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INDONESIA
Program Kreativitas Mahasiswa - Penelitian
Published by DITJEN DIKTI KEMDIKBUD RI
ISSN : -     EISSN : -     DOI : -
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Articles 105 Documents
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PIPERANTHA:INOVASI TERAPI KOMBINASI EKSTRAK DAUN SALAM (EUGENIA POLYANTHA) DAN SIRIH MERAH (PIPER CROCATUM) TERHADAP PENINGKATAN AKTIVITAS FAS/FAS-L PADA REGRESI PERTUMBUHAN KANKER SERVIKS SECARA IN VITRO Wicaksono, Firman Mulyo; Sari, Desie Suci Permata; Sekti, Beta Herilla; Sari, Yitania; Natalia, Ellen; Lyrawati, Diana; Febriyanti, Alifia Putri
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

In this study, we evaluated Eugenia polyantha and Piper crocatum leaves alone and in combination for their anti-cancer properties on HeLa cells. The extraction method by using soxhlet and maceration. The phytochemical constituents of extract were evaluated by qualitative and quantitative analysis. The anti-cancer property and mechanism of the extract were evaluated by its effect on cell viability and apoptosis. Total flavonoids content was higher in maceration than soxhlet extracts. Single extracts of Eugenia polyantha alone or Piper crocatum showed better anti-cancer activity than their combination. However, Eugenia polyantha extracts showed better anti-cancer activity than Piper crocatum extracts. Keywords : HeLa cell, Eugenia polyantha, Piper crocatum, single, combination
POTENSI PERMEN TIRAMISU YANG BERKHASIAT ANTIKOLESTEROL Waliyuddin, Waliyuddin; Yunita, Elvira; Karomah, Nailatul; Irshan, Yusuf; Amellia, Amellia
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Tiramisu candy is made of oyster mushroom extract ethanol. Oyster mushroom (Pleurotus ostreatus) contains lovastatin that inhibit cholesterol synthesis in the body. Ethanol extract of oyster mushroom was expected to give an effect in lowering cholesterol. This experiment used 35 male Sprague dawley rats that were divided into 5 groups (n=7).  The treatment period was for 14 days, normal group fed by standard woof, hypercholesterolemic group (HK) were fed by high- cholesterol woof (3%) and PTU (0.5 mg/kg BW), the group of lovastatin(lovastatin+HK0.2857mg/kgBW), treatment I group (HK+ oyster mushroom ethanol extract 30 mg/kg BW), and treatment II group (HK+ oyster mushroom ethanol extract 60 mg/kg BW). Blood was taken through the eyes of rats with hematocrit-heparin. Candy is made with a mixture of 5% starch, maltodextrin 10%, 4% magnesium stearate, sucrose 81%, and ethanol extract 2.1 grams of white oyster mushroom.The results showed that the ethanol extract of oyster mushroom (30 mg/kg BW and 60 mg/kg BW ) may decrease 53.89%  and 66.43% of cholesterol concentration. AST and ALT results of the analysis showed that the ethanol extract of white oyster mushroom dose of 30mg/ kg and 60 mg/ kg did not cause liver damage. Based on HPLC analysis,  a gram of oyster mushroom ethanol extract containing 3.6x10- 6 grams of lovastatin. Tiramisu candy successfully made by weight 100 mg to extract content of 2.1 mg and 7.56x10-6mg of lovastatin. Keywords : AST ALT, candy, cholesterol, lovastatin, Pleurotus ostreatus.
LAPAS ROKOK (LAMPU PENGHILANG ASAP ROKOK) BERBASIS FOTOKATALITIK NANOPARTIKEL ZnO Milarsih, Yulia; Wibowo, Arif Sony; Wuning, Sri; Prasetya, Nor Basid Adiwibawa
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

ZnO is a photocatalyst essence that has economical value which can be able to degrade any dangerous organic compound by photocatalytic reaction. The purpose of this research is to fix any problems which are caused by smoke in Indonesia by innovation of smoke-disappeared light based on photocatalyst of  ZnO nanoparticles. The zinc oxide (ZnO) has disadventage which can be initiated only by the UV light, so adding Co(Cobalt) is needed to decrease the gap-energy in order for it can work at visible light. The experiment method was carried out in three steps: (1) synthesis of  ZnO nanoparticles by sol gel method, (2) the veneering was used the spray coating. The result showed that bandgap of  ZnO which doped by Co is 2,28 eV, the size of nanoparticles which layered at the light-glass is about 40 nm, and can reduce CO until 3.69 ppm or 793,35 x 1019 particles for 10 minutes Keywords: LAPAS ROKOK, ZnO, nanoparticles, photocatalyst
EFEK PROTEKSI MENGKUDU (Morinda citrifolia L.)TERHADAP JUMLAH SPERMATID TESTIS MENCIT (Mus musculus) YANG DIPAPAR ASAP ROKOK Larassuci, Fitria Dewi; Annisah, Fitroh; Aviani, Rifki; Rizky, Syifa Marhattya; Nurhidayah, Siti
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Free radicals of the cigarette smoke can decrease the male fertility. In present study, Morinda citrifolia L. extract was evaluated for its protective effect on the number of spermatids which induced by cigarette smoke in Swiss webster mice. Four groups of mice were arranged as follows: KK (control group), KP0 (cigarette smoke), KP1(low dose extract + cigarette smoke), KP2 (high dose extract + cigarette smoke). After 14-day treatment, all mice were sacrificed. The LSD test showed significant differences between each pair of groups. Morinda citrifolia L. extract showed protective effect to the number of spermatids which induced by cigerette smoke. Keywords: Morinda citrifolia L. extract, cigarette smoke, number of spermatids
KIT DETEKSI KANKER LEHER RAHIM BERBASIS ANTIBODI TELOMERASE: PENDEKATAN SECARA IMMUNOMOLEKULAR Hidayatullah, Furqan; Wijaya, Andreas Budi; Gersom, Camoya; Pahlevi, Faizal Reza; Setyabudhi, Veronica Verina
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Cervical cancer is the first leading cause of cancer death in Indonesia. About 95% telomerase activity is associated with cervical cancer’s malignancy. Therefore, telomerase is very potential as a biomarker for cervical cancer detection. This research’s purpose is to produce  cut-off point of cervical cancer telomerase. Telomerase antibody is produced and detected using Western Blotting and ELISA, 15 samples of each cancer and normal patients were collected from RSSA. ELISA Absorbance value of antibody and antigen binding were collected and analyzed using independent t-test and ROC. cut off point is found at 0.092 with 81,25% specificity and 80% sensitivity. Keywords: Cervical Cancer, Telomerase, Telomerase Antibody, Cut-Off point
PENGARUH PENAMBAHAN LOGAM FE(II) TERHADAP LAJU PERTUMBUHAN FITOPLANKTON CHLORELLA VULGARIS DAN PORPHYRIDIUM CRUENTUM Rizky, Yusi Anda; Suharja, Jaya; Dirga, Ayusti; Ilham, Ilham
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Research about the Effect of Fe(II) Addition Toward Growth rate of Phytoplankton Chlorella vulgaris and Porphyridium cruentum have been done.  It used sea water that was added by Conway medium and vitamin as culture media on the second species of phytoplankton test. Exposure of Fe (II) was conducted in culture media whose concentration were 0,0; 0,1; 0,2; 0,3; 0,4; 0,6; 0,8; 1,0; 1,5; and 2,0 ppm in order to increase the growth rate of phytoplankton. The result indicated that phytoplankton C. vulgaris is the higher cell density 3.060 x 104 cell/mL.  Maximum tolerance concentration of Fe (II) by phytoplankton C. vulgaris is   0,6 ppm and density cell is 9.612 x 104 cell/mL. Keywords: Chlorella vulgaris, Fe(II), Growth rate, Phytoplankton, Porphyridium cruentum
UJI AKTIVITAS ANTIPLASMODIUM EKSTRAK BENALU SECARA IN VIVO PADA MENCIT GALUR SWISS Faiqoh, Zulfa; Baskara, Anak Agung Ngurah Nata; Budi, Danang Setia; Putra, Pramana Pananja; Nitari, Wahyu; Solikhah, Eti Nurwening
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Malaria is one of the most prevalent tropical disease in the world. Until now, the use of antimalarials in malaria patients generated a lot of resistance so many scientists began the development of research using herbal plant ingredients, for example mistletoe (Dendrophthoe pentandra) This study was conducted to determine the effect of antiplasmodium in vivo. Antiplasmodium test conducted on P. berghei which were injected into mice suppression method. The results show that the Dendrophthoe pentandra extract has antiplasmodium activity with ED50 of 146,2 mg/kgBW. It can be concluded that Dendrophthoe pentandra has the potential as an antimalarial agent in vivo. Keywords: Dendrophthoe pentandra, malaria, antiplasmodium, mice, parasitemia,  Plasmodium berghei.
PERANAN EKSTRAK KULIT PISANG UNTUK MENGATASI KATARAK DENGAN HEWAN COBA TIKUS (Rattus norvegicus) Mahmudah, Gustin; AS, Hanindhitya Lintang; F, Fabianus Winant; F, Syifai Triana
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

This study aimed to determine the benefits of banana peel extract to prevent and cure of cataracts. Twenty four rats, 19 days old were divided into eight experimental groups. To develop cataract models, rats were induced by sodium selenites 15 μmol/kg body weight/subcutan (sc). The groups of rats that were induced by sodium selenites and banana peel extract, showed the healing progress of eyes with the thickness of the fog on eyes. The banana peel extract could prevent of cataracts at a concentration of 25% and cure of cataracts at a concentration of 50%.
DESAIN PENGEMBANGAN GREEN ARCHITECTURE DI KAWASAN DAGO DENGAN PENDEKATAN ARSITEKTUR TRADISIONAL SUNDA Iswanto, Hadi Yanuar; Priyadi, Adam; Nurtadril, Ikhwan; Pratama, Luthfi
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

This PKM is come from global warming which to be seriously concern issue around the world. Solution for it has been encourage with carbon emissions reduction program. Another way to support the program is movement of green architecture. This movement emerged as an awareness to create a building with friendly to earth. This movement are to be trending topic around the world. In Indonesia, particularly in Bandung, many developer and owner choose Dago area to build green architecture. Dago is located at North of Bandung and surrounding of hill topography. Dago also has beautiful view which made a reason to place green architecture on there. But, Dago has a special regulation because it’s water conservasion area. So, developed house with green architecture term are interesting to research. Green architecture not only impact to living of humanities but also contribute to preservation of environment. This research are to finding green technology on architecture in Dago. Methods are used in this research is check list system trhrough an interview and observation. Rating did based on GBCI rating tools with appropriate to green building theory and government regulation in North of Bandung, so made the output of research is appropriate with green architecture theory. Minus point on rating component can be complete with Sundanese architecture, because Sundanese architecture has natural characteristics such as water, bamboo, and stone.    Keywords: green architecture, sundanese architecture, bandung
PEMANFAATAN α – KERATIN BULU AYAM SEBAGAI ADSORPSI ION Pb DALAM LIMBAH TEKSTIL Latifah, Rais Nur; Ernia, Roro; Yulianto, Erick Rian; Pramono, Edi
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

The present study was undertaken to develop a cost effective biosorbent and to study the biosorption process involved in the adsorption of heavy metal-contaminated textile wastewater using the developed biosorbent. Biomass chicken feathers was activated by Na2S 0.1 N to produce adsorbent for lead in aqueous solution. This study focuses on the effectiveness of lead removal by batch adsorption method. The feather samples both activated and non-activated with adsorbed Pb (II) ions were analyzed by spectroscopic methods (Surface Area Analyzer, Atomic Absorption Spectroscopy and Fourier transform infrared spectroscopy). Particularly, the effect of pH, agitation time, adsorbent concentration, and particle size were considered. Optimum adsorption pH values of Pb (II) for activated and non-activated feathers were 8 whereas optimum adsorption contact time of Pb (II) for activated and non-activated feathers were 60 minutes and 90 minutes respectively. At the optimal adsorption conditions, adsorption ratio could get to 97.52% for activated feathers and 98.67% for non-activated feathers. The higher concentration of lead has a greater adsorption as well as high adsorption capability of feathers. The Freundlich adsorption model agrees well with experimental data, because of the high correlation coefficient that the former exhibited, thus, indicating to the applicability of multilayer coverage of the Pb (II) on the pores of adsorbent surface. The applicability of the Ho and Lagegren kinetic model has also investigated. Lead ions from the sample of textile wastewater were adsorbed on activated feathers with efficiency up to 90%. Laboratory tested and proven more effective and efficient in removing Pb (II) ions from aqueous solution by using activated feathers. The low cost and simplicity of the technique hold great potential applications in environmental protection.Keywords: Adsorption; Biomass of chicken feather; Heavy metals; Pb (II) ions; Textile wastewater

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