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Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences
Published by Universitas Brawijaya
ISSN : 20875517     EISSN : 25274376     DOI : -
Core Subject : Agriculture, Social,
Agriculture, Biological Sciences & Forestry Environmental Science
The Journal of Tropical Life Science (JTLS) provides publication of full-length papers, short communication and review articles describing of new finding or theory in living system, cells and molecular level in tropical life science and related areas. The journal publishes articles that report novel findings of wide Tropical Life system phenomenon in the areas of biodiversity, agriculture, fisheries, health, husbandry, forestry and environmental technology. JTLS has 1 volume with 3 issues per year.
Arjuna Subject : -
Articles 14 Documents
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Search results for , issue "Vol 7, No 2 (2017)" : 14 Documents clear
Structural Stability of ADTC5 Peptide: Conformational Insights into Dynamics and Its Binding Mode Siahaan, Parsaoran; Prasasty, Vivitri Dewi; Simanjuntak, Bungaran David; Hildayani, Suci; Anam, Khairul
Journal of Tropical Life Science Vol 7, No 2 (2017)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.07.02.09

Abstract

The cyclic structure of ADTC5 (Ac-CDTPPVC-NH2) peptide is known has ability to modulate homo dimer E-cadherin interactions to form adherens junction at the intercellular junction.  The ability to inhibit E-cadherin interaction has become important to increase paracellular porosity in delivering drug molecules to the target cell. There are two types of ADTC5 state: opened-cyclic state (OCS) and closed-cyclic state (CCS). OCS of ADTC5 is affected by distance constraint and CCS is formed by disulfide bond from terminal cysteines through force restraint. The aim of this research is to investigate the inhibition activity of ADTC5 peptide upon E-cadherin. Here we used molecular docking and molecular dynamics approaches. The structure of ADTC5 peptide was generated by PyMOL program. GROMACS v4.5.5 was utilized to simulate molecular dynamics. The optimized ADTC5 molecule was placed in aqueous or polar condition at physiological pH. Furthermore, ADTC5 was docked with EC1-EC2 coupled domain of E-cadherin using AutoDock 4.2 and be refined using molecular dynamic (MD). The result showed that CCS ADTC5 peptide has stronger affinity and more stable interaction with EC1-EC2 coupled domain than the OCS one.
Ethnobotanical Study of Plants Used by People in Hiang Indigenous Forest Kerinci, Jambi Andesmora, Evan Vria; Muhadiono, Muhadiono; Hilwan, Iwan
Journal of Tropical Life Science Vol 7, No 2 (2017)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.07.02.02

Abstract

Indonesia is a high-abundance tropical forests country. It plays a very important role for world life because of its species richness than others. One of the forest resources in Indonesia is indigenous forests. Indonesia is rich of local wisdom such as that possessed by indigenous peoples. Indigenous peoples have a potential of the biological resources conservation. As a sustainable management tradition, communities around indigenous forest also have the efforts to preserve the forest.  The data collection of community knowledge about plants was conducted by interviews and direct-field observation. Data were analyzed using index of cultural significance. The results showed that there are 48 species of plants utilized by communities in Hiang Indigenous Forest, 27 species are used as firewoods, 15 species as building materials, 7 species as medicinal plants, 6 species as traditional handicraft ingredients and 4 species as secondary foods and traditional ritual materials. Most of widely-used plants by the community are Altingia excels, and Styrax benzoin is used as incense in a traditional ritual.
Population Study of the Golden Chicken Fern (Cibotium barometz (L.) J. Sm. in Riau Province, Sumatra Praptosuwiryo, Titien Ngatinem; Puspitaningtyas, Dwi Murti; Pribadi, Didit Okta; Rugayah, Rugayah
Journal of Tropical Life Science Vol 7, No 2 (2017)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.07.02.13

Abstract

Cibotium barometz (L.) J.Sm. (Cibotiaceae) is an important export commodity for both traditional and mod-ern medicine. Populations of this species in several countries have decreased rapidly due to the uncontrolled collection of the rhizome parts for medicinal purposes. Since 1976, this species has been included in Appendix II of the Convention on International Trade in Endangered Species (CITES). This means that no export is allowed without a prior permit issued by the CITES committee.  In order to utilize an endangered species sustainably, the global NDF (Non-Detriments Finding) system is applied for determining annual quotas. Therefore, monitoring and updating the inventory of C. barometz in its natural habitat should be carried out annually. A population study of C. barometz carried out in 2011 in Riau Province, Sumatra, is reported here. The aims of the study were: 1) to inventory C. barometz and determine its variation in Riau Province, Suma-tra, 2) to study the distribution and ecology of C. barometz, and 3) to assess the population size of this spe-cies by using random search methodology incorporating belt line transects. Two variants of C. barometz are recognized; they are the golden yellow and golden brown variants. C. barometz is distributed in eight loca-tions of Kampar District of Riau Province, in the secondary forest and rubber agroforest between 80 m and 600 m above sea level (asl). This species grows well in open to partially opened areas of secondary forest and rubber plantation in hills with a range of slope between 30° and 90°, with a relatively high humidity, 60 – 90%, in acid to nearly neutral soil, with a range of soil fertility from very poor to very humus rich soil.  The average population density determined in our study was 20 plants per 100 square meter. The highest popula-tion size was in the secondary forest of Bukit Kuda Beban at 590 – 600 m asl., viz. 9405 plants with a popula-tion density  of 47 plants per 100 square meter.
Prominently Increased of Mannose Binding Lectin (MBL) and Myeloperoxidase (MPO) Levels in Severe Valve Regurgitation and Heart Failure of Rheumatic Heart Disease Putri, Rachmania; Suwarniaty, Renny; Fitri, Loeki Enggar; Nugroho, Susanto; Rahman, Mohammad Saifur
Journal of Tropical Life Science Vol 7, No 2 (2017)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.07.02.04

Abstract

Rheumatic heart disease (RHD) is mediated by an abnormal immunological response following a Streptococcus pyogenes infection that induces a disturbance of oxidants and antioxidants balances. Mannose-binding lectin (MBL) binds to N-acetylglucosamine, a molecule present on the Streptococcus cell wall and human heart valves. There is a disturbance of oxidant and antioxidant balance in rheumatic disease. Myeloperoxidase (MPO) is a marker of oxidative stress and inflammation. This study was aimed to determine the correlation of MBL and MPO levels and severity of valvular regurgitation and heart failure (HF) in RHD patients. A case-control study was conduct using human peripheral blood samples from 32 children aged 6 to 14 years old. The subjects were divided into two groups: 16 RHD patients included in the case group and 16 healthy children as a control group. The level of MBL and MPO was investigated using ELISA method. There were significant differences on MBL and MPO level between patient and control group. The level of MBL and MPO were significantly increased in RHD group, especially on severe valvular regurgitation. There was a strong correlation between MBL and MPO levels and the severity of valvular regurgitation (r = 0.94 and r = 0.88). The least significant diff-erence (LSD) analysis showed that significant difference occurs in the severe heart failure group. Our research revealed that the MBL and MPO levels in pediatric RHD patients were significantly higher than in healthy children. The MBL and MPO levels were significantly correlated with the severity of valvular regurgitation and heart failure.

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