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Kab. jember,
Jawa timur
INDONESIA
Journal of Agromedicine and Medical Sciences
Published by Universitas Jember
ISSN : 24609048     EISSN : 27145654     DOI : -
Core Subject : Health,
Health Professions
Jurnal Agromedicine and Medical Sciences (AMS) adalah jurnal berkala empat bulan (Februari, Juni dan Oktober) yang berisi berbagai artikel dalam bentuk penelitian, tinjauan sistematis dan laporan kasus dalam bidang kedokteran dengan fokus pada ilmu-ilmu kedokteran dasar, kedokteran klinis dan agromedis.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol 2 No 1 (2016)" : 5 Documents clear
Hydroquinone Identification in Whitening Creams Sold at Minimarkets in Minomartini, Yogyakarta Dian Wuri Astuti; Hieronimus Rayi Prasetya; Dina Irsalina
Journal of Agromedicine and Medical Sciences Vol 2 No 1 (2016)
Publisher : Faculty of Medicine, University of Jember

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Abstract

Whitening cream is a cosmetic which is contains chemicals and other materials that can etiolate black (brown) stain on the skin. Hydroquinone is a supplemental ingredient in whitening cream. Hydroquinone is the active ingredient that can control the production of uneven pigment, rather serves to reduce or inhibit the formation of melanin. The use of hydroquinone in cosmetics should not be more than 2%.The excessive use of hydroquinone can cause oochronosis,a rough, speckled bluish skin. The purpose of this study is to determine whether or not there are any hydroquinone in whitening cream sold at Minimarket in Minomartani, Yogyakarta. If found, further testing is done to determine the level of hydroquinone in it. This research describes the presence or absence of hydroquinone in the whitening creams and find out how much the percentage is. The method used is Thin Layer Chromatography (TLC) and serimetri titration. The qualitative study test results that 64% of the samples positively contain hydroquinone, whereas from the quantitative assay it is obtained that 89% of the samples are not suitably qualified according to Permenkes No.445/MENKES/PER/V/1998. There are 9 out of 14 whitening cream brands that contain hydroquinone and 8 of them contain levels of hydroquinone more than normal (> 2 %).Keywords: face whitening cream, hydroquinone, Thin Layer Chromatography, serimetri titration.
The Selectivity of Ethanolic Extract of Buah Makassar (Brucea javanica) on Metastatic Breast Cancer Cells Ika Rahmawati Sutejo; Herwandhani Putri; Edy Meiyanto
Journal of Agromedicine and Medical Sciences Vol 2 No 1 (2016)
Publisher : Faculty of Medicine, University of Jember

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Abstract

Treatment of cancer such as surgery, radiotherapy and chemotherapy has many side effects. Chemopreventive agent is needed to reduce the side effect and increase the effectivity of therapy. The discovery of  cochemopreventive agent should consider on its selectivity to reduce side effects. The selective cochemopreventive agents work effectively in cancer cells and safe for normal cells. Buah Makassar (Brucea javanica) is a natural product that is empirically used for anti-inflammatory and antitumor. The purpose of this study is to determine the cytotoxic effect of ethanolic extract of buah Makassar against 4T1, MCF7, HeLa, and Vero cell lines. The cytotoxic test is performed by MTT assay. The parameter obtained from the cytotoxic test was IC50. Selectivity index is determined from IC50 ratio of cancer cells to normal cells. The results showed that ethanolic extract of buah Makassar has a cytotoxic activity on 4T1, MCF7, HeLa, and Vero cells with IC50 were 49,9±0,83 μg/mL; 107,6±8,14 μg/mL; 228,9±4,16 μg/mL and 395,5± 4,21 μg/mL respectively. It also has high selectivity on 4T1 metastatic breast cancer cell with selectivity index of 7,93. It can be concluded that the ethanolic extract of buah Makassar has potential to be delevoped as cochemopreventive agent especially on metastatic breast cancer. Keywords: Brucea javanica, MTT assay, selectivity index, 4T1, MCF7, HeLa, Vero
The Effect Of Mefenamic Acid On Longitudinal Development Of Growth Plate In Young Male White Rats Muhamad Hasan
Journal of Agromedicine and Medical Sciences Vol 2 No 1 (2016)
Publisher : Faculty of Medicine, University of Jember

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Abstract

The past epidemiologic studies did not have definite explanation about the effect of consuming Mefenamic Acid on Longitudinal Bone Development. The aim of this study is to explain the effect of Mefenamic Acid on Longitudinal Bone Development. The design of this study was the Separate pretest, Posttest Only Control Group Design using 40 male wistar strain rats and divided into four groups. They  consists of one pretest group, one control group and two treatment groups. The treatment groups were given mefenamic acid orally in the dose of 27 mg/200 g BW/day, and 54 mg/200 g BW/day which were dissolved in 2 ml of distilled water. After 4 weeks, the length of femur, length of growth plate  and number of longitudinal cell of growth plate are noticed. The result was showed in all of experimental animals had a significant difference to control groups (p<0.05). Pair wise comparisons showed  that significant difference (p<0.05) occurred in all of groups except between mefenamic acid 27 mg and mefenamic acid 54 mg that not significant difference. This study show that mefenamic acid treatment cause decrease of femur length, decrease of growth plate length and decrease number of growth plate cell. Keywords: mefenamic acid, chondrocyte, growth plate
The Effect of Mirabilis jalapa Leaf Ethanolic Extract against Streptococcus pyogenes Bagus Satrio Pambudi; Enny Suswati; Jauhar Firdaus
Journal of Agromedicine and Medical Sciences Vol 2 No 1 (2016)
Publisher : Faculty of Medicine, University of Jember

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Abstract

Streptococcus pyogenes is a Gram positive bacteria that commonly cause disease in human. If not treated immediately, this bacteria can cause serious complication such as reumatic fever that causing heart valve tissue damage. Penicilin, drug of choice to eradicate S. pyogenes, oftenly cause various side effects such as anaphylaxis. This study aimed to investigate the effect of Mirabilis jalapa leaf ethanolic extract against S. pyogenes growth using in vitro techniques. The study design was a quasi experimental design. S. pyogenes culture as the study subject were divided into positive control group (penicilin V 100 IU), negative control group (NaCMC 0,5%), and eight treatment groups that were given with M. jalapa leaf ethanolic extract as much as 0,1 mg/ml, 1 mg/ml, 5 mg/ml, 10 mg/ml, 20 mg/ml, 30 mg/ml, 40mg/ml, and 50 mg/ml. After 24 hours incubation periods, the inhibition zone were found in all treatment group except in concentration 0,1 mg/ml. This study showed that M. jalapa leaf ethanolic extract could inhibit the growth of S. pyogenes. There was significant correlation between the concentration of M. jalapa leaf ethanolic extract and the diameter of inhibition zone (p=0,00), the higher concentration of M. jalapa leaf extract, the larger diameter of inhibition zone of S. pyogenes. Keywords: Mirabilis jalapa, leaf extract, antimicrobial activity
The Correlation between Service Quality of Maternal and Child Healthcare/Family Planning Clinic and Degree of Maternal and Child Health at Two Primary Health Care Centers in Jember Kunthi Kencana Makayasa Putri; Ida Srisurani Wiji Astuti; Sugiyanta Sugiyanta
Journal of Agromedicine and Medical Sciences Vol 2 No 1 (2016)
Publisher : Faculty of Medicine, University of Jember

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Abstract

The high Maternal Mortality Rate (MMR) and Infant Mortality Rate (IMR) is still a major health problem in Indonesia. As an one of indicator to assess the quality of maternal and child healthcare is MMR and IMR. Service quality consists of five dimensions i.e., tangible, responsiveness, reliability, assurance, and empathy. The aim of this research was to determine the correlation between service quality of maternal and child healthcare/family planning polyclinic and degree of maternal and child health at Two Primary Health Care Centers in Jember. This research used cross-sectional design with 144 respondents. Service quality was measured using ServQual questionnaire and degree of maternal and children health were measured using MMR and IMR. The results of statistical test with Spearman correlation test showed that the significance (p) = 0.000 and correlation coefficients (r) = 0.690. Thus, it can be concluded that there were a strong correlation between service quality of maternal and child healthcare/family planning clinic and degree of maternal and child health at Two Primary Health Care Centers in Jember. Keywords: Maternal Mortality Rate, Infant Mortality Rate, ServQual. 

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