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Jurnal Kimia (Journal of Chemistry)

jchem
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Published by Universitas Udayana

ISSN : 19079850 EISSN : 25992740 DOI : 10.24843/JCHEM

Core Subject : Science,

Chemistry

Jurnal Kimia (Journal of Chemistry) publishes papers on all aspects of fundamental and applied chemistry. The journal is naturally broad in scope, welcomes submissions from across a range of disciplines, and reports both theoretical and experimental studies.

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 17 Documents

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Search results for , issue "Vol.13 No.2 Juli 2019" : 17 Documents clear

KOMPOSIT DEGRADABEL POLIETILENA TEREFTALAT DENGAN SELULOSA MENGGUNAKAN REAGEN FENTON (H2O2/Fe2+) I M. Trimastiya; I M. S. Negara; O. Ratnayani; I N. Simpen
Jurnal Kimia (Journal of Chemistry) Vol.13 No.2 Juli 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

PET is a non-degradable type of plastic that can cause environmental problems. This study aimed to form composites by cross-linking PET with cellulose using Fenton reagent initiator, finding out the effect of the addition of H2O2 on the fenton reagent used as an initiator in the mixture of PET-cellulose composites to water absorption and the rate of degradation in wet and dry soil media. The steps carried out in making PET-cellulose composites was refining PET using swelling techniques, followed by the formation of PET-cellulose composites by cross-linking through free radical reaction using fenton (H2O2/Fe2+) as the initiator with the variation of H2O2 amount (30 grams, 60 grams, 90 grams). The resulting composites were tested for water absorption and degradation properties in wet soil media and dry soil with untreated PET control. Characterization was carried out by functional group analysis using FTIR and its morphology with SEM. The results of the study showed that the composite making using the technique of cross-linking between polyethylene terephthalate and cellulose using fenton reagents was successfully carried out where the degradation rate of PET-cellulose composites slowed as the amount of hydrogen peroxide was used. In PET-cellulose composites, the more amount of H2O2 used, the weaker the absorption of the composite to water was. Keywords: degradable, fenton (H2O2/Fe2+), PET (Polyethylene Tephthalate), cellulose, composite.

SPESIASI DAN BIOAVAILABILITAS Pb DAN Cu DALAM TANAH PERTANIAN ORGANIK DI BEDUGUL SERTA KANDUNGAN LOGAM TOTALNYA DALAM SAYUR BROKOLI I M. Siaka; H. Nurcahyani; I B. P. Manuaba
Jurnal Kimia (Journal of Chemistry) Vol.13 No.2 Juli 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Bedugul area is a vegetable producing center in Bali that also develops organic farming. This study aimed to determine the bioavailability of Pb and Cu in an organic farm in Bedugul and the content of both metals in broccoli before planting and at harvest. Metal extraction was carried out through wet digestion and its bioavailability was determined by the application of the sequential extraction methods. The measurement of the two metals was accomplished by using AAS. The total Pb content in the organic soils before and after harvesting were found to be 746.102-897.3754 mg/kg and 277.778-328.88217 mg/kg, while Cu were of 93.1212-11-114.3259 mg/kg, and 48,608-92.3708 mg/kg, respectively. The bioavailability of Pb and Cu in soils before planting was different from that of at harvest. Pb metal in organic soil before planting which were readily bioavailable, bioavailable, and nonbioavailable were were found to be (17.80-21.62)%, (44.07-47.65)%, and (30.73-36, 89 )%, while Cu were of (5.02-7.89)%, (55.73-60.57)%, and (32.81-39.25)%, respectively. The total Pb and Cu contents in broccoli were of (27,2968-30,3621) mg/kg and (27,0303-30,0223) mg/kg, respectively. Keywords: bioavailability, broccoli, organic agriculture soil, Pb and Cu, speciation

MOLECULAR DOCKING AKTIVITAS ANTIKANKER DARI KUERSETIN TERHADAP KANKER PAYUDARA SECARA IN SILICO M. B. O. Rastini; N. K. M. Giantari; K. D. Adnyani; N. P. L. Laksmiani
Jurnal Kimia (Journal of Chemistry) Vol.13 No.2 Juli 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Breast cancer can be initiated by either overexpression of HER-2 protein which can induce dimerization and autophosphorylation so that it triggers the activation of Focal Adhesion Kinase (FAK) resulting in migration and metastasis in breast cancer cells. Quercetin which has another name 3,5,7,3 ', 4'-pentahydroxyflavon with the molecular formula of (C15H10O7) is a flavonoid compound which is very widely found in nature. The purpose of this study was to determine the mechanism of inhibition of overexpression of HER-2 proteins by quercetin compounds by in silico molecular docking. In silico molecular docking was carried out in several stages namely method validation, optimization of 3D quercetin compound structure, docking between quercetin compounds optimized with HER-2 protein based on bond energy parameters the lower the bond energy the stronger and the more stable the bond is. The results of docking expressed by the binding energy of quercetin compounds with HER-2 protein are -8.24 kcal / mol, while the energy of the native ligand bond with HER-2 protein is -10.45 kcal / mol. The bonding energy shows that quercetin compounds have the potential as breast anticancer because they can modulate the overexpression of HER-2 proteins. Keywords: quercetin, breast cancer, HER-2, in silico

AKTIVITAS DARI KUERSETIN SEBAGAI AGEN PENCERAH KULIT SECARA IN SILICO K. D. Adnyani; L. W. E. Lestari; H. Prabowo; P. A. I. A. Siaka; N. P. L. Laksmiani
Jurnal Kimia (Journal of Chemistry) Vol.13 No.2 Juli 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Increasing melanogenesis process causes excessive melanin synthesis resulting in darkening of the skin color. The melanogenesis process requires mealnogenesis enzymes, one of which is tyrosinase-related protein 1. One of the flavonoid compounds that has the potential as a skin lightening agent is quercetin. The antioxidant activity of quercetin plays a very important role in antimelanogenesis. This study aims to determine the affinity and molecular mechanism of quercetin on the target protein tyrosinase-related protein 1 using in silico molecular docking method. Molecular docking is carried out through stages including optimization of the structure of quercetin compounds, preparation of the target protein tyrosinase-related protein 1, validation of the molecular docking method, and docking of quercetin on the tyrosinase-related protein 1. Docking of quercetin with tyrosinase-related protein 1 produces binding energy values of -7.81 kcal/mol, while docking of native ligand with tyrosinase-related protein 1 produces binding energy values of -5.39 kcal/mol. Quercetin has a strong affinity for tyrosinase-related protein 1 which is indicated by the binding energy from the docking results. Quercetin has activity as a skin whitening agent with in silico test with molecular mechanisms through inhibition of the activity of tyrosinase-related protein 1 enzyme. Keywords: skin whitening agent, in silico, quercetin, tyrosinase-related protein 1

AKTIVITAS ANTI-RHEUMATOID ARTHRITIS DARI BRAZILIN DAN BRAZILEIN SECARA IN SILICO G. A. K. Amarawati; N. M. P. Susanti; N. P. L. Laksmiani
Jurnal Kimia (Journal of Chemistry) Vol.13 No.2 Juli 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Rheumatoid arthritis is an autoimmune disease that occur by inflammation chronic which persist as a permanent symptom. That inflammatory process caused joint destruction. Production of pro-inflammatory sytokin such as Tumor Necrosis Factor Alpha (TNF-?) stimulate an autoimmunity. Active TNF-? plays a role in the occurrence of chronic inflammation, in which the formation of active TNF-? is regulated by TNF-? Converting Enzyme (TACE). Brazilin and brazilein are known to have anti-inflammatory activity and immunommodulator potentially as anti-rheumatoid arthritis. The purpose of this study were to determine the affinity and mechanisms of brazilin and brazilein against TACE proteins as anti-rheumatoid arthritis perfomed using molecular docking method. The study was conducted exploratively with several steps such as databases preparation of 3D structures brazilin, brazilein, TACE protein, optimization of brazilin and brazilein 3D structures, protein preparation, molecular docking method validation, and docking brazilin and brazilein in these proteins. The docking results are assessed from the binding energy and hydrogen bonds formed between brazilin and brazilein in proteins. The smaller value to the binding energy, will made the bond between brazilin and brazilein with proteins will be stronger and more stable. The results showed that brazilin and brazilein have activities as anti-rheumatoid arthritis because they are able to inhibit TACE proteins with respective bond energy values -7,24 for brazilin and – 7,59 kcal/mol for brazilein. These results show that brazilin and brazilein have the potential to inhibit inflammatory process and joint destruction in rheumatoid arthritis. Keywords : brazilin, brazilein, in silico, rheumatoid arthritis

SUPLEMEN EKSTRAK DAUN SIRIH, Piper betle, Lin DALAM MENURUNKAN KADAR MALONDIALDEHID PADA TIKUS WISTAR I W. Suirta; I. A. R. A. Asih
Jurnal Kimia (Journal of Chemistry) Vol.13 No.2 Juli 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Betel leaf extract supplements, Piper betle Lin , was made by extracting maceration of betel leaves with ethanol 96%. Phytochemical screening of betle leaf extract obtained secondary metabolites such as : terpenoids, steroids, phenolics, and saponins . The results of the antioxidant activity test test showed that n-hexane fraction was more reactive as an antioxidant (IC50 26,73 mg/L) than the diethyl ether fraction (IC50 114,54 mg/L). The MDA analysis showed that the betel leaves have a very good ability to reduce MDA levels. The concentration of MDA with addition of allopurinol (as positive control) was 0,41±0,0021?L/mL, while with addition of betel leaves the level was 0,44±0,0021?L/mL. The structure identification obtained active antioxidant compounds such as: cavicol, eugenol, caryophilene and isoeugenol. Keywords : betel leaf, malondialdehyde, Piper betle, wistar rat

EFEK ANTIOKSIDAN FRAKSI ETIL ASETAT MINUMAN SINOM CAMPURAN JERUK NIPIS DAN MADU (curcuma domestica val-tamarindus indica L.) TERHADAP GULA DARAH TIKUS PUTIH SPRAQUE DAWLEY DIABETES MELITUS N. K. Wiradnyani; I M. M. Arimathea
Jurnal Kimia (Journal of Chemistry) Vol.13 No.2 Juli 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Sinom drinks mixed with lime and honey are made from rhizome of turmeric and young tamarind leaves which are added with lime juice and honey. The aim of the study was to determine the effect of antioxidant compounds of ethyl acetate on sinom drinks mixed with lime juice and honey (SCJM) various doses on fasting blood sugar spraque dawley (SD) white rats diabetes mellitus. Experimental research using RAK, ANOVA analysis with further BNT testing consisted of two stages: 1) test the antioxidant capacity of various solvents of SCJM yielding 29691.1 µg AAEAC / g ingredients namely the highest number of ethyl acetate fractions of n- hexane, chloroform, and water. Phase 2 Ethyl acetate fraction of SCJM was further tested in vivo to SD white rats with diabetes mellitus with various doses, namely: control (-) normal mice, 50, 100, 150, 200 mg/dl BW, control (+) of diabetic rats. The results of the study of the effect of the antioxidant compound SCJM ethyl acetate fraction of various doses significantly affected (p <0.01) in decreasing fasting blood sugar (GDP) white SD diabetes mellitus rats, a dose that can reduce the lowest GDP based on statistical tests is 150 mg/kg BW of rats, 168.4 mg/dl from other doses. Keywords: ethylacetate, blood sugar, antioxidant, sinom

SPESIASI DAN BIOAVAILABILITAS LOGAM BERAT Cu DAN Zn DALAM TANAH PERTANIAN ORGANIK DAN ANORGANIK N. W. B. S. Devi; I M. Siaka; K. G. D. Putra
Jurnal Kimia (Journal of Chemistry) Vol.13 No.2 Juli 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Agriculture in Indonesia generaly applies agrochemical to improve the quality and quantity of the products, but the impact is, both lands and their products could be contaminated by pollutans especially heavy metals. This study aimed to determine the total metals, speciation, and bioavailability of Cu and Zn in organic and inorganic agricultural soils in Blahbatuh District, Gianyar Regency. The sequential extraction method was performed to release the bonds of heavy metals in each soil component and the determination of the metal concentration was carried out using AAS. The total metals of Cu and Zn in both organic and inorganic soils indicated that both type of soils were still classified as uncontaminated soils because the metal contents were below the maximum limit allowed. The total contents of Cu and Zn in the organic soil were of 45.3922 mg/kg and 47.7645 mg/kg, respectively, while Cu and Zn in the inorganic soil were 48.9121 mg/kg ??and 49.9474 mg/kg, respectively. Fractination in the organic and inorganic soil EFLE (easly, freely,leachable, and exchangeable), reducible, oxidisable, dan resistant including F4> F3> F2> F1 for Cu and F4> F3> F1> F2 for Zn. The bioavailability of Cu and Zn in the organic soils were 10.52-23.79% and 3.79-7.21% bioavailable, 10.03-25.50% and 14.99-32.68% potentially bioavailable, 38.64-63.19% and 41.20- 60.28% non bioavailable, while in the inorganic soil and were 18.31-32.63% and 4.54-7.85% bioavailable, 9.86-13.85% and 15.26-32.55% potentially bioavailable, and 40.20-59.14% and 42.84-58.26% non bioavailable. Consuquenthy, both types of the agricultural soils would be safe for planting various types of rice. Keywords: bioavailability, Cu and Zn, speciation, agricultural soil

POTENSI EKSTRAK DAUN CENDANA (Santalum album L.) SEBAGAI SENYAWA PENGHAMBAT JAMUR Candida albicans K. Swandiyasa; N. M. Puspawati; I. A. R. A. Asih
Jurnal Kimia (Journal of Chemistry) Vol.13 No.2 Juli 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Diseases caused by C. albicans (C. albicans) such as mouth, skin and nail diseases are still commonly found in Indonesia. This study aimed to examine antifungal activity of n-hexane, chloroform, and n-butanol extracts of Santalum album (S.album) leaves in inhibiting the growth of C. albicans and to determine the minimum inhibitory concentration of the most active extract as well as to identify their active compounds. Antifungal activity testing was carried out using disc diffusion method and identification of active compound was performed using LC-MS /MS. Extraction of 1 kg sandalwood leaf powder with methanol yielded 86.80 gram of crude methanol extract. Partiiton 40 gram of the crude methanol extract with n-hexane, chloroform, and n-buthanol gave 12.60, 6.20 and 1.20 g of extracts respectively. The antifungal activity test results revealed that n-hexane extract was the most active in inhibiting the growth of C.albicans with inhibitory diameter of 13 mm as compared to chloroform 9 mm and n-buthanol 8 mm. The active n-hexane extract which is active as an antifungal is then made various variations to obtain a minimum inhibitory. The n-hexane extract, at concentrations of 95, 90 and 85% inhibited the growth of C.albican with inhibitory diameter of 12.04, 15.8, and 13 mm respectively. While at the concentarion of 80 % showed minimum inhibitory diameter of 9.32 mm. Based on analysis mass spectra of two peaks of LC-MS / MS chromatogram with MassLynx V4.1 programe and Chemspider web database suggested the presence of benzofurazan and picolylamine compounds which may contribute to the antifungal activityof n-hexane extract of S.album. Keywords: Sandalwood (Santalum album L.), antifungal, C. albicans, n-Hexane, LC-MS/MS

LAJU HIDROLISIS HEROIN DALAM AIR DAN PLASMA I M. A. G. Wirasuta; M. A. Ningtyas; E. I. Setyawan
Jurnal Kimia (Journal of Chemistry) Vol.13 No.2 Juli 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Heroine is hydrolyzed spontaneously in water and plasma. This will influence the determination, especially on the drug profiling. Spectrophotodensitometry has been used to analyze drug profiling of illicit heroine. This article reports the AL-TLC separation of heroine, 6-monoacetylmorphine (6-MAM), morphine, acetyl codeine, and the heroine hydrolysis in water and plasma. Heroin, 6-MAM, morphine, and acetyl codeine can be well-separated by mobile phase of toluene:siclohexane:diethyl amine (75:15:10, v/v). The limit of detection was 165.16 ng/spot and the limit of quantification was 550.55 ng/spot. Heroine was hydrolyzed in water and plasma under first order reaction. The rate of reaction was 0.55 min-1 in water with the half time reaction of 12.47 minutes. On the other hand the hydrolysis rate in plasma was slower with the half time of 16 minutes. Keywords : hydrolysis, heroin, water, TLC-spectrophotodensitometer

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Ni Putu Diantariani

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Program Studi Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Udayana Kampus Bukit Jimbaran, Jimbaran, Bali, Indonesia

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Home Page

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Contact Name Ni Putu Diantariani

Contact Email jurnalkimia@unud.ac.id

Phone +628123640424

Journal Mail Official jurnalkimia@unud.ac.id

Editorial Address Program Studi Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Udayana Kampus Bukit Jimbaran, Jimbaran, Bali, Indonesia

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Contact Name
Ni Putu Diantariani

Contact Email
jurnalkimia@unud.ac.id

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+628123640424

Journal Mail Official
jurnalkimia@unud.ac.id

Editorial Address
Program Studi Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Udayana Kampus Bukit Jimbaran, Jimbaran, Bali, Indonesia

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Kota denpasar,

Bali

INDONESIA