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Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)

Farmasi
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Published by Universitas Wahid Hasyim Semarang

ISSN : 16937899 EISSN : 27163814 DOI : 10.31942

Core Subject : Health,

Medicine & Pharmacology

Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.

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Search results for , issue "JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 4 NO. 1 JUNI 2007" : 7 Documents clear

Jurnal Ilmu Farmasi & Farmasi Klinik Journal of Pharmaceutical Science & Clinical Pharmacy fakultas farmasi
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 4 NO. 1 JUNI 2007
Publisher : Universitas Wahid Hasyim Semarang

iJurnalIlmu Farmasi &Farmasi KlinikJournal of Pharmaceutical Science & Clinical PharmacyPemimpin Umum/ Penanggung jawabDekan Fakultas Farmasi Universitas Wahid HasyimPemimpin RedaksiKetua Program Studi FarmasiFakultas Farmasi Universitas Wahid HasyimRedaktur AhliProf. Dr. Suwaldi MSc. Apt.Prof. Dr. Sasmito, Apt.Prof. Dr. Suwijiyo Pramono, Apt.Prof. Dr. Mustofa, MKes. Apt.Redaktur PelaksanaDrs. Ibrahim Arifin, Apt.Staf Redaksi :Riyanta Aribawa, SSi. Apt.Yulias Ninik Windrati, SSi. M.Si., Apt.Sri Susilowati, SSi. M.Si., Apt.Maulita Cut Nuria, SF. Apt.Aqnes Budiarti, SF. Apt.Sekretaris RedaksiYance Anas, S.Farm.,. Apt.DistributorAndi Heru Wahyanto.Alamat Redaksi/Tata UsahaFakultas Farmasi Universitas Wahid HasyimJl. Menoreh Tengah X/22 Sampangan SemarangTelp. 024-8505680, 8505681 Fax. 024-8505680E-mail : jiffk_uwh@yahoo.comTerbit 2 kali setahun sejak September 2004ISSN : 1693-7899Volume 4 No 1 Juni 2007iiJurnalIlmu Farmasi &Farmasi KlinikJournal of Pharmaceutical Science & Clinical PharmacyDAFTAR ISIPengaruh Perbedaan Konsentrasi Ekstrak Etanolik Umbi Bengkuang (Pachyrrhizuserosus, Urb.) dalam Sediaan Krim terhadap Sifat Fisiknya.Yulias Ninik Windriyati, Diah Pitaloka Wahyuningrum, Mimiek Murrukmihadi………. 1 – 3Penyidikan Efek Samping Haloperidol dan Chlorpromazin, Studi Kasus pada PasienRawat Inap Rumah Sakit Jiwa Daerah Dr. Amino Gondohutomo Semarang Periode2005Sri Susilowati……………………………………………………………………… 4 – 9Pengaruh Penambahan Sukrosa terhadap Stabilitas Asetosal dalam Dapar FosfatYance Anas, Ifiet Pantilata, Suwaldi………………………………………………. 10 – 15Kerasionalan Penggunaan Obat Bebas dan Obat Bebas Terbatas Common Colddalam Upaya Swamedikasi oleh Masyarakat di Kecamatan Gajahmungkur SemarangAqnes Budiarti Dharmika Wijaya, Mufrod………………………………………... 16 - 18Aktivitas Mukolitik Ekstrak Etanolik Herba Meniran (Phyllanthus niruri, L.)Menggunakan Sampel Mukosa Usus Sapi Secara In vitroYulias Ninik Windriyati., Nissa Ratna Junita, Mimiek Murrukmihadi……………. 19 – 22Evaluasi Kerasionalan Pengobatan Diabetes Melitus Tipe 2 pada Pasien Rawat Inapdi Rumah Sakit Bhakti Wira Tamtama Semarang Tahun 2006Ibrahim Arifin, Erna Prasetyaningrum, Tri Murti Andayani ……………………… 23 – 29ISSN : 1693-7899Volume 4 No 1 Juni 2007iiiPENGANTAR REDAKSIAssalamualaikum Wr. Wb.Alhamdulillah seiring dengan perjalanan Fakultas Farmasi Universitas Wahid Hasyim Semarang, Jurnal Ilmu Farmasi dan Farmasi Klinik (JIFFK) telah memasuki tahun ke-empat semenjak penerbitan perdana tahun 2004. kami tetap berharap bahwa JIFFK dapat memberikan kontribusi bagi perkembangan ilmu farmasi dan farmasi klinik.Kami berharap bahwa JIFFK ini dapat digunakan sebagai wadah bagi para peneliti, akademisi dan pemerhati ilmu farmasi dan farmasi klinik untuk mempublikasikan hasil penelitian atau pemeikirannya. Demi menjaga eksistensi dan sustainabilitas JIFFK kami senantiasa memohon sumbangan tulisan atau artikel dari para peneliti. Kami selalu berusaha untuk dapat meningkatkan kualitas dari setiap penerbitan JIFFK ini, karena kami memiliki cita-cita supaya JIFFK dapat terakreditasi dari Dikti, DepDikNas-RIAkhir kata kami sampaikan terima kasih yang sebesar-besarnya kaepada semua pihak yang telah membantu terlaksananya penerbitan ini. Kritik dan saran selalu kami nantikan dari pembaca sekalian demi perbaikan dan kemajuan JIFFK.Wassalamu’alaikum Wr. Wb.Semarang, Juni 2007Hormat kamiRedaksi

PENGARUH PERBEDAAN KONSENTRASI EKSTRAK ETANOLIK UMBI BENGKUANG (Pachyrrhizus erosus, Urb) DALAM SEDIAAN KRIM TERHADAP SIFAT FISIKNYA yulias ninik windriyati; diah pitaloka wahyuningrum; mimik murukmihadi
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 4 NO. 1 JUNI 2007
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTPeople has been used juicy tuber as food and cosmetic for delicated skin. Juicy tuber extract was formulated in cream in order to practical and effective. The aim of this research is to know the influence of difference concentration of juicy tuber extract in cream and storage duration to its physical properties. Extract was obtained from juicy tuber by remaceration method using 70% ethanol. Cream were made in five formulas with extract concentration 0,5 %, 1,0 %, 1,5 %, 2,0 % and 2,5 % w/w using standard formula cold cream. The physical stability of the cream was tested such as homogeneity, creaming and cracking, stickness, and spreadibility for 4 weeks storage. The data obtained were statistically analyzed using Friedman test with the 95 % confident level, followed by Mann Whitney test. Result of this research indicate that the cream of juicy tuber extract homogeneous and no creaming for 4 weeks storage. The difference of extract concentration and storage duration had not influence to physical stability of cream. Keyword: Extract of Juicy tuber, Cream, Physical TestPENDAHULUANPerawatan kesehatan dan kecantikan dengan memanfaatkan bahan alamiah selain lebih murah juga lebih aman dan tidak menimbulkan efek samping yang membahayakan. Berbagai hasil penelitian dibidang kosmetik mengungkapkan bahwa perawatan kecantikan kuno dengan bahan alamiah bisa dibuktikan secara ilmiah (Surtiningsih, 2005).Kosmetika pada prinsipnya adalah obat namun tujuan pemakaiannya sedikit mengalami perubahan bila dibandingkan dengan tujuan pemakaian obat-obatan pada umumnya. Kosmetika dirancang untuk tujuan estetika yaitu mempercantik, memperbaiki, dan mengubah penampilan seseorang (Depkes RI., 2003).Tanaman bengkuang (Pachyrrhizus erosus, Urb) biasa dimanfaatkan sebagai buah atau bagian dari beberapa jenis masakan. Bengkuang juga dimanfaatkan sebagai penghalus kulit, dan berkhasiat sebagai obat beri-beri, demam, diabetes, sariawan dan wasir. Sifat kimiawi dan efek farmakologis tanaman bengkuang adalah manis, dingin, sejuk dan berkhasiat mendinginkan. Kandungan kimianya adalah Pachyrhiton, rotenone, vitamin B1 dan C (Anonim, 2003).Bengkuang supaya mudah digunakan sebagai penghalus kulit perlu dilakukan pengembangan formulasinya dalam sediaan krim. Penelitian ini bertujuan untuk mengetahui pengaruh perbedaan konsentrasi ekstrak etanolik umbi bengkuang dalam sediaan krim dan lama penyimpanan terhadap sifat fisiknya.METODOLOGIAlat

PENYIDIKAN EFEK SAMPING HALOPERIDOL DAN CHLORPROMAZINE : STUDI KASUS PADA PASIEN RAWAT INAP RUMAH SAKIT JIWA DAERAH Dr. AMINO GONDOHUTOMO SEMARANG PERIODE 2005 sri susilowati
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 4 NO. 1 JUNI 2007
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTHaloperidol and chlorpromazine antipsycotic were used for broad and so long time. That drugs used could shown undesire side effect. Objective of this study was to investigate haloperidol and chlorpromazine side effect, especially was to know relative risk (RR) of extrapiramidal and hypotension orthostatic side effects of haloperidol and chlorpromazine antipsycotic used in Dr. Aminogondohutomo Mental Hospital durimg 2005. Non experimental, retrospective and Case Control study design was done. Population of this study was patient ward in Dr. Aminogondohutomo Mental Hospital durimg 2005. Data was taken retrospectively from medical record. Analytical of data used Chi Kuadrat and Odds Ratio (OR) was to know relative risk (RR) of extrapiramidal and hypotension orthostatic side effects of haloperidol and chlorpromazine antipsycotic used. The results showed there were 27,17% extrapiramidal side effects of haloperidol used and 15,24 % hypotension orthostatic side effects of chlorpromazine used. That were the first rank of side effect in every that antipsycotic.The value of relative risk (RR) of extrapiramidal side effects of haloperidol used was 5 and 3 for hypotension orthostatic side effects of chlorpromazine used. That meaned patient who used haloperidol could 5 more time got extrapiramidal side effects than haloperidol unused and patient who used chlorpromazine could 3 more time got hypotension orthostatic side effects than chlorpromazine unused. Keyword : Extrapiramidal and hypotension orthostatic side effects, haloperidol and chlorpromazine antipsycotic, , Dr. Aminogondohutomo Mental Hospital

PENGARUH PENAMBAHAN SUKROSA TERHADAP STABILITAS ASETOSAL DALAM DAPAR FOSFAT ifiet pantilata; suwaldi suwaldi
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 4 NO. 1 JUNI 2007
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTAsetil salisilat acid or known as acetosal or aspirin is a class of analgetic and antipyretic medicine that used widely. In this research we used acetosal to know it stability for sucrose effect. Acetosal stability examination of temperature effect and pH that done in several sucrose concentration, they are 5,0 %; 10,0 %; and 15,0 % which pH 7,0; 8,0; 9,0 and 10,0 in the 40 0C, 50 0C and 60 0C. The result of research showed that acetosal degradation reaction the sucrose fluid in pH 7,0; 8,0; 9,0 and 10,0 at the 40 0C can speedyacetosal degradation where the speed degradation with sucrose effect has more higher value than the degradation without sucrose effect, while in the 50 0C and 60 0C sucrose made stability of acetosal where degradation value with sucrose effect that smaller than degradation speed without sucrose effect. Key words : asetosal, stability, sucrose

KERASIONALAN PENGGUNAAN OBAT BEBAS DAN OBAT BEBAS TERBATAS COMMON COLD DALAM UPAYA SWAMEDIKASI OLEH MASYARAKAT DI KECAMATAN GAJAHMUNGKUR KOTA SEMARANG aqnes budiarti; dharmika wijaya sakti; tri murti andayani
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 4 NO. 1 JUNI 2007
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTThe research about rationality of using over the counter drugs common cold for self medication in district of Gajahmungkur Semarang has been carried out. Data gotten from the result of field survey which is using the questioners that has been filled by Gajahmungkur’s people. Data will be analyzed with non analytical descriptive method. Based on the survey result, knowing that people in Gajahmungkur’s district choosing OTC drugs especially analgetic, antihistamin and decongestan (66,4%). The evaluation of rationality of using drugs for common cold has result: 1) Drugs of choice for common cold is correct. 2) Correct patient are 92,1%. 3) Correct dosage form 96,0%. 4) The most adverse drugs happens is sleepy (53,4%). Key words: Drugs rationality, common cold, self medication, people in district of Gajahmungkur Semarang

AKTIVITAS MUKOLITIK IN VITRO EKSTRAK ETANOLIK HERBA MENIRAN (Phyllanthus niruri L) TERHADAP MUKOSA USUS SAPI yulias ninik windriyati; mimik murrukmihadi; nissa ratna junita
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 4 NO. 1 JUNI 2007
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTPhyllanthus niruri L has been traditionally used by Indonesian people to treat cough. However, scientific basic of using this plant as mucolytic agent is still less observed. The aim of this research is to evaluate in vitro mucolytic activity of ethanol extract of P. niruri against bovine bowels mucose. In vitro mucolytic activity of P. niruri was tested through method as like as Haslinda (1999) and Setyawati (2004). Ethanol extract of P. niruri at various concentrations 0,25; 0,5; 0,75; 1,0; and 1,25% b/v mixed with mucose solution 50% b/v in fosfat buffer pH 7. The solution incubated at 37ºC during 30 minute. Solutions viscosity measured by stormer viscometer and evaluated its fluid flow properties. Negative control was mucosa solution without extract and positive control was asetilsistein. Mucolytic activity was shown by a concentration of extract which decrease viscosity of mucose solution. Ethanol extract of P. niruri had mucolytic activity againts bovine bowels mucose which decrease viscocity of mucose. However, statistically there was no difference between various concentrations of ethanol extract to mucolytic activity. Ethanol extract of P. niruri at concentrations 0,25; 0,5; and 0,75% in mucose solution had fluid flow properties thiksotropi pseudoplastic and at concentrations 1,0 and 1,25% had fluid flow properties pseudoplastic.

EVALUASI KERASIONALAN PENGOBATAN DIABETES MELITUS TIPE 2 PADA PASIEN RAWAT INAP DI RUMAH SAKIT BHAKTI WIRA TAMTAMA SEMARANG TAHUN 2006 ibrahim arifin; erna prasetyaningrum; tri murti andayani
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 4 NO. 1 JUNI 2007
Publisher : Universitas Wahid Hasyim Semarang

ASTRACTDiabetes melitus is metabolic disease characterized hiperglikemia that caused disparity of insulin secretion, insulin activity or both. WHO had predicted there were increasing of diabetes mellitus patients in next time, included in Indonesia. This study aim to know and evaluate the rational of in patients diabetes mellitus type 2 medication in Bhakti Wira Tamtama Hospital Semarang at 2006. This study is non experimental research that analyzed by non analytical descriptive method. Data were collected retrospectively from medical record comprised patient identity, diabetes melitus type 2 medication, and rational antidibetic usage. Data obtained were analysed with Standard of Perkeni 2006. The result of this study showed that 34 in-patient diabetes mellitus type 2 in Bhakti Wira Tamtama Hospital Semarang at 2006 were 40-50 years old (47,06%). Diabetes mellitus type 2 patients comprised 18 men and 16 women, 8 cases (23,52 %) were diabetes mellitus type 2 without additional diseases and 26 cases (76,47%) diabetes mellitus type 2 with additional diseases. Patients had diagnosis appropriate were 94,12 %, drug choise appropriate were 100 %, which biguanid metformin usage were 15 patients (46,87%). Dosis appropiate 100%, patient appropriate 100%, while drug interaction had happened to 1 case, that was antidiabetic and thiazid diuretic. Key words: Rational evaluation, diabetes mellitus type 2, Bhakti Wira Tamtama Hospital Semarang

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