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Medula
Published by Universitas Lampung
ISSN : -     EISSN : 97726154     DOI : -
Core Subject : Health, Science, Education,
Education Medicine & Pharmacology Neuroscience Public Health
Medical Profession Journal of Lampung didirkan pada tahun 2013. Medula hadir memenuhi kebutuhan publikasi jurnal bagi mahasiswa Fakultas Kedokteran, Dosen ataupun klinisi dan profesi lain dibidang kedokteran. Medula diterbitkan dengan frekuensi 4 kali dalam setahun yang tiap nomornya mencakup 30 jenis artikel ilmiah seperti artikel penelitian, laporan kasus, tinjauan pustaka dan lain-lain. Medula sudah memiliki nomor ISSN media cetak sejak tahun 2013
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 10 Documents
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Search results for , issue "Vol 11 No 3 (2021): Medula" : 10 Documents clear
Penerapan Bioteknologi DNA Rekombinan: Pengembangan Vaksinasi COVID-19 Ni Putu Pranita; Rizki Novtarina; Robby Cahyo Nugroho; Rani Himayani; Helmi Ismunandar
Medula Vol 11 No 3 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i3.177

Abstract

The role of science and technology in all sectors is getting bigger and bigger. The development of science and technology encourages innovation in all fields including in the health sector. Specifically regarding advances in science and technology in the health sector, it relies on research by experts, including medical biotechnology. One form of utilization of medical biotechnology is the development of vaccinations. In dealing with the Covid-19 pandemic, the application of medical biotechnology can be done by developing vaccinations using recombinant DNA technology. All researchers around the world in all related fields such as genomic and structural biology experts work together to develop this vaccine. Of these several agencies, InoVio as one of the research agencies developed a DNA vaccine. The DNA vaccine has several advantages, including fast production time and formulation, can be produced in large quantities, is safer, more stable to temperature so that it is easy to store and transport. Currently the DNA vaccine for the SARS-CoV-2 virus is still in the next clinical trial phase and is mass produced for emergency use.The role of science and technology in all sectors is getting bigger and bigger. The development of science and technology encourages innovation in all fields including in the health sector. Specifically regarding advances in science and technology in the health sector, it relies on research by experts, including medical biotechnology. One form of utilization of medical biotechnology is the development of vaccinations. In dealing with the Covid-19 pandemic, the application of medical biotechnology can be done by developing vaccinations using recombinant DNA technology. All researchers around the world in all related fields such as genomic and structural biology experts work together to develop this vaccine. Of these several agencies, InoVio as one of the research agencies developed a DNA vaccine. The DNA vaccine has several advantages, including fast production time and formulation, can be produced in large quantities, is safer, more stable to temperature so that it is easy to store and transport. Currently the DNA vaccine for the SARS-CoV-2 virus is still in the next clinical trial phase and is mass produced for emergency use.
Pengaruh Pemberian Buah Mengkudu (Morinda citrifolia) Terhadap Penyakit Dislipidemia Chania Forcepta; Khairun Nisa; Dian Isti Anggraini
Medula Vol 11 No 3 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i3.188

Abstract

Dyslipidemia is a lipid metabolism disorder characterized by an increase in the lipid fraction in the blood. Dyslipidemia is an important problem because it is a major risk factor for heart disease. The cause of dyslipidemia is caused by disruption of lipid metabolism due to the interaction of genetic and environmental factors. An alternative treatment for dyslipidemia is to use noni (Morinda citrifolia) fruit which contains xeronin, proxeronin, ascorbic acid, linoleic acid, β-carotene, flavonoids and caprylit acid. Compounds that are thought to lower cholesterol are flavonoids. The flavonoid compounds in noni inhibit HMG-CoA reductase so that total cholesterol and LDL will decrease. Noni fruit can also be useful as an antioxidant, anti-inflammatory, antinociceptive, anti-cancer, anti-diabetes and anti-hypertension. Consumption of noni fruit must be careful with gastritis sufferers because noni is acidic. With antidiabetic drugs hypoglycemia and hypotension can occur, because they can reduce blood glucose and potassium levels. The color of urine can be pink to brownish red. May interact with ACE inhibitor drugs, angiotensin II receptor antagonists, potassium-sparing diuretics. May reduce the effect of immunosuppressant drugs.
Sistem Saraf Pusat dan Perifer Syalwa Meutia Syalwa Meutia; nurul utami; Rani Himayani; selvi rahmawati
Medula Vol 11 No 3 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i3.189

Abstract

The structure of the central nervous system consists of the cerebrum, cerebellum, and spinal cord which are located in the cranial cavity and vertebral canal. The primary functional unit of the neural network is nerve cells (neurons) which function to form and transmit information in the form of electrical impulses and supporting cells (neuroglia) which are located around neurons and are more numerous than neurons. The parts of a neuron include the cell body (soma or perikaryon), dendrites and axons. Based on the number of dendrites and axons, neurons are classified into multipolar, bipolar and pseudounipolar neurons. Neuroglia consist of astrocytes, oligodendrocytes, microglia, and ependymal cells. Neuroglia play a role in providing a conducive microenvironment for the activity of neurons. The peripheral nervous system is a nervous system that connects all parts of the body with the central nervous system, this system consists of nervous tissue located outside the brain and spinal cord (spinal cord) such as the skin and other senses, the peripheral nervous system consists of cells Nerve cells group together to form ganglia, nerve fibers, and nerve end bodies
Bacillary Dysentery jefri irawan; Meilisa Hidayah Putri; Rani Himayani; Ratna Dewi Puspita Sari
Medula Vol 11 No 3 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i3.211

Abstract

Gastrointestinal infection due to amoeba is one of the causes of diarrhea which appears to be a public health problem with a high incidence in the community. Bacillary dysentery/shigellosis has become a major cause of morbidity and mortality in children in developing countries, and is also an important cause of morbidity in industrialized countries. Shigella sp. is a diarrheal pathogen that is closely related to Escherichia coli. The pathogen was named by Kiyoshi Shiga, who in 1898 identified the most virulent strain of shigella, Shigella dysenteriae, as the causative agent of shigellosis. Shigella spp. is a Gram-negative bacillus from the family Enterobacteriaceae. Therefore, the aim of this literature review is to further review the management of bacillary dysentery. Shigellae is transmitted by the faecal-oral route or through ingestion of contaminated food and water. This research is a literature review involving as many as 10 library sources with the keywords used, namely 'management and shigellosis' with the year published between 2012 - 2021. Abstracts and full text of the journal are read and examined, then an analysis of the contents contained in the research objectives is carried out and research results/findings. Results. Various studies have shown over the last few decades, Shigella spp. have undergone mutations, developing mechanisms to damage cell processes in the gastrointestinal tract. Therefore, innovative methods and appropriate management are needed to prevent antibiotic resistance in the treatment of shigellosis.
HUBUNGAN PERILAKU PERSONAL HYGIENE DENGAN KERACUNAN PESTISIDA MELALUI PENGUKURAN KADAR CHOLINESTERASE DALAM DARAH PADA PETANI DI PEKON SRIKATON KECAMATAN ADILUWIH KABUPATEN PRINGSEWU TAHUN 2017 Devi Liani Octiara; fitria saftarina
Medula Vol 11 No 3 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i3.256

Abstract

Pesticides are very popular chemicals used to control the development or growth of pests, diseases, and weeds. Farmers are the largest working group in Indonesia to improve optimal agricultural output, farmers apply various technologies, including the use of chemicals. This study aims to analyze the relationship of personal hygiene behavior with pesticide poisoning in the blood of farmers in Pekon Srikaton Adiluwih Pringsewu District. This research used cross sectional research design with sampling technique such as consecutive sampling. The samples of this research are 86 farmers in Pekon Srikaton Adiluwih Pringsewu District. The statistical analysis was calculated using fisher exact test with a significance value a<5%. The statistical test showed that 20 farmers (91,9%) is pesticide poisoning and not pesticide poisoning is 7 farmers (8,1%), 20 farmers has work experiences less than 10 years (23.3%) and 66 farmers (76,7%) more than 10 years work experiences. Fisher test results obtained p value 0.508. There isn't  a relationship between work experiences and pesticide poisoning in blood to farmers in Pekon Srikaton Adiluwih Pringsewu District. This study conclude that there isn’t a relationship between work experiences and pesticide poisoning in the blood of farmers in Pekon Srikaton Adiluwih Pringsewu District.
Vasopressin pada Manajemen Syok Septik Iswandi Darwis; Rizka Humardewayanti Asdie; Neema Putri Prameswari
Medula Vol 11 No 3 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i3.288

Abstract

Sepsis is a systemic inflammatory response caused by an infection, which can involve multiple organs. Sepsis and multiple organ dysfunction syndrome (MODS) are the main causes of death in the intensive care unit of a hospital. In sepsis, septic shock, defined as sepsis-induced persistent hypotension despite adequate fluid resuscitation causing tissue hypoperfusion, can occur. Norepinephrine and dopamine are the vasopressors of choice for initial treatment septic shock, but the use of high-dose catecholamine vasopressors can cause adrenergic side effects that can increase mortality. Therefore, a septic shock patient with increased heart rate, it is necessary to use a vasopressor that does not cause adrenergic side effects. Vasopressin is a hormone secreted by the posterior pituitary. In hypotensive condition, vasopressin physiologically helps maintain blood pressure by acting as a potent vasoconstrictor. Vasopressin administration does not cause side effects caused by adrenergic stimulation such as increased tissue oxygen demand, decreased renal and mesenteric flow, increased pulmonary resistance and arrhythmias. This literature review also discusses the effects of vasopressin on blood pressure, the cardiovascular system, the immune system, the coagulation system, the respiratory system, the urinary system and the central nervous system in patients with septic shock.
Penatalaksanaan Holistik Pada Pasien Tuberkulosis Anak Usia 2 Tahun Di Puskesmas Pasar Ambon Melalui Pendekatan Kedokteran Keluarga ASY SYADZALI; Reni Zuraida
Medula Vol 11 No 3 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i3.293

Abstract

Tuberculosis (TB) is a disease caused by infection with the bacterium Mycobacterium tuberculosis in the lungs. This disease usually attacks the lungs (pulmonary TB) but can also affect other organs (extrapulmonary TB). This study is a case report with analysis of primary data obtained through history taking, physical examination and home visits to complement family data, psychosocial and environmental data. Secondary data were obtained from the patient's medical record at the puskesmas. Assessment is carried out based on a holistic diagnosis from the beginning, process, and end of the study quantitatively and qualitatively. Patient An. N, 2 years old with TB and poor nutritional status, so there needs to be an intervention to improve the patient's nutritional status to support the success of TB treatment. In this case, a diagnosis of tuberculosis was made in accordance with the theory and technical guidelines for the management and management of TB in children, the Ministry of Health of the Republic of Indonesia. The management of category 1 pulmonary tuberculosis given was in accordance with evidence based medicine. After the intervention, there was a decrease in clinical symptoms and behavioral changes in the patient's family, seen after the family was given the intervention and finally understood better to motivate the patient and always remind and accompany the patient when taking medication, as well as providing food with balanced nutrition to the patient. The management given to the patient was in accordance with the technical instructions for the management and management of TB in children, the Ministry of Health of the Republic of Indonesia.  
Wanita 37 tahun P3A0 post-SSTP Atas Indikasi Hidrocephalus dengan Polihidramnion dan Presentasi Bokong veny anisya; Nurul Islamy; Efriyan Imantika; Rizki Dwi Prasetia; Caesaria Sinta Zuya; Imraatul Husniah; Maharani Amanulloh
Medula Vol 11 No 3 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i3.298

Abstract

Hydrocephalus is an enlargement of the ventricle of the brain as a result of an increase in the amount of cerebrospinal fluid (CSS) caused by an imbalance between its production, circulation and absorption. Sectio caesaria can also be selected for fetal deformity in the form of hydrocephalus because itcan risk tearing of the uterus if the delivering is done by pervaginam. Sectio Caesarea is a surgicalprocedure that aims to deliver a baby by opening the abdominal wall and uterus of the mother. Sectio caesarean sectional is more commonly chosen compared to pervaginam delivery for breech presentation management, where the cause of the incidence of breech presentation is still unknown, but there are several risk factors other than prematurity, namely structural abnormalities of the uterus, polyhidramnion, placenta previa, multiparitas, fetal anomaly (anencephaly, hydrocephalus), and previous history of breech presentation. Hydrocephalus is a health problem that affects the retirement system. Polyhidramnions is a term used to describe the accumulation of excess amniotic fluid, this clinical condition is associated with a high risk of poor pregnancy outcomes. Mrs. S's 37-year-old patient came to give birth with contraction that felt increasingly frequent, 37 weeks pregnant, with the results of ultrasound are polyhydramnion and hydrocephalus. From the physical examination obtained general state: moderate pain; temperature: 36.7 oC; blood pressure: 120/80 mmHg; heart rate: 92x/min; respiratory rate: 18 x/min. On leopold I examination obtained a height of fundus uteri is 40 cm, palpable round, hard, head impression. Leopold II palpable flat long part on the right side of the back impression. Leopold III palpable soft round part, the breech impression. Fetal heart rate 155x/min, fetal estimated weight 4.300 grams. In patients performed secio caesarea on indications of hydrocepalus, polyhydroamnion and breech persentation, so that this patient is diagnosed with P3A0 post sectio caesarea on indications of hypocephalus with polyhidramnion and breech presentation. treatment in these patients post SC is seftriaxone, ketorolac and oxytocin drip.
Tatalaksana Aritmia: Fibrilasi Atrial Gede Agus Andika; Asep Sukohar; Ade Yonata
Medula Vol 11 No 3 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i3.309

Abstract

Abstract Arrhythmias are a problem with the rate or rhythm of the heartbeat. The four main types of arrhythmias are premature or premature beats, ventricular arrhythmias, bradiarimia, and supraventricular arrhythmias. Supraventricular arrhythmias are tachycardia (rapid heartbeat) starting at the atrial or atrioventricular (AV). Types of supraventricular outbreaks include atrial fibrillation (AF), atrial flutter, paroxysmal supraventricular tachycardia (PSVT), and Wolff-Parkinson-White syndrome (WPW). Atrial fibrillation is the most common type of arrhythmia. In general, the management of AF patients has 5 objectives: thromboembolic events, coping with AF related symptoms, optimal management of accompanying cardiovascular disease, controlling heart rate, and improving rhythm disturbance. Antithrombotic therapy used for stroke prevention in FA patients includes anticoagulants (vitamin K or AVK antagonists and new anticoagulants or IMR), and antiplatelets. AKB which is not AVK in Indonesia market, that is dabigatran, rivaroxaban, and apixaban. Dabigatran works by dealing directly with trombinlah rivaroxaban and apixabanacas works by presenting the Xa factor.
A Tumor Ampulla Vater pada Pasien Dewasa Muda Aleya Yostha Kaban; Risal Wintoko; Anggi Setiorini
Medula Vol 11 No 3 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i3.315

Abstract

Ampullary tumors are known as tumors that grow at the end of the common bile duct that passes through the duodenal wall of the papilla ampullaris of the pancreatic duct and the common bile duct which then coalesces and exits through the duodenal ampulla. The most common symptoms of this tumor are signs of biliary obstruction. Tumors in the gallbladder and bile ducts are generally asymptomatic early in the course of the disease and only manifest when the tumor is at an advanced stage so that the possibility of curative resection decreases. Malignancy of the ampulla of vater often manifests at an early stage so the prognosis is likely to be better. Etiological factors include smoking and previous partial gastrectomy. There is no established association between tumors of the ampulla of Vater and drinking coffee or alcohol. This case was found in a male patient, aged 33 years who came to Dr. H. Abdoel Moelok with complaints of abdominal pain on the right side accompanied by thick tea-colored urine, enlarged stomach, shortness of breath. The results of examination and support in the form of abdominal ultrasound led to the diagnosis of an ampulla of Vater tumor. The treatment given to the patient was supportive treatment in the form of a blood transfusion of three kolf to increase the hemoglobin level before being carried out in the form of a whipple operation procedure.

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