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Synthesis Octyl p-Methoxycinnamate as Sunblock by Transesterification Reaction with the Starting Material Ethyl p-methoxycinnamate Suzana, .; Irawati, Nunuk; Budiati, Tutuk
Indonesian Journal of Cancer Chemoprevention Vol 2, No 2 (2011)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4.399 KB)

SynthesisÃÂ octylÃÂ p-methoxycinnamateÃÂ substanceÃÂ asÃÂ sunblock,ÃÂ hasÃÂ beenÃÂ doneÃÂ by transesterificationÃÂ reaction.ÃÂ TheÃÂ startingÃÂ materialÃÂ ofÃÂ theÃÂ reactionÃÂ wasÃÂ ethylÃÂ p-methoxycinnamateÃÂ isolatedÃÂ fromÃÂ KaempferiaÃÂ galangaÃÂ L.TheÃÂ transesterificationÃÂ reactionÃÂ was carried out by reactingÃÂ ethyl p-methoxycinnamate with octanol. The product was identified by UV-VIS,Infra Red and Mass Spectroscopy. The result of measurements on erythemic %T at various concentrations demonstrate that octyl p-methoxycinnamate is applicable as a sunblock compound. KeyÃÂ wordsÃÂ :ÃÂ octylÃÂ p-methoxycinnamate,ÃÂ transesterification,ÃÂ ethylÃÂ p-methoxycinnamate,ÃÂ sunblock

Synthesis, analgesic and anti-inflammatory activities of substituted benzoylthioureas Tutuk Budiati; Suzana .; Siti Surdijati
Indonesian Journal of Pharmacy Vol 21 No 1, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Three compounds (i.e. benzoylthiourea, 4-nitrobenzoylthiourea, and 4-chlorobenzoylthiourea) have been synthesized from ammonium thiocyanate, substituted benzoyl chlorides, and ammonia as starting materials. The structures of sythesized compounds were confirmed by means of ultra-violet, infrared, magnetic resonance, and mass spectroscopy. All compounds were evaluated for their analgesic and anti-inflamatory activities by tail-flick technique and carragenan-induced paw oedema test respectively. Substitution of p-NO2 and p-Cl group to benzoylthiourea increased the analgesic and anti-inflamatory activities. The two compounds, 4-nitrobenzoylthiourea and 4-chlorobenzoylthiourea, were significantly more potent as analgesic but their antiinflamatory actvity was weaker than Na-diclofenac.Keywords: benzoylthioureas, p-Cl dan p-NO2substituents, analgesic and anti-inflamator activities

REVITALISASI USAHA KECIL MENENGAH DHARMA BOGA BOJONEGORO MELALUI PELATIHAN CARA PRODUKSI DAN REGISTRASI PANGAN YANG BAIK SERTA HALAL Isnaeni; Noor Erma Nasution; Sugijanto; Hadi Poerwono; Juni Ekowati; Siswandono; Marcellino Rudyanto; Kholis Amalia Nofianti; Achmad Syahrani; Suzana
Panrita Abdi - Jurnal Pengabdian pada Masyarakat Vol. 5 No. 2 (2021): Jurnal Panrita Abdi - April 2021
Publisher : LP2M Universitas Hasanuddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/pa.v5i2.5754

Abstract. The independence of food supply in Indonesia is supported by the abundant diversity of natural ingredients from vegetable, animal and mineral sources. Compared to drugs, dependence on food products in other countries is relatively lower, because the fabrication requires facilities and infrastructure that can be fulfilled domestically. The regulatory system managed by the Republic of Indonesia Drug and Food Control Agency (BPOM-RI) has been implemented to ensure that food products consumed by the public are of high quality, nutritious, safe, halal, and affordable and with a taste that satisfies user communities. Circular-worthy products must at least meet the registration requirements of halal aspects, maximum microbial limits and chemical contamination. The growth of Micro, Small and Medium Enterprises (MSMEs) is also facilitated by the government. Dharma Boga is one of the Small and Medium Enterprises (UKM) in Klangon sub-district, Bojonegoro which is engaged in food production for more than 10 years. Some problems related to registration, halal certification and handling of production, especially food additives that meet requirements, has been communicated to the Community Service Team (PENMAS) Faculty of Pharmacy, Airlangga University (FFUA). Alhamdulillah, PENMAS activities with training materials on how to produce and register good and halal food have been carried out with satisfactory results, although it still needs to be followed up with a partnership for the MSME revitalization program in the future. Of the three parameters used to measure participants' understanding of training material, the average obtained more than 30% showed an increase. For the introduction of the halal logo and the dangers of formaldehyde, 100% of the message is understood. The training involved experts and stakeholders in the authority of the East Java Indonesian Ulama Council and the teaching staff and the Airlangga University Faculty of Pharmacy Testing Service Unit. Abstrak. Kemandirian penyediaan pangan di Indonesia didukung oleh diversitas bahan alam yang melimpah baik dari sumber nabati, hewani, maupun mineral. Dibandingkan obat, ketergantungan produk pangan pada negara lain relatif lebih rendah, karena fabrikasinya membutuhkan fasilitas dan infrastruktur yang dapat terpenuhi di dalam negeri. Sistem regulasi yang dikelola oleh Badan Pengawas Obat dan Makanan Republik Indonesia (BPOM-RI) telah diberlakukan untuk menjamin produk makanan yang dikonsumsi masyarakat berkualitas, bergizi, aman, halal, dan terjangkau serta dengan rasa yang memuaskan selera masyarakat. Produk yang laik edar minimal harus memenuhi persyaratan registrasi dari aspek halal, batas maksimum mikroba dan cemaran bahan kimia. Tumbuh kembangnya Usaha Mikro, Kecil dan Menengah (UMKM) juga difasilitasi oleh pemerintah. Dharma Boga adalah salah satu Usaha Kecil Menengah (UKM) di kecamatan Klangon, Bojonegoro yang bergerak dibidang produksi makanan selama lebih dari 10 tahun. Beberapa permasalahan terkait registrasi, sertifikasi halal dan penanganan produksi terutama bahan tambahan makanan yang memenuhi persyaratan, telah dikomunikasikan kepada Tim Pengabdian kepada Masyarakat (PENMAS) Fakultas Farmasi Univeritas Airlangga (FFUA). Alhamdulillah kegiatan PENMAS dengan materi pelatihan cara produksi dan registrasi pangan yang baik serta halal telah dilaksanakan dengan hasil yang memuaskan, walaupun masih perlu ditindaklanjuti dengan jalinan kerjasama untuk program revitalisasi UMKM di masa mendatang. Dari tiga parameter yang digunakan untuk mengukur pemahaman peserta terhadap materi pelatihan, rerata yang diperoleh lebih dari 30% menunjukkan peningkatan. Untuk pengenalan logo halal dan bahaya formalin, 100% peserta sudah paham. Pelatihan melibatkan pakar dan pemangku kewenangan dari Majelis Ulama Indonesia Jawa Timur dan para staf pengajar serta Unit Layanan Pengujian Fakultas Farmasi Universitas Airlangga.

Synthesis Octyl P-Methoxycinnamate as Sunblock by Transesterification Reaction with the Starting Material Ethyl P- Methoxycinnamate Suzana Suzana; Nunuk Irawati; Tutuk Budiati
Indonesian Journal of Cancer Chemoprevention Vol 2, No 2 (2011)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev2iss2pp217-221

Synthesis octyl p-methoxycinnamate substance as sunblock, has been done by transesterification reaction. The starting material of the reaction was ethyl p-methoxycinnamate isolated from Kaempferia galanga L.The transesterification reaction was carried out by reacting ethyl p-methoxycinnamate with octanol. The product was identified by UV-VIS,Infra Red and Mass Spectroscopy. The result of measurements on erythemic %T at various concentrations demonstrate that octyl p-methoxycinnamate is applicable as a sunblock compound.Keywords: octyl p-methoxycinnamate, transesterification, ethyl p-methoxycinnamate, sunblock

Pemanfaatan Iradiasi Gelombang Mikro pada Sintesis Metil orto-metoksisinamat Istna Nur’ainul Yaqin; Juni Ekowati; Kholis Amalia Nofianti; Suzana Suzana
Jurnal Sains Farmasi & Klinis Vol 8, No 2 (2021): J Sains Farm Klin 8(2), Agustus 2021
Publisher : Fakultas Farmasi Universitas Andalas

Tujuan penelitian ini adalah mensintesis senyawa metil orto-metoksisinamat (MOMS) yang terbukti berdasarkan uji in silico dapat digunakan mengobati penyakit kardiovaskular, yaitu sebagai antiplatelet. Sintesis MOMS dilakukan dari material awal asam orto-hidroksisinamat (AOHS) dengan metode iradiasi gelombang mikro dan membandingkan profil KLT selama proses reaksi sintesis pada tiga daya iradiasi gelombang mikro tersebut (120, 280 dan 400Watt). Reaksi yang digunakan adalah reaksi metilasi pada gugus OH asam karboksilat dan gugus fenolik dari senyawa AOHS dengan dimetil sulfat sebagai agen pemetilasi. Kondisi reaksinya diatur dalam suasana basa K2CO3 menggunakan pelarut aseton. Pengambilan sampel pada proses reaksi sintesis dilakukan setiap 30 detik pada masing-masing daya microwave dan dievaluasi noda yang terbentuk pada plat kromatografi lapisan tipis (KLT), dan dilanjutkan sampai reaksi sempurna. Hasil penelitian menunjukkan bahwa kesempurnaan reaksi semakin cepat dengan bertambahnya daya microwave. Prosentase hasil yang diperoleh 72%. Berdasarkan analisis senyawa menggunakan spektrofotometer FT-IR, spektrometer 1H-NMR dan 13C-NMR, disimpulkan bahwa reaksi sintesis senyawa MOMS dapat dilakukan dengan memanfaatkan iradiasi gelombang mikro, hal ini disebabkan adanya gugus polar pada AOHS yang dapat menyerap iradiasi gelombang mikro. Semakin tinggi daya yang digunakan pada reaksi metilasi AOHS, maka semakin cepat waktu yang dibutuhkan untuk kesempurnaan reaksi

Effect of para (p) position methoxy group on thesynthesis of Benzohydrazide derivatives from Methylbenzoate starting material Suzana Suzana; Erlina Ardhayanti; Kholis Amalia Novianti; Juni Ekowati; Tutuk Budiati
Berkala Ilmiah Kimia Farmasi Vol. 9 No. 2 (2022): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v9i2.42705

The synthesis of N'-benzylidenebenzohydrazide and N'-(4-methoxybenzylidene)benzo hydrazide had performed through condensation reaction. The reaction was performed in two stageswith methylbenzoate as the initial material. The firstphase was obtained benzohydrazide by reacting methylbenzoate and hydrazine hydrate, the second phase was obtainedthe compound of N'-benzylidenebenzohydrazide and N '-(4-methoxyibenzylidene)benzohydrazide by reacting benzohydrazide and benzaldehyde/4-methoxybenzaldehyde. The results were obtained respectively 87% and 92%. Puritytest was done by thin layer chromatography (TLC) and melting point. The melting point of benzohydrazide was 108-111oC. N'-benzylidene benzohydrazide m.p. 104-108oC and N'-(4-methoxybenzylidene)benzohydrazide m.p. 159-161oC.Identifications synthesized were confirmed by UV-VIS, FT-IR and 1H-NMR spectroscopy.

Peningkatan Pemahaman Pengelolaan Obat Keluarga dan Pangan Sehat untuk Anak sebagai Implementasi SDGS 3 di Bojonegoro: Increased Understanding of Family Medicine Management and Healthy Food for Children as Implementation of SDGS 3 in Bojonegoro Suzana Suzana; Juni Ekowati; I Nyoman Wijaya; Rosita Handayani; Siti Rahmah; Bambang Tri Purwanto; Dewi Melani Hariyadi
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 8 No. 4 (2023): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v8i4.4719

This service activity is motivated by efforts to maintain health after the Covid-19 pandemic. The community carries out preventive efforts by providing stocks of their medicines at home. The culture of storing medicines in the household requires proper drug management to prevent drug damage due to improper storage, drug use errors, and environmental pollution due to errors in handling damaged or expired drugs. The pharmacist's role is vital in providing drug management education to the community. Another preventive effort undertaken by the community is to maintain a healthy body by applying a diet where fast food currently contains a lot of Food Additives (BTP), which can threaten long-term public health. For this reason, people need to get an education directly, so they are wise in using BTP. The solution is to educate the public regarding managing household medicines and healthy food for parents and guardians of RA Al Manshur Play Group (KB) students in Bojonegoro. Activities are packaged in counseling methods and training/practice activities. The expected outcome of the activity is an increase in the understanding of guardian parents, as indicated by an average post-test score of >65 with an increase in score of >10% compared to the pretest. By increasing the understanding of parents and teachers about managing medicines and healthy food in the family, it is hoped that conditions of good health and well-being in society will be achieved.

Peningkatan Kualitas Produksi dan Keamanan Pemasaran Minuman Kesehatan Berbasis Bunga Telang pada Ibu PKK Kecamatan Rungkut Surabaya dalam mendukung SDGs-3 Good Health and Well Being: Improving the Quality of Production and Marketing of Telang Flower Based Health Drinks to PKK Women, Rungkut District, Surabaya in support of SDGs-3 Good Health and Well Being Juni Ekowati; Neny Prawitasari; Farida Ifadotunnikmah; Bastiana Bastiana; Mochammad Yuwono; Suzana Suzana; Julian Dwi Susanto; Angkasa Megistra Ulvan; Thalia Vanessa Hartono; Fawaz Shihab; Ryan Afandi; Albertus Aditya Setiawan; Winanda Rizki Febrianti
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 2 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i2.5984

To support SDGs-3 to achieve conditions of good health and well-being amidst the conditions of society, support is needed for resilient community groups who are economically creative. The residents of Penjaringan Sari Village are among the village residents who have won Surabaya SMART City 2020. They are an alternative tourist village developing a productive economy by selling processed drinks based on Telang flowers. However, in this community group, many problems still require assistance. Efforts need to be made to solve the problems of PKK women's partners in the Penjaringansari sub-district to improve production quality, starting from preparing raw materials, selecting and using packaging correctly, and increasing the diversification of partners' processed products and product branding. This activity aims to provide community service from a team of lecturers from the Faculty of Pharmacy, Airlangga University, in collaboration with lecturers from the Faculty of Medicine, Nahdatul Ulama University, Surabaya. This activity is a tri dharma of higher education where the community can feel lecture materials, research results, and previous community service products as partners in supporting SDGs-3 Good Health and Well-being. The outcome is an increase in participants' understanding, indicated by an average post-test score of 75, with an increase of 26% compared to the pretest. Apart from that, there is an increase in skills in making syrup and Telang flower powder drinks.

Pemanfaatan Iradiasi Gelombang Mikro pada Sintesis Metil orto-metoksisinamat Istna Nurâ€™ainul Yaqin; Juni Ekowati; Kholis Amalia Nofianti; Suzana Suzana
JSFK (Jurnal Sains Farmasi & Klinis) Vol 8 No 2 (2021): J Sains Farm Klin 8(2), Agustus 2021
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.8.2.157-163.2021

Tujuan penelitian ini adalah mensintesis senyawa metil orto-metoksisinamat (MOMS) yang terbukti berdasarkan uji in silico dapat digunakan mengobati penyakit kardiovaskular, yaitu sebagai antiplatelet. Sintesis MOMS dilakukan dari material awal asam orto-hidroksisinamat (AOHS) dengan metode iradiasi gelombang mikro dan membandingkan profil KLT selama proses reaksi sintesis pada tiga daya iradiasi gelombang mikro tersebut (120, 280 dan 400Watt). Reaksi yang digunakan adalah reaksi metilasi pada gugus OH asam karboksilat dan gugus fenolik dari senyawa AOHS dengan dimetil sulfat sebagai agen pemetilasi. Kondisi reaksinya diatur dalam suasana basa K2CO3 menggunakan pelarut aseton. Pengambilan sampel pada proses reaksi sintesis dilakukan setiap 30 detik pada masing-masing daya microwave dan dievaluasi noda yang terbentuk pada plat kromatografi lapisan tipis (KLT), dan dilanjutkan sampai reaksi sempurna. Hasil penelitian menunjukkan bahwa kesempurnaan reaksi semakin cepat dengan bertambahnya daya microwave. Prosentase hasil yang diperoleh 72%. Berdasarkan analisis senyawa menggunakan spektrofotometer FT-IR, spektrometer 1H-NMR dan 13C-NMR, disimpulkan bahwa reaksi sintesis senyawa MOMS dapat dilakukan dengan memanfaatkan iradiasi gelombang mikro, hal ini disebabkan adanya gugus polar pada AOHS yang dapat menyerap iradiasi gelombang mikro. Semakin tinggi daya yang digunakan pada reaksi metilasi AOHS, maka semakin cepat waktu yang dibutuhkan untuk kesempurnaan reaksi

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