan fraksi n-heksana H. verticillata. Senyawa steroid diekstraksi menggunakan pelarut metanol. Ekstrak pekat metanol dihidrolisis dengan HCl 2 N dan dipartisi dengan n-heksana. Fraksi n-heksana hasil partisi diuji fitokimia dan dipisahkan senyawanya menggunakan KLT (Kromatografi Lapis Tipis). Identifikasi dilakukan menggunakan UV-Vis, FTIR, dan LC-MS/MS. Hasil penelitian menunjukkan ekstraksi maserasi menghasilkan rendemen 5,14%, sedangkan rendemen partisi n-heksana sebesar 47,95%. Pemisahan steroid menggunakan KLT analitik menunjukkan bahwa variasi eluen terbaik adalah n-heksana: etil asetat (4:1) dengan 12 noda, sedangkan pemisahan KLT preparatif menghasilkan 19 noda. Isolat steroid hasil KLT preparatif memiliki aktivitas antioksidan dengan EC50 5,109 ppm. Identifikasi senyawa steroid menggunakan UV-Vis menunjukkan bahwa panjang gelombang maksimum sebesar 203,9 dan 276 nm, sedangkan untuk identifikasi isolat steroid menggunakan FTIR menunjukkan gugus fungsi O-H, geminal dimetil, C=O, C=C, C-OH sekunder dan =C-H (alkena) yang diduga merupakan senyawa steroid. Hasil LC-MS/MS menunjukkan adanya senyawa steroid β-sitosterol.   
Variasi Komposisi Eluen pada Isolasi Steroid dan Triterpenoid Alga Merah Eucheuma cottonii dengan Kromatografi Kolom Basah Armeida Dwi Ridhowati Madjid; Dwi Anik Rahmawati; Ahmad Ghanaim Fasya
ALCHEMY:Journal of Chemistry Vol 8, No 1 (2020): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v8i1.10040

Abstract

Steroid and triterpenoid compounds in petroleum ether fractions of red algae Eucheuma cottonii were isolated by slurry column chromatography. Isolation was started with maceration extraction using methanol solvent. The methanol extract was hydrolyzed with HCl 2 N and partitioned using petroleum ether solvent. The presence of steroid and triterpenoid was determined by phytochemical test using Lieberman Burchard reagent. Petroleum ether fraction was separated by slurry column chromatography with the variation of eluent composition n-hexane: ethyl acetate 16:4; 17:3; 18:2. The isolates were monitored by analytical thin-layer chromatography (TLC) and the best result was identified using FTIR. Percent yields of methanol extract and petroleum ether fraction were 11.866% and 8.03%, respectively. The optimum eluent composition in column chromatography for separation was n-hexane : ethyl acetate (18:2) obtained 2 steroid and 3 triterpenoid fractions. FTIR analysis gives information about functional groups of –OH, C=C, C-O, CH2, -C(CH3)2forsteroids and functional groups of –OH, C=O, C=C, CH2, -C(CH3)2 for triterpenoid.Keywords: Eucheuma cottonii, column chromatography, steroid, triterpenoid, variation of eluent composition  Senyawa steroid dan triterpenoid dalam fraksi petroleum eter alga merah Eucheuma cottonii telah diisolasi menggunakan kromatografi kolom basah. Isolasi dilakukan dengan cara ekstraksi maserasi menggunakan pelarut metanol. Ekstrak pekat metanol dihidrolisis dengan HCl 2 N dan dipartisi menggunakan pelarut petroleum eter. Senyawa steroid dan triterpenoid diuji fitokimia menggunakan reagen Lieberman Burchard. Fraksi petroleum eter dipisahkan menggunakan kromatografi kolom basah variasi komposisi eluen n-heksana:etil asetat dengan perbandingan 16:4; 17:3; dan 18:2. Hasil isolasi dimonitoring menggunakan kromatografi lapis tipis (KLT) analitik. Hasil monitoring yang terbaik diidentifikasi gugus fungsinya menggunakan FTIR. Hasil penelitian menunjukkan rendemen ekstrak metanol dan fraksi petroleum eter masing-masing sebesar 11,866% dan 8,03%. Pemisahan kolom dengan variasi komposisi eluen n-heksana:etil asetat terbaik adalah 18:2 dengan diperoleh 2 kelompok fraksi steroid dan 3 kelompok fraksi triterpenoid. Hasil analisis FTIR pada isolat steroid memberikan informasi gugus –OH, C=C, C-O, CH2, -C(CH3)2, sedangkan isolat triterpenoid memberikan informasi gugus –OH, C=O, C=C, CH2,-C(CH3)2. Gugus gem dimetil (-C(CH3)2)merupakan ciri khas rantai samping steroid ataupun triterpenoid.Kata kunci: Eucheuma cottonii, kromatografi kolom, steroid, triterpenoid, variasi komposisi eluen

Page 1 of 1 | Total Record : 7

 1 

Filter by Year

2020 2020


Reset
Filter By Issues
All Issue Vol 11, No 2 (2023): ALCHEMY: JOURNAL OF CHEMISTRY Vol 11, No 1 (2023): ALCHEMY: JOURNAL OF CHEMISTRY Vol 10, No 2 (2022): ALCHEMY: Journal of Chemistry Vol 10, No 1 (2022): ALCHEMY: Journal of Chemistry Vol 9, No 2 (2021): ALCHEMY JOURNAL OF CHEMISTRY Vol 9, No 1 (2021): ALCHEMY: Journal of Chemistry Vol 8, No 2 (2020): ALCHEMY: Journal of Chemistry Vol 8, No 1 (2020): ALCHEMY: Journal of Chemistry Vol 7, No 2 (2019): ALCHEMY: Journal of Chemistry Vol 7, No 1 (2019): ALCHEMY: Journal of Chemistry Vol 6, No 2 (2018): ALCHEMY: Journal of Chemistry Vol 6, No 1 (2018): ALCHEMY: JOURNAL OF CHEMISTRY Vol 5, No 4 (2017): ALCHEMY Vol 5, No 3 (2017): ALCHEMY Vol 5, No 2 (2016): ALCHEMY Vol 5, No 1 (2016): ALCHEMY ALCHEMY (Vol. 4, No.2 ALCHEMY (Vol.4, No.1 ALCHEMY (Vol.4, No.1 ALCHEMY (Vol.3, No.2 ALCHEMY (Vol.3, No.1 ALCHEMY (Vol.2, No.3 ALCHEMY (Vol.2 No.2 ALCHEMY (Vol.2 No.1 ALCHEMY (Vol 2 No 1 ALCHEMY (Vol 1 No 2 ALCHEMY (Vol.1 No.2 ALCHEMY (Vol.1 No.1 More Issue