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All Journal El-Hayah : Jurnal Biologi Alchemy : Journal of Chemistry Bioeduca : Journal of Biology Education
Mujahidin Ahmad
Jurusan Biologi, Fakultas Sains dan Teknologi, Universitas Islam Negeri Maulana Malik Ibrahim Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Aktivitas Antioksidan Isolat Steroid Hasil Kromatografi Lapis Tipis dari Fraksi n-Heksana Hydrilla verticillata Fasya, Ahmad Ghanaim; Purwantoro, Bagas; Ulya, Lulu'atul Hamidatu; Ahmad, Mujahidin
ALCHEMY Vol 8, No 1 (2020): ALCHEMY: Journal of Chemistry
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (732.05 KB) | DOI: 10.18860/al.v8i1.9936

Abstract

 Hydrilla verticillata is one of Allah SWT creations that potential as an antioxidant. This study’s objectives were to determine antioxidant activity and identify steroid isolates of n-hexane fraction of H. verticillata. The steroid compounds were extracted using methanol solvent. The methanol extract was hydrolyzed with HCl 2 N and partitioned using n-hexane. The n-hexane fraction was tested phytochemically and separated using thin-layer chromatography (TLC). The steroids compounds were identified using UV-Vis spectrophotometer, FTIR, and LC-MS/MS. The result showed that maceration extraction produced 5.14% yield, whereas n-hexane fraction produce 47.95% yield. Steroid separation through analytical TLC revealed that n-hexane: ethyl acetate (4:1) as the best eluant with 12 spots, while separation using preparative TLC yielded 19 spots. Steroid isolate from TLC preparative has antioxidant activity with EC50 of 5.109 ppm. Identification of steroid compounds using UV-Vis produced maximum wavelengths at 203.9 and 276 nm, while using FTIR indicated the presence of O-H group, geminal dimethyl, C=O, C=C, secondary C-OH, and =C-H (alkene) which might contain steroid compounds. The result of LC-MS/MS showed the presence of β-sitosterol. Hydrilla verticillata merupakan salah satu ciptaan Allah SWT yang memiliki potensi sebagai antioksidan. Penelitian ini bertujuan mengetahui aktivitas antioksidan dan mengidentifikasi senyawa steroid pada isolat hasil pemisahan fraksi n-heksana H. verticillata. Senyawa steroid diekstraksi menggunakan pelarut metanol. Ekstrak pekat metanol dihidrolisis dengan HCl 2 N dan dipartisi dengan n-heksana. Fraksi n-heksana hasil partisi diuji fitokimia dan dipisahkan senyawanya menggunakan KLT (Kromatografi Lapis Tipis). Identifikasi dilakukan menggunakan UV-Vis, FTIR, dan LC-MS/MS. Hasil penelitian menunjukkan ekstraksi maserasi menghasilkan rendemen 5,14%, sedangkan rendemen partisi n-heksana sebesar 47,95%. Pemisahan steroid menggunakan KLT analitik menunjukkan bahwa variasi eluen terbaik adalah n-heksana: etil asetat (4:1) dengan 12 noda, sedangkan pemisahan KLT preparatif menghasilkan 19 noda. Isolat steroid hasil KLT preparatif memiliki aktivitas antioksidan dengan EC50 5,109 ppm. Identifikasi senyawa steroid menggunakan UV-Vis menunjukkan bahwa panjang gelombang maksimum sebesar 203,9 dan 276 nm, sedangkan untuk identifikasi isolat steroid menggunakan FTIR menunjukkan gugus fungsi O-H, geminal dimetil, C=O, C=C, C-OH sekunder dan =C-H (alkena) yang diduga merupakan senyawa steroid. Hasil LC-MS/MS menunjukkan adanya senyawa steroid β-sitosterol.   
Predictive Pharmacological Activity of Galangal Rhizome (Alpinia galanga (L.) Willd.) Through in Silico Analysis as an Effort to Accelerate The Research of Indonesian Medicinal Plants Jamil, Ahmad Shobrun; Ahmad, Mujahidin
El-Hayah : Jurnal Biologi Vol 7, No 4 (2020): EL-HAYAH (VOL 7, NO 4 MARET 2020)
Publisher : Department of Biology Science and Technology Faculty UIN Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/elha.v7i4.10819

Abstract

Indonesia has high biodiversity, especially plant species. There are many benefits that can be Obtained from various plants that grow in Indonesia, one of which is as a health supplement or medicinal raw material. Fast researches are important in the use of these plants so that bio-based products can be widely accepted. One of the important fast methods in analysing the benefits of plant chemical compounds is the in-silico prediction utilizing metadata spread over various pages providing scientific data about plants, their chemical compound content and biological activity. This study was focused on predictively observing the biological activity of the compounds in the rhizome of Alpinia galanga. The research method is by analysing metadata from various sources. Data on the content of chemical compounds can be accessed through the page https://phytochem.nal.usda.gov/, classification of metabolite compounds contained in plants using http://classyfire.wishartlab.com/, prediction of absorption, distribution, metabolism and excretion (ADME) uses http://www.swissadme.ch/, to determine the relationship between plant compounds and body proteins, http://www.swisstargetprediction.ch/ and prediction of cellular mechanisms seen through https://string-db.org. Based on in silico analysis by utilizing some of the above software, it can be seen that the rhizome of the Alpinia galangal plant has 80 active compounds, 47 have high bioavailability and 9 compounds with tight cell proteins. Based on in silico exploration, it is also known that A. galangal has potential as an antioxidant, antimicrobial, anti-cancer and various other pharmacological activities
SKRINING AKTIVITAS ANTIOKSIDAN JAMU SUBUR KANDUNGAN KOMERSIAL Ahmad, Mujahidin
El-Hayah : Jurnal Biologi Vol 5, No 2 (2015): EL-HAYAH (VOL 5, NO 2, Maret 2015)
Publisher : Department of Biology Science and Technology Faculty UIN Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/elha.v5i2.3024

Abstract

Selection of traditional medicine is often considered as a choice since the affordable price and low side effects than chemical drugs. One of the well-known herbal medicine produced and consumed in java is Madura Herbal Medicine (MHM). MHM "Subur Kandungan" is one of the original medicinal products which is widely known in inducing fertility, but has not been scientifically standardized so make this many doubt for its usefulness. With the standardization and scientific assessment, MHM ought to be accepted in the modern medical system as well as lead in increasing both society revenues and public health. MHM "Subur Kandungan" consist of garlic (Allium sativum L.), Sweet Flag (Acorus calamus L.), and Intersection rhizome mango (Curcuma mangga Val.) is widely recognized as efficacious herbal medicine for inducing fertility. To determine the potency of those three plants, these were extracted by ethanol and continued by testing the antioxidant potential (DPPH) both individually and mixed. Assessments of phytochemical and antimicrobial potency were discussed. Test results showed that antioxidant activity represented by DPPH IC50 values of ethanol extract of A. sativum, A. calamus, C. mangga  and a mixture of those are 383.56, 335.68, 32.48, 27.773 µg/ml (ppm) respectively. Allium sativum and A.calamus are weak antioxidants as having IC50 in the range of 250-500 ppm, while the C. mangga and a mixture of those have strong antioxidant content as having IC50 of less than 50 ppm. Allegedly due to the high antioxidant content of the content of steroids, phenols, tannins, flavonoids, glycosides, diterpene, triterpenes, and alcaloids in A. calamus, also contains steroids, flavonoids, glycosides, diterpene, triterpenes and alaloids on A. sativum and also the presence of terpenoids as compound intersection primary contained in C. mangga respectively.
Antioxidant and Antifungal Activity of Jeringau (Acorus calamus L.) Extract In Some Organic Solvents In Vitro Muchtaromah, Bayyinatul; Ahmad, Mujahidin; Hasan, M. Nur; Wahyudi, Didik
El-Hayah : Jurnal Biologi Vol 6, No 3 (2017): EL-HAYAH (VOL 6, NO 3,September 2017)
Publisher : Department of Biology Science and Technology Faculty UIN Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/elha.v6i3.5334

Abstract

Candidiasis is one disease that has experienced by 75% of women in Indonesia caused by fungal infection,Candida albicans. Candidiasis can cause serious complications such as infertility. One of the best known ingredients to cure infertility problems is jeringau rhizome (Acoruscalamus L.). This research is the first step to process for  standardization and scientification of jeringau rizhome as one of the basic ingredients of Madura traditional medicine, jamu "SuburKandungan". It was aimed to investigate antioxidant and antifungal activity of jeringau rizhome in some organic solvents. Samples were extracted by maceration method using ethanol, chloroform, and n-hexane. Antioxidant activityassaywas determined using DPPH method.Ascorbic acid was used as control.  Antifungal activity test on Candida albicans was done by usingkirby bauer method to measure diameter of inhibition zone and microdilution plate method to determine MIC and MFC. The highest antioxidant activity was revealed by ethanolfollowed by chloroform and n-hexane, while the highest antifungal activity was obtained by ethanol followed by n-hexane and chloroform. The MIC value of ethanol, chloroform and n-hexanewere founded at concentration of 0.39% and the MFC at a concentration of 0.78%.
Konservasi Air dan Energi dengan Menghidupkan Sunnah Nabi Ahmad, Mujahidin
El-Hayah : Jurnal Biologi Vol 4, No 1 (2013): EL-HAYAH (VOL 4, NO 1, September 2013)
Publisher : Department of Biology Science and Technology Faculty UIN Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/elha.v4i1.2618

Abstract

Islam is a universal religion. Not only governs the relationship between servant and God but also regulates the relationship with fellow beings. Among the teachings of Islam that governs the relationship with the creatures is how the adherents of Islam set to be considerate of the environment, ie, how should humans maintain balance of nature and not ruin it. The use of water and energi, including matters governed by Islam through the Qur'an and the instructions Prophet Sallallaahu 'alaihi wasallam. Instructions regarding the procedure of which the Prophet made ablution, bathing, brushing teeth closely related to water conservation, while the doctrine of fasting, to walk to the mosque, turn off a light during sleep so strongly associated with the doctrine of the conservation of energy. By following the Sunnah of a Moslem not only to be rewarded, but also contribute to the conservation of natural resources whose benefits will be felt by all mankind
KUNCI TADABBBUR DAN INTEGRASI AL-QUR’AN DALAM PEMBELAJARAN BIOLOGI Ahmad, Mujahidin; Minarno, Eko Budi; Suyono, Suyono
BIOEDUCA : Journal of Biology Education Vol 2, No 2 (2020): Vol 2, Nomor 2, BIOEDUCA: Journal of Biology Education
Publisher : Universitas Islam Negeri Walisongo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/bioeduca.v2i2.6319

Abstract

Islam sebagai agama yang sempurna (din-al kamil) dan universal (din-asy syamil) selalu menarik dijadikan sebagai sumber inspirasi pemikiran. Hal ini karena Al-Qur’an tidak hanya mengatur aspek hubungan manusia dengan tuhannya namun juga termasuk mengatur hubungannya dengan sesama makhluk. Upaya pendekatan hubungan antara sains dan al-quran khusunya biologi adalah sebuah upaya implementasi sains dalam kehidupan sehari hari terutama sebagai masyarakat yang religius. Diharapkan dengan adanya pengenalan model baru dapat memudahkan upaya integrasi Al-Qur’an dalam pembelajaran biologi. Metode yang digunakan dalam penelitian ini adalah telaah pustaka. Dalam pembelajaran Biologi, integrasi Sains-Islam dapat dilakukan dengan tiga macam model pendekatan yaitu; Model Integrasi Al-Qur’an sebagai Sumber Inspirasi, Konfirmasi dan Dogma-empiris. Ketiga model pendekatan dapat dijalankan secara simultan dalam proses pembelajaran Biologi.
Co-Authors Ahmad Ghanaim Fasya, Ahmad Ghanaim Ahmad Shobrun Jamil Bayyinatul Muchtaromah Didik Wahyudi Eko Budi Minarno Hasan, M. Nur Purwantoro, Bagas Suyono Suyono Ulya, Lulu'atul Hamidatu