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INDONESIAN JOURNAL OF PHARMACY

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Published by Universitas Gadjah Mada

ISSN : 23389427 EISSN : 23389486 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.

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Articles 7 Documents

Search results for , issue "Vol 18 No 4, 2007" : 7 Documents clear

Technological capability and R&D strengthening : a pharmaceutical industrial challenge in Indonesian Sampurno .
Indonesian Journal of Pharmacy Vol 18 No 4, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Technology and R&D capabilities are essential determinants of pharmaceutical competition in the global market. For the last thirty years, pharmaceutical industry has been dramatically changed as the impact of more significant roles of biotechnology in this industry. Pharmaceutical firms with strong capabilities in technology and R&D become market leaders and get better opportunities to sustain their competitive advantages. Indonesian pharmaceutical industry can not avoid of being involved from the trend of both regional and global competition. The harmonization of ASEAN pharmaceutical regulation in 2008 will create a single ASEAN pharmaceutical market with more complicated and wider dynamic implication, resulted in the formation of significantly competitive landscape of pharmaceutical market in the ASEAN region.Key words: Technology capabilities, R&D, Indonesian Pharmaceutical Industry

Effect of the curcuma plusÂ® syrup on the pharmacokinetics of rifampicin in rats Wahyono, Djoko; Hakim, Arief Rahman; ., Purwantiningsih
Indonesian Journal of Pharmacy Vol 18 No 4, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The research was aimed to observe the effect of Curcuma plusÂ® syrup on rifampicin pharmacokinetics in rats.The study of interaction Curcuma plusÂ® syrup with rifampicin pharmacokinetics was conducted employing a completely randomized design using male Sprague Dawley rats which were divided into 3 groups (5 rats for each group). The groups were given a single oral rifampicin dose of 50 mg/kg BW as a control group and were confered single oral Curcuma plus syrup 2.7 mL/kg BW one hour before rifampicin and daily dose for 7 days, then is given rifampicin after that. Serial blood samples (0,2 mL) were withdrawn at various interval via the vein for HPLC analysis of unchanged rifampicin in blood. The concentration of rifampicin was determined based on a standard curve, and from the concentration to time data was determined rifampicin pharmacokinetic parameters (Cmaks, tmaks, AUC0-âˆ¼, Vd/F, t1/2, ClT dan K).The results indicated that Curcuma plusÂ® syrup single dose 2.7 mL/kg BW one hour before rifampicin could increased rifampicin volume of distribution by 225.80% (P<0.05) and caused decreased Cmaks 72.81% and AUC0-inf 63.93% (P<0.05), while daily dose Curcuma plusÂ® syrup for 7 days could rise rifampicin total clearance 225.60% (P<0.05) and caused decrease by 76.94% of AUC0-inf (P<0.05).Key words : pharmacokinetics, Curcuma plusÂ® syrup, rifampicin

Antiplasmodial activity of two fractions obtained from n-hexane extract of Garcinia parvifolia Miq stem bark Syamsudin .; Soesanto Tjokrosonto; Subagus Wahyuono; Mustofa .
Indonesian Journal of Pharmacy Vol 18 No 4, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Antiplasmodial activity of fractions A and B obtained from n-hexane extract of stem bark of Garcinia parvifolia have been evaluated. The in vitro antiplasmodial activity was investigated on two strains of Plasmodium falciparum, FCR-3 a chloroquine resistant and D10, a chloroquine sensitive strains and their antiplasmodial activity was expressed by the concentration inhibiting 50.% of the parasite growth (IC50). The results showed that the fractions A and B were active against P. falciparum with the IC50 values of 2,79 ± 0,10 μg/mL and 12,30 ± 1,21.μg/mL on FCR-3 strain and 1,52 ± 0,24.μg/mL and 4,66 ± 1,24 μg/mL on D10 strain. Identification of active constituents in the both fractions showed the existence of triterpenoide, steroide and flavonoide compounds.Key words: Antiplasmodial activity , Garcinia parvifolia, active constituents.

Suppression of DMBA-induced carcinogenesis of breast cancer in post initition stage by ethanolic extract of Gynura procumbens (Lour), Merr leaves Edy Meiyanto; Sri Tasminatun; Sri Susilowati; Retno Murwanti; Sugiyanto .
Indonesian Journal of Pharmacy Vol 18 No 4, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Gynura procumbens (Lour) Merr., has been shown to suppress lung cancer development in mice and breast cancer development in rat when the extract was given at initiation stage. The aim of this research is to examine the potential of ethanolic extract of G. procumbens to suppress DMBAinduced breast cancer development at early development (post initiation I) and late development (post initiation II). Sprague Dawley Rats were used in this research and were grouped as indicated treatment. Ethanolic extract of G. procumbens was administered into 2 levels of doses, namely 250, 750 mg/kgBW. Tumor development was examined by palpation every week and terminated at week 16th after the end of DMBA treatment. The result showed that extract treatment at the dose of 250, and 750 mg/kgBW at the post initiation I could not reduce tumor incidence but suppressed of tumor multiplicity. However, the treatment at the post initiation II, the extract could not reduce neither incidence nor multiplicity. In conclusion, ethanolic extract of G. procumbens performs potential effect to suppress breast cancer development at the dose of 250 mg/kgBW when administered at the early stage of carcinogenesis.Key words : Carcinogenesis inhibition, G. procumbens, breast cancer, post initiation

Biochemical research of phenyclidine reseptor : Interaction to specific bonding to the lower affinity receptor Gusdinar, Tutus; Chicheportiche, Robert
Indonesian Journal of Pharmacy Vol 18 No 4, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Fixed concentration of MK-801 molecule had been used as a specific ligand for differenciating two kinds of phencyclidine (PCP) and thienylphencyclidine (TCP) receptors. By using several drug molecules which have different pharmacological action, as well as such molecular affinity (IC50) to the rat brain, it was obtained that both of these interacting receptors had equal character for its higher or lower affinity sites. The MK-801 molecule inhibited much strongly (IC50 is about 10 nM) fixation of 3HTCP to its higher affinity receptor and much weakly (IC50 is about 10 μM) fixation of 3H-PCP to its lower affinity receptor. The MK-801 molecule could be used as well for differenciating two 3H-TCP receptors, the higher and the lower affinity.Key words : phencyclidine – thienylphencyclidine – MK-801 – higher affinity receptor– lower affinity receptor.

Optimization of synthesis of 4-dimetilamino benzalaseton by speed and duration variation of stirring using sodium hydroxide as catalyst ., Sardjiman; Utami, Dwi; ., Dachlan; Intani, Dei; Susanty, Rinnny F.
Indonesian Journal of Pharmacy Vol 18 No 4, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Aldol condensation is followed by dehydration used 4-dimetilamino benzaldehida and aseton will produce 4-dimetilamino benzalaseton. A factor which influences the rendement of 4-dimetilamino benzalaseton producing is stirring. Due to of that, should be researched about the speedy influencing of stirring in synthesis of 4-dimetilamino benzalaseton used NaOH as catalyst for production of yield produced.The variation of stirring speed that used in the research are 500 rpm; 700 rpm; 900 rpm. Synthesis process taken place for 5 hours 10 minute. The synthesis compound was isolated and counted its yield. The purification was done by recrystalization using etanol absolute : aquadest and counted its recovery. The identification of synthesis compound was conducted by Infrared Spectrometer and NMR Spectrometer.The result showed that the average from the variation of stirring speed 500 rpm; 700 rpm; 900 rpm in gradually are 78,61 %; 85,0 %; 86,1 %. The ANAVA statistic analyzing that the confidence level of 95 % showed in which many variation of stirring speed hasn't given influence for production of yield was produced. The highest yield has found in stirring speed 700 rpm. From the result of melting point data was found that synthesis was produced in stirring speed 500 rpm possessed melting point 129,4OC Â 131,6OC, 700 rpm possesses melting point 131,63OC -133,13OC, 900 rpm possesses melting point 128,67OC-131,23OC while from result of TLC, The retention factor is 0.2 in average. The identification of synthesis compound was conducted by using Infrared Spectrometer and NMR after were compared with starting material showed that the synthesis product was 4-dimetilamino benzalasetonKey words : Benzalaseton, 4-dimetilamino benzalaseto.

Isolation of cytotoxic substance from Kaliapsis sponge Erna Prawita Setyowati; Umar Anggara Jenie; Sudarsono .; Broto Kardono; Rachmaniar Rahmat; Edy Meiyanto
Indonesian Journal of Pharmacy Vol 18 No 4, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

An isolation of cytotoxic substance of Kaliapsis sponge has been conducted. The substance was isolated using maceration, partition, vacuum liquid chromatography and preparative thin layer chromatograpy methods.The result of research showed that peak 1 has the most cytotoxic activity. Cytotoxicity test with MTT [3 (4,5-dimetiltiazol-2-il)-2,5-difeniltetrazolium bromide] reagen on myeloma cell showed that the peak 1 had a high activity against myeloma cell. It has IC50 equal to 0,18 μg/mL.Key word: Kaliapsis sponge, cytotoxic, myeloma cell

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