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Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)

Farmasi
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Published by Universitas Wahid Hasyim Semarang

ISSN : 16937899 EISSN : 27163814 DOI : 10.31942

Core Subject : Health,

Medicine & Pharmacology

Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.

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Articles 7 Documents

Search results for , issue "Vol 19, No 1 (2022): Jurnal Ilmu Farmasi " : 7 Documents clear

PENINGKATAN DISOLUSI NIFEDIPIN DENGAN PELARUT PVP K-30 MENGGUNAKAN METODE DISPERSI PADAT Asri Prahmanita Sadiarti; Endang Diyah Ikasari; A.Ariani Hesti W.S
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 19, No 1 (2022): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Nifedipine is an anti-hypertensive included in the Biopharmaceutics Classification System (BCS) class II to its nature of being poorly soluble in water, resulting in low bioavailability. One technique that can be used to improve the solubility of the dispersion technique. This research aimed to determine the effect of the concentration of PVP K-30 on physical characteristics, the dissolution rate of solid dispersions, and the interactions that occur between nifedipine with PVP K-30. The method of manufacturing solid dispersion is a melting-solvent method. FI - F III is a solid dispersion and F IV-VI F is a physical mixture. Formula used is the ratio of nifedipine: PVP K-30 FI (10%: 90%), F II (20%: 80%), F III (30%: 70%), F IV (10%: 90%), FV (20%: 80%), F VI (30%: 70%), and used as a control of pure nifedipine. Testing was conducted on the organoleptic test, flow rate, moisture content, melting point, dissolution testing, and FT-IR analysis. Dissolution test parameters used C (20). The data was obtained and analyzed by non-parametric test KruskalWallis and Mann-Whitney with a level of 95%. The results showed that solid dispersions aregranulated, yellow, and have a free-flowing nature. Test results C (20) FI, F II, F III, F IV, FV, F VI, and controls respectively were 89,48%; 51,75%; 22,58%; 12,88%; 24,07%; 26,34%; 24,95%. The results showed that the FI has the highest dissolved. Results of FT-IR spectra showed no interaction between nifedipine with PVP K-30.

SKRINING EKSTRAK JAMUR ENDOFIT DARI TANAMAN MELINJO (Gnetum gnemon L.) SEBAGAI KANDIDAT ANTIBAKTERI, ANTIJAMUR DAN ANTIOKSIDAN Muhlisun Azim; Puspawan Hariadi; Yuyun Febriani; Tri Puspita Yuliana
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 19, No 1 (2022): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Endophytic fungi are potential microorganisms in lead compounds investigation as research objects for antibacterial and antifungal drug candidates. These microorganisms are able to produce various secondary metabolites, moreover they can even be regulated according to the needs of researchers. This is an advantage of endophytic fungi with good adaptability response. This study aims to explore the antibacterial, antifungal and antioxidant activity of endophytic fungi from the branch of the Melinjo tree (Gnetum gnemon L.) by qualitative analysis. This study resulted in 13 potential endophytic fungi extracts to be explored further for their compounds. Based on the results of the TLC test of the fungal extracts with 10% vanillin in H2SO4 as a reagent, it showed that the dominant compounds were alkaloids and polyphenols. The antibacterial activity test of extracts of the endophytic fungi was carried out by the disc diffusion agar method against Staphylococcus aureus and Pseudomonas aeruginosa bacteria, while antifungal agents were used for Candida albicans and Aspergillus clavatus.. Meanwhile, the qualitative test of antioxidants from fungal extracts using the DPPH spray reagent showed positive results of 8 fungal extracts. Screening of endophytic fungi from melinjo represented a source of endophytes potential as antibacterial, antifungal and antioxidant to be developed in exploration of secondary metabolites from natural products of microbial.

PENGGUNAAN ANTIBIOTIK PADA PASIEN BPJS DI IGD RSUD dr. GONDO SUWARNO KABUPATEN SEMARANG Rias Ayu Kartika; Maria Caecilia Nanny Setiawati; Erna Prasetyaningrum
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 19, No 1 (2022): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

The antibiotics used for patients in the ER (emergency room) needs special attention, because the inappropriate use of antibiotics at the beginning of treatment can affect subsequent antibiotic therapy. This study intents to evaluate antibiotics used in BPJS patients in the emergency department of RSUD dr. Gondo Suwarno, Semarang Regency. This research was conducted using prescription data for BPJS patients at the ER at RSUD dr. Gondo Suwarno, Semarang Regency for the period January-June 2020. We used purposive sampling as a technic sampling and the data is collective retrospectively. The results showed that 30.64% of the total prescriptions for antibiotics were prescribed for 478 patients, most of whom were adult patients (26-45 years), which were 29.71%. Most route of administration is per oral (76.09%). Diagnosis of antibiotics, the most are trauma and open wounds (40.38%). 75.94% of antibiotics were given singly, most in order were ciprofloxacin (17.36%), amoxicillin (15.9%) and cefixime (13.81%) all orally. The most common combination antibiotics were oral amoxicillin and topical gentamicin (14.44%). All antibiotics prescribed were in accordance with the national formulary. According to the WHO criteria, the total drug prescribed per sheet and the percentage of antibiotic prescriptions for BPJS patients in the emergency room of RSUD dr. Gondo Suwarno, Semarang Regency, has not been rational, while the percentage of injection prescriptions, generic antibiotic prescriptions and conformity with National Formulary is rational.

EVALUASI WAKTU TUNGGU RESEP OBAT TERHADAP KEPUASAN PASIEN RAWAT JALAN DI INSTALASI FARMASI RUMAH SAKIT ASSYIFA KOTA TANGERANG Ekadipta Ekadipta; Muhammad Zuhriyanto; Siti Nurahayu
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 19, No 1 (2022): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Hospital is an important health service center and is needed to meet health needs. This study aims to evaluate the waiting time for prescription non-concoction and concoction medicines based on the hospital's minimum service standards and their effect on general outpatient satisfaction at the Pharmacy Installation of RSIA Assyifa, Tangerang. This study used a descriptive research design of outpatients who redeemed non-concoction and concoction medicines. Calculation of the waiting time for prescription services for non-concoction and concoction medicine is using a digital clock. Satisfaction was measured using a questionnaire which was analyzed multivariate. The samples taken in the study were 222 respondents. The results showed that the average waiting time for prescription of non-concoction medicine (8.9 minutes) and concoction medicine (16.6 minutes) had met the standards set by the hospital's SPM in the pharmaceutical sector according to the Minister of Health of the Republic of Indonesia NO. 129 of 2008 and by RSIA Assyifa. The results in the multivariate analysis obtained t = 10.126 and the standard coefficient of 0.88, indicating that waiting time has a strong positive effect on patient satisfaction with prescription of non-concoction and concoction medicine services at RSIA Assyifa.

PENGARUH JENIS MINYAK NABATI TERHADAP KARAKTERISTIK FISIK SEDIAAN BALSAM STICK EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) Fitria Nugrahaeni; Ari Widayanti; Gede Andika Primatama
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 19, No 1 (2022): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Cherry leaves extract contain flavonoids which function as anti-inflammatory can be formed into stick balm preparations. The Stick balm is a preparation in the form of a stick consisting of a mixture of oil, wax and fat with a composition such that it can produce hardness and melting pont of as needed. The different properties of fatty acids in each type of oil can affect the physical properties of the balsam stick preparation in the form of melting point and hardness. This study aimed to determine the effect of adding olive oil, virgin coconut oil, castor oil, jojoba oil on the physical properties of the stick balm of Muntingia calabura L leaf extract. Physical characteristic of stick balm includes organolepti, homogeneity, melting point, hardness, and pH test. The results showed that all formulas met the physical characteristics of stick balms but each formula had differences in melting point, hardness, adhesion, and pH. The formula with the addition of olive oil showed the highest melting points and hardness at 55.3ºC and 8.16 mm. The results of statistical data was sig <0.05. This means that there are differences in melting point and hardness in each equation. Based on obeservations, it was concluded that the addition of vegetable oil to the balsam stick formulation affected the melting point and hardness.

AKTIVITAS BAWANG PUTIH (Allium sativum L.) SEBAGAI AGEN ANTIBAKTERI Debi Kristiananda; Juvita Lisu Allo; Veronica Arien Widyarahma; Lusiana Lusiana; Jeanne Magistra Noverita; Florentinus Dika Octa Riswanto; Dewi Setyaningsih
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 19, No 1 (2022): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Garlic (Allium sativum L.) has various potentials in overcoming diseases, one of which is as an antibacterial. The purpose of this study was to explore, analyze and review the activity of garlic (Allium sativum L.) as an antibacterial agent. This study uses a literature search method using search sites such as Google Scholar, Pubmed, ScienceDirect, AYU, NCBI, Elsevier, PlosOne, and Google Scholar. by entering keywords such as antibacterial, Garlic, and Allium sativum L. Garlic contains secondary metabolites that function as antibacterial agents such as alkaloids, tannins, saponins, flavonoids, allicin. Garlic has been shown to inhibit the growth of gram-positive and negative bacteria species Escherichia, Salmonella, Staphylococcus, Streptococcus, Klebsiella, Proteus, Bacillus, Clostridium, P. aeruginosa, K. pneumoniae and, Bifidobacterium lactis predominantly using the paper disk and well diffusion method.

ISOLASI DAN KARAKTERISASI EKSTRAK KULIT JENGKOL (Pithecellobium jiringa) SEBAGAI INHIBITOR ENZIM PENYAKIT MALARIA Plasmodium falciparum MALATE QUINONE OXIDOREDUCTASE Rhamal Amir; Chaidir Chaidir; Aden Dhana Rizkita; Anis Herliyanti
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 19, No 1 (2022): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

In order to discover and identify antimalarial active compounds, jengkol peel extract was isolated and tested for antimalarial activity. This study aims to determine the antimalarial active compound from jengkol peel extract which functions as an inhibitor of the Malate Quinone Oxidoreductase (MQO) enzyme. In this study, the extraction process was carried out using methanol as a solvent with the maceration method. The maceration results were then concentrated using a rotary evaporator with low pressure at a temperature of 40-45°C to obtain a Crude extract of 203 grams. Then liquid-liquid fractionation was carried out with four types of solvents, namely n-hexane, ethyl acetate, methanol, and water according to the level of polarity. Each fraction obtained was 400 ml which was then tested for enzyme inhibition using the MQO enzyme formation inhibition method. The fraction that had the highest inhibitory activity was the ethyl acetate fraction of 80%. Confirmation was done again with the same separation using column chromatography so as to produce the ethyl acetate fraction which was confirmed to be identified using HPLC producing peaks at retention times of 22 and 23 minutes. The results showed that in jengkol peel extract there were active compounds that acted as inhibitors of the MQO enzyme but further tests were needed to confirm these peak compounds.

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