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Kab. jember,
Jawa timur
INDONESIA
Journal of Agromedicine and Medical Sciences
Published by Universitas Jember
ISSN : 24609048     EISSN : 27145654     DOI : -
Core Subject : Health,
Health Professions
Jurnal Agromedicine and Medical Sciences (AMS) adalah jurnal berkala empat bulan (Februari, Juni dan Oktober) yang berisi berbagai artikel dalam bentuk penelitian, tinjauan sistematis dan laporan kasus dalam bidang kedokteran dengan fokus pada ilmu-ilmu kedokteran dasar, kedokteran klinis dan agromedis.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol 2 No 3 (2016)" : 5 Documents clear
Antiinflamatory Activity Test N-Hexane Extract of Breadfruit Leaf (Artocarpus altilis) for Erythema on Skin White Rat (Rattus novergiccus) Desi Suryani Dewi; Intan Zhofir Asyur Lazuardi; Nurlaila Ayu Purwaningsih
Journal of Agromedicine and Medical Sciences Vol 2 No 3 (2016)
Publisher : Faculty of Medicine, University of Jember

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Abstract

Ultraviolet radiation (UV) is part of a spectrum of electromagnetic radiation emitted by the sun. UV-C has the shortest wavelength than the wavelength of UV-A and UV-B. UV-C is able to penetrate the earth due to the reduction of ozone in the stratosphere and is capable of causing skin cancer. The initial symptoms of cancer of skin erythema. Researchers used the N-Heksane extract of leaves of breadfruit for the treatment of erythema skin white rat (Rattus novergiccus) were exposed to UV-C radiation for 168 hours. Rats were divided into two groups of control and three experimental groups. The control group was not given the therapy and were treated dexamethasone 1 mg / kg / day while the experimental group was given the extract N-Heksane leaves of breadfruit (Artocarpus altilis) at a dose of 50 mg / kg / day, 100 mg / kg / day and 200 mg / kg /day. The method used is pure experimental (true experimental design) in vivo by design pretest-posttest control group design. Results are extensive changes erythema and ultrastructural changes in the epidermis and dermis rats were observed microscopically before and after therapy in rats irradiated skin UV-C light.Keywords: N-Hexane Extract Leaves Breadfruit (Artocarpus altilis), rat (Rattus novergiccus), UV-C radiation
Bioinformatics Approach towards Transcriptomics of Filaggrin Dito Anurogo; Arli Aditya Parikesit
Journal of Agromedicine and Medical Sciences Vol 2 No 3 (2016)
Publisher : Faculty of Medicine, University of Jember

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Abstract

Filaggrin, or filaments which combines protein, is one of the important structural protein that works for the development, maintenance, and the formation of the skin as an intact barrier. Filaggrin breakdown products regulate the hydration of the skin; contribute to the acidic pH of the skin, which in turn is essential for the activity of various proteases in the stratum corneum desquamation and lipid synthesis. Filaggrin produced by keratinocytes granular as a major precursor called profilaggrin, encoded by the FLG gene, located in the epidermal differentiation complex on chromosome 1 (1q21 locus). The locus contains a group of genes involved in epidermal differentiation. Filaggrin deficiency has some consequences on the organization and function of epidermal with important implications such as increased risk for atopic disease or a microbial infection. FLG mutation, a gene that encodes filaggrin, has been shown to cause ichthyosis vulgaris, increasing the risk of atopic dermatitis and other atopic diseases. This research examined the FLG gene based bioinformatics approach to search for conserved region of representative mammals that encode coding (m) and non-coding (nc) RNAs. Expected mRNA expression can be used as a diagnostic and therapeutic agent against deficiencies and filaggrin mutations.Key words: filaggrin, FLG, profilaggrin, filaggrin deficiency, bioinformatics.
Modulation of Antibiotic Activity Against Streptococcus pneumoniae by N-acetylcysteine and ascorbic acid Dini Agustina; Bagus Dwi Kurniawan; Intan Palupi
Journal of Agromedicine and Medical Sciences Vol 2 No 3 (2016)
Publisher : Faculty of Medicine, University of Jember

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Abstract

Streptococcus pneumoniae is one of the bacterial pathogens that cause pneumonia. Pneumonia is the biggest cause of infant mortality in Indonesia around 23%. The main therapy pneumonia is antibiotics, but in some cases combined with ascorbic acid or N-acetylcysteine, which serves as a complementary therapy. The purpose of this study was to determine the effect of adding ascorbic acid or N-acetylcysteine ​​on antibiotics towards the growth of S. pneumoniae in vitro. The method used in this research is the method of germ-disc diffusion susceptibility test with S. pneumoniae growth inhibition is indicated by the formation of inhibition zone. Positive controls used clindamycin and erythromycin. The average diameter of inhibition zone on the negative control, positive control, and treatment of 1 to 5 on the addition of clindamycin with ascorbic acid are respectively 5; 24.12; 24.62; 26.08; 27.58; 28.74; and 29.76 mm. The data has a strong correlation to the Pearson test (R=+0,910). On a logarithmic regression analysis found minimal concentration of ascorbic acid can inhibit is 1.767 mg/ml. While the addition of erythromycin with N-acetylcysteine ​​are respectively 28.02; 25.62; 23.46; 22.42; and 21.68 mm. Pearson correlation test results of these data are the opposite relationship between the diameter of inhibition zone and the concentration of N-acetylcysteine ​​with a very strong correlation coefficient. Logarithmic regression of the minimum concentration of N-acetylcysteine ​​which may decrease the antibacterial activity of erythromycin inhibit the growth of Sreptococcus pneumoniae amounted 1,66mg/ml. It is concluded that ascorbic acid increases the activity of clindamycin in inhibiting the growth of S. pneumoniae in vitro and N-acetylcysteine ​​may decrease the antibacterial activity of erythromycin in inhibiting the growth of S. pneumoniae in vitro. Keywords: S. Pneumoniae, ascorbic acid, N-asetilsitein, inhibition zone
Analysis of Risk Factors for Obesity in Urban Children in Some Elementary School in Jember Regency Jasmine Fachrunnisa; Cholis Abrori; Dwita Aryadina Rachmawati
Journal of Agromedicine and Medical Sciences Vol 2 No 3 (2016)
Publisher : Faculty of Medicine, University of Jember

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Abstract

The prevalence of obesity in children has steadily increased, not only in the world but also in Indonesia. Urban area as a central of economic led the higher prevalence of childhood obesity than in rural areas. The objective of this study was to analyze the risk factors associated with obesity among urban elementary school childrens in Jember. A cross sectional study was conducted with a total sample of 176 pupils. Anthropometric status determined using body mass index for age and obesity stated if z-score exceed >+2SD based on WHO 2007. The questionnaire about risk factors was filled with interview. Analysis data performed with univariate, bivarate, and multivariate analysis. This study showed the prevalence of obesity was 17%. Overall, our result showed that in non modifiable risk factors, the prevalence of obesity was significantly higher in children who had obese parent when compared to children who hadn't. Children who had obese parent had the more risk of obesity by 6 times. In modifiable risk factors, children who had meal more than 3 times per day had the more risk of obesity by 2 times. Drinking milk frequently according to Dietary Guideline for American 2015 has a protective factors against obesity.Keywords: childhood obesity, urban, risk factor
Correlation of the Mastoid Pneumatization and Bone Destruction in CSOM with Acquired Cholesteatoma using Computed Tomography Dyah Nilasari; Farah H Ningrum; Zulfikar Naftali
Journal of Agromedicine and Medical Sciences Vol 2 No 3 (2016)
Publisher : Faculty of Medicine, University of Jember

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Abstract

Chronic Suppurative Otitis Media (CSOM) is still a public health problem especially in developing countries. CSOM with acquired cholesteatoma accompanied referred to as the type of hazard, as they often lead to dangerous complications and have a high rate of morbidity and mortality. Mastoid CT with 0,625mm slice thicness may reveal detail cholesteatoma and bone destruction. It’s an analytic observational study with cross sectional design. This study consisted of 30 cases CSOM, aged 18-60 years and had a 0,625mm slice thicness CT scan mastoid examinations in Dr. Kariadi Hospital Semarang and indicating a cholesteatoma and bone destructions. The result showed that hypopneumatization type and mild degree of bone destructions obtained in most subjects, each 20 and 21, but there’s no correlation between mastoid pneumatization and bone destruction (p 0,367 or p > 0,05). This study showed more lower type of the mastoid pneumatization, more severe degree of bone destructions.Keywords: CSOM, mastoid pneumatization, Mastoid CT

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