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The Journal of Pure and Applied Chemistry Research

jpacr
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Published by Universitas Brawijaya

ISSN : 23024690 EISSN : 25410733 DOI : http://dx.doi.org/10.21776/ub.jpacr

Core Subject : Health, Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

The Journal of Pure and Applied Chemistry Research focuses in publishing research articles in the field of Chemistry and Applied Chemistry. The target is in exploring, investigating, and developing chemicals sources from local and/or Indonesian to increase the value. Scope of the journal is organic chemistry, analytical chemistry, inorganic chemistry, biochemistry, and physical chemistry. Included the topic also organic chemistry natural product, theoretical and computational chemistry.

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 9 Documents

Search results for , issue "Vol 6, No 1 (2017): Edition of January - April 2017" : 9 Documents clear

Investigation of the Electronic and pH-Sensing properties of Hydroxyl-Functionalized Imine-Linked Polymers via the UV-vis Absorption Spectra and the Density Functional Theory (DFT) Calculations Ibtesam Y. Aljaafreh; Suha S Altarawneh; Mohammed Ibrahim Alomari; Alaa M. Almaabreh; Muna M. Al Amelat
The Journal of Pure and Applied Chemistry Research Vol 6, No 1 (2017): Edition of January - April 2017
Publisher : Chemistry Department, The University of Brawijaya

In this report, a synergetic computational and experimental studies were demonstrated on examples of poly-imine polymers; P(PI-IPI) and P(PIOH-IPI) to explore the role of hydroxyl substituent on their sensing and electronic properties. The polymer P(PIOH-IPI) bearing the OH-group on the ortho-position to the imine-bond, while the structure of the polymer P(PI-IPI) reveal the imine-bond only. The sensing property of the polymers was investigated via the UV-vis absorption in different solvents, acidic and basic solutions. Both polymers have shown significant sensing behavior in the acidic medium, while unpronounced behavior was noticed in the case of the polymer P(PI-IPI) in basic medium. Upon the incorporation of the OH-group, the polymer P(PIOH-IPI) has indistinguishable sensing behavior, a similar blue-shift in the acidic and basic medium, which can be attributed to the presence and the position of OH-group. The optical band gap of the polymers was determined experimentally and theoretically from the UV-vis absorption spectra and DFT calculations in the DMSO solvent. Other factors that affect the band gap values such as the structural conformation and length of conjugation were explored theoretically. In general, as the length of the optimized chain increased, the spectrum is red-shifted and the band gap decreased, which is attributed to the possible loss of chain planarity and conjugation beyond the monomer structure. Interestingly, the UV-vis spectra of the monomer-optimized structures were in a good match with the experimental UV-vis spectra. However, the band gap difference can be attributed to the method of band gap determination.

Effect of Calcination at Synthesis of Mg-Al Hydrotalcite Using co-Precipitation Method Niar Kurnia Julianti; Tantri Kusuma Wardani; Ignatius Gunardi; Achmad Roesyadi
The Journal of Pure and Applied Chemistry Research Vol 6, No 1 (2017): Edition of January - April 2017
Publisher : Chemistry Department, The University of Brawijaya

The use of hydrotalcite in catalysis has wide attention in academic research and industrial parties. Based on its utilization, hydrotalcite can be active catalyst or support. This research is focused on the investigation of characteristic like spesific surface area of Mg-Al hydrotalcite which is prepared with different temperature of calcination. Synthesis of Mg-Al hydrotalcites with Mg/Al molar ratio 3:1 were prepared by co-precipitation method. Mg(NO3)3.6H2O and Al(NO3)3.9H2O as precursors of Mg-Al hydrotalcite. Na2CO3 was used as precipitant agent and NaOH was used as buffer solution. The solution was mixed and aging for 5 hours at 650oC. The dried precipitate was calcined at 2500oC, 3500oC, 450oC, 550oC and 650oC. The characterization of functional group was determined by Fourier Transform Infra Red (FT-IR). The Identical peaks diffractogram were analyzed by X-Ray Diffraction (XRD). The spesific surface area was determined by adsorption-desorption of nitrogen. The largest surface area that obtained from the calcination temperature of 650oC is 156.252 m2/g.

Chemical Cues in Tritrophic Interaction on Biocontrol of Insect Pest Nurindah Nurindah; Surjani Wonorahardjo; Dwi Adi Sunarto; Sujak Sujak
The Journal of Pure and Applied Chemistry Research Vol 6, No 1 (2017): Edition of January - April 2017
Publisher : Chemistry Department, The University of Brawijaya

Tritrophic interaction among host plant-herbivore-parasitoid involves chemical cues. The infested plant by herbivores has been reacted to produce volatiles which is a cue used by the herbivore parasitoids for host location. These volatiles can be developed to enhance natural control of insect pests, especially by optimally use of parasitoids. Egg parasitoids are biocontrol agents that play an important role in natural control of herbivores. This research used a tritrophic interaction model of rice plant-brown plant hopper (BPH)-egg parasitoid of BPH. Research on analysis of chemical cues in tritrophic interactions was aimed to identify volatiles that are used by the parasitoid to find its host. The volatiles that effectively affect the parasitoid orientation behavior could be developed into a parasitoid attractant. Extraction of volatiles as the egg parasitoid cues was done using soxhlet, and identification of the volatiles using Gas Chromatography-Mass Spectrometry (GC-MS). Bioassay of the volatiles on the BPH parasitoid orientation behavior was performed using Y-tube olfactometry. The volatiles that are used for host location cues by the parasitoid affect the parasitoid orientation behavior by showing the preference of the parasitoid females to the odor of volatile. Volatiles extracted from BPH-egg-infested plants and uninfested plants contain alcohol, hydrocarbon, and ester compounds. Based on the difference of the compound composition of both extractions, five compounds of long-chain hydrocarbon, both branched and unsaturated compounds are the main volatile components which caused positive orientation behavior of the egg parasitoid. The egg parasitoids showed positive behavior orientation toward the volatiles extracted from BPH-egg-infested plant. Those hydrocarbon compounds are potential materials to be developed into bio attractants of BPH egg parasitoid.

Temperature Effect of Crystalinity in Cellulose Nanocrystal from Oil Palm Empty Fruit Bunch (OPEFB) using Sonication-Hydrothermal Methods Zulnazri Zulnazri; Fika Anjana; Achmad Roesyadi
The Journal of Pure and Applied Chemistry Research Vol 6, No 1 (2017): Edition of January - April 2017
Publisher : Chemistry Department, The University of Brawijaya

Production of cellulose nanocrystals (CNCs) from cellulose of oil palm empty fruit bunches (OPEFB) have been done. The delignification of OPEFB was mixed with 17,5% NaOH and carried out in the three-neck flask with refluxed for 2 hour at 80oC. Further the suspension was bleached with NaOCl 2% for 1 hour at 70oC. Then, to produce CNCs, Cellulose was firstly sonicated for 30 minutes at 40oC. After that cellulose was hydrolized at hydrothermal reactor for 0,1,2,3,4,5, hours at 110 and 120oC respectively. After filtration and washing, CNCs was analyzed by X-Ray Diffraction and the result shows that the grade of the highest CNCs crystalinity at consentration of HCL 2 M at a temperature of 110oC with reaction time of 2 hours is equal to 75.87%. It can be concluded that sonication-hydrothermal can increase the grade of crystalinity of cellulose nanocrystal.

Effect of Radioactivity of Technetium-99m on the Autosterilization Process of non-sterile Tetrofosmin Kits Widyastuti Widyastuti; Enny Lestari; Darma Sangaji
The Journal of Pure and Applied Chemistry Research Vol 6, No 1 (2017): Edition of January - April 2017
Publisher : Chemistry Department, The University of Brawijaya

Technetium-99m labeled radiopharmaceutical is commonly used in nuclear medicines as a diagnostic agent, by mixing the sterile kit with Tc-99m. Manufacturing of kits requires an aseptic facility which need to be well designed and maintained according to cGMP, since mostly kits can not be terminally sterilized. Radiopharmaceuticals as pharmaceuticals containing radionuclide is assumed to have an autosterilization property, but correlation between radioactivity and capability of killing microorganisms has to be studied so far. The aim of this study is to investigate the effect of radioactivity on the autosterilization process of radiopharmaceuticals. The study was carried out by adding Tc-99m of various radioactivity into non-sterile tetrofosmin kits, then the samples were tested for sterility. Sterile tetrofosmin kit and non-sterile kit with no Tc-99m added will be used as a negative control and positive control respectively. The sterility was tested using standard direct inoculation method, by inoculating samples in culture media for both bacteria and fungi and observing qualitatively within 14 days. The results showed that the samples with radioactivity of 1, 3 and 5 mCi changed the clarity of the media to turbid, conformed with the performance of positive controls but samples with radioactivity of 10 mCi and 20 mCi did not change the clarity of the media, conformed with the performance of negative control, indicating neither growth of bacteria nor fungi. It is concluded that Tc-99m behaves as an autosterilizing agent at certain radioactivity. Therefore the preparation of Tc-99m radiopharmaceutical can be considered as terminal sterilization rather than aseptic preparation.

A Flavonoid Glycoside Compound Isolated from Macaranga gigantifolia Merr Leaves Gian Primahana; Akhmad Darmawan
The Journal of Pure and Applied Chemistry Research Vol 6, No 1 (2017): Edition of January - April 2017
Publisher : Chemistry Department, The University of Brawijaya

Apigenin-8-C-glycoside (1), a flavonoid glycoside compound has been isolated from the leaves of Macaranga gigantifolia Merr. Isolation and purification conducted by chromatography methods and chemical structure characterization carried out by spectroscopic methods. Cytotoxicity of Apigenin-8-C-glycoside has been tested against Murine leukemia P-388 cell lines and has moderate activity with IC50 values 55.4 μg/mL.

Antimicrobial, antioxidant, and cytotoxic activities of endhopitic fungi Chaetomium sp. isolated from Phyllanthus niruri Linn: in vitro and in silico studies Rollando Rollando; Dion Notario; Eva Monica; Martanty Aditya; Rehmadanta Sitepu
The Journal of Pure and Applied Chemistry Research Vol 6, No 1 (2017): Edition of January - April 2017
Publisher : Chemistry Department, The University of Brawijaya

Endophytic fungi Chaetomium sp isolated from Phyllanthus niruri Linn. Mycelium powder was extracted by using ethyl acetate. Extract was fractionated using n-hexane, dichloromethane and ethanol 96%. The antimicrobial test was carried out using disc diffusion and microdilution methods. The antioxidant activity of the fraction was determined using hydrogen peroxide free radical scavenging and reducing power capacity activities. The cytotoxicity assay of the fraction against T47D breast cancer cell was carried out using dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide method (MTT). The in silico prediction of chemical substances which are reported exist in Chaetomium sp. performed using AutoDockVina embedded in PyRx version 8.0. Dichloromethane fraction was found as the most active sample against Escherichia coli (IC50 20.76 mg/mL), Staphylococcus aureus (IC50 70.15 mg/mL), Salmonella typhi (49.13 mg/mL) and was found as the most high phenolic content with value 47.44 mg GAE/g fraction, whereas the best antioxidant activity was performed by ethanol 96% fraction (85%). Cytotoxicity assay against T47D cell line showed dichloromethane fraction have highest activity with IC50 10.76 mg/mL. The docking studies showed that compounds bearing xanthone structure were potential for maltose binding periplasmic and human aromatase associating with their potencies as antibacteria and anticancer. Endophytic fungi Chaetomium sp. was isolated from Phyllanthus niruri using n-hexane, dichloromethane and ethanol fractions was studied its various biological activities as antimicrobial, antioxidant and cytotoxic agent against breast cancer cell.

Antibacterial Activity Test, Evaluation of Pharmacognosy and Phytochemical Screening of Some Extracts of Globe Amaranth (Gomphrena globosa) Kusmiati Kusmiati; Dody Priadi; Romah K.B. Rahayu
The Journal of Pure and Applied Chemistry Research Vol 6, No 1 (2017): Edition of January - April 2017
Publisher : Chemistry Department, The University of Brawijaya

Indonesia is a rich biodiversity country where various medicinal plants are existed. One species of medicinal plants is Globe Amaranth (Gomphrena globosa, Amaranthaceae). This species is native to Central America and has been widely spread to the tropics. To date the species can be easily found at the home gardens as an ornamental plant. Medicinal plants has been used for generations by traditional people. It was empirically proven that medicinal plants have ability to cure certain diseases such as dysentery. All parts of this plant can be used as medicine. However, only the flower of the species was used in this study. Objective of the study was to identify the highest antimicrobial activity of Gomphrene globosa flower extract using ethanol, petroleum ether, ethyl acetate and n-butanol solvents. Gomphrena globosa flower was extracted using 96% ethanol and then was by partitied using petroleum ether, ethyl acetate and n-buthanol respectively. The extracts were then evaporated using a rotapavor until condensed extract was obtained. Phytochemical screening was done on both of the flower powder and extract. Result of Pharmacognosy evaluation of the Globe Amaranth flower as follows: water content 8.17%, total ash content 9.11%, acid-insoluble ash 1.50%, acid-soluble ash 6.43%, water-soluble extract 10.79%, ethanol-soluble extract 3.51% and dry content 10.19%. The condensed extracts were tested for antimicrobial activity against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Shigella dysenteriae. Result of antibacterial activity test by agar diffusion method showed that the higner concentration of the extract led to higher bacterial inhibition zone. The highest antimicrobial activity was obtained from n-butanol extract as indicated by a significant inhibition zone around paper disk

Comparative Analysis of Chemical Components of Purified Essential Oil from Nilam Plants using Gas Chromatography Emas Agus Prastyo Wibowo; Fadila Mauliani; Utami Nofitasari; Atik Setyani; Nuni Widiarti
The Journal of Pure and Applied Chemistry Research Vol 6, No 1 (2017): Edition of January - April 2017
Publisher : Chemistry Department, The University of Brawijaya

This study aimed to determine the chemical components of the patchouli oil. Patchouli oil is one of the export commodities that have high economic value for Indonesia. In general, patchouli oil obtained from the hydrodistillation of patchouli leaves. Most industries are still using patchouli oil refiners made by ferrous metal. The rust will dissolve in patchouli oil obtained and led to the resulting of dark oil and patchouli aroma becomes lower. The main purpose of this research is to improve the quality of patchouli oil by the purification process technologies after oil refining process. In this research the purification of the impure and crude oil can be carried out using adsorption process with bentonite. Purification results with UV-VIS spectrophotometer showed that the activation energy at a wavelength of 510 nm-550 nm with 3.9 x 10-19 Joules. GC (Gas Chromatography) analysis showed that there are 13 components from patchouli oil, the 6 dominant peaks were compounds of patchouli alcohol (29.64%), delta-guanine (23.26%), alpha-guanine (21.9%), alpha-patchouline (4.24%), pogostol (4.15%), palustrol (4.00%), beta-pinene (3.9%). Based on the physical properties, the main constituent component content, and the Fe2+ content, refined patchouli oil meets the requirements of the Indonesian National Standards.

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Masruri

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jpacr@ub.ac.id

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Departemen Kimia, Fakultas MIPA, Universitas Brawijaya, Jl. Veteran 65145 Malang

Location
Kota malang,

Jawa timur

INDONESIA

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Masruri

Contact Email masruri@ub.ac.id

Phone +62341-575838

Journal Mail Official jpacr@ub.ac.id

Editorial Address Departemen Kimia, Fakultas MIPA, Universitas Brawijaya, Jl. Veteran 65145 Malang

Location Kota malang, Jawa timur INDONESIA

Abstract

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Contact Name
Masruri

Contact Email
masruri@ub.ac.id

Phone
+62341-575838

Journal Mail Official
jpacr@ub.ac.id

Editorial Address
Departemen Kimia, Fakultas MIPA, Universitas Brawijaya, Jl. Veteran 65145 Malang

Location
Kota malang,

Jawa timur

INDONESIA