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INDONESIAN JOURNAL OF PHARMACY

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Published by Universitas Gadjah Mada

ISSN : 23389427 EISSN : 23389486 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.

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Articles 8 Documents

Search results for , issue "Vol 14 No 3, 2003" : 8 Documents clear

The Anticarcinogenic Activity Of Plants Compounds Sugiyanto .; B. Sudarto; Edy Meiyanto; Agung Endro Nugroho
Indonesian Journal of Pharmacy Vol 14 No 3, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The study was conducted to observe the effect of extracts of ngokilo (Gynura procumbens), beluntas (Pluchea indica), murbei (Morus alba) dan tapak doro (Vinca alba) leaves. Showed anticarcinogenic activity on lung tumor growth of mice. In the nex step, compounds having anticarcfinogenic effect was isolated and identified, and evaluated on the cultures of meiloma and Vero cells. The results showed that non-polar fraction of ethanol extract of ngokilo leaves did not have anticarcinogenic activity, whereas the polar fraction show anticarcinogenic activity. At least there were three flavonoids (flavon or flavonol groups) in this polar fraction. It was only two of these flovonoids which could inhibit the growth of myeloma and Vero cells.Key words : ngokilo, Gynura procumbens, anticarcinogenic, flavonoid.

ISOLATION AND IDENTIFICATION OF ANTIFUNGAL (Candida albicans) COMPOUND FROM THE HULL OF DELIMA FRUITS (Punica granatum L.) Purwantini, Indah; Wahyuono, Subagus
Indonesian Journal of Pharmacy Vol 14 No 3, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The hull of delima fruits (Punica granatum L.) are traditionally used to cure dysmenorhoe. Preliminary study indicated that extract of the hull was able to inhibit the growth of Candida albicans. Therefore this study was aimed to isolate and identify active compounds responsible for the activity from the hull of P. granatum. The study was initiated by extracting the powdered material with petroleum ether followed by methanol. Antifungal activity test (100 mg/ml) indicated that the petroleum ether extract was more active than the methanol extract (inhibition zone: 10.59 vs 6.92 mm). The pet. ether extract was triturated by n-hexane to give n-hexane insoluble and n-hexane soluble fractions. The latter that was active (inh. zone: 9.50 vs 0.00 mm) was fractionated by vacuum liquid colomn chromatography (vlc; SiO2, n-hexane with increasing amount of ethylacetate) to give 7 fractions (F1-F7). Fraction 2 (inh. zone: 9.05 mm) and 3 (11.05 mm) displayed antifungal activity, then F3 was subjected to contact bioautography to give 2 active compounds [Rf. 0.50 (major) and 0.10 (minor)]. Preparative tlc [SiO2 F-254 nm; nhexane: ethylasetate 4-1, developed 2x) of F3 was aimed to separate 2 active compounds. Due to limited amount of the minor compound, the MFC was applied only for the major compound (Rf. 0.50; 200 mg/ml). The structure identification was done by mean of spectroscopic methods (uv, ir, ms and nmr) to be a setrol type of compound having stigmastane skeleton, esterified by a long-chain fatty acid.Keywords: Punica granatum L., Candida albicans, active compound, terpenoid

CHEMICAL CONSTITUENT DETECTION AND OXYTOXIC EFFECT OF INSOLUBLE ETHANOLIC FRACTION OF INFUSION OF Kaempferia angustifolia Roscue LEAVES ON ISOLATED UTERUS OF GUINEA PIGS Pramono S.; Sumastuti R.
Indonesian Journal of Pharmacy Vol 14 No 3, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

To establish the scientific base on the use of Kaempferia angustifolia leaves as Indonesian post partus traditional drug, an experiment was done on isolated uterus guinea pigs. The infusion of Kaempferia angustifolia leaves was evaporated and the residu was then extracted with ethanol. The ethanolic fraction and the insoluble fraction were tested on isolated uterus guinea pig after addition of 1 ml of 10 IU/ml oxytocin. The active fraction was then dissolved in distlled water in order temterature. The chemical constituents of the active fraction were detected by thin layer chromatographic method. The results showed that the insoluble ethanolic fraction of the infusion increased significantly the contraction of uterus after the addition of oxytocin (p<00.5). Further more, the water soluble fraction and the residue of the active fraction had also similar activities.Keywords : Kaempferia angustifolia, oxytoxic effect, flavonoids, tanin, pectin

In Vivo ANTIPLASMODIAL ACTIVITY AND MECHANISM OF ACTION OF 1,10-PHENANTHROLINE DERIVATIVES ., Mustofa; Yapi, Ange Desire; Valentin, Alexis
Indonesian Journal of Pharmacy Vol 14 No 3, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The rapidly increasing resistance of Plasmodium falciparum to the most commonly used antimalarial drug indicates the urgent need for new antimalarial compounds. Previous study showed that among thirteen derivatives of 1,10-phenanthroline, four compounds were active in vitro and potential for further development. The study was conducted to provide the in vivo antiplasmodial activity of four 1,10-phenanthroline derivatives and to evaluate the possibility of their mechanism of action. The in vivo antiplasmodial activity of the four compounds was evaluated by a standard 4-day test on Plasmodium venckei petteri infected mice. The study of haem polymerization inhibitory activity (HPIA) and the potentiating of those compounds in combination with halofantrine and inhibitor protease (E64) were carried out to evaluate its mechanism of actions. The results showed that among four compounds tested, compound 1 (2,10-methyl-3-(2-chloroethyl)-4-chloropirydo [2,3-i] quinolineium iodide) was the most active compound with DE50 was 0.22 ± 0.03 mg/kg BW. This molecule less active than halofantrine, but more active than chloroquine. The HPIA of 1,10-phenanthroline derivatives tested (IC50 HPIA was 1.57-1.95 mmol/well) did not vary significantly. These IC50 HPIA values were significantly lower than halofantrine (CI50 HPIA was 0.12 ± 0.04 mmol/well) and than chloroquine (CI50 HPIA was 0.75 ± 0.03 mmol/well). Combination the 1,10-phenanthroline derivatives and halofantrine produced simple additive effect that implies that each drug posses a different mechanism of action. Conversely, there was antagonist interaction between 1,10-phenanthroline derivatives and E64 showing that the drugs have a similar mechanism of action. It can be concluded that the compound 1 appears as a potential antimalarial compound. In addition, the possible mechanism of action of this compound is inhibitation of protease involved in haemoglobine degradation within the malaria parasite.Key words : 1,10-phenanthroline – in vivo antiplasmodial – haem polymerization inhibitoryactivity – protease inhibitor .

Isolation of Tracheopasmolytic Compounds From Piper cubeba Fruits Wahyono .; L. Hakim; S. Wahyuono; A. Mursyidi; R. Verpoorte; H. Timmerman
Indonesian Journal of Pharmacy Vol 14 No 3, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The fruits of Piper cubeba (kemukus;Javanese)have been used in traditional medicine to treat illnesses such as asthma. Extracts were prepared by gradual maceration of the dried fruits with n-hexane, and by extraction of the residue with ethanol, and were tested for their tracheospasmolytic effects on isolated guinea-pig trachea contracted with metacholine at a dose of 0.25 mg/ml. Both extracts demonstrated spasm inhibition but the effect of the ethanol extract was lower than that of the n-hexane extract. However, TLC analysis did not distinguish between the extracts. The ethanol extract was then partitioned with n-hexane, and the first and second n-hexane extracts were combined and dried before further fractionation using vacuum liquid chromatography. The fractions were tested for tracheospasmolytic effects. Two active fractions were obtained and separated by column chromatography and preparative TLC. Four pure compounds were obtained. One of these is a lignan compound and identified as dihydrocubebin, had tracheospasmolytic activities.Key words: Piper cubeba; lignan, dihydrocubebin; tracheospasmolytic effect.

Antiproliferative Effect of The Bark and Leaves of Erythrina Fusca Lour Against HeLa Cells Meiyanto, Edy; ., Sismindari,; Candra, Lany; ., Moordiani
Indonesian Journal of Pharmacy Vol 14 No 3, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Erythrina fusca Lour (Indonesian: Cangkring) has been traditionally used to cure skin virus infection, cancer and inflammation. This experiment, therefore, was conducted to test its ability as anticancer through its antiproliferative effect using HeLa examine cell line as model. The bark and leaves powder were extracted using ethanol (70 %) and were used in the experiment after freezed drying. Those bark and leaves extracts have LC50 values of 110 and 140 mg/ml respectively. Antiproliferative effect was tested by examining the doubling time effect of the extract against the proliferating cells. Three different concentration were used to treat the cells for each extract, and cells were counted within time courses. The growth profiles were then compared between treated and control cells by calculating the doubling times. Either bark and leaves extract treated cells showed prolongation of the doubling times. This result indicated that such extract possess inhibitory effect or Antiproliferative effect against HeLa cells. Morphology analysis and nuclear staining of the cells indicated that one of the mechanism of the antiproliferative effect possibly through cell cycle modulation and apoptotic pathway. Keywords: Erythrina fusca, Antiproliferative, Doubling time, HeLa Cell

The Keto-Enol Tautomerism of Curcumin and Some 4-substituted Curcumin Derivatives : A Theoretical Study Based on Computational Chemistry Approach Enade Perdana Istyastono; Supardjan A. Margono; Harno Dwi Pranowo
Indonesian Journal of Pharmacy Vol 14 No 3, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Heat formation (DHf) for the enol and diketo tautomers of curcumin and some 4-substituted curcumin derivatives has been studied using semiempirical AM1 quantum-chemical calculations. The calculations on curcumin, 4-methylcurcumin, 4-ethylcurcumin, 4-npropylcurcumin, 4-isopropyl-curcumin, 4-n-butylcurcumin, and 4-benzylcurcumin showed that the more steric hindrance resulted from the subtituents, the more stable they were in the form of diketo tautomers than enol tautomers. Whereas, calculations on 4-phenylcurcumin, 4-(o-methoxyphenyl)-curcumin, and 4-(p-methoxyphenyl) curcumin showed that though steric hindrance influenced the keto-enol tautomerism, they were found more stable in the form of enol tautomers. This phenomenon was estimated to be related with conjugation effect of the aromatic groups with the enol moiety of the main bone structure.Keywords : 4-Substituted curcumin, the keto-enol tautomerism, AM1, semiempirical calculations.

FORMULATION OF PGV-0 A NEW ANTIINFLAMMATORY AGENT AS A TABLET DOSAGE FORM Oetari, R. A.; ., Sardjiman; Yuwono, Tedjo; Fudholi, Achmad
Indonesian Journal of Pharmacy Vol 14 No 3, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The specific objective of this study is to get the best formulation for PGV-0 as a tablet dosage form. By optimation of formulation a more potent and safe antiinflamatory drug could be obtained. This study was started with determination of physical properties which included: appearance, particle size, partition coefficient, and hygroscopicity. In the formulation of PGV-0 6 formulas were chosen with amylum and lactose as fillers, tween 80 as surfactant, solutiogelatine and solutio PVP as binding agent and talc and Mg stearate as lubricants. From these six formulas chosen physical properties of the granules and tablets were determined. PGV-0 powder was not free flowing and has bad compressibility. PGV-0 could not be proccesed by direct compression but should be formulated by wet granulation method. The best formula found was formula V which used solutio PVP 2 % as binding agent and tween 80 0,25 % as wetting agent.Key words: PGV-0, antiinflammation, formulation of tablet dosage form.

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