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INDONESIA
INDONESIAN JOURNAL OF PHARMACY
Published by Universitas Gadjah Mada
ISSN : 23389427     EISSN : 23389486     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.
Arjuna Subject : -
Articles 19 Documents
 1   2 
Search results for , issue "Vol 21 No 1, 2010" : 19 Documents clear
Synthesis, analgesic and anti-inflammatory activities of substituted benzoylthioureas Tutuk Budiati; Suzana .; Siti Surdijati
Indonesian Journal of Pharmacy Vol 21 No 1, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (261.607 KB) | DOI: 10.14499/indonesianjpharm0iss0pp68-76

Abstract

Three compounds (i.e.  benzoylthiourea,  4-nitrobenzoylthiourea,  and  4-chlorobenzoylthiourea) have  been  synthesized  from  ammonium  thiocyanate, substituted benzoyl chlorides, and ammonia as starting materials. The structures of  sythesized  compounds  were  confirmed  by  means  of  ultra-violet,  infrared, magnetic resonance, and mass spectroscopy. All compounds were evaluated for their  analgesic  and  anti-inflamatory  activities  by  tail-flick  technique  and carragenan-induced  paw  oedema  test  respectively.  Substitution of p-NO2 and p-Cl  group  to  benzoylthiourea  increased  the  analgesic  and  anti-inflamatory activities.  The  two  compounds,  4-nitrobenzoylthiourea  and  4-chlorobenzoylthiourea,  were  significantly  more  potent  as  analgesic  but  their  antiinflamatory actvity was weaker than Na-diclofenac.Keywords: benzoylthioureas, p-Cl dan p-NO2substituents, analgesic and anti-inflamator activities
Identification of physical interaction between trimethoprim and sulfamethoxazole by contact method koflerand crystallization reaction Erizal Zaini; Yeyet C. Sumirtapura; Sundani N. Soewandhi; Auzal Halim
Indonesian Journal of Pharmacy Vol 21 No 1, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (734.118 KB) | DOI: 10.14499/indonesianjpharm0iss0pp32-39

Abstract

Identification  of  solid  state  interaction  between  TMP  and  SMZ  by  hot contact  method Kofler and  crystallization  reaction  had  been  carried  out.  The results of hot contact method Koflershown formation a new crystalline habit as long  and thin needle  shaped  on  contact  zone  (mixing  zone) between Solid  TMP and SMZ. It had a different melting point in compared to its single component. Crystallization  reaction  between  two  of  supersaturated  solution  of  component TMP and  SMZ  in methanol  solvent  also  indicated  the  growth  of crystal  habit  as similar as   hot contact method Kofler.  Solid  state  interaction between  TMP  and SMZ  was confirmed  by  microscopic  SEM, powder  X-ray diffraction,  and  thermal DSC.  Microscopic  analysis by  SEM  showed significantly  the  change  of habit and morphology  of   crystal  as  long  and  thin  needle  shaped.  New  powder  X-ray diffraction  (PXRD)  interferences  peaks  were  observed  in  addition  to  PXRD interference  peaks  of  each  component  that  proved  formation  of  cocrystalline phase.  Thermogram  DSC  indicated  a  new   endothermic  peak  corresponding  to melting point of a new cocrystalline phase at temperature 178,82 °C.Key words : trimethoprim, sulfamethoxazole, physical interaction, cocrystalline phase
Toxicity effect of Centella asiatica Linn. extract on mice (Mus musculus) organ and tissue ., Praptiwi; Wulansari, Dewi; ., Chairul
Indonesian Journal of Pharmacy Vol 21 No 1, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (827.085 KB) | DOI: 10.14499/indonesianjpharm0iss0pp40-47

Abstract

Toxicity test ofCentella asiaticaLinn. water extract had been carried out. Extract  were  administered  via  oral,  single  and  daily  doses  in  mice  (Mus musculus).  The  effect  of  extract  on  organs  and  tissue  were  evaluated  by observing  the  pathology  anatomy  of  heart,  liver  and  kidney  and  alsoLD50 value. The influences of acute and sub-chronic toxicity on morpho-anatomy organs and histo-pathology tissue were in accordance with LD50experiment. The results of morpho-anatomy showed that all organs were still in normal condition at  low  dose  treatment,  but stain  and  white  spots  appeared  on  liver, black  spot on  heart  and  white  spots  on  kidney  at  higher  dose.  Histo-pathology  indicated that low dose administration of extract resulted that, all of tissue observed were in  good  and  normal  condition,  but  at  higher  dose  resulted  injure  of   muscle fibres  and  also  injure  of  nucleus  cells  of  heart  tissue  also  the  colour  of  liver tissue  was  brick  red  and  white  stain  manifestation  (because  the  damaged  of cells  and  accumulation  of  leucocytes).  Degeneration  and  congestive  sinus occurred  in  liver  tissue,  while  necrosis  and  protein  degeneration  formed  in kidney  because  of  glomerulus  membrane  damaged.  LD50 of Centella extract was  13.6  g/kg.  This  dose  indicated   that  Centella  extract   is   slightly   toxic (5 - 15 g/kg), so that it is suggested that if it was used in phyto-therapy had to be under supervision of an expert or specialist and administered in low dose and short period.Keywords : Centella  asiatica Linn;  extract;  acute  and  subchronic  toxicity;  anatomy pathology
Freeze drying and calcining hydrotalcite for improving acid neutralizing capacity Deny Puriyani Azhary; Sundani Nurono Soewandhi; Saleh Wikarsa
Indonesian Journal of Pharmacy Vol 21 No 1, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (523.754 KB) | DOI: 10.14499/indonesianjpharm0iss0pp54-58

Abstract

Acid  neutralizing  capacity  (ANC)  is  one  of  the  important  factor  on effectivity  determination  of  antacid  dosage  forms.  Antacid dosage forms have different values depend on their ANC.  The objective of this research was to modified physical and chemical properties of hydrotalcite which can increase its acid neutralization capacity.  Hydrotalcite was treated by freeze drying and calcination at different temperature 100, 200, 300, and 500°C. This hydrotalcite was characterized by X-Ray Diffractometer  (XRD)  and  Scanning  Electron Microscope (SEM); and was determined acid neutralization capacity. The results showed  that  acid  neutralization  capacity  of  hydrotalcite  increased  after  it  was freeze  dried and  calcined  at  200,  300  and  500  °C.  The  result  of  XRD  for  the hydrotalcite  calcined  at  200  °C  have  showed  the  lower  intensity  of  peaks, whereas the calcination at 300 and 500 °C were disappeared and appeared new peaks at different 2θ.Key words: Acid neutralization capacity, hydrotalcite, calcination, XRD, SEM
Bioaccumulation of poly-aromatic hydrocarbons in plankton, algae and fish in south sea waters in Jogjakarta Endang Lukitaningsih; Ari Sudarmanto
Indonesian Journal of Pharmacy Vol 21 No 1, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (322.381 KB) | DOI: 10.14499/indonesianjpharm0iss0pp18-26

Abstract

As  a  pollutant,  the  presence  of Poly  Aromatic  Hydrocarbons  (PAH)  in  the environment must be always monitored, because of their ability to spread widely through  the  food  chain  and  also  their  carsinogenic  properties.  The  solubility  of PAH  in  water  is  very  low,  therefore  it  is  difficult  to  analyze  their  presence  in water environment by using water as a sample. By utilizing the phenomenon of the  accumulation  of  PAH  in  biolipids,  the  analysis  method  has  been  developedusing  bioindicators.  In  this  research,  the  concentration  of  four  kinds  of  PAH (pyrene,  benzo(a)anthracene,  benzo(k)fluoranthene  and  perylene)  in  several samples  (water,  plankton,  algae  and  fish)  that  collected  from  the  south  sea Jogjakarta  has  been  determined. The bioaccumulation  factor  (BAF)  of  PAH  in each  sample  has  been  calculated  and  the  results  were  from  4498  to  432754; 2552  to  49265;  14156  to  730991,  respectively  for  plankton,  algae  and  fish. Based on the BAF values, plankton can be used as a bioindicator for short term PAH monitoring, while the Upeneus moluccensisfish primarily gills organ can be used as a bioindicator for medium term (months) PAH monitoring.Key  words  :  poly  aromatic  hydrocarbons,  bioaccumulation  factor,  bioindicator,  Upeneus moluccensis
Brand extensions’ influence on brand image : empirical study on Bodrex’sbrand Rokhman, M. Rifqi; ., Sampurno; S., Suci Paramitasari
Indonesian Journal of Pharmacy Vol 21 No 1, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (371.688 KB) | DOI: 10.14499/indonesianjpharm0iss0pp59-67

Abstract

Bodrex’s manufacturer is attempting to use Bodrex brand success to enter flu  and  cough  medicine  category  by  releasing  Bodrex  Flu  dan  Batuk.  The launching  of  Bodrex  Flu  dan  Batuk  will  affect  Bodrex’s  brand  image.  The objective of this research is to examine the influence of Bodrex Flu dan Batuk on Bodrex’s brand  image.  This  research  was  conducted  in  Yogyakarta  using purposive  sampling  method  on  respondents  that  have  been  using  Bodrex  for  6 months.  Data  were  collected  by  using  questionnaire  with  Likert  scale  that measured  initial  brand  image,  category  fit,  image  fit,  consumers’  attitude towards  brand  extension,  innovativeness,  and  final  brand  image.  Structural Equation Modeling  (SEM) application was  used  to analyse data.  Research result showed that brand extension has its effect on Bodrex’s brand image, in which its final  brand  image  was  affected  significantly  by  consumers’  attitude  towards brand  extension  (t-value  =  4.88)  and  initial  brand  image  (t-value  =  15.14). However, initial brand image (standardized solution = 0,88) has a larger role in final  brand  image  formation  than  consumers’  attitude  towards  brand  extension (standardized  solution  =  0.15).  Consumers’  attitude  towards  Bodrex’s  brand extension  affected  significantly  by  image  fit  (t-value  =  5.29),  category  fit  (tvalue = 1.99) and insignificantly by initial brand image (t-value = 0.49). The   result    also    showed   that  innovativeness  significantly  (t-value  =  -2.79) moderates  category  fit  relation  with  consumers  attitude  towards  brand extension.Key words: brand extension, brand image, Bodrex, innovativeness
Production of artemisinin in shoot cultures of Artemisia cinairradiated callus Aryanti .
Indonesian Journal of Pharmacy Vol 21 No 1, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (272.725 KB) | DOI: 10.14499/indonesianjpharm0iss0pp27-31

Abstract

Artemisinin  is  an  antimalaria  agent  that  is  only  found  in Artemisia  sp. medicinal  plant.  This  compound  is  occurred  at  very  low  level  in  that  plant. Irradiated callus of Artemisia cinahave been conducted by the dose of 40 Gy to improve  artemisinin content  in shoot  cultures.  Regeneration  of irradiated  callus to  shoot  cultures  formation  has  been  successful  in  Murashige  &  Skoog  (MS) medium  combined  with  Naphtalene  Acetic  Acid  (NAA)  1  mg/g,  Benzyl  Amino Purin (BAP) 2 mg/L and 15 % coconut water. Ten mutant lines of shoot cultures have  been  analyzed  for  the  artemisinin  content.  The  artemisinin  content  of mutant lines were higher than the original plant. The highest artemisinin content is  5  mg/g  found  in  mutant  line  number  404,  this  line  also  has  wider  leaf  area than original plant.Key word : artemisinin, Artemisia cina, shoot cultures, irradiated callus
Pharmacokinetic profile of carbamazepine and its metabolites on Javanese and Chinese ethnics in Indonesia Djojosaputro, Mulyadi; ., Sugiyanto; Hubeis, A. Aziz; Ismadi, M.
INDONESIAN JOURNAL OF PHARMACY Vol 21 No 1, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (418.066 KB) | DOI: 10.14499/indonesianjpharm0iss0pp1-7

Abstract

Carbamazepine  (CBZ)  is  an  anticonvulsant  widely  used  for  epilepsy treatment. However, it is difficult  to  establish suitable dosage  regimens  for  this drug because of the variation on its pharmacokinetics profiles. A lot of evidences indicate  that  ethnic  differences  may  affect  pharmacokinetics  and  hence  dosage requirements. The study was conducted to document pharmacokinetic profile of CBZ  and  its  metabolites  on  Javanese  and  Chinese  ethnics  in  Indonesia.  The study was carried out in 26 Javanese and 24 Chinese ethnics healthy volunteers, Blood  samples  were  collected  serially.  Carbamazepine  and  its  metabolites was  assayed  by  HPLC.  The  results  showed  that  no  significant  differences in  pharmacokinetic  parameters  were  observed  between  both  ethnics.  The values  of  AUC0-~, Cmax,  Tmax,  and  t1/2 CBZ  on  Javanese  ethnic  are  652.44  ± 254.79  µg/mL.h,  8.93  ±  3.58  µg/mL,  11.53  ±  2.16  h,  and  43.70  ±  12.50  h respectively,  while  on  Chinese  ethnic  are  830.27  ±  809.57  µg/mL.h,  13.29  ± 17.46  µg/mL,  9.97  ±  2,90  h,  and  41.27  ±  13.50  h,  respectively.  However,  a significant  interindividual  variation  in  CBZ  metabolism  was  observed  in  both ethnics  as  shown  in its  large  variation in metabolic  ratio.  The  metabolic  10,11-epoxide  CBZ  and  trans-10,11  CBZ  concentration  ratio  on  Javanese  ethnic are 0.07 ± 0.03 and 0.13 ± 0.14, while on Chinese ethnic are 0.35 ± 0.99 and 0.14  ±   0.11.   It  can  be  concluded,  that  the  Pharmacokinetic  of  CBZ  and  its metabolites  on  Javenes  ethnic  is  not  different  compared  to  Chinese  ethnic.  In addition, there  is  a  significant  interindividual  variation  in  pharmacokinetics profile on both ethnics.Key words: Carbamazepine, Javanese, Chinese, pharmacokinetics, epilepsy
The influence of mfp-implant on tissue pertinent changes of wistar rattus-rattus ., Widjijono
Indonesian Journal of Pharmacy Vol 21 No 1, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (487.78 KB) | DOI: 10.14499/indonesianjpharm0iss0pp48-53

Abstract

Fluoride  for  caries  prevention  if  consumes  for  a  long  period,  it  is sometimes  made  bored.  Normally, fluoride intake is uncontrolled and cause fluorosis.  Alternatively, implant fluor becomes the controlled method.  The study was  aimed  to  determine  the  influence  of  MFP-implant  on  tissue  pertinent changes  of  Wistar  Rattus-rattus.  The research subjects were Rattus-rattus mother of 20 rats (2 days pregnant).  Twenty  rats  were  divided  into  4  groups, namely  control  (K),  implant  P1,  implant  P2  and  implant  P3.  Subcutaneous implantation was done on rat back.  On the 8th day, euthanasia was done. Excission  was  done  surround  the  implant  tissue,  then  blocked  and  fixed  by formalin  buffer.  The specimen was cut along the implant tissue were examined by light microscope.  The data were analyzed by descriptive statistic.  The result showed that the incision was cured on the 5th – 7th day.  Tissue pertinent changes determination showed that there was lipid cell infiltration and relatively thicker of tissue on implant P3 and.  There was not any inflammation cell infiltrated and fibrous tissue. In conclusion, the infiltration of lipid cell on implant P3. The implant P2 was fulfilled the requirement of implant devices.Key words: MFP-implant, pertinent changes, rat
Hesperidin increase cytotoxic effect of doxorubicin in MCF-7 cells Hermawan, Adam; Meiyanto, Edy; Susidarti, Ratna Asmah
Indonesian Journal of Pharmacy Vol 21 No 1, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (514.522 KB) | DOI: 10.14499/indonesianjpharm0iss0pp8-17

Abstract

Hesperidin,  a  flavonoid,  shows  strong  cytotoxic  effect  in  several  cancer cell  lines.  The  aim  of  this  research  was  to  investigate  cytotoxic  activities  of hesperidin  alone  and  in  combination  with  doxorubicin.  Cell  viability  assay  of hesperidin,  doxorubicin,  and  combination  treatments  were  carried  out  by  using MTT  assay.  Apoptosis  assay  was  done  using  double  staining  method  using Ethidium  Bromide-Acridine  Orange.  Hesperidin  did  not  show  cytotoxic  effect but doxorubicin showed cytotoxic effect with IC50467 nM. Hesperidin (5, 50 and 100  µM)  increased  cytotoxic  effect  of  doxorubicin  compared  with  doxorubicin alone.  The  strongest  cytotoxic  activity  was  showed  by  the  combination  of  200 nM  doxorubicin  and  100  µM  hesperidin.  Combination  treatment  of  doxorubicin 200  nM  and  hesperidin  100  µM  induced  apoptosis  in  MCF-7 cells.  Hesperidin  is potentially  to  be  developed  as  co-chemotherapeutic  agent  for  breast  cancer, while molecular mechanism need to be explored.Key words: Hesperidin, doxorubicin, synergism, MCF-7, apoptosis 

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