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INDONESIAN JOURNAL OF PHARMACY

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Published by Universitas Gadjah Mada

ISSN : 23389427 EISSN : 23389486 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.

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Articles 8 Documents

Search results for , issue "Vol 14 No 4, 2003" : 8 Documents clear

Antioxidant activity of aqueous extract of Sonchus arvensis L. in-vitro Sofnie M. Chairul; Ros Sumarny; Chairul .
Indonesian Journal of Pharmacy Vol 14 No 4, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Antioxidants are the compounds which have ability to inhibit reactive oxygen species (ROS) and free radicals in human body. Based on this activitiy the antioxidants prevent cell damage and various pathological processess e.q. cardiovascular, diabetes mellitus, atherosclerosis, respiratorydiseases, carcinogenesis, inflammation, cell degenerative. One of the famous Indonesian traditional medicine is tempuyung or S. arvensis L.(Asteraceae). The antioxidant test has been conducted on the dried water extract by measuring the peroxide value (POV) and in-vitro antioxidant activity test was carried out by spectrophotometry applying thiocyanate method at the wave length of 500 nm.The results showed that peroxide value of dried water extract of tempuyung (S. arvensis L. ) by titration iodometric method has a lower value (865.60) compared to positive control -tocoferol (1142.77). In-vitro antioxidant activity test has remarkable results at the various extract concentrations (1, 5 dan 10 %) and had significant differential absorbance(A) with positive control (K+) as well as negative control (K-), and among the extract concentrations (P  0,5). Absorbance value increased along with increasing storage time, in which negative control reached higher value of A (0,987) in the seven days and maximal value after eight days (A  1), while the absorbance value of positive control (K+) was 0.648, and dried water extract of tempuyung 1, 5 & 10 % was 0.576, 0.488 & 0.314 after 14 days, respecticly. The absorbance value of absorbance (A) was inversely compared to extract concentrations. Increasing of extract concentrations resulted in decreasing A value, in other words increasing extract concentration resulted in the increas of antioxidant activity.Key words : Sonchus arvensis L, Asteraceae, POV, antioxidant, thiocyanate method.

The effect of betle (Piper betle L.) leaf juice pretreatment on the pharmacokinetics of propranolol on male white rat Agung Endro Nugroho; Arief Rahman Hakim
Indonesian Journal of Pharmacy Vol 14 No 4, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Drug interaction phenomenon, between drugs on drug and ford (fruit, vegetables on others), can happen in drug therapy of a disease due to the existence of compounds other than the drug (fruits, vegetables or drink). This interaction can alter and affect the action and effect of the drug. The aim of the research is to study an interaction between betle leaf (a vegetable ) and propranolol, which is a beta-blocker with a high hepatic extraction ratio, in male white rat. The study was conducted by employing a completely randomized design in male wistar inbreed rat (aged 2-2.5 months, 150-250 g). The animals in group I were given propranolol with an oral single dose of 7.5 mg/kg BW (control group) and in group II were given pretreatment with betle leaf juice dose of 17 mL/kg BW at an hour prior propranolol administration. After collected at some certain times, the drug concentration on bloods were analyzed with a Spectropflurometer.The results shown that pretreatment of betle leaf juice did not affect the absorption rate constant (Ka) significantly (P>0.05), and increase the total clearence (ClT) and volume of distribution in steady state (Vdss) significantly (P<0.05). The increasing of both ClT and Vdss caused alteration of the secondary pharmacokinetics parameters of propranolol and these derivates significantly(P<0.05) except the mean residence time value (MRT). This it is concluded that the pretreatment of betle leaf juice with the dose of 17 mL/kg BW affect the pharmacokinetics of propranolol or decrease the propranolol concentration in blood.Key words : propranolol, betle leaf, pharmacokinetics and drug interaction

The anticarcinogenic activity of plants compounds Sugiyanto .; B. Sudarto; Edy Meiyanto; Agung Endro Nugroho; Umar A. Jenie
Indonesian Journal of Pharmacy Vol 14 No 4, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The study was conducted to observe the effect of extracts of ngokilo (Gynura procumbens), beluntas (Pluchea indica), murbei (Morus alba) dan tapak doro (Vinca alba) leaves. Showed anticarcinogenic activity on lung tumor growth of mice. In the nex step, compounds having anticarcinogenic effect was isolated and identified, and evaluated on the cultures of meilomaand Vero cells. The results showed that non-polar fraction of ethanol extract of ngokilo leaves did not have anticarcinogenic activity, whereas the polar fraction show anticarcinogenic activity. At least there were three flavonoids (flavon or flavonol groups) in this polar fraction. It was only two of these flavonoids inhibit the growth of myeloma and Vero cells.Key words : ngokilo, Gynura procumbens, anticarcinogenic, flavonoid.

Isolation of aphrodisiac active fraction from sanrego bark (Lunasia amara Blanco) ., Arnida; Donatus, Imono A.; Wahyuono, Subagus
Indonesian Journal of Pharmacy Vol 14 No 4, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Sanrego (Lunasia amara Blanco) bark is traditionally utilized as an aphrodisiac although scientifically has yet been proven. Therefore, this study is aimed to prove aphrodisiac activity, determine the compounds and the dose of the active fraction. Initially sanrego bark (600 g) was extracted in a Soxhlet apparatus with methanol (MeOH) to give MeOH extract (A, 80 g). The MeOH extract was fractionated by Ethylacetate (EtOAc) to give EtOAC soluble (B, relatively non-polar, 15.23 g) and EtOAc insoluble (C, relatively polar, 50.20 g). The aphrodisiac test was performed in male Wistar rats that were divided into 6 groups (5 rats each) [I, treated with Na-CMC 0.5%, 50 mg/kg BW; II, yohimbine, 5 mg/kg BW; III, distilled water , 2 ml/200 g BW; IV, extract A; V, fraction B; VI, fraction C], and the doses given to groups IV-VI were similar (10, 50, 100, and 200 mg/kg BW). The maleâ€™s behaviors to female rats ( introduction, climbing and coitus ) were recorded and analysed at p= 0.5. Determination of the active compounds were performed by thin layer chromatography (TLC) using various detection reagents. The result indicated that the highest aphrodisiac effect was demonstrated by fraction B, followed by extract A and fraction C . Fraction B demonstrated introduction (84.2%), climbing (84.9%) and coitus (85.2%). TLC profile suggested that fraction B contain alkaloids and terpenoids as the main components.Keywords: Sanrego bark, Lunasia amara, Aphrodisiac, Active fraction .

Effect of oral administration of mushroom Panaeolus infusion on motoric activity and curiousity of male mice Andreanus A. Soemardji; IG.N.A. Supradja
Indonesian Journal of Pharmacy Vol 14 No 4, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The motoric activity and the curiosity tests on Swiss Webster male mice orally treated with infusion of mushroom panaeolus were studied. A 10% infusion of mushroom administered orally at the dose of 0.5; 1.0 and 2.0 g/kg of body weight showed to decrease in motoric activity and curiousity, but the decrease was less than that shown by diazepam with the dose 5 mg/kg body weight administered intraperitoneally.Keywords :Mushroom, Panaeolus, motoric activity, curiousity.

The effect of extract Kaempferia galanga rhizomes on the elimination kinetics of quinidine in rabbits Hayati, Farida; Hakim, Lukman
Indonesian Journal of Pharmacy Vol 14 No 4, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The research was aimed to observe the effect of the juice of Kaempferia galanga rhizomes on quinidine elimination kinetics in rabbits. The study on interaction of extract Kaempferia galanga rhizomes to quinidine elimination kinetic was conductedly employing a cross randomized design using male rabbits which were divided into 3 groups (6 rabbits for each group). The groups were given a single oral quinidine 30 mg/kg BW as a control group and were conferred single oral extract “kencur” 4.8 mi/kg BW each dose for 4 days prior to the treatment with quinidine. Serial blood samples(0,2 ml) were withdrawn at various interval time via the ear marginal for spectrofluorometric analysis of unchanged quinidine in blood. The concentration of quinidine was determined using a standard curve and the concentration to time data was used to determine quinidine elimination kinetics i.e. Clt and MRT. The results indicated that extract “Kencur” was found to decrease quinidine clearance 17,19% and 7,07% (P>0,05) and increase quinidine MRT198,89% and 71,70% (p>0,05).Key words : Kaempferia galanga rhizomes, quinidine, elimination

Investigation on drug dosage form : analysis of prescriptions available in pharmacy in kotamadya Yogyakarta Chairun Wiedyaningsih; Oetari .
Indonesian Journal of Pharmacy Vol 14 No 4, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The analysis of dispensing prescriptions available in Pharmacy in Yogyakarta was performed. The analysis included observation problems of dosage form preparations, and examination compounds of medicines which were mentioned in dispensing prescriptions. The study was conducted by sampling dispensing prescriptions from the pharmacy located in Yogyakarta. Questionnaires and interviews to pharmacists were also conducted in order to support the prescription data. The result showed that the oral solid dosage forms were the majority (71%) of dispensing prescriptions written. tablet crushing was the major problems of. The majority objective of therapy with this type of dispensing were for asthma, infection and allergy. It was also found that brand names (74%) medicine were more written than generic names. The most generic name written/added was CTM (chlorpheniramin maleat). Results of questionnaire evaluation showed that semi solid (unguentum, cream) was the major problem (69%) of pharmaceutical dispensing in the Pharmacy. Dispensing Salicylic acid with other semi solids were the most problems. Prescription analysis showed that about 14,2% dispensing prescriptions contain salycilic acid mixed with cream, and 26,5% dispense prescriptions contains salicylic acid mixed with any kinds of drugs or other semi solid forms. Liquid were the minor (7,2%) dispensing prescriptions written by physicians. However problems were still remain caused bycrushing coated tablets and dispensing to the liquid.Keywords : prescription, pharmaceutical stores, dosage forms, Yogyakarta

Tracheospasmolytic activity of vitetrifolin-E isolated from the leaves of Vitex trifolia L. Alam, G.; Gandjar, I.G.; Hakim, Lukman; Timmerman, H.; Veerporte, R.; Wahyuono, S.
Indonesian Journal of Pharmacy Vol 14 No 4, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

In searching of tracheospasmolytic active compounds from Vitex trifolia, we are now reporting isolation and identification of vitetrifolin-E from active fraction obtained from n-hexane extract of V. trifolia. Vitetrifolin-E blocked spontaneous contraction of male guinea pig trachea induced by histamine and was active in a model using sensitized guinea pig trachea stimulated by ovalbumin. Vitetrifolin-E inhibited tracheal contraction by 22.6% at dose of 1.3 x 10-4 M and by 86.1% at dose of 4.10-4 M. In a model using sensitized male guinea pig trachea, vitetrifolin-E also inhibited the contraction 83.5% (1.3 x 10-5 M).Keywords: vitetrifolin-E, Vitex trifolia, tracheospasmolytic

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