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Althea Medical Journal

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Published by Universitas Padjadjaran

ISSN : - EISSN : 23374330 DOI : 10.15850/amj

Core Subject : Health,

Medicine & Pharmacology

Althea Medical Journal (AMJ) is a peer reviewed electronic scientific publication journal which is published every 3 months (March, June, September, and December). Althea Medical Journal publishes articles related to research in biomedical sciences, clinical medicine, family-community medicine, and public health.

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Articles 10 Documents

Search results for , issue "Vol 5, No 4 (2018)" : 10 Documents clear

Relationship between Diet, Cosmetics and Degree of Acne Vulgaris in Dermatovenereology Outpatients at Dr. Soetomo General Hospital, Surabaya Mah Zhook Yueng; Diah Mira Indramaya; Arifa Mustika
Althea Medical Journal Vol 5, No 4 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Background: Acne vulgaris (AV) is a chronic inflammatory multifactorial disease that involves the pilosebaceous unit. The lesions of acne may be either non-inflammatory (comedones, which are blackheads or whiteheads) or inflammatory lesions (papules, nodules or pustules). The effects of diet and cosmetics on acne are still inconclusive. The objective of this study was to analyse the relationship between diet, cosmetics and the degree of AV.Methods: This was a hospital-based, analytic observational study with cross-sectional design. The subjects were patients from the Outpatient Clinic of Dermatovenereology Department of Dr. Soetomo General Hospital. The questionnaire was filled by the respondents and the degree of AV was graded by the specialist. Results: Among the types of diet, white bread (p=0.039), chocolate (p=0.044) and oily food (p=0.013) are significantly associated with the degree of AV. However, white rice, potatoes and milk were insignificantly related to degree of AV (p>0.05). No significant association was found in cosmetics (cleanser, moisturizer, facial protection, exfoliators and decorative cosmetics) with the degree of AV (p>0.05).Conclusions: The factors that have an influence on the degree of AV are white bread, chocolate and oily food intake.

Inhibitory Effect of Neem Leaves on Glucose Transport Lia Safitrie Johansyah; Vycke Yunivita; Anna Martiana; Augusta Y. L. Arifin
Althea Medical Journal Vol 5, No 4 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Background: Neem leaf is known as a diabetic herbal treatment in India, however, its antihyperglycemic effect and the mechanism is still unknown. Quercetin is proven to inhibit glucose transporter in the small intestine, and this active substance is present in Neem leaves. The study was conducted to explore the inhibitory effect of Neem leaves infusion on glucose transport and whether the effect was reversible or irreversible.Methods: This study was conducted in the Biochemistry Laboratory Faculty of Medicine Universitas Padjadjaran in the period of October to November 2012 by using in situ perfusion method. Five male Wistar rats were given three treatments; glucose as initial control, glucose with Neem infusion, and glucose again as last control. The samples of perfusion solution were taken for every treatment and were measured using spectrophotometry method.Results: There was a reduction in glucose absorption (15.9%) between the first (47.28+17.57 mg/dL) and the second treatment (39.75+14.85 mg/dL). The transported glucose level in the third treatment was further reduced after the first treatment (37.15+13.15 mg/dL).Conclusions: Neem leaves infusion has inhibitory effect on glucose transport that irreversibly reduced further. Further study is needed with a larger sample size to confirm this phenomenon.

Vitamin D Levels in Chronic Kidney Disease Stage 3, 4, and 5 David Kristianus; Rudi Supriyadi; Siska Wiramihardja
Althea Medical Journal Vol 5, No 4 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Background: Hypovitaminosis D is highly prevalent in chronic kidney disease (CKD). This conditionmay increase CKD progression and cause various complications, since kidney has a pivotal role in metabolizing the vitamin D. The aim of this study was to find the difference in vitamin D levels among CKD stage 3 to 5.Methods: A cross-sectional study involving patients aged over 18 years with CKD stage 3 to 5 who visited Dr. Hasan Sadikin General Hospital, Dustira Hospital, and Kidney Special Hospital Ny. R.A. Habibie in 2017 was conducted. CKD stages were determined based on glomerular filtration rate (GFR). Kruskal-Wallis test was used to analyzethe difference in vitamin D levels among CKD stage 3 to 5.Results: One hundred subjects consisting of 57 men and 43 women met the study criteria. There were 97% of subjects experienced hypovitaminosis D, with 20% having vitamin D insufficiency and 77% having vitamin D deficiency. In subjects with vitamin D insufficiency, a decrease in the mean vitamin D levels was observed along with advancing stages of CKD (p=0.255). No vitamin D level difference was observed among CKD stage 3 to 5 [11.1 (3.8-27.7) ng/mL vs 14.45 (5.10-50.90) ng/mL vs 11.7 (4.2-38.0) ng/mL, p>0.05].Conclusions: There is no difference in vitamin D levels among CKD stage 3, 4 and 5.

The Analgesic Effect of Ethanol Extract Soursop (Annona muricata L.) Leaves in Wistar Rats Kuswinarti Kuswinarti; Kendry Savira; Reno Rudiman
Althea Medical Journal Vol 5, No 4 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Background: Pain is an emotional and sensory experience that is unpleasant and related to tissues damage. In the past, Soursop (Annona muricata L.) leaves have been believed to be able to relieve pain. This study aimed to explore the analgesic effect of soursop leaves and its effective dose in an animal model. Methods: Wistar rats (n=25) had been used in this experimental study, divided into 5 groups; consisting of a negative control group, experiment groups using extract soursop leaves with doses of 200mg/kgbw, 400 mg/kgbw and 600 mg/kgbw, and natrium diclofenac as a positive control. One hour after treatment, all groups of rats were induced by carrageenan-lambda in the feet. The basal retraction of rats’ legs was measured in 47oC water and repeated at two, four, and six hours. The data were analyzed using analysis of variance and Tukey’s test. Result: The dose of 200 mg/kgbw had no analgesic effect (p>0.05), while the dose of 600 mg/kgbw had the highest analgesic effect at 7.72 seconds on the 4th hour of induction. On the 6th hour, the dose of 400 mg/kgbw had the highest analgesic effect at 3.58 seconds.Conclusions: Extract soursop (Annona muricata L.) leaves in this study have been proven to have an analgesic effect.

Macrosomic Newborn and Glucose Level in Lean Pregnant Diabetes Mellitus Patients at Dr. Soetomo General Hospital Surabaya Sonea Venugopal; Hermanto Tri Joewono; Pudji Lestari
Althea Medical Journal Vol 5, No 4 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Background: Gestational diabetes mellitus, defined as glucose intolerance in variable degree with onset during pregnancy, is a risk factor for the development of fetal macrosomia, a newborn with the birthweight of more than 4000g. The objective of this study was to explore an association between glucose level in lean pregnant diabetes mellitus patients, resulting in babies and the incidence of macrosomia in Dr Soetomo General Hospital in Surabaya.Methods: This was a retroprospective analytic study with a cross sectional design by using medical records at Dr. Soetomo General Hospital Surabaya, collected from January 2016 to December 2017. The correlation between fasting glucose level, 2-hour postprandial glucose and glucose level at the time of birth and weight of newborn was assessed.Results: Controlled and uncontrolled fasting glucose level, 2-hour postprandial glucose level and glucose level at the time of birth of mother were not significantly associated with macrosomia newborns. Macrosomia newborn were born with gestational diabetes mellitus mothers compare with pregestational mellitus mothers.Conclusions: There is no association between macrosomia with glucose level of lean gestational and pregestational diabetes mellitus, however, therapeutic approach such as physical exercise should be implemented to reduce effects of uncontrolled glucose level.

Characteristics of Elderly Patients with Sarcopenia at Geriatric Outpatient Clinic Dr. Hasan Sadikin General Hospital Period 2012–2014 Sania Putri Darwita; Yuni S. Pratiwi; Lazuardhi Dwipa
Althea Medical Journal Vol 5, No 4 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Background: Sarcopenia can lead to difficulty in physical activities, therefore, elderly cannot live independently. However, data on sarcopenia are not yet available in Dr. Hasan Sadikin General Hospital. This study was conducted to identify the frequency of occurrence and characteristics of elderly patients with sarcopenia.Methods: This study used descriptive method and was conducted from May to October 2014. Total sampling method was performed to medical records of elderly patients with sarcopenia at Geriatric Outpatient Clinic Dr. Hasan Sadikin General Hospital during the period 2012–2014. Variables observed were age, gender, body mass index (BMI), activities of daily living (ADL), timed up and go test (TUG), mini nutritional assessment (MNA), disease record, and medication record. Patients with sarcopenia were then grouped based on characteristics of age, gender, BMI, ADL, TUG, MNA, disease record, and medication record.Results: Out of 255 registered elderly patients, 22(8.63%) were with sarcopenia and one was excluded due to incomplete data. Sarcopenia was most prevalent in patients aged 80 years and older (15.38%), and commonly in men (57.1%). Most patients had hypertension history (66.6%), multiple comorbidities (61.9%), normal BMI (33.3%), normal ADL (85.7%), normal MNA (76.1%), and normal TUG scores (80.9%), and polypharmacy (52.3%) history.Conclusions: Sarcopenia is prevalent in men aged 80 years and older. Although sarcopenia patients have hypertension history, multiple comorbidities and history of polypharmacy, most patients live with normal daily activities and have good body mass index, however, quality of life of elderlies needs to be improved further.

Knowledge, Attitude, and Behavior Regarding Homosexualilty among New Students in Universitas Padjadjaran Ade Nea; Rudi Wisaksana; Enny Rohmawaty
Althea Medical Journal Vol 5, No 4 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Background: Homosexualilty has raised a controversy in the society, which commonly has a negative attitude towards homosexual. It is important to develop knowledge and attitude about homosexuality in new students as agents of change. This study aimed to identify the knowledge, attitude, and behavior of new undergraduate students in Universitas Padjadjaran about homosexual.Methods: This was a descriptive quantitative cross-sectional study using primary data obtained from questionnaires, distributed not randomly to new undergraduate students of 2016/2017 academic year in Universitas Padjadjaran (n=122) from October to November 2016. Questions asked were demographic data, knowledge and attitude towards homosexualilty, and homosexual behavior.Results: Respondents had a good knowledge (18%; n=22), average (66.4%; n=81) and low knowledge (15.6%; n=19) about homosexuality and the majority (55.7%; n=68) of respondents had a negative attitude towards homosexuality. A heterosexual behavior had been showed in 92.6% (n=113) respondents, and 7.4% (n=9) had a heterosexual dominant behavior.Conclusions: In our new undergraduate students’ community, the majority has average knowledge, however, with a negative attitude towards about homosexuality. The role of new students as agents of change is to educate the community to prevent potential health issues. The developing of knowledge, attitude, and behavior towards homosexual through a holistic education from health workers should be promoted.

Qualitative Analysis of Establishing Diagnosis and Management of Hypertension from Patient’s Perspective in Jatinangor Yulia Sofiatin; Nazmun Lailah; Trully Deti Rose Sitorus; Rully M. A. Roesli
Althea Medical Journal Vol 5, No 4 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Background: Blood pressure control is necessary to prevent complications in patients with hypertension. A previous study in Jatinangor showed the failure of controlling blood pressure even with pharmacological treatment. Proper diagnosis and effective management are considered to influence the condition. This study was performed to describe the process of establishing diagnosis and management for hypertension from the patient’s perspective in Jatinangor.Methods: A phenomenological approach was used. Data were collected through semi-structured questions in focus group discussions (FGDs) led by a moderator. Participants of FGDs were patients with hypertension who had undergone antihypertensive drugs therapy based on a previous study, and were invited by the local health cadres. The study was held in two villages in Jatinangor, namely Hegarmanah and Cilayung in the period of July to August 2015. Data were presented as narration and figures.Results: There were five and eight hypertensive participants for Hegarmanah and Cilayung villages FGD, respectively. Diagnosis of hypertension in FGD participants was not only confirmed by doctors but also other health professionals, due to various accessibilities to health care facilities. Diagnosis establishment and management of hypertension were not following the protocol. Education on pharmacological and non-pharmacological management was provided by health professionals, however still lacked details and was not reviewed on every visit, resulting in a lack of compliance. Conclusions: Process of establishing diagnosis and management of hypertension from the patient’s perspective in Jatinangor is unfortunately not following the protocol, thus may influence the blood pressure control outcome.

Clinical Manifestations of Systemic Lupus Erythematous in Children at Dr. Hasan Sadikin General Hospital Bandung, Indonesia Reni Ghrahani; Priya Darshani Ganesan; Reni Farenia Soedjana Ningrat
Althea Medical Journal Vol 5, No 4 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Background: Systemic Lupus Erythematous (SLE) is an autoimmune disease, characterized by production of autoantibodies, leading to damage caused by inflammation, directed toward multiple organs in the body. It is difficult to diagnose due to its mimicry with other diseases. The differential diagnosis of SLE is broad, including infection, malignancy and other inflammatory disorders. It is important to recognize the clinical manifestation of SLE from other possible diseases.Methods: A descriptive study was conducted on 56 SLE patientsfrom the Department of Child Health in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, in which the medical records was collected from 2010 to 2014. A total sampling method was used and incomplete records were excluded.Results: Out of the 56 subjects, 82.1% were female, with female to male ratio was 4.6:1. Most of the subjects (52%) was in the age category of 11 to 15 years old. Hematologic involvement was the most common clinical manifestation based on the diagnostic criteria (83.9%), and fever was the most common chief complaint (41.1%).Conclusions: From this study, fever, rash, and joint pain are the common chief complaints among SLE patients in children with hematologic and renal disorders are also found to occur.

Is Zuspan Regimen Adequate for Preventing Eclampsia?: A Case Report Raymond Surya; Budi Iman Santoso; Surahman Hakim
Althea Medical Journal Vol 5, No 4 (2018)
Publisher : Faculty of Medicine Universitas Padjadjaran

Magnesium sulphate (MgSO4) is believed to treat preeclampsia and eclampsia for more than a century with a total dose of MgSO4 varying from 2 to 5g per 24 hours. Zuspan and Pritchard are two internationally recommended regimens that are accepted as the standard regimen. In this case report, we presented a 41 year old woman with puerperal preeclampsia prescribed with a complete Zuspan regimen. She had eclamptic seizure after completing Zuspan regimen with Mg SO4 level of 4.3 mg/dL. In this case, the possibility of eclamptic seizures might be due to a lack of MgSO4 dose. The administration of MgSO4 for preeclampsia with severe features and prophylactic of eclampsia should be adjusted.

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Editorial Address Gedung Rumah Sakit Pendidikan Unpad/Pamitran Unpad (Teaching Hospital Building) Faculty of Medicine Unpad, 3rd Floor Jl. Prof. Eyckman No. 38, Bandung, 40161, Indonesia

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Contact Name
-

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Journal Mail Official
chiefeditor.amj@gmail.com

Editorial Address
Gedung Rumah Sakit Pendidikan Unpad/Pamitran Unpad (Teaching Hospital Building) Faculty of Medicine Unpad, 3rd Floor Jl. Prof. Eyckman No. 38, Bandung, 40161, Indonesia

Location
Kota bandung,

Jawa barat

INDONESIA